Pancreas disorder

This study tested a new insulin called icodec that is injected just once a week, compared to the standard daily insulin glargine, in 429 adults with type 2 diabetes. Participants received either the weekly or daily insulin for 6 months. The goal was to see if the weekly shot cont…

This study investigates whether a structured, personalized exercise plan—tracked with a smartwatch and supported by regular phone check-ins—can help control blood sugar, blood pressure, and weight gain in pregnant women with gestational diabetes, chronic hypertension, or obesity.…

This trial investigates whether adding antroquinonol (Hocena) to standard chemotherapy (nab-paclitaxel and gemcitabine) can safely treat people with metastatic pancreatic cancer that has not yet been treated. The study has two phases: first, finding the best dose, and second, che…

This study looked at whether children with cystic fibrosis (CF) who are taking CFTR modulator drugs and have regained normal pancreatic function can safely stop taking pancreatic enzyme replacement therapy (PERT). Seventeen children were followed for six months after stopping enz…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study tests whether giving the antibiotic vancomycin directly into the bone (intraosseous) during diabetic foot amputation works better than the standard IV method to prevent surgical site infections. It includes 40 adults with diabetes who need a below-knee amputation. Rese…

This study tests an experimental drug called NT-0796 in 176 obese adults, some with type 2 diabetes. Participants take the drug or a placebo alongside a reduced-calorie diet and increased physical activity for 6 months. The goal is to see if the drug helps with weight loss and re…

This trial investigates whether eating 100 grams of curd cheese daily as part of a personalized diet for 8 weeks can improve cholesterol levels, blood sugar, and body measurements in overweight adults aged 40 to 64. Participants are randomly assigned to either a curd cheese-suppl…

This study tests the long-term safety of an experimental oral drug called orforglipron in adults with type 2 diabetes whose blood sugar is not well controlled by diet, exercise, or other diabetes pills. Participants take the drug once daily for about a year, and researchers monit…

This completed trial tested whether daily omega-3 fish oil supplements can help maintain healthy blood vessels in the eyes of adults with type 1 diabetes. 82 participants took either a 1000 mg omega-3 capsule or a placebo for the study, with regular eye exams to monitor retinal c…

This study compares a new drug, HRS-7535, to an existing diabetes medication, dapagliflozin, in adults with type 2 diabetes whose blood sugar is not well controlled with metformin alone. The goal is to see if HRS-7535 works better at lowering blood sugar and body weight over 32 w…

This study tests a family-based behavioral program for youth aged 6-17 with type 1 diabetes who are overweight or obese, along with an overweight parent. The program focuses on healthy meal planning, food literacy, and family habits to improve weight and diabetes control. Twenty …

This pilot study tests whether dialectical behavioural therapy (DBT) — a type of talk therapy that teaches skills like mindfulness and emotion regulation — can help Indigenous youth with type 2 diabetes improve their quality of life and diabetes control. The study enrolls 20 yout…

This study tested two lifestyle programs for overweight or obese pregnant women to help them manage weight gain during pregnancy. One group received weekly group sessions on diet and activity, while the other got extra health information and classes. Researchers tracked weight ga…

This trial investigates whether changing how often and when people with type 2 diabetes eat can improve weight, blood sugar, and cholesterol. Over 12 weeks, participants follow one of three eating plans: a standard 6-meal diet, a 3-meal diet, or time-restricted eating (eating all…

This study tests a new procedure called ReCET that uses gentle electrical pulses to regenerate the lining of the small intestine. Combined with a diabetes drug (semaglutide), the goal is to help people with type 2 diabetes stop using insulin. The study involves 32 adults and comp…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study investigates whether drinking galactose before cycling can prevent low blood sugar (hypoglycemia) in people with type 1 diabetes. Fourteen participants will try four different drinks—dextrose, galactose, lactose, or a sweetened placebo—on separate days, then cycle for …

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tests a 6-week online group program designed to help African American women with type 2 diabetes reduce diabetes-related distress and improve blood sugar control. The program combines diabetes education, motivational interviewing, and cognitive behavioral therapy, deli…

This study tested a family-focused diabetes education program delivered in Marshallese faith-based organizations. Over 300 adults with type 2 diabetes and their family members took part. The goal was to see if group education in a familiar community setting could improve blood su…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This completed study tested whether a customizable texting program could help veterans with type 2 diabetes improve their blood sugar control. 366 veterans were randomly assigned to receive either standard daily diabetes texts or a more interactive version with check-ins, medicat…

This study tested a 12-week program where nurses provided diabetes education and support through video calls to 128 adults with type 2 diabetes in Thailand. Participants had uncontrolled diabetes and owned a smartphone. The program included an initial in-person session followed b…

This study tested whether giving adults with type 2 diabetes and food insecurity a small weekly incentive ($10.50 per household member) to buy healthy foods could improve their blood sugar control. 597 participants were randomly assigned to receive either the food incentive plus …

This trial tests whether giving intravenous thiamine (vitamin B1) alongside standard treatment helps people with diabetic ketoacidosis recover faster. Diabetic ketoacidosis is a serious condition where the blood becomes too acidic. The study includes adults hospitalized with this…

This study tested a 6-week diabetes self-management program for ethnic minority elderly (aged 60+) in rural Thailand. The program included weekly group sessions on diet, exercise, medication, and emotional coping, plus two home visits. Researchers measured changes in blood sugar …

This study tests whether an artificial intelligence system can safely and effectively adjust insulin doses for people with type 2 diabetes while they are in the hospital. About 144 participants will be randomly assigned to have their insulin doses set either by the AI system or b…

This study tested a new medicine called survodutide (BI 456906) to see if it helps people with overweight or obesity and type 2 diabetes lose weight. Over 750 adults received either the drug or a placebo injection once a week for about 76 weeks, along with diet and exercise advic…

This study tested an updated version of the Control-IQ system, which automatically adjusts insulin delivery for people with type 1 diabetes. Sixty-six adults and adolescents used the new software along with a continuous glucose monitor for several weeks. The main goal was to see …

This large study tested whether evolocumab (Repatha), a cholesterol-lowering injection, could reduce major cardiovascular events like heart attacks, strokes, or death in over 12,000 adults at high risk but without a prior heart attack or stroke. Participants received either evolo…

This study tested whether giving extra support to Black adults who don't lose weight early in a diabetes prevention program helps them lose more weight. Over 400 participants joined a 12-week program at churches or community centers. Those not losing weight early got extra phone …

This study tested an electronic glucose management system (eGMS) designed to help doctors decide insulin doses for hospitalized patients with type 2 diabetes. The trial compared the eGMS to the usual insulin ordering protocol in 140 patients. The goal was to see if the eGMS could…

This completed trial tested whether laser acupuncture could improve body shape index (ABSI) in 50 women aged 40-50 with uncontrolled type 2 diabetes and obesity. Participants received either real or sham laser acupuncture twice a week for 12 weeks, plus a low-glycemic diet. The s…

This study tests whether giving doctors a reminder and providing patients with a one-page handout can help women who had gestational diabetes or high blood pressure during pregnancy get a primary care visit within six months of delivery. The goal is to prevent future diabetes and…

This study looked at whether delivering healthy food to the homes of rural adults with type 2 diabetes and food insecurity could improve their blood sugar control and diet. Over 400 participants either received standard care alone or standard care plus free healthy food deliverie…

This trial tests whether a family-centered diabetes education program helps people with type 2 diabetes manage their blood sugar better than standard education. About 1,100 adults with type 2 diabetes and their family members take part. Participants are randomly assigned to eithe…

This study tested a mobile health tool called REACH-Español, which sends interactive text messages to help Latino adults with type 2 diabetes remember and take their medications. The trial included 70 participants who were at least 18 years old, identified as Latino or Hispanic, …

This trial compares two types of surgery for pancreatic cancer in the body or tail of the pancreas: minimally invasive (laparoscopic or robot-assisted) versus traditional open surgery. The goal is to see if the less invasive approach can remove the tumor just as completely. Adult…

This study tested whether a team of specialists—an endocrinologist, diabetes educator, and dietician—could help people with type 2 diabetes and heart disease control their blood sugar better than standard care. 169 patients were split into two groups: one received usual care from…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This study tested whether personalized dietary advice helps people with early-stage type 2 diabetes control their blood sugar better than standard advice or usual care. About 255 participants were split into three groups: personalized diet, standardized diet, or usual care. Resea…

This study tested whether taking two doses of sodium bicarbonate (baking soda) over 24 hours could reduce uric acid crystals in the urine of adults with type 1 diabetes. Uric acid crystals can harm the kidneys, so lowering them might help prevent diabetic kidney disease. The tria…

This study tested whether transplanting insulin-producing islet cells, along with immune-suppressing drugs, could safely prevent severe low blood sugar episodes in people with type 1 diabetes who don't feel warning signs. Ten participants received the transplant and were monitore…

This Phase II trial tested a combination of chemotherapy drugs (FOLFIRINOX) plus the blood pressure drug losartan, followed by proton radiation, in 50 people with locally advanced pancreatic cancer. The goal was to see if this approach could shrink tumors enough to allow complete…

This study tested whether adding mindful eating training to a low-carb diet education helps people with type 2 diabetes follow the diet better. About 125 adults were randomly assigned to get either diet education alone or diet education plus mindful eating sessions. The main goal…

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into…

This early-phase trial tested a new drug called RO7496353 combined with an immunotherapy (atezolizumab) and sometimes chemotherapy in 102 people with advanced lung, stomach, or pancreatic cancer. The main goal was to check safety and side effects. Researchers also looked at how t…

This trial tested a new treatment called EGFR BATs for people with advanced pancreatic cancer. The treatment uses a patient's own immune cells, armed with a special antibody, to target cancer cells. The study included 22 participants who had already received chemotherapy. The goa…

This study tested whether a smartphone app that lets people log their blood sugar readings at home can improve diabetes control. One hundred adults with poorly controlled type 2 diabetes used the app or continued usual care for 3 months. Researchers measured changes in HbA1c, a k…

This study tested a culturally tailored program called Together Overcoming Diabetes (TOD) for American Indian families in Ojibwe communities. Adult caregivers with type 2 diabetes and their youth (ages 10-16) worked with local health coaches to set health goals. The program inclu…

This completed study tested whether resveratrol, a natural compound found in grapes and berries, can improve blood vessel health and blood sugar control in people with type 2 diabetes. 48 adults took either a resveratrol pill or a placebo daily for 12 weeks. Researchers measured …

This study tested a new insulin called icodec that is injected just once a week, compared to standard daily insulin shots, in over 1,000 adults with type 2 diabetes who had never used insulin before. The goal was to see if the weekly shot controls blood sugar just as well as dail…

This pilot study tested whether a combination of phentermine and topiramate, two drugs used for weight loss, could help shrink uric acid kidney stones in obese people with type 2 diabetes or pre-diabetes. Nineteen participants were randomly assigned to receive the drug combo or c…

This study tested whether making U.S. dietary guidelines more culturally relevant for African Americans could improve diet quality and reduce type 2 diabetes risk. 63 overweight or obese African American adults with at least three diabetes risk factors attended weekly classes for…

This study tested whether adding a smartphone app with short videos on mental health, diet, exercise, and insulin adjustment to standard care could improve blood sugar control and birth weight in pregnant women with diabetes. Over 600 women participated. The goal was to see if th…

This study tested whether an educational mobile game could help children aged 7 to 14 with type 1 diabetes better manage their blood sugar. 76 children played the game alongside their usual care. Researchers measured changes in HbA1c (a long-term blood sugar marker) and how satis…

This early-phase study tested whether a single infusion of donor stem cells could help repair damaged blood vessels in 26 adults with type 2 diabetes and symptomatic heart disease. Researchers measured blood vessel function and looked for signs of repair in the lab. The goal was …

This study tested whether a special vacuum dressing (negative pressure wound therapy) helps wounds heal better after major leg amputations. 158 adults who had a leg amputation (not due to injury) took part. The goal was to see if this dressing reduces problems like infection, reo…

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to wo…

This phase 2 trial tested whether adding an immunotherapy drug called botensilimab to standard chemotherapy could help people with metastatic pancreatic cancer who had already progressed on a common chemo regimen (FOLFIRINOX). The study enrolled 81 participants and compared the c…

This study tested a new insulin called icodec, taken just once a week, against a standard daily insulin (degludec) in 588 adults with type 2 diabetes who had never used insulin before. Participants received either weekly icodec plus a daily placebo, or daily degludec plus a weekl…

This study tested whether using a continuous glucose monitor (CGM) helps adults with type 2 diabetes control their blood sugar better than traditional finger-prick testing. About 600 participants from two community health centers in China wore a CGM device for three 2-week period…

This study tested a new once-a-week injection called IcoSema, which combines insulin and semaglutide, against semaglutide alone in 683 adults with type 2 diabetes. The goal was to see if IcoSema improves blood sugar levels more effectively. Participants received weekly shots for …

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This study tested a new once-weekly injection called MET097 in 133 adults with obesity or overweight and type 2 diabetes. The goal was to see if it helps with weight loss and blood sugar control compared to a placebo. Participants received either the drug or a placebo for 28 week…

This study looked at 100 people with severe leg artery disease (including some with diabetes) who needed bypass surgery above the knee. Doctors compared using a man-made tube (Dacron or PTFE) versus the patient's own leg vein to reroute blood flow. The goal was to see which metho…

This Phase 3 study tested a new drug called IBI362 (mazdutide) against the well-known semaglutide in 349 Chinese adults with early type 2 diabetes and obesity. Participants received weekly injections for 32 weeks, with some continuing for an extra 24 weeks. The main goal was to s…

This early-phase trial tested a new type of vaccine made from a patient's own immune cells (dendritic cells) that are engineered to target a protein called WT1 found in many cancers. Ten people with advanced esophageal, pancreatic, ovarian, or liver cancer received six vaccines o…

This study tested whether dapagliflozin, a drug used for type 2 diabetes, can lower blood pressure in people who have received a kidney transplant. Fifty-two participants took either the drug or a placebo for 12 weeks. The goal was to see if the drug helps control blood pressure …

This study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …

This study tested two anti-inflammatory drugs (etanercept and alpha-1 antitrypsin) in 43 adults with severe chronic pancreatitis who had their pancreas removed and their insulin-making cells (islets) transplanted into the liver. The goal was to see if these drugs could protect th…

This study tested whether regularly removing blood (like donating blood) can lower iron levels and improve diabetes control and fatty liver disease. 132 adults aged 40-75 with prediabetes or diabetes took part. The treatment group gave blood several times, while the control group…

This study tested a new closed-loop system that automatically delivers both insulin and pramlintide to manage blood sugar in 33 adults with type 1 diabetes. Pramlintide slows digestion to prevent blood sugar spikes after meals. The system was compared to insulin alone. Researcher…

This study looked at how safe a new once-weekly insulin (insulin icodec) is during exercise and long periods without food in 30 adults with type 2 diabetes. Participants first took a daily insulin for a week, then switched to the weekly insulin for up to 14 weeks. The goal was to…

This study tested a new drug called MK-1200 in 13 people with advanced solid tumors, including stomach, esophageal, bile duct, and pancreatic cancers. The goal was to find safe doses and see if the drug could shrink tumors. The study is complete, but results are not yet available…

This study tests a new medicine called SHR-3167 against a standard insulin (insulin glargine) for people with type 2 diabetes. About 275 adults who are not on insulin yet, but take metformin (alone or with another diabetes drug), will receive either SHR-3167 or insulin glargine. …

This study tested a new once-weekly injection called IcoSema, which combines two diabetes drugs (insulin icodec and semaglutide), against daily insulin glargine in 485 adults with type 2 diabetes whose blood sugar was not well controlled on oral medications. The goal was to see i…

This early study tested a single injection of a new drug called ENT-03S in 49 people who were either obese but otherwise healthy, or had both obesity and type 2 diabetes. The main goal was to check safety and how the drug moves through the body. Participants were randomly assigne…

This study tested whether community health workers (trained members of the community) can help people with type 2 diabetes and food insecurity use a program that provides free fruits and vegetables. 104 Hispanic adults on Medicaid in Connecticut took part. The goal was to see if …

This study followed 543 adults aged 18-60 who had bariatric surgery at four hospitals in Norway. Each hospital used a different surgical method, allowing researchers to compare how well each approach helped with weight loss and type 2 diabetes remission. The goal was to find whic…

This study tested a smartphone app designed to help women with gestational diabetes manage their condition during pregnancy. The app was developed with input from patients in Nepal and aimed to support self-care like tracking blood sugar and lifestyle habits. Researchers enrolled…

This completed trial tested a new automated insulin delivery system called twiist in 307 adults with insulin-treated type 2 diabetes. The system combines an insulin pump, a continuous glucose monitor, and a smart algorithm to automatically adjust insulin. The main goal was to see…

This study tested whether eating all meals earlier in the day and getting bright light therapy at specific times can improve blood sugar control in adults with type 2 diabetes. Researchers measured blood sugar, insulin, and other health markers in 190 participants. The goal was t…

This study tested a new fully-closed insulin delivery system that automatically adjusts insulin based on activity and missed meals, compared to a standard hybrid system. 29 adults with type 1 diabetes used both systems to see which kept blood sugar in a healthy range more often. …

This study tested a next-generation automated insulin delivery system in 48 adults with type 2 diabetes aged 16–70. The goal was to see if the smart algorithm could keep blood sugar in a safer range, reducing both low and high blood sugar events. Participants used a continuous gl…

This completed Phase 3 study tested whether adding semaglutide to a new once-weekly insulin (insulin icodec) improves blood sugar control in 148 adults with type 2 diabetes. Participants first received insulin icodec alone for 26 weeks; those with still-high blood sugar then adde…

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This study tested three different diet plans in 108 overweight adults with type 2 diabetes to see which best improves blood sugar control. Participants followed either standard nutrition advice, a structured meal plan with special diabetes drinks, or that same structured plan plu…

This study looked at whether eating more dairy products (full-fat or low-fat) helps people with type 2 diabetes manage their blood sugar, weight, and heart health. 112 adults with type 2 diabetes who ate fewer than 3 servings of dairy per day were assigned to add either full-fat …

This study tested whether adding a smart, AI-powered insulin boost before meals could improve blood sugar control in adults with type 1 diabetes. Nineteen participants used either a standard automated insulin system or the same system with the AI boost during hotel stays and at h…

This completed study tested an oral supplement made from generally recognized as safe (GRAS) ingredients in 8 people with end-stage kidney disease. Two participants had not produced urine for 16 and 22 years. The goal was to see if the supplement could restore even a small amount…

This completed phase 1/2 trial tested an experimental drug called Y101D combined with standard chemotherapy (gemcitabine and nab-paclitaxel) as a first treatment for 71 people with advanced pancreatic cancer. The goal was to find a safe dose and see if the combo helps shrink tumo…

This study tested whether adding a Chinese herbal formula (QingyiHuaji) to standard chemotherapy helps people with stage IV pancreatic cancer live longer. About 305 adults with advanced pancreatic cancer were randomly assigned to receive either the herbal formula plus chemo or a …

This study looked at whether a dietary fiber called OptiFibre can help people with type 2 diabetes control their blood sugar and lose weight. About 80 adults with diabetes were observed for 3 months. The goal was to see if adding this fiber to their routine improved blood sugar l…

This study tested a device called VasQ that wraps around a surgically created blood vessel connection (fistula) used for dialysis in people with kidney failure. The device is designed to improve blood flow and reduce complications. 144 patients received the device and were follow…

This early-stage study tested an oral drug called LY3502970 in 68 adults with type 2 diabetes. The main goal was to check safety and side effects, while also measuring how the drug moves through the body and affects blood sugar. Participants took the drug or a placebo for up to 1…

This completed study looked at whether giving chemotherapy before surgery (neoadjuvant chemo) helps people with resectable pancreatic cancer live longer compared to having surgery right away. Thirty patients took part. The main goal was to see which approach leads to better overa…

This study looked at whether starting tirzepatide, a once-weekly injection for type 2 diabetes, before Ramadan helps people manage their blood sugar safely while fasting. 166 adults with uncontrolled diabetes who planned to fast took part. Researchers measured changes in blood su…

This study tested a smart insulin system called Control-IQ+ in 319 adults with type 2 diabetes who use insulin. The goal was to see if the technology helps control blood sugar better than standard care. Participants used the system for a period, and researchers measured changes i…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This early-phase trial tested two drugs together—pembrolizumab (Keytruda) and XL888—in 47 people with advanced gastrointestinal cancers like colorectal and pancreatic cancer that had spread or could not be removed. The main goal was to find the safest dose and check for side effe…

This study looked at whether gastric bypass surgery or the best medical care is more effective for obese people with poorly controlled type 2 diabetes. Researchers tracked 66 participants to compare death rates, weight loss, blood sugar control, quality of life, and costs. The go…

This completed phase 3 trial tested three doses of the oral drug HRS-7535 against a placebo in 284 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The main goal was to see if HRS-7535 could lower HbA1c (a measure of average blood …

This study tested a new magnetic device (MagDI System) that creates a connection between two parts of the small intestine without staples or stitches. The goal was to help adults with obesity and type 2 diabetes lose weight and control blood sugar. Twenty-seven participants recei…

This study tested a new drug called NIS793 added to standard chemotherapy for people with metastatic pancreatic cancer that has spread. The goal was to see if the combination could help patients live longer by reducing scar tissue in the tumor. About 511 adults with this advanced…

This phase 2 trial tested whether adding the drug veliparib to standard chemotherapy (FOLFIRI) helps people with metastatic pancreatic cancer live longer. 123 patients whose cancer had returned after initial treatment were randomly assigned to get FOLFIRI alone or FOLFIRI plus ve…

This completed study followed more than 3,200 Japanese adults with type 2 diabetes who were prescribed Ozempic (semaglutide) by their doctors. Over about 3 years, researchers monitored side effects and checked how well the drug controlled blood sugar and weight. The goal was to s…

This study tested whether applying a probiotic (Lactobacillus reuteri) directly into gum pockets, alongside standard deep cleaning, improves gum health in people with type 2 diabetes. Fourteen adults with moderate to severe gum disease and controlled diabetes took part. Each pers…

This study tested whether using activity trackers, text reminders, and short exercise videos could help people with type 2 diabetes reduce the time they spend sitting at work. Forty-six adults with type 2 diabetes who had mostly desk jobs took part. The goal was to see if these m…

This study tested whether a daily postbiotic capsule (a substance that helps good gut bacteria) could improve blood sugar control in adults with type 2 diabetes. 106 participants took either the postbiotic or a placebo for 12 weeks. Researchers also analyzed genetics and gut bact…

This early-phase trial tested whether adding a new drug called NP137 to standard chemotherapy (mFOLFIRINOX) is safe and could help shrink tumors in people with locally advanced pancreatic cancer that cannot be removed by surgery. 43 participants received the combination. The main…

This study looked at whether using epidural anesthesia (a numbing shot in the back) during pancreatic cancer surgery helps people live longer and stay cancer-free longer. About 540 adults having surgery for pancreatic cancer took part. The goal was to see if this type of pain con…

This study tested whether verapamil, a drug usually used for high blood pressure, can help preserve insulin-making cells in adults newly diagnosed with type 1 diabetes. 136 participants received either verapamil or a placebo for 12 months. The main goal was to see if verapamil co…

This study tested whether oat flakes containing β-glucan, a type of fiber, could help adolescents aged 12–18 with type 1 diabetes improve their blood sugar control, pancreatic function, and cholesterol levels. Sixty participants were randomly assigned to eat the oat flakes or a c…

This study tested whether taking a melatonin supplement (3 mg each night for 6 months) could improve sleep, thinking skills, and blood sugar control in 70 adolescents with type 1 diabetes. Half received melatonin and half received a placebo. The researchers measured changes in bl…

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with overweight or obesity lose weight. About 242 people took part, comparing the drug to a placebo over roughly one year. The main goal was to see how much weight they lost and how many lost at least 5% …

This study looked at 708 patients with a rare, low-grade pancreatic tumor called solid pseudopapillary neoplasm. Researchers compared a less invasive surgery that saves healthy pancreas tissue to a more extensive surgery that removes more of the organ. They also examined whether …

This study tested whether a daily probiotic capsule containing Lactobacillus johnsonii N6.2 is safe for adults with type 1 diabetes and whether it affects the immune system. 46 participants took either the probiotic or a placebo for 24 weeks. Researchers monitored blood counts, m…

This study tested whether a class of diabetes drugs called SGLT2 inhibitors can slow the progression of kidney disease in adolescents with type 1 diabetes. Researchers measured changes in urine protein levels and blood sugar control over 6 months in 86 participants aged 10-18. Th…

This phase 2 trial tested a combination of four chemotherapy drugs—irinotecan liposome, oxaliplatin, 5-fluorouracil, and levoleucovorin—in 41 Japanese adults with metastatic pancreatic cancer who had not received prior treatment. The goal was to see how well the drugs shrank tumo…

This study tested whether a mobile app helps elderly people (70+) with diabetes better control their blood sugar, maintain physical function, and improve quality of life. Sixty participants were split into two groups: one used the app, the other did not. The app was designed to b…

This study tested a personalized approach using custom-made shoes and inserts to prevent foot ulcers from returning in people with diabetes. 126 adults with a history of foot ulcers were followed for 12 months. The goal was to see if this tailored approach could reduce ulcer recu…

This study looked at whether a daily prebiotic supplement (Molkosan®) could improve blood sugar and other health markers in people with type 2 diabetes. Twelve adults took a low dose (20 ml per day) for 12 weeks. Researchers measured changes in glucose tolerance, insulin levels, …

This study looked at whether giving underserved patients with type 2 diabetes a continuous glucose monitor (CGM) plus monthly telehealth visits with a pharmacist helps them manage their blood sugar better. 46 adults with uncontrolled diabetes took part. Researchers compared those…

This small study tested a new tool called InsuLearn that helps people with type 1 diabetes calculate their insulin doses without needing to count carbohydrates. Seven adults on multiple daily injections used the tool for a day and were compared to their usual care. The goal was t…

This study tested whether adding two experimental drugs (TTX-030 and budigalimab) to standard chemotherapy could help people with metastatic pancreatic cancer live longer without their disease getting worse. 194 adults who had not yet received treatment for their advanced cancer …

This pilot study tested whether using an automated insulin delivery (AID) system for just 10 days can help people with type 2 diabetes safely adjust their long-acting insulin doses. 23 adults who already used insulin injections took part. The goal was to see if the device was saf…

This study tested whether a short period of intensive insulin therapy, followed by a combination of basal insulin, metformin, and vildagliptin, could help people with poorly controlled type 2 diabetes simplify their long-term treatment. The goal was to see if more participants co…

This study compared insulin injections and metformin pills in 60 pregnant women with gestational diabetes to see which is safer and more effective. Participants were randomly assigned to receive either insulin or metformin, and researchers monitored blood sugar levels and newborn…

This study tested whether adding pioglitazone to the standard two-drug therapy (metformin and empagliflozin) helps people with type 2 diabetes who still have high blood sugar. Over 600 adults took part in this Phase 3 trial. The main goal was to see if the extra drug lowers HbA1c…

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study tested a smartphone app called T2.coach that tracks diet, blood sugar, activity, and sleep, then uses machine learning to give personalized behavioral goals. About 280 adults with type 2 diabetes and high blood sugar used the app for 6 months alongside standard diabete…

This study looked at whether three different low-calorie diets could improve blood sugar and body composition in 120 shift workers who are overweight and have prediabetes or type 2 diabetes. Each diet had a different amount and timing of protein. The goal was to see which approac…

This study tested a phone-based program for 100 African Americans aged 50+ with poorly controlled type 2 diabetes. The program combined diabetes education and help with social needs like food or housing. Results aim to show if this approach improves blood sugar control and qualit…

This completed study tested whether lotus seed capsules could improve nerve health, blood sugar, and immune function in 60 people with type 2 diabetes and nerve damage. Participants took either lotus seed or placebo capsules for 9 months alongside their regular diabetes treatment…

This study tested whether adding a weekly semaglutide injection to a lower dose of insulin works as well as a higher dose of insulin alone for controlling blood sugar in people with type 2 diabetes who are overweight. About 573 adults took part for roughly 11 months. The goal was…

This study tested whether giving insulin as an extended bolus (over time) instead of all at once helps control blood sugar after high-fat, high-protein meals in teens with type 1 diabetes. Thirty teens using a closed-loop insulin pump ate a standardized breakfast and received eit…

This study tested a combination of three drugs (nivolumab, BMS-813160, and GVAX) in 22 people with locally advanced pancreatic cancer who had already received chemotherapy and radiation. The goal was to see if the treatment was safe and could help the immune system better attack …

This study tested whether an enhanced continuous glucose monitor (eCGM) linked to a decision-support system can help older adults (65+) with type 1 diabetes manage their blood sugar. The system automatically uploads glucose, insulin, and activity data to give personalized insulin…

This study tested a new self-learning bolus calculator that simplifies meal announcements for adolescents and young adults with type 1 diabetes using automated insulin delivery. Two participants used the system first in a hotel and then at home to see if it was safe and feasible.…

This study looked at how the diabetes drugs glyburide and metformin work in pregnant women with gestational diabetes. 177 women between 20 and 32 weeks pregnant took part. The goal was to find the right dose and understand how these drugs control blood sugar and improve insulin f…

This study tested whether resveratrol, a natural substance found in grapes and peanuts, could improve blood sugar control and kidney health in 60 teenagers with type 1 diabetes and early kidney damage. Participants took resveratrol tablets twice daily for 6 months. The study meas…

This study tested a combination of three chemotherapy drugs (paclitaxel protein bound, gemcitabine, and cisplatin) in 34 people with metastatic pancreatic cancer that had not been treated before. If the cancer got worse, a fourth drug (paricalcitol) was added. The goal was to see…

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This study tested whether GLP-1 receptor agonists, a type of diabetes drug, can improve heart function and reduce fat around the heart in 44 obese adults with type 2 diabetes. Participants received the drug BYETTA along with metformin. Researchers used MRI scans to measure heart …

This early-stage study tested a custom-made yeast vaccine designed to train the immune system to recognize and attack leftover cancer cells. Five adults with various cancers (like colorectal, breast, or lung) who had completed initial treatment received the vaccine. The goal was …

This study looked at whether giving diabetes patients who are at risk for food insecurity money to buy fruits and vegetables, along with nutrition education, can improve their blood sugar control and reduce emergency room visits. Over 2,000 adults participated, with one group rec…

This study tested whether taking a probiotic called Hafnia alvei HA4597 can help people lose more weight and control blood sugar better after gastric bypass surgery. 49 adults with obesity and type 2 diabetes took either the probiotic or a placebo twice a day for 90 days, startin…

This early-stage study tested a new drug called BI 765049, alone or combined with another drug (ezabenlimab), in 21 Asian adults with advanced solid tumors (stomach, colorectal, pancreatic, liver, head and neck, or lung cancer) that have a specific marker called B7-H6. The main g…

This study tested a visual injection site map to help people with diabetes rotate where they inject insulin. The goal was to reduce lipohypertrophy—lumpy fatty tissue caused by repeated shots in the same spot—and improve blood sugar control. 170 adults on insulin for at least six…

This study tested whether taking phytosterols (plant-based supplements) for 3 months can improve liver health, cholesterol, and insulin levels in people with nonalcoholic fatty liver disease (NAFLD). 27 participants took either phytosterol pills or a placebo. Researchers measured…

This study tested whether eccentric training (a type of exercise that lengthens muscles) done in a low-oxygen (hypoxic) chamber or with creatine supplements could improve blood sugar control, muscle strength, and fitness in people with type 1 diabetes. 28 adults with type 1 diabe…

This study tested a new once-weekly injection called UBT251 in 211 adults with type 2 diabetes. Participants received either UBT251, a placebo, or the existing drug semaglutide for 24 weeks. The main goal was to see how well UBT251 lowers blood sugar (HbA1c) and to find the right…

This pilot study tested a mobile app and wearable devices to give personalized diet and activity advice to 27 adults with type 2 diabetes or prediabetes. The goal was to see if the app could help them improve their blood sugar levels and make healthier food choices. The study als…

This small pilot study tested whether a remote digital care program (TELEDUC-DIAB) could help 10 teens aged 12-17 with poorly controlled type 1 diabetes. Participants used a monitoring platform and educational app alongside their usual care. The main goal was to see if their bloo…

This study looked at whether dapagliflozin, a diabetes medication, can improve how the heart uses sugar and blood flow in people with type 2 diabetes and stable coronary artery disease. 25 adults took either the drug or a placebo for 4 weeks. The goal was to see if the drug helps…

This phase 1 trial tested a personalized vaccine made from each patient's unique cancer mutations (neoantigens) combined with an immune booster (poly-ICLC) in 33 people with pancreatic cancer. The vaccine was given after standard chemotherapy, either before or after surgery. The …

This study tested a program to help teens and young adults (ages 16-25) with type 1 diabetes better manage their blood sugar. The program focused on supporting their independence and self-care. 113 participants took part to see if this approach could improve their long-term healt…

This study tested whether a probiotic called Lactobacillus johnsonii N6.2 is safe and affects the immune system in 30 children and teens with type 1 diabetes. The goal was to see if the probiotic could help preserve the body's ability to produce insulin by improving gut health. P…

This study looked at how well adults with obesity or complicated overweight could stick to different very low-calorie ketogenic diets (VLCKD) in a real-world clinic. Participants chose one of four diet plans, ranging from all-natural foods to all meal replacements, and followed a…

This study tested a new insulin delivery system called Tandem Freedom in 10 adults with type 1 diabetes. Participants used their usual system at home for a week, then switched to the new system in a supervised hotel setting. The goal was to check safety and how well it controls b…

This study tested whether giving Hispanic teenagers a Fitbit and sending them text messages could help them be more active and sleep better. The goal was to reduce their risk of type 2 diabetes. 43 teens aged 14-16 with obesity took part. The study measured how many teens joined,…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers like breast, ovarian, stomach, colorectal, brain, bile duct, or pancreatic cancer that had stopped responding to standard treatments. The goal was to see if the combo c…

This study tested whether a dietary supplement called phosphatidylserine can improve blood flow in people with type 2 diabetes. 36 adults took either the supplement or a placebo for 4 weeks. Researchers measured blood flow in the leg and arm to see if the supplement helped blood …

This study tested a wearable insulin pump system (Omnipod M) in 40 adults aged 18-75 with type 2 diabetes. The goal was to see if the system helps keep blood sugar in a safe range and reduces dangerous highs and lows. Participants used the system for 6 weeks, and researchers meas…

This study tested whether custom silicone toe orthoses (inserts) could reduce foot pressure and prevent pre-ulcerative lesions in people with diabetic neuropathy. Sixty participants with diabetes and foot deformities wore the orthoses for six months. The goal was to see if these …

This study tested an artificial pancreas system that learns a person's exercise patterns to prevent low blood sugar (hypoglycemia) during and after moderate exercise. Fifteen adults with type 1 diabetes used the system for about 4 months, comparing it to a standard version. The g…

This study tested whether helping people with type 2 diabetes address unmet basic needs—like food, housing, and safety—can improve their blood sugar control. About 473 adults on Medicaid received either a 6-month navigation program or usual care. The goal was to see if this suppo…

This study tested whether a continuous glucose monitor (CGM) that alerts nurses to high or low blood sugar can help surgical patients with diabetes keep their glucose levels in a safe range. About 200 adults with diabetes who had surgery wore the Dexcom G7 device for up to 10 day…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested a new insulin (22011) to see if it works as well as an existing insulin (Ryzodeg) for people with type 2 diabetes. About 414 adults in China took part. The goal was to compare blood sugar control and safety. Results suggest the new insulin is a similar option fo…

This study tested a new approach for people with type 2 diabetes: a once-weekly insulin injection (insulin icodec) combined with a flash glucose monitor, a small sensor worn on the arm that tracks blood sugar continuously. The goal was to see if this combination helps control blo…

This pilot study tested a wearable device that delivers low-intensity electric fields (TTFields) together with immunotherapy (atezolizumab) and two chemotherapy drugs (gemcitabine and nab-paclitaxel) in 84 people with metastatic pancreatic cancer who had not received prior treatm…

This study looked at whether keeping blood sugar very low (under 130 mg/dL) is better than standard control (130-180 mg/dL) for non-critically ill patients with diabetes in the hospital. Researchers tracked 600 patients for complications like death, severe low blood sugar, infect…

This early study tested a single dose of the drug rongliflozin in 32 Chinese adults with type 2 diabetes who had normal, mildly, or moderately reduced kidney function. Researchers measured how the drug moved through the body and how it affected blood sugar and urine glucose. The …

This completed study looked at two diabetes drugs, tirzepatide and sitagliptin, to see which one better prevents heart attacks, strokes, or death in people with type 2 diabetes and heart disease. Researchers analyzed data from over 49,000 patients. The goal was to learn how well …

This early-stage study tested a new medicine called ANG003 in 57 adults with cystic fibrosis who have trouble digesting food due to a lack of digestive enzymes. Participants took a single dose of the drug with a meal to see if it was safe and helped with digestion. The goal was t…

This early-stage trial tested a new drug, ProAgio, in 46 people with advanced solid tumors, including pancreatic cancer, who had already tried other treatments. The main goal was to find a safe dose and check for side effects. The study did not aim to cure the disease, but to con…

This pilot study tested a 12-week phone program for 60 African American women aged 40-64 with type 2 diabetes and multiple caregiving responsibilities. Half received extra support for their caregiving stress plus diabetes education, while the other half got standard diabetes educ…

This study tested a combination of four drugs (tadalafil, pembrolizumab, ipilimumab, and CRS-207) in 17 people with advanced pancreatic cancer that had worsened after at least one round of chemotherapy. The goal was to see if the combination was safe and could shrink tumors. The …

This study looked at whether testosterone therapy can improve bone health in men who have both type 2 diabetes and low testosterone. About 92 male veterans aged 35 to 70 took part. Researchers measured bone strength using special scans and blood tests over 12 months to see if tes…

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This completed Phase 3 trial tested a high 7.2 mg weekly dose of semaglutide (a drug already used for diabetes and weight loss) in 512 adults with obesity and type 2 diabetes. Participants received either the high dose, a lower dose, or a placebo, along with lifestyle counseling.…

This early study tested whether transplanting insulin-making islet cells could help people with type 1 diabetes who already had a kidney transplant. Only 3 patients took part, and they stayed on anti-rejection drugs. The goal was to see if the procedure was safe and could reduce …

This study looked at how well the TouchCare Nano automated insulin delivery system works for children and teens with type 1 diabetes in everyday life. Researchers tracked 76 kids aged 6 to 18 over six months to see if the system helped them spend more time with healthy blood suga…

This study looked at 781 adults with moderate-to-severe plaque psoriasis and metabolic syndrome (a cluster of conditions like high blood pressure and obesity). Researchers wanted to see if adding a lifestyle intervention (diet and exercise) to the drug Secukinumab (Cosentyx) impr…

This early-phase study tested a combination of three drugs (gemcitabine, capecitabine, and erlotinib) in 30 people with advanced pancreatic cancer that had already been treated. The main goal was to find the safest dose and understand side effects. This is not a cure, but aims to…

This study tested a combination of four drugs (paclitaxel protein bound, gemcitabine, cisplatin, and paricalcitol) given before surgery to people with pancreatic cancer that could or could not be removed. The goal was to see if the treatment could shrink tumors and improve surgic…

This study looked at whether a 12-week intensive lifestyle program focused on weight loss and diabetes control could improve diabetic peripheral neuropathy, a common nerve complication. Fifty adults with diabetes and a BMI between 30 and 45 took part. The program included diet, e…

This study tested whether eating more protein (1.5 grams per kilogram of body weight daily, instead of the usual 0.8 grams) could help older adults with type 2 diabetes prevent muscle loss and improve muscle function. Twenty-five participants followed either a high-protein or sta…

This study tested a new drug called FF-10502-01 in 106 adults with advanced solid tumors or lymphomas that had stopped responding to standard treatments. The goal was to find the safest dose and see if the drug could shrink tumors or slow disease progression. While not a cure, th…

This study tested a new investigational drug called CagriSema against a currently available medicine, tirzepatide, in over 1,000 adults with type 2 diabetes. The goal was to see which works better at lowering blood sugar and body weight. Participants received weekly injections of…

This study tested whether providing medically tailored meals (10 ready-to-eat meals per week for 6 months) plus phone-based lifestyle coaching could improve blood sugar control in adults with type 2 diabetes who also face food insecurity. 215 participants were randomly assigned t…

This phase II trial tested a combination of three chemotherapy drugs (nab-paclitaxel, cisplatin, and gemcitabine) in 42 people with metastatic pancreatic cancer that had not been treated before. The main goal was to see how many patients were alive after 12 months. The study also…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested whether empagliflozin, a diabetes medication, lowers blood pressure more than other diabetes pills in adults with type 2 diabetes and high blood pressure. 300 participants took either empagliflozin or another diabetes drug for 12 weeks. Researchers measured bloo…

This study tested a once-daily pill called orforglipron in 559 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The pill was compared to a placebo (a dummy pill) over about 54 weeks to see if it safely lowers blood sugar levels. Th…

This study tests a new, less invasive way to measure stomach acid using a small wireless capsule (SmartPill) that patients swallow. It compares the capsule's accuracy to the standard method, which involves a tube placed through the nose into the stomach. The study includes health…

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study uses machine learning to tell apart diabetic kidney disease from other kidney diseases in people with type 2 diabetes. Researchers analyzed data from over 2,200 patients across 14 medical centers to build a model that uses routine clinical and lab information. The goal…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study tested whether a PET scan using a tracer called 18F-FAZA can measure low oxygen levels (hypoxia) in pancreatic cancer. Hypoxia can affect how the cancer grows and responds to treatment. 48 adults with pancreatic cancer received the scan, and researchers also collected …

This completed Phase 3 trial tested a special PET-CT scan using a radioactive tracer called gallium-68 DOTATOC to find neuroendocrine tumors in the stomach, intestines, and pancreas. 69 adults with confirmed or suspected tumors received the scan. The goal was to see how accuratel…

This study looked at whether a 1-hour glucose test (using 50 grams of sugar) can accurately diagnose gestational diabetes, so pregnant women might not need the longer 3-hour test. Researchers analyzed results from 351 women with singleton pregnancies who had already completed bot…

This study tested a new rapid blood test (LumiraDx HbA1c) to see how well it measures blood sugar control in people with diabetes. Researchers compared it to a standard lab method in 177 adults. The goal was to see if the quick test is accurate enough for routine diabetes monitor…

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study tested a radioactive tracer called [68Ga]FAPI-46, used with a PET scan, to see if it can better detect pancreatic cancer cells. 63 adults with early-stage pancreatic cancer received the tracer before surgery. The goal was to see how well the scan matches the actual can…

This study tested a new device called LabPatch, a small patch worn on the arm that measures blood sugar levels continuously. Researchers compared its accuracy to standard lab tests and two commercial glucose meters. The study involved 30 adults with type 1 or type 2 diabetes to s…

This phase 1 trial tested a new radioactive imaging agent called 64Cu-DOTA-ECL1i to see if it can detect a protein called CCR2 in pancreatic tumors using PET scans. The study involved 69 adults with pancreatic ductal adenocarcinoma at various stages. The goal was to see if the sc…

This completed study tested whether a special laser technique called surface-enhanced Raman spectroscopy (SERS) can diagnose diabetes from a blood sample. Researchers analyzed blood from 52 people (healthy and diabetic) to see if the laser could tell them apart. The goal is to de…

This study tested two simple bedside tools—the Neuropathy Disability Score and Neuropathy Symptom Score—to screen for diabetic nerve damage. Researchers compared them to standard nerve tests in 228 adults with diabetes. The goal was to see if these easy-to-use tools could help de…

This study tested a new, noninvasive technique called magnetogastrogram (MGG) to measure the stomach's electrical activity without radiation. Researchers studied 22 people, including those with diabetes, gastroparesis, and other stomach conditions, to see if the test can tell nor…

This study tested a phone-based health coaching program for pregnant women with a higher body mass index. The goal was to help them gain a healthy amount of weight during pregnancy and prevent problems like gestational diabetes and later obesity in both mothers and children. Over…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study looked at two different exercise programs in 24 adults with prediabetes (higher than normal blood sugar but not yet diabetes). One group did short bursts of intense exercise (HIIT), the other did steady moderate exercise. Researchers measured changes in blood sugar, ch…

This study looked at whether giving low-dose blood pressure medication to people with high-normal blood pressure and other risk factors could prevent them from developing full-blown hypertension, diabetes, or heart problems. 690 participants aged 50-79 were given either telmisart…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested a diabetes prevention program adapted for American Indian men living on the Colville reservation. Overweight and obese men without diabetes took part in a culturally informed program aimed at weight loss and reducing diabetes risk. The trial enrolled 113 men and…

This study tested whether giving rectal indomethacin (an anti-inflammatory drug) along with extra fluids before an ERCP procedure could prevent pancreatitis, a painful complication. The trial included 60 patients who needed ERCP. The goal was to see if this simple, low-cost appro…

This study tested a six-month home-based exercise program using elastic bands to prevent frailty in 120 adults aged 50-85 with type 2 diabetes and chronic kidney disease. The program aimed to improve muscle strength and daily functioning. Researchers measured changes in frailty s…

This study looked at whether telling overweight East Asians their genetic risk for type 2 diabetes, combined with using a Fitbit, could encourage them to be more active. 355 participants aged 40-60 were split into groups: some got just a Fitbit, others got their genetic risk plus…

This pilot study tested a home-based lifestyle program for 7-to-10-year-old children living in rural areas. The program included activity packs, health coach sessions, and a resource toolbox to promote healthy eating and physical activity. Researchers measured changes in diet, fr…

This study tests whether a self-help app called MyDiaMate can reduce diabetes distress in adults with type 1 diabetes. Researchers are enrolling 660 participants across the Netherlands, UK, Spain, and Germany. The app aims to support mental health alongside usual care.

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This study looks at whether people with diabetes experience more pain after a second root canal treatment compared to those without diabetes. About 50 adults with a single-rooted tooth needing retreatment will take part. Pain levels and painkiller use will be tracked for a week a…

This pilot study tested a word game-based workbook to help people with diabetes learn about managing their condition, focusing on diet and carbohydrate control. 25 participants used the workbook during clinic visits or at home, completing puzzles and goal-setting exercises. The s…

This study tested custom-made insoles for people with diabetic foot to see if they improve balance and walking. Twenty-five participants aged 40 to 65 with early-stage diabetic foot issues were included. The insoles were designed using pressure measurements to offload high-pressu…

This study tests whether inhaling medical cannabis three times a day can safely reduce pain in people with diabetic peripheral neuropathy. 122 adults will receive either a low, medium, or high dose of THC or a placebo using a special inhaler. The main goal is to see if pain score…

This study tested whether a remote nutrition coaching program is practical and well-liked by people with pancreatic cancer who are undergoing chemotherapy. Forty participants were asked to complete online food questionnaires and attend coaching sessions over 12 weeks. The goal wa…

This study tested whether a 12-week Pilates program could improve erectile function in 60 men aged 40-60 with type 2 diabetes and erectile dysfunction. Participants did Pilates three times a week for 60 minutes each session. The study measured blood flow in the penis and used a q…

This study tested a group telehealth program called TREAT-ED for young adults aged 18-26 with type 1 diabetes. The program used video sessions led by a diabetes educator to teach self-management skills. The goal was to see if this approach could improve participation in diabetes …

This completed phase 1 study tested whether a weekly injection of retatrutide helps people with type 2 diabetes recover faster from low blood sugar (hypoglycemia). 80 participants on metformin and diet/exercise received either retatrutide or a placebo for 16 weeks. Researchers me…

This study investigates whether laughter yoga can lower stress and improve quality of life for pregnant women diagnosed with gestational diabetes. Participants will practice laughter yoga sessions that combine breathing exercises, clapping, and playful activities. The trial measu…

This study tested two local anesthesia techniques—intraseptal and periodontal ligament—in 120 adults with controlled type 2 diabetes who needed a tooth pulled. The goal was to see which method numbs better and how it affects blood pressure and heart rate. Results help dentists ch…

This study compared two devices used during a procedure called ERCP to remove stones from the pancreatic duct in people with chronic pancreatitis. One group used a basket first, the other a balloon first. The goal was to see which tool cleared more stones. A total of 104 adults w…

This study tested a smartphone app called SNAQ that estimates the carbohydrate content of a meal from a single photo. The goal was to see if using the app helps people with type 1 diabetes keep their blood sugar in a healthy range. 44 adults who already use an automated insulin p…

This trial investigates whether drinking coffee after pancreatic surgery can help the bowel start working again sooner. About 200 adults who had open pancreatic surgery will receive either regular coffee, decaf coffee, or water twice a day. The main goal is to see how quickly the…

This study tested whether semaglutide, a diabetes medicine, improves walking ability in people with type 2 diabetes and peripheral artery disease (narrowed leg arteries). About 792 adults received weekly injections of semaglutide or a placebo for 59 weeks. The main goal was to se…

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This study tested an investigational drug called ponsegromab in 187 adults with lung, pancreatic, or colorectal cancer who also had cachexia—a condition causing severe weight loss, loss of appetite, and fatigue. The goal was to see if ponsegromab could help patients gain weight a…

This study tested custom 3D printed insoles for people with diabetes who are at risk of foot ulcers. Thirty participants wore different types of insoles in a lab to see which ones best reduced pressure on the bottom of the feet. The goal was to improve foot health and mobility.

This completed study tested whether a continuous glucose monitor with predictive alerts (Dexcom G7) can reduce low blood sugar better than a standard alert monitor (Dexcom ONE+) in 11 adults with glycogen storage disease or congenital hyperinsulinism. Participants wore each devic…

This pilot study tested a scalp cooling device (Paxman) to prevent hair loss in 9 people with advanced pancreatic cancer receiving chemotherapy. The goal was to see if the cap could keep hair loss mild (less than 50% hair loss) and improve comfort. Results focused on hair preserv…

This study tested whether silkworm pupa tablets can improve nutrition and reduce frailty in people who had surgery for stomach, colorectal, esophageal, or pancreatic cancer. 120 participants took the tablets for 3 months. Researchers measured weight, frailty, muscle mass, and qua…

This study tested a program called PREP-DC that teaches teens and young adults with type 1 diabetes how to communicate better with their doctors and get ready for adult diabetes care. 52 participants aged 17-23 were split into two groups: one received the program, the other got s…

This early-stage study tested a new medicine called MK-2828 in 46 adults with type 2 diabetes. The main goal was to see if the drug is safe and well-tolerated. Researchers also measured how the drug moves through the body and its effect on a marker of inflammation (hsCRP). This i…

This study tested a program called T1DES designed to help Black young adults aged 18-30 with type 1 diabetes feel less stressed about their condition. Researchers wanted to see if the program was practical and could improve blood sugar levels and emotional well-being. The study i…

This study tested two ways to clean teeth and gums in 82 people with poorly controlled type 2 diabetes and severe gum disease. One method cleaned all teeth in one day (full mouth disinfection), while the other cleaned one quarter of the mouth at a time over four weeks. Researcher…

This pilot study tested a culturally tailored mindfulness program for 18 low-income, Spanish-speaking Latina pregnant women. The goal was to see if the program could reduce stress and improve markers of inflammation and blood sugar control. Participants were split into two groups…

This study tested a smart technology platform with a serious game for 200 adolescents with type 1 diabetes. The game was designed to help them build emotional and social skills, cope with their condition, and improve quality of life. Researchers measured changes in well-being, em…

This study tested a new insulin dosing calculator for adults with type 2 diabetes when they are admitted to the hospital. The goal was to see if the calculator helps control blood sugar without causing dangerously low levels. Thirty-eight participants received their initial insul…

This study tested whether a special type of lighting, called a tailored lighting intervention, could help people with mild to moderate Alzheimer's disease and type 2 diabetes sleep better and improve their metabolism. Sixty-one participants living in assisted living or nursing ho…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested problem-solving therapy (PST) for adults with type 2 diabetes or heart disease who also have poor mental well-being. PST is a structured talk therapy where patients list their problems, weigh solutions, and take action. The trial involved 147 patients in general…

This study tested a culturally tailored education and support program called T1DES for Black young adults aged 18-30 with type 1 diabetes. The goal was to see if the program could reduce diabetes distress and improve blood sugar control. Forty-three participants received either s…

This pilot study tested a mindfulness-based diabetes education program for adults with type 2 diabetes who feel overwhelmed by their condition. Thirty-six participants were randomly assigned to either the mindfulness program or standard diabetes education. The main goal was to se…

This study tested whether a web-based self-management program is feasible and acceptable for people with chronic pancreatitis who have ongoing abdominal pain. Thirty-one participants were given access to a tailored website with pain management modules over 12 weeks. The goal was …

This study tested a 7-session anti-stigma psychoeducation program for adults with Type 1 diabetes. The goal was to see if it could reduce feelings of stigma and improve quality of life. 36 participants completed the program and were compared to a group that did not receive it. Re…

This study tested whether a special set of exercises, called modified Otago exercises, could help people with type 2 diabetes who have nerve damage in their feet. 38 participants did these exercises for 8 weeks, and researchers measured their balance, joint position sense, blood …

This study looked at whether exercising in the morning or evening helps control blood sugar better in pregnant women with gestational diabetes or glucose intolerance. 39 women walked or stepped for 30 minutes either after breakfast or after dinner. The researchers measured blood …

This study tested whether personalized text messages could help young adults with type 1 diabetes feel more confident managing their condition as they moved from pediatric to adult care. 234 participants received either usual care or usual care plus a text messaging program. The …

This study tested a procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) to treat pain in 19 people with advanced pancreatic cancer that could not be removed by surgery. The goal was to see if zapping the celiac ganglion—a bundle of nerves—could reduce …

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study tests how well a dummy patch pump (with no electronics or medicine) sticks to the skin of 175 adults with insulin-requiring diabetes. The goal is to see if the adhesive can stay on for 5 to 7 days in different body locations. The results will help design a future comme…

This study investigates whether type 2 diabetes changes the levels of key growth factors and inflammatory markers in Albumin Platelet-Rich Fibrin (Alb-PRF) membranes—a blood-derived material used to support wound healing and dental tissue repair. Researchers will compare Alb-PRF …

This completed study looked at how to best find and manage tumors in people with Zollinger-Ellison syndrome, a rare condition that causes too much stomach acid. Researchers used imaging tests and tissue samples to locate tumors and check for a related genetic condition called MEN…

This study looked at whether having a special consultation with a radiotherapy technician (called a manipulator) helps cancer patients feel more informed about their treatment. Researchers enrolled 308 adults with various cancers who were getting radiation therapy. They compared …

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study investigates whether exercising in the morning versus the afternoon changes how the body handles blood sugar and burns fat in people with type 1 diabetes. Twelve adults with type 1 diabetes will do one hour of moderate exercise at 9 AM and another session at 4 PM on se…

This study investigates why athletes with type 1 diabetes often experience higher blood sugar during competitions compared to regular training. Researchers will monitor 12 athletes with type 1 diabetes and 12 healthy athletes during a 5K race and a 5K training session, measuring …

This study tested whether training healthcare providers to prescribe continuous glucose monitors (CGMs) increases their use among patients with type 2 diabetes. Researchers trained clinic staff at three community health centers serving a mostly Hispanic/Latino population. They th…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This study tests French versions of three questionnaires that measure fear of low blood sugar (hypoglycemia) in children with type 1 diabetes and their parents. The goal is to ensure these tools are reliable for French-speaking families. About 194 children aged 2 to 18 and their …

This study looked at how the heart fills and pumps blood when the body is tilted or exposed to lower body pressure. Researchers compared 30 people with type 1 diabetes and healthy volunteers. They used heart monitoring and ultrasound to measure changes, aiming to understand how d…

This study reviewed medical records of 148 adults admitted to the ICU with severe acute pancreatitis. The goal was to find risk factors for infected pancreatic necrosis, a serious complication that raises the risk of death. By identifying these factors, doctors hope to diagnose a…

This observational study investigates whether a substance in the blood called nociceptin is linked to overactive nerves in people who have both type 2 diabetes and metabolic fatty liver disease. Researchers will compare 50 patients with both conditions to 50 healthy volunteers, m…

This study analyzed health records of over 118,000 adults with obesity, type 2 diabetes, and related heart, kidney, and liver conditions. Researchers compared people who added a second type of diabetes drug (GLP-1 or SGLT2) early to those who did not. The goal was to see if early…

This study looked at 347 children and teens with type 1 diabetes who use the Medtronic MiniMed 780G insulin pump. Researchers tracked how much carbohydrate they ate each day and measured their blood sugar control over time. The goal was to understand the link between daily carb i…

This completed study looked at how well Danish hospitals followed official guidelines for managing blood sugar in people with diabetes who had major, non-cardiac surgery. Researchers reviewed records from over 13,000 patients treated between 2017 and 2023. They focused on whether…

This completed study at Northwestern University brought together 35 patients, caregivers, and healthcare providers to discuss how to improve the identification and management of high blood sugar (hyperglycemia) and diabetes during hospital stays and when moving between care setti…

This study tested whether an online diabetes self-management program could help newly diagnosed adults with type 2 diabetes learn about their condition and improve health measures. 123 participants were split into online education, face-to-face education, or a no-education contro…

This study tests whether a lifestyle program held at senior centers can help older adults (age 60+) with type 2 diabetes improve their physical function and quality of life. About 20 participants will take part in the program, which includes education and activity sessions. The m…

This study creates a registry of adults with pancreatic exocrine insufficiency (PEI), a condition where the pancreas does not produce enough enzymes to digest food properly. Researchers at eight specialist centers across Europe will track how doctors prescribe pancreatic enzyme r…

This study analyzed health records from over 450,000 adults with obesity and type 2 diabetes to see if adding a GLP-1 or SGLT2 drug early improves survival and kidney health. Researchers compared those who added the other drug class within 90 days to those who added a different d…

This study investigates whether stress hormone activity is linked to depression and brain changes in children with type 1 diabetes. Researchers will measure cortisol levels and use brain scans in children aged 6–12 who have had diabetes for at least a year, comparing them to thei…

This observational study investigates the role of hormonal and metabolic disorders in the development of gestational diabetes mellitus (GDM). Researchers are analyzing data from over 600 pregnant women to identify risk factors and markers that could predict adverse outcomes for b…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study checked how well two continuous glucose monitors (Dexcom G6 and FreeStyle Libre) work when oxygen levels are low. Thirty people with type 1 or type 2 diabetes took part. Researchers compared sensor readings to blood tests during controlled low-oxygen conditions to see …

This study follows up on 370 mothers and their children who were part of a larger trial testing metformin for gestational diabetes. Researchers want to see if taking metformin during pregnancy reduces the risk of diabetes, obesity, and heart problems in mothers up to 10 years lat…

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study analyzed health records from nearly 195,000 people in Denmark, Sweden, and Norway to see if semaglutide (the drug in Ozempic and Rybelsus) is linked to a higher risk of pancreatic cancer. Researchers compared new users of semaglutide to new users of other diabetes medi…

This study looked at 58 patients scheduled for pancreatic surgery due to suspected cancer. Researchers collected blood samples before and after surgery to measure immune function and inflammation. They then tracked complications like low blood pressure and infections. The goal wa…

This study reviewed medical records of 500 adults treated for benign or malignant pancreatic and stomach diseases from 2005 onward. Researchers looked at overall survival after various treatments. The goal was to understand real-world outcomes, not to test a new drug or procedure…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This study tested whether a special fiber supplement changes intestinal gas production over 36 hours in 29 adults. Participants included lean healthy people and those with insulin resistance or prediabetes who were overweight. Researchers measured gas levels, energy use, and gut …

This completed study observed 40 people with type 2 diabetes to find blood markers that could identify those at risk for a serious liver condition called NASH. Researchers measured liver stiffness and calculated scores like FIB-4 and ELF to see which patients might have liver sca…

This early-stage study tested different oral versions of the drug AZD5004 in 65 healthy adults. The goal was to see how the body absorbs and processes each version, and whether taking it with food changes those effects. The study is complete, but results are not yet available.

This completed study took small tissue samples from the colons of 40 people during routine colonoscopies. Using advanced genetic techniques, researchers created a detailed map of the different cell types and their gene activity. The goal is to better understand how colon diseases…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This completed study followed over 1,000 children with newly diagnosed type 1 diabetes and their healthy siblings for up to three years. Researchers collected genetic information, measured diabetes-related antibodies, and asked about environmental exposures. The goal was to build…

This study analyzed health records from nearly 75,000 people with type 2 diabetes in Hungary to see if different diabetes medications are linked to cancer risk. Researchers compared various drugs, including metformin, and adjusted for age, gender, and other health factors. The go…

This study tested whether an educational video and action plan, called 'Prepare for Your Diabetes Care,' could help older adults (75+) with type 2 diabetes reduce their risk of dangerously low blood sugar. Over 12 months, 669 participants were randomly assigned to receive the int…

This study looked at how a diabetes medicine called ertugliflozin affects fat tissue around the heart. Researchers took fat samples from 61 adults with type 2 diabetes and heart disease during heart surgery. They tested the fat in a lab to see if the drug improved how the fat cel…

This completed study in India looked at 362 hospital patients to understand how common high blood sugar (hyperglycemia) is and how it affects their hospital stay. Researchers measured blood sugar levels, checked for diabetes, and looked at body composition and certain blood marke…

This study looked at how gut bacteria affect the development of type 2 diabetes and help personalize treatment. Researchers followed 100 adults newly diagnosed with type 2 diabetes who had not taken diabetes medication before. They analyzed stool samples and blood tests, then ass…

This study looked at how a new insulin (NNC0363-1063) interacts with a non-glucose carbohydrate (a type of sweetener) in 36 adults with type 1 diabetes. Participants received fixed doses of the insulin and different amounts of the carbohydrate in random order over 4 tests. The go…

This completed study looked at risk factors for diabetes and heart disease in 146 healthy African, African-American, and white women who were federal employees or contractors. Researchers compared things like triglyceride levels and insulin resistance to see if the best screening…

This completed study looked at 1759 adults aged 18-55 to uncover why some people develop type 2 diabetes. Researchers measured how the body handles sugar, uses energy, and stores fat, and also collected genetic samples. The goal was to find genetic and lifestyle factors that lead…

This long-running study follows over 12,000 people from the Gila River Indian Community in Arizona to understand why type 2 diabetes develops and how it leads to complications. Participants receive regular check-ups every two years, including blood tests and physical exams. The g…

This study looks at how type 2 diabetes affects young people aged 12 to 25. Researchers want to see if giving the pancreas a 2-week rest with insulin shots can improve its ability to make insulin. Participants take metformin, follow a diet, and some also get insulin. The study al…

This study looked at how different ways of taking a blood sample from a finger affect blood sugar readings in people with diabetes. Researchers compared the first and second drops of blood, and also tested with and without squeezing the finger. The goal was to find the most accur…

This study looked at whether a 15-20 minute educational program helps pregnant women decide to take a glucose test for gestational diabetes. 199 women between 24-28 weeks of pregnancy took part. Half got standard advice, the other half got a structured video and guidebook. The re…

This study tested whether a special heart ultrasound (speckle tracking strain echocardiography) can detect early heart muscle changes in 61 adults with type 1 diabetes, before symptoms appear. Researchers looked for links between these changes and small blood vessel damage (micro…

This completed study looked at 238 people who received a pancreas and kidney transplant for type 1 diabetes. The goal was to understand why diabetes sometimes returns even after a new pancreas is working. Researchers checked for immune system markers, like antibodies and T cells,…

This completed study tested a 4-week group program designed to boost confidence (self-efficacy) in managing type 2 diabetes. Sixteen adults from primary health centers in Indonesia took part. Researchers measured changes in self-care behaviors and self-efficacy using questionnair…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study checks if a program called COPE helps Navajo people with diabetes and related health problems. The program uses community health workers to support patients and connect them with doctors. Researchers compared nearly 29,000 people who took part in COPE with those who di…

This study looked at how quickly bringing high blood sugar under control, combined with moderate treadmill walking, affects certain proteins linked to bone health in people with type 2 diabetes. The goal was to understand why some patients develop a rare but serious joint conditi…

This study looked at 295 adults with type 2 diabetes in Kharga City, Egypt, to see how many also had other conditions like high blood pressure, heart disease, kidney disease, or eye problems. Researchers used blood tests, urine tests, and heart tracings to check for these issues.…

This study looked at the genes of 40 adults with type 2 diabetes to find DNA differences that might explain why some develop Charcot foot, a serious joint problem. Half of the participants had Charcot foot, and half did not. Researchers compared their exomes (the part of DNA that…

This study looked at how a single dose of HR17031 moves through the body in people with mild, moderate, severe, or end-stage kidney disease compared to those with normal kidneys. A total of 24 adults with type 2 diabetes took part. The goal was to understand how kidney function a…

This early-stage trial tested the safety and how the body processes a new drug called HR011408 in 62 healthy adults. Participants received two different versions of the drug to compare them. The goal was to check for side effects and measure drug levels in the blood, not to treat…

This study looked at 115 adults with prediabetes to understand why different people develop the condition. Researchers tested how each person's body responds to different foods, aiming to create personalized diet plans that prevent diabetes. The goal was to find biological marker…

This study looked at how the COVID-19 lockdown changed blood sugar control and self-care in 77 young people aged 13 to 25 with type 1 diabetes. Researchers used data from a glucose monitoring platform to compare blood sugar levels before, during, and after the two-month lockdown …

This study tested a digital program that monitors both the emotional well-being of caregivers and the glucose levels of children with type 1 diabetes. Thirty families used the system for two months to see if it was practical and easy to use. The goal was to learn how stress and b…

This study looked at whether people with severe, long-term uncontrolled type 1 diabetes would accept and benefit from a closed-loop insulin delivery system (an 'artificial pancreas'). Researchers followed 66 adults with very high blood sugar levels over several years. The goal wa…

This study looked at how much blood sugar levels go up and down during the day in frail or disabled patients over 75 with diabetes who use basal insulin. Researchers used a continuous glucose monitor for 5 days to compare two types of insulin: human NPH and long-acting analogues.…

This study looked at 100 pregnant women with gestational diabetes to see if they were taking the recommended amount of iodine. Iodine is important for both mother and baby, and health authorities suggest supplements during pregnancy. The goal was simply to find out if these women…

This study looked at a thin layer inside blood vessels called the glycocalyx in 78 adults having major abdominal surgery. Researchers used a special camera to measure changes in this layer during and after surgery. The goal was to see if tracking glycocalyx thickness could help d…

This completed study tested a new biosensor designed to measure blood glucose every 10 minutes in people with type 1 diabetes who use an insulin pump. The sensor uses microdialysis to sample interstitial fluid and was compared to standard continuous glucose monitors (CGM) during …

This early-stage trial tested two experimental oral drugs, HL1113-R1 and HL1113-R2, in 35 healthy adults to see if they are safe and how the body processes them. The drugs are being developed for high blood pressure and type 2 diabetes. Participants took the drugs alone and toget…

This completed study surveyed over 4,600 people living with type 2 diabetes and multiple health conditions, along with their family members, to identify their health literacy strengths and needs. Participants answered a 44-question questionnaire about how well they understand and…

This study looked at whether exercising in the morning (7-11am) or afternoon (4-8pm) makes a difference for people with type 2 diabetes or prediabetes. Thirty-six adults did 10 supervised exercise sessions at a high intensity. Researchers measured changes in body weight, blood su…

This early-stage study tested a new drug (HL1113) in 37 healthy adults to see how the body processes it. The drug combines two existing medicines for high blood pressure and type 2 diabetes. Participants took the drug in different ways to compare safety and drug levels. The resul…

This study looked at whether an AI computer program could suggest cancer treatments that match what experts recommend. Researchers reviewed medical records of 30 people with stomach, colon, or pancreatic cancer. They entered key details into the AI and compared its suggestions to…

This completed study looked at 126 people with different fat distribution patterns—including those with lipodystrophy (abnormal fat loss or distribution), obesity, and normal weight—to understand how fat tissue relates to insulin resistance and immune signals. Researchers measure…

This study followed 159 people with metastatic colorectal, pancreatic, biliary, or esophageal cancers who were starting a new line of therapy. Researchers collected blood samples (tumor markers and liquid biopsies) and patient-reported quality-of-life data to see if these could p…

This study looked at whether getting an islet transplant after a kidney transplant helps people with type 1 diabetes avoid kidney failure or death. Researchers reviewed data from 327 people in France who had a kidney transplant between 2000 and 2017. They compared those who also …

This study looked at how type 1 diabetes and long-term blood sugar control (HbA1c) affect the body's ability to deliver and use oxygen during exercise. Researchers compared 79 people with and without diabetes to understand why fitness levels may be lower in those with high blood …

This study looked at whether certain gene changes (in the TCF7L2 gene) make ICU patients with organ failure more likely to develop high blood sugar. Nearly 1,000 adults in the ICU were checked for these gene changes and their blood sugar levels. The goal was to understand the lin…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

This study looked at whether women with different types of gestational diabetes respond differently to meals with varying amounts of carbs, protein, and fat. Nineteen women with gestational diabetes wore a continuous glucose monitor and ate two test meals. The goal was to see if …

This study tested a new way to help women with heart risks like high blood pressure or diabetes get better care after giving birth. Researchers interviewed new moms to understand what makes it hard to attend follow-up visits, then designed a coordinated care system. They tested i…

This study tested whether a pop-up alert in the electronic medical record could help doctors remember to refer patients with fatty liver disease (NASH) to a liver specialist. Thirty doctors from internal medicine, family medicine, and endocrinology took part. The goal was to see …

This study looked at whether taking vitamin C (and vitamin E) supplements for 8 weeks can make red blood cells more flexible in people with type 2 diabetes. Stiff red blood cells can lead to tiny blood vessel damage. Researchers measured red blood cell flexibility before and afte…

This completed study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. 78 adults were divided into three groups: those with sleep apnea, those with diabetes or high blood pressure, and healthy people.…

This study tested a Turkish version of a questionnaire that helps people with diabetes take better care of their feet to prevent ulcers. Researchers interviewed 202 adults with diabetes to see if the tool was accurate and reliable. The tool covers daily foot care, checking for ea…

This completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…

This completed study looked at 172 people with and without HIV to understand why those with HIV have a higher risk of diabetes. Researchers examined fat tissue and immune cells to see if chronic immune activation in fat contributes to insulin resistance. The goal was to learn how…

This early-stage trial looked at how a single 50mg dose of pyroglutamate rongliflozin capsules behaves in 32 adults with mild or moderate liver damage and type 2 diabetes, compared to healthy volunteers. Researchers measured drug levels in the blood and tracked side effects to un…

This study looked at how different levels of exercise change the bacteria in the gut of people with type 2 diabetes. Forty adults with type 2 diabetes did either moderate or high-intensity endurance and strength training for 16 weeks. Researchers compared changes in blood sugar a…

This study looked at over 4,000 ICU patients to find out how many have undiagnosed diabetes or prediabetes. Researchers used a blood test (HbA1c) to check blood sugar control and tracked whether these conditions led to more organ failure or death. The goal is to better understand…

This study looked at how short periods of low oxygen (from holding your breath) affect blood sugar levels after drinking a sugary drink. Researchers tested 20 healthy adults, people with prediabetes, and people with type 2 diabetes. The goal was to learn more about how oxygen lev…

This completed study looked at whether the Dexcom G7 continuous glucose monitor stays accurate in diabetes patients who have poor blood circulation during hospital stays. Researchers compared CGM readings to standard finger-stick blood tests in 60 adults undergoing surgery or in …

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study tested a new way to help young adults (ages 18-30) with type 1 or type 2 diabetes move from pediatric to adult diabetes care. Researchers compared a collaborative care model to usual care, looking at how many visits patients completed and changes in diabetes-related di…

This study looked at how inherited gene variants influence the body's response to two common type 2 diabetes medications, metformin and glipizide. Over 1,000 participants took each drug and had their glucose and insulin levels measured. The goal was to understand why some people …

This study looks at how the body processes HRS9531, an experimental diabetes drug, in people with different levels of kidney function. Researchers gave a single dose to 32 volunteers—some with healthy kidneys and some with mild impairment—and measured drug levels over time. The g…

This study looked at whether shared medical appointments—where teens with type 2 diabetes meet together with their care team—are an acceptable way to deliver care. Researchers designed four group activities focused on nutrition, peer support, exercise, and stress management, and …

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This study analyzed data from over 16,500 adults with chronic heart failure who were part of a remote monitoring program in France. Researchers looked at how having diabetes, other health conditions, and short-term weight changes were linked to survival. The goal was to better un…

This study used ultrasound to measure how much fluid remains in the stomach after standard preoperative fasting in 592 adults scheduled for elective surgery. Researchers compared diabetic and non-diabetic patients to see if diabetes affects stomach emptying. The goal is to help t…

This completed study looked at 141 people with acute pancreatitis to understand how blood clotting changes during the illness. Researchers took blood samples over several days and will analyze them for markers that might predict whether the disease becomes mild, moderate, or seve…

This study tracked 295 adults who had high-risk surgery for stomach, esophagus, pancreas, or liver cancer. Researchers measured quality of life before surgery and again at 6 and 12 months after. They also asked patients and their family members if they regretted the decision to h…

This study looked at whether cutting basal insulin by half before exercise helps keep blood sugar stable in people with type 1 diabetes. Eighteen active adults using insulin pumps completed two treadmill sessions—one with the insulin reduction and one without. Researchers measure…

This completed trial tested whether electronic alerts in the emergency room can improve care for people with type 2 diabetes. The alerts prompted doctors to order an A1c test when blood sugar was very high, and to consider admitting the patient for better diabetes management. Res…

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar, weight, and kidney function for up to a year after leaving the hospital. The goal was to learn how COVID-19 affects long-term diabetes control and to…

This study tested a computer tool that helps doctors classify the type of diabetes in adults diagnosed before age 50. Researchers interviewed 21 patients and staff to see if the tool was useful and acceptable. The goal is to gather initial data for a future, larger trial.

This study tested whether people with diabetes would use a special foot mat at home every day. The mat, called the Podimetrics SmartMat, measures foot temperature to spot early signs of foot ulcers. Twenty people who had a foot ulcer in the past used the mat for six months. The m…

This study looked at 142 people who had a sinus lift procedure using cow bone mineral before getting dental implants. Researchers measured how much bone was left around the implants years later, and checked if the original jawbone height, implant type, smoking, or diabetes played…

This completed study looked at how two substances—GIP, a natural gut hormone, and alanine, an amino acid from protein—work together to release glucagon, a hormone that raises blood sugar. Researchers tested 10 people with and without type 1 diabetes to see if combining GIP and al…

This pilot study tested a text-based platform that sends diabetes educational materials and resource referrals to emergency department patients with poorly controlled or new-onset diabetes. Researchers measured changes in diabetes knowledge, distress, and self-care among 50 Engli…

This study followed 99 people who had both an operable pancreatic tumor and diabetes for one year after surgery. Researchers tracked their fatigue, blood sugar control, diabetes self-care, and quality of life to understand how these factors change over time. The goal was to learn…

This study looked at how the nervous system helps control blood sugar in people with type 1 diabetes who had islet cell transplants. Nine participants received drugs that block nerve signals or a placebo during controlled low blood sugar experiments. The goal was to learn whether…

This study looked at how the hormone glucagon affects the liver's ability to break down proteins and fats in people with obesity, type 2 diabetes, and fatty liver disease. Researchers wanted to understand if the body becomes resistant to glucagon in these conditions. A total of 2…

This completed study surveyed 166 adults with type 1 diabetes to understand what factors influence their choice of hybrid closed-loop (artificial pancreas) systems. Participants included those already using, waiting to start, or considering such technology. The goal was to learn …

This completed study from Denmark looked at 101 people to see if nerve damage from type 2 diabetes is linked to memory and thinking problems. Researchers compared people with and without diabetes using tests of thinking skills, nerve function, and brain scans. The goal was to und…

This completed Phase 4 trial looked at how evolocumab (Repatha), a cholesterol-lowering drug, affects markers of inflammation and blood clotting in 41 people with type 2 diabetes and heart disease. Participants received either evolocumab or a placebo injection every 4 weeks for 1…

This completed study looked at why people with type 1 diabetes lose their natural defense against low blood sugar—the hormone glucagon. Researchers tested whether blocking a hormone called GLP-1 with a drug (exendin(9-39)amide) could restore glucagon release during low blood suga…

This early-stage study looked at how two different tablet versions of the experimental diabetes drug HRS-7535 are absorbed in the body, and whether food changes that. It involved 24 healthy adults who took the tablets under fasting and fed conditions. The goal was to compare the …

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This study looked at how two drugs, metformin and HRS-7535, behave in the bodies of 18 healthy men aged 18-50. The goal was to measure drug levels and safety, not to treat any disease. Results will help guide future diabetes research.

This study worked with community groups to screen Hispanic/Latinx adults for kidney disease and diabetes, then referred them to a primary care doctor. It also gave local clinics guidelines to help doctors screen and treat Hispanic and Black patients with diabetes. The goal was to…

This completed Phase 1 trial tested how four diabetes medications (HRS-1780, henagliflozin, metformin, and HRS-7535) affect each other's levels in the body. Twenty-four healthy men took the drugs in a fixed order, and researchers measured drug concentrations and side effects. The…

This study looked at two easy methods to measure hidden belly fat in 110 adults with type 2 diabetes. Researchers compared a simple waist measurement to a device that sends a mild electrical signal through the body. The goal was to see which method better relates to heart disease…

This study aimed to find biological markers (biomarkers) in pancreatic tumor cells and blood that could help predict how well a patient might respond to treatment. Researchers analyzed genetic and protein information from tumor samples collected via ultrasound-guided biopsy, as w…

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This study tested whether tagatose, a low-calorie sweetener, can act as a prebiotic—meaning it selectively feeds beneficial gut bacteria and improves blood sugar control. Fifty-nine healthy adults with slightly high blood sugar or insulin resistance took either tagatose or a plac…

This pilot study tested whether taking metformin 30 or 60 minutes before a meal affects carbohydrate absorption in people with obesity and prediabetes or type 2 diabetes. One participant completed three oral glucose tolerance tests—one without metformin, one with metformin taken …

This completed study in 130 adults with type 2 diabetes and fatty liver disease tested whether a blood marker called adiponectin can predict how well certain diabetes drugs reduce liver fat. Participants received either an SGLT2 inhibitor, a GLP-1 receptor agonist, or both for si…

This study looked at over 2,000 older adults (80+) with pancreatic cancer that hadn't spread, all in good general health. Researchers compared those who had surgery to remove the tumor with those who didn't, using data from a German cancer registry. The goal was to see if surgery…

This study looked at the gut bacteria of 200 heart attack patients, comparing those with high blood sugar to those with normal levels. Researchers collected stool samples before treatment and again at 6 and 12 months to see if changes in gut bacteria relate to survival. The goal …

This study looked at 150 people with coronary artery disease who had bypass surgery, comparing those with and without diabetes. Researchers measured the fat around the heart (epicardial fat) and checked how it relates to death and heart problems after surgery. They also tested if…

This study looked at whether taking short, regular walks during long periods of sitting can lower blood sugar and cholesterol after meals—key risk factors for Type 2 diabetes and heart disease. Researchers compared the effects in normal-weight and overweight/obese South Asian adu…