New drug aims to control blood sugar in kids with rare condition

NCT ID NCT03941236

Completed Disease control Sponsor: Zealand Pharma Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 04, 2026 · Updated 5 times

Summary

This study is testing the long-term safety of dasiglucagon, a drug given as a continuous injection under the skin, in children with congenital hyperinsulinism (a condition causing dangerously low blood sugar). The trial includes 42 children who completed earlier studies. Researchers will monitor side effects and check if the drug helps reduce the need for tube feeding or surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dasiglucagon (a glucagon analog given as a continuous injection under the skin)
What this could lead to: If successful, dasiglucagon could provide a long-term treatment option to control blood sugar levels in children with congenital hyperinsulinism, potentially reducing the need for tube feeding or surgery.
What could go wrong: This is an extension trial with no placebo group, so results may be less definitive. The drug may cause side effects, and long-term benefits are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Congenital Hyperinsulinism familial hyperinsulinism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL HYPERINSULINISM

Contacts and locations

Locations

Alder Hey Children's Hospital NHS Foundation Trust

Liverpool, United Kingdom
Children's Hospital Colorado

Aurora, Colorado, 80045-7106, United States
Cook Children's Endocrinology and Diabetes Clinic

Fort Worth, Texas, 76104-2710, United States
Great Ormond Street Hospital for Children NHS Foundation Trust

London, United Kingdom
Hadassah Medical Center

Jerusalem, 9765422, Israel
Manchester University NHS Foundation Trust

Manchester, United Kingdom
NHS Greater Glasgow and Clyde

Glasgow, United Kingdom
Otto von Guericke University Magdeburg, Department of Pediatrics

Magdeburg, 39120, Germany
The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
University Hospital Düsseldorf, Department of Pediatrics

Düsseldorf, 40225, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.