TYPE 2 DIABETES MELLITUS (T2DM)

This study tests a program to help doctors better screen and treat chronic kidney disease (CKD) in adults with type 2 diabetes. About 420 participants will receive enhanced monitoring and care recommendations. The goal is to increase use of proven treatments to slow kidney damage…

This study tests whether a 12-week multimodal exercise program can improve physical performance and muscle function in middle-aged adults (45-64 years) with type 2 diabetes. 66 participants will be randomly assigned to either receive standard care or join the exercise program. Th…

This study looks at whether providing healthy food and lifestyle coaching can help people with high blood pressure and type 2 diabetes better manage their conditions. About 80 adults living in Baltimore areas with limited access to healthy food will be randomly assigned to receiv…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce these health risks. About 200 adults with HIV who are patients at a North Carolina clin…

This study in Pokhara, Nepal, tests whether home visits by female community health volunteers combined with regular SMS reminders can help adults better manage high blood pressure, type 2 diabetes, and smoking. About 2,070 participants will be split into two groups: one gets the …

This study tests a new medicine called ALN-4324 in two groups: first in healthy overweight volunteers to check safety, then in overweight adults with type 2 diabetes to see if it helps control blood sugar. The study is early-stage and focuses on safety and how the drug works in t…

This study tests whether starting two diabetes drugs early—metformin plus either semaglutide or empagliflozin—improves blood sugar control more than metformin alone in adults recently diagnosed with type 2 diabetes. Participants will take their assigned pills daily for 26 weeks a…

This study tests a 12-week exercise program for adults aged 45-85 with type 2 diabetes and sarcopenia (age-related muscle loss). The program combines supervised training, home exercises, and digital support to improve muscle strength, physical function, and blood sugar control. R…

This study tests whether giving people with type 2 diabetes a continuous glucose monitor and a smart insulin pen cap at hospital discharge helps them stick to their insulin schedule and control blood sugar better. About 80 adults who start insulin while in the hospital will be sp…

This study tests whether a new combination of diabetes drugs can help people with type 2 diabetes achieve more stable blood sugar levels throughout the day. Researchers will enroll 178 adults whose blood sugar is not well controlled with their current medications (metformin and a…

This study compares a 12-week course of semaglutide injections with a calorie-restricted diet in 100 adults with type 2 diabetes and fatty liver disease. Researchers will measure changes in blood sugar, weight, liver fat, and inflammation to see which approach works better. Parti…

This study looks at two dental treatments for a painful tooth condition called irreversible pulpitis in people with type 2 diabetes. Researchers will compare a simpler procedure (pulpotomy) with standard root canal treatment to see which works better and improves quality of life.…

This study tests whether a para-probiotic toothpaste and mouthwash can improve gum health and blood sugar control in 40 adults with type 2 diabetes and gum disease. All participants receive standard gum treatment, then use either the probiotic products or a standard antiseptic ri…

This study tests whether meals designed for specific ethnic groups (Asian Indian or Filipino) can improve blood sugar control in people with type 2 diabetes. Thirty participants will wear a continuous glucose monitor for one month while eating their usual diet and then the tailor…

This study tests a program called 'Disfrutando' that helps people with type 2 diabetes manage their blood sugar and weight. It is designed for groups that face extra challenges, like limited access to healthy food or safe places to exercise. About 31 adults with an A1C of 5.7 or …

This study tests whether replacing regular starchy foods with quinoa products (noodles, powder, cookies) for 14 weeks can improve blood sugar control, cholesterol levels, and glucose stability in people with early-stage type 2 diabetes. Sixty adults aged 20–70 with diabetes for l…

This study tests whether personalized marketing and discounts in an online grocery store can encourage people with prediabetes or type 2 diabetes to buy more whole grains instead of refined grains. About 216 adults aged 45-70 from Pennsylvania who already shop online for grocerie…

This study tests whether breathing a special mix of low and high oxygen air (called IHHT) for 3 or 10 days can help control blood sugar in people with type 2 diabetes, including older adults. About 250 participants aged 50-74 will be randomly assigned to short or long treatment o…

This study tests whether a single dose of the experimental drug ALN-4324 can improve how the body responds to insulin in people with type 2 diabetes. About 40 adults on stable metformin therapy will receive either the drug or a placebo. The main goal is to measure changes in insu…

This study tests a new surgical device (a clip) to treat type 2 diabetes and obesity in people with a BMI of 25-35. The surgery creates a second food pathway to help control blood sugar, similar to popular diabetes drugs. About 90 adults will be randomly assigned to different gro…

This study aims to translate and test a questionnaire called PainPREDICT in Thai, and build a mobile app to help screen for painful diabetic neuropathy—a common nerve complication in diabetes. Researchers will enroll 277 adults with type 1 or type 2 diabetes to check if the tool …

This study tests whether using a smartwatch and a digital health coach can help people at risk for chronic diseases like high blood pressure, diabetes, and obesity become more active. Researchers will enroll 1,700 adults aged 21-75 who have risk factors or early signs of these co…

This study tests whether a diet tailored to a person's unique metabolism (called a 'metabotype') can prevent type 2 diabetes better than standard dietary advice. Researchers will enroll 240 adults with overweight or obesity who are at risk for diabetes. Participants will follow e…

This study looks at whether regularly screening for diabetes-related emotional distress can help adults with type 2 diabetes improve their blood sugar and cholesterol. About 1,250 adults with type 2 diabetes and high blood sugar will take part. The goal is to see if addressing em…

This study tests whether a 4-week online self-compassion training program is feasible and helpful for adults with type 1 or type 2 diabetes who are struggling with diabetes-related distress. About 50 participants will be randomly assigned to the program or a control group. The go…

This study looks at whether using a continuous glucose monitor (CGM) helps people with diabetes feel more in control of their blood sugar after they leave the hospital. About 60 adults with type 1 or type 2 diabetes who need insulin will use a CGM for a short time and answer ques…

This study tests a program to help doctors better screen for chronic kidney disease in adults with type 2 diabetes. About 750 participants will be included. The goal is to see if the program increases the number of patients who get the recommended kidney function and urine tests.

This study looks at adults with type 2 diabetes who are malnourished or at risk. Researchers will track their health and nutrition after they are prescribed a special high-calorie, high-protein drink with fiber. The goal is to understand patient profiles and how this supplement a…

This study gives 40 Hispanic/Latinx young adults (ages 18-45) with type 2 diabetes a continuous glucose monitor for 30 days. Researchers will interview participants to learn what helps or hinders using the device, how it changes awareness of blood sugar patterns, and what kind of…

This study follows 296 people with type 2 diabetes to compare how insulin-producing cells change over one year in those diagnosed before age 40 versus those diagnosed later. Researchers will measure blood markers like C-peptide and HbA1C at 3, 6, 9, and 12 months. The goal is to …

This study looks at how body weight influences physical activity, balance, and quality of life in 50 adults with type 2 diabetes. Participants will undergo tests like walking, strength measurements, and balance assessments. The goal is to better understand these connections to im…

This observational study looks at how the pancreas works in 310 adults with type 2 diabetes. Researchers want to see if some patients actually have a different form of diabetes called pancreatogenic diabetes. Participants will give blood and stool samples, have a pancreas ultraso…

This study looks at how people with type 2 diabetes imagine movements, sense their bodies, and think. Researchers will test 100 adults aged 18-65 who have had diabetes for at least 5 years. Participants complete questionnaires and timed tasks—no treatment or medication is involve…

This study looks at how people with type 2 diabetes break down polyphenols—natural compounds found in plants—compared to healthy individuals of the same age. Researchers will measure these compounds in urine after participants take a polyphenol-rich pill. The goal is to understan…

This study looks at how to better detect and manage diabetic retinopathy, an eye problem caused by type 2 diabetes. Researchers will use eye images, clinical data, and blood tests to create an early warning system and tailor treatment based on when diabetes started and other heal…

This study looks at whether a continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes track their blood sugar better than the usual finger-stick method. About 70 participants will be randomly assigned to one of two groups: using a CGM sensor on the arm or testi…

This study looks at how common memory problems are in older adults (65+) with type 2 diabetes. It also tests whether a program involving lifestyle changes and medical care can help prevent or slow down memory loss. The study will involve 420 participants from three hospitals in D…

This study is observing 500 adults with type 2 diabetes to understand how their mental well-being, depression, and quality of life are connected. Participants will fill out questionnaires about their feelings and daily life. The goal is to find patterns that can help doctors offe…

This study tests an experimental drug called MKP10241 in healthy adults and people with obesity, with or without type 2 diabetes. The main goals are to see if food changes how the drug works, how safe it is, and how the body processes it. About 68 participants will take either th…

This study looks at whether giving people with type 2 diabetes a Fitbit and sending them personalized text messages can help them become more active and improve their health. About 36 adults who are not very active will wear a Fitbit and answer texts for 12 weeks. The goal is to …