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Can a 12-Week exercise program boost brain and body health in older adults with diabetes?

NCT ID NCT07711834

Disease control Sponsor: Harbin Sport University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study investigates whether a 12-week program combining aerobic and resistance exercise can improve blood sugar control and cognitive function in adults aged 65-79 with type 2 diabetes and mild memory issues. Participants follow a supervised exercise routine that gradually increases in intensity. The study also explores whether a specific gene variant (PPARGC1A rs8192678) affects how much individuals benefit from the exercise.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a 12-week combined aerobic and resistance exercise program
What this could lead to
If successful, this could show that a tailored exercise program helps manage blood sugar and thinking skills in older adults with diabetes and memory decline, and that genetic differences may influence how much someone benefits.
What could go wrong
This is a small, single-arm study with no control group, so results may not be generalizable. The exercise program is supervised and may not be feasible for all older adults outside a research setting.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

45 people

The number who actually took part.

Started

Mar 2025

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 79 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Diagnosed with type 2 diabetes mellitus. 2. No regular exercise training during the previous six months. 3. Aged 65 to 79 years. 4. Self-reported memory decline and Montreal Cognitive Assessment score \<26. 5. Stable antidiabetic medication use and stable dietary control. 6. Participant or family member provided informed consent. Exclusion Criteria: 1. Diabetic ketoacidosis within the previous three months. 2. Visual or hearing impairment or other conditions affecting cognitive assessment. 3. Fracture, limb disability, or other motor disorders affecting exercise participation. 4. History of psychiatric disorders. 5. History of stroke, brain tumor, hypothyroidism, or other diseases that may affect cognitive function. 6. Poor compliance or failure to follow the prescribed diet or exercise requirements.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive impairment Type 2 diabetes mellitus (T2DM)

Contacts and locations

Locations

  • Harbin Sport University

    Harbin, Heilongjiang, China

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