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New shot aims to tackle obesity and diabetes together

NCT ID NCT06845202

Ongoing Disease control Sponsor: Alnylam Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This early-stage study tests an experimental drug called ALN-4324 in two groups: healthy overweight volunteers and overweight patients with type 2 diabetes. The goal is to check the drug's safety and how well it controls blood sugar. Participants receive either the drug or a placebo, and researchers monitor side effects and blood sugar levels over time.

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Conditions

The condition(s) this trial relates to.

Obesity type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESE OR OVERWEIGHT HEALTHY VOLUNTEERS TYPE 2 DIABETES MELLITUS (T2DM)

Contacts and locations

Locations

  • Clinical Trial Site

    Montclair, California, 91763, United States

  • Clinical Trial Site

    Washington D.C., District of Columbia, 20009, United States

  • Clinical Trial Site

    Miami, Florida, 33126, United States

  • Clinical Trial Site

    Marlton, New Jersey, 08053, United States

  • Clinical Trial Site

    Monroe, North Carolina, 28112, United States

  • Clinical Trial Site

    Dallas, Texas, 75230, United States

  • Clinical Trial Site

    Dallas, Texas, 75246, United States

  • Clinical Trial Site

    Buenos Aires, C1060, Argentina

  • Clinical Trial Site

    Buenos Aires, C1061AAE, Argentina

  • Clinical Trial Site

    Buenos Aires, C1061, Argentina

  • Clinical Trial Site

    San Miguel de Tucumán, T4000IHE, Argentina

  • Clinical Trial Site

    Concord, L4K 4M2, Canada

  • Clinical Trial Site

    Mount Royal, H3P 3P1, Canada

  • Clinical Trial Site

    Vancouver, V5Y 3W2, Canada

  • Clinical Trial Site

    Santiago, 7500710, Chile

  • Clinical Trial Site

    Santiago, 7770086, Chile

  • Clinical Trial Site

    Santiago, 8320000, Chile

  • Clinical Trial Site

    Essen, 45355, Germany

  • Clinical Trial Site

    Gdansk, 80-546, Poland

  • Clinical Trial Site

    Tarnów, 33-100, Poland

  • Clinical Trial Site

    Warsaw, 02-507, Poland

  • Clinical Trial Site

    Wroclaw, 51-162, Poland

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