New diabetes pill shows promise in japanese trial

NCT ID NCT07271251

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This study tests whether a new tablet formulation of semaglutide (oral semaglutide D) works as well as the approved version in Japanese adults with type 2 diabetes. About 264 participants will take either the new or approved tablet once daily for 27 weeks. Researchers will compare changes in blood sugar levels and body weight, and monitor side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oral semaglutide (a diabetes medication taken as a tablet once daily)
What this could lead to: If successful, this could show that the new tablet formulation works as well as the approved version, offering an alternative for managing type 2 diabetes.
What could go wrong: This is a small, short-term study in Japanese participants only, so results may not apply to other groups. The new formulation might not prove equally effective or safe.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 2 DIABETES

Contacts and locations

Locations

Futata Tetsuhiro Clinic Meinohama_Internal medicine

Fukuoka-shi, Fukuoka, 819-0006, Japan
Hayashi Diabetes Clinic_Internal Medicine and Diabetes Medicine

Chigasaki-shi, Kanagawa, Japan, 253-0044, Japan
Heiwadai Hospital_Internal Medicine

Miyazaki, Miyazaki, 880-0034, Japan
Jinnouchi Hospital_Internal Medicine

Kumamoto, Kumamoto, Japan, 862-0976, Japan
Kato Clinic of Internal Medicine_Internal Medicine

Tokyo, 125-0054, Japan
Naka Kinen Clinic_Internal medicine

Ibaraki, 311-0113, Japan
Oodouri Diabetes, Internal medicine Clinic_Internal Medicine, Diabetes Internal Medicine

Hokkaido, 060-0001, Japan
Oyama East Clinic_Internal Medicine

Tochigi, 323-0022, Japan
Seino Internal Medicine Clinic_Internal medicine

Koriyama-shi, Fukushima, Fukushima, Japan, 963-8851, Japan
Shonan Takai Clinic_Internal Medicine

Kanagawa, 247-0055, Japan
Soka Sugiura Internal Medicine Clinic

Soka-shi, Saitama, 340-0015, Japan
TOSAKI Clinic for Diabetes and Endocrinology_Diabetes and Endocrinology

Aichi, 468-0009, Japan
Tokuyama clinic_Diabetic internal medicine

Chiba, 261-0004, Japan
Tokyo-Eki Center-building Clinic_Internal Medicine

Tokyo, 103-0027, Japan
Yokohama Minoru Clinic_Internal medicine

Kanagawa, 232-0064, Japan

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