TYPE 2 DIABETES MELLITUS (T2DM)

This study tests a new weekly injection called enicepatide (CT-388) in 447 overweight or obese adults with type 2 diabetes. Participants receive either the drug or a placebo for 48 weeks. The goal is to see if the drug helps with weight loss and improves blood sugar levels.

This study tests whether home visits by female community health volunteers plus regular SMS messages can help adults in Pokhara, Nepal, better control high blood pressure, type 2 diabetes, and smoking. About 2100 participants are split into two groups: one gets the home visits an…

This study tests whether a 12-week multimodal exercise program can improve physical performance and muscle function in adults aged 45-64 with type 2 diabetes. Participants are randomly assigned to either the exercise program or standard care. The goal is to find a practical way t…

This study tests a 3-month lifestyle program called the PILI Pasifika Program for Native Hawaiian and Pacific Islander adults who are overweight or have conditions like high blood pressure or diabetes. The program includes group lessons on healthy eating and physical activity, pl…

This study tests whether using a continuous glucose monitor (CGM) along with remote dietitian support helps people with type 2 diabetes better control their blood sugar. About 160 adults across Australia will use a CGM and receive online dietary advice for several months. The goa…

This study tests whether a text-message based mobile health program can help people with type 2 diabetes in Nepal better manage their condition. 154 adults with type 2 diabetes will be randomly assigned to receive either the text-message program plus standard care, or standard ca…

This study looks at how the timing of meals and sleep patterns influence blood sugar, heart health, and weight loss in adults with type 2 diabetes, obesity, or high blood pressure. Researchers will provide nutritional guidance and track changes in weight, lab results, and body me…

This early-stage trial is testing whether a rosemary extract supplement can improve markers of oxidative stress and inflammation in people with type 2 diabetes. Forty adults with stable diabetes will take either the extract or a placebo for 12 weeks. The study focuses on blood bi…

This study tests a digital tool called DIPAR that sends reminders to adults with type 2 diabetes to get important lab tests, like kidney function and blood sugar checks. About 200 participants use the tool through a patient portal to see if it helps them stay on track with their …

This study tests whether regular exercise and cognitive training, alone or together, can improve physical and mental function in adults aged 60+ who have had a stroke and also have high blood pressure or diabetes. Over 400 participants from five Chinese cities will take part in 1…

This study aimed to see if a single pill combining two diabetes medications works better than taking them separately for people with type 2 diabetes already on metformin. The goal was to improve blood sugar control and reduce side effects like weight gain and swelling. However, t…

This phase 3 study tests a new injectable drug called GZR18 in about 1,100 Chinese adults with type 2 diabetes whose blood sugar is not well controlled by metformin or other oral medications. Participants receive either GZR18 or the approved drug semaglutide to compare how well e…

This Phase 3 study tests an injectable drug called GZR18 in 274 Chinese adults with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. Participants receive either GZR18 or a placebo to see if the drug improves blood sugar levels, weight, and wais…

This Phase 2 study tests a new injectable drug called maridebart cafraglutide in 409 adults with type 2 diabetes. The main goal is to see if it improves blood sugar control compared to a placebo. Researchers will also check if it helps with weight loss. The trial is active but no…

This study tests two experimental injections, GZR102 (once a week) and GZR18 (every two weeks), in adults with type 2 diabetes whose blood sugar is not well controlled on current GLP-1 medications. About 90 Chinese participants will receive one of the two treatments to see which …

This pilot study tests MPowerHub, a smartphone app that helps adults with type 2 diabetes make sense of data from continuous glucose monitors and activity trackers. The app shows combined trends and prompts daily questions about diet, sleep, stress, and medication. Researchers wa…

This registry will follow 500 people with type 2 diabetes who have already been treated with the Endogenex System. The goal is to collect long-term safety data and see how the device performs in everyday use. Participants must agree to share their medical records and attend follo…

This Phase 1 trial tests two experimental drugs (L03RD1 and L03RD2) in 48 healthy adults to see how safe they are and how the body processes them. Participants take the drugs alone or together in a single dose. The study does not aim to treat diabetes, but to gather information f…

This study looks at how fasting and temporarily stopping the diabetes drug dulaglutide affect how much food and liquid stays in the stomach after a meal. About 20 people with type 2 diabetes will have their stomachs checked with ultrasound after eating. The goal is to understand …

This pilot study tests whether diabetes care can be successfully integrated into primary healthcare centers in Abuja, Nigeria. Researchers will screen, diagnose, treat, and educate 106 adults with uncomplicated type 2 diabetes. The goal is to see if this approach is feasible and …

This study follows 50 obese patients who are having weight-loss surgery (laparoscopic sleeve gastrectomy). Researchers use MRI scans and blood tests before surgery and at 1, 3, and 6 months after to measure changes in pancreatic fat and insulin function. The goal is to see if los…

This study looks at whether a common diabetes medicine (SGLT2 inhibitor) can help prevent future heart problems in people with type 2 diabetes who have had a heart attack. Researchers will compare health records of 200,000 adults in Korea who took either an SGLT2 inhibitor or ano…