TYPE 2 DIABETES MELLITUS (T2DM)

This study tests a program called 'Disfrutando' that helps people with type 2 diabetes manage their blood sugar and weight. It is designed for groups that face extra challenges, like limited access to healthy food or safe places to exercise. About 31 adults with an A1C of 5.7 or …

This study tests whether meals designed for specific ethnic groups (Asian Indian or Filipino) can improve blood sugar control in people with type 2 diabetes. Thirty participants will wear a continuous glucose monitor for one month while eating their usual diet and then the tailor…

This study tests whether replacing regular starchy foods with quinoa products (noodles, powder, cookies) for 14 weeks can improve blood sugar control, cholesterol levels, and glucose stability in people with early-stage type 2 diabetes. Sixty adults aged 20–70 with diabetes for l…

This study tests whether starting two diabetes drugs early (metformin plus either semaglutide or empagliflozin) works better than metformin alone for people recently diagnosed with type 2 diabetes. About 90 adults will take the pills daily for 26 weeks and wear a continuous gluco…

This study tests a program to help doctors better screen and treat chronic kidney disease (CKD) in people with type 2 diabetes. About 420 adults with diabetes and signs of kidney disease will take part. The goal is to see if the program helps more patients get the right medicines…

This study tests whether a para-probiotic toothpaste and mouthwash can improve gum health and blood sugar control in 40 adults with type 2 diabetes and gum disease. All participants receive standard gum treatment, then use either the probiotic products or a standard antiseptic ri…

This study tests a 12-week exercise program for adults aged 45 to 85 who have both type 2 diabetes and sarcopenia (age-related muscle loss). The program combines supervised and home-based exercises with digital support to improve muscle strength, physical function, and blood suga…

This study tests whether a 12-week course of semaglutide injections works better than a calorie-restricted diet for people with type 2 diabetes and fatty liver disease. About 100 adults aged 18-75 with a BMI of 25 or higher will be enrolled. Researchers will track changes in bloo…

This study tests whether personalized marketing and discounts in an online grocery store can encourage people with prediabetes or type 2 diabetes to buy more whole grains instead of refined grains. About 216 adults aged 45-70 from Pennsylvania who already shop online for grocerie…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a bilingual program that combines peer support and mobile health tools to help reduce these health risks. About 200 adults from a North Carolina HIV clinic will ta…

This study tests whether adding another drug to metformin and an SGLT-2 inhibitor can improve blood sugar stability in people with type 2 diabetes. About 178 adults with poor blood sugar control will receive the combination therapy for 12 weeks. The main goal is to see if it redu…

This study tests whether breathing a special mix of low and high oxygen air (called IHHT) for 3 or 10 days can help control blood sugar in people with type 2 diabetes, including older adults. About 250 participants aged 50-74 will be randomly assigned to short or long treatment o…

This study looks at whether regularly screening for diabetes-related emotional distress can help adults with type 2 diabetes improve their blood sugar levels. About 1,250 adults with high blood sugar (A1C over 8%) will take part. Researchers will track changes in A1C and choleste…

This study tests whether providing healthy food and lifestyle coaching can help adults with high blood pressure and type 2 diabetes living in areas with few grocery stores. About 80 participants will be randomly assigned to receive either standard diet advice or extra coaching an…

This study tests whether home visits from female community health volunteers, combined with regular text messages, can help adults in Pokhara, Nepal, better manage high blood pressure, type 2 diabetes, and smoking. About 2,070 participants will be split into two groups: one recei…

This study tests a new medicine called ALN-4324 in two groups: first in healthy overweight volunteers, then in overweight people with type 2 diabetes. The goal is to see if it is safe and helps control weight and blood sugar. Participants receive either the drug or a placebo, and…

This study tests whether a single dose of the experimental drug ALN-4324 can improve how the body responds to insulin in people with type 2 diabetes. About 40 adults on stable metformin therapy will receive either the drug or a placebo. The main goal is to measure changes in insu…

This study looks at whether using a continuous glucose monitor and a smart insulin pen cap can help people with type 2 diabetes who just started insulin in the hospital stick to their insulin schedule and control their blood sugar after going home. About 80 adults aged 18 to 70 w…

This study tests a new surgical device (a clip) to treat type 2 diabetes and obesity in people with a BMI of 25-35. The surgery creates a second food pathway to help control blood sugar, similar to popular diabetes drugs. About 90 adults will be randomly assigned to different gro…

This study looks at two common dental procedures—pulpotomy (removing only the infected part of the tooth's nerve) and root canal (removing the entire nerve)—to see which works better for people with type 2 diabetes who have a painful, inflamed tooth nerve. About 106 adults aged 1…

This study aims to translate and test a questionnaire called PainPREDICT in Thai, and build a mobile app to help screen for painful diabetic neuropathy—a common nerve complication in diabetes. Researchers will enroll 277 adults with type 1 or type 2 diabetes to check if the tool …

This study will test a new way to detect and manage diabetic retinopathy, an eye problem caused by type 2 diabetes. About 2,920 adults will have their eyes checked and give blood samples to help create better models for early warning and treatment. The goal is to prevent vision l…

This study tests whether using a smartwatch and a digital health coach can help people at risk for chronic diseases like high blood pressure, diabetes, and obesity become more active. Researchers will enroll 1,700 adults aged 21-75 who have risk factors or early signs of these co…

This study looks at how common thinking problems are in people aged 65+ with type 2 diabetes. It then tests a program that combines healthy habits, exercise, and mental activities to see if it can prevent or slow down memory and thinking decline. About 420 participants will be fo…

This study tests whether a diet tailored to a person's unique metabolism (called a 'metabotype') can prevent type 2 diabetes better than standard dietary advice. Researchers will enroll 240 adults with overweight or obesity who are at risk for diabetes. Participants will follow e…

This study tests whether a 12-week multimodal exercise program can improve muscle function and physical performance in middle-aged adults (45-64 years) with type 2 diabetes. 66 participants will be randomly assigned to either receive standard education or join the exercise progra…

This study tests whether a 4-week online self-compassion training program is feasible and helpful for adults with type 1 or type 2 diabetes who feel distressed about their condition. About 50 participants will be randomly assigned to the program or a control group. The goal is to…

This study looks at whether using a continuous glucose monitor (CGM) after hospital discharge helps people with type 1 or type 2 diabetes feel more in control and satisfied with their care. About 60 adults who need insulin while in the hospital will use a CGM at home and answer q…

This study follows 296 Vietnamese adults with type 2 diabetes for one year to compare how beta cells (which make insulin) change in people diagnosed before age 40 versus those diagnosed at 40 or older. Researchers will measure blood sugar control and insulin production at 3, 6, 9…

This study looks at how body weight influences physical activity, balance, and quality of life in 50 adults with type 2 diabetes. Researchers will measure things like walking ability, muscle strength, and body composition through simple tests and questionnaires. The goal is to be…

This study tests a program to help doctors better screen for chronic kidney disease (CKD) in people with type 2 diabetes. Researchers will enroll 750 adults who are missing key kidney tests. The goal is to see if the program increases the number of patients who get the recommende…

This study looks at how people with type 2 diabetes break down polyphenols—natural compounds found in plants—compared to people without diabetes. Researchers will collect urine samples from 100 participants after they take a polyphenol pill. The goal is to understand differences …

This observational study will examine how the pancreas works in 310 adults with type 2 diabetes. Researchers want to see if some patients actually have a different form of diabetes called pancreatogenic diabetes. Participants will give blood and stool samples, have a pancreas ult…

This study gives continuous glucose monitors (CGMs) to 40 Hispanic/Latinx young adults aged 18-45 with type 2 diabetes for 30 days. Researchers want to learn what helps or hinders using CGMs, how users become more aware of their glucose patterns, and what they would want in a fut…

This study looks at whether a continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes track their blood sugar better than the usual finger-stick method. About 70 participants will be randomly assigned to use either a CGM or finger-stick testing from enrollment …

This study observes adults with type 2 diabetes or drug-induced diabetes who are malnourished or at risk. Researchers will track their health and use of a special high-calorie, high-protein nutritional drink with fiber. The goal is to understand patient profiles and treatment pat…

This study looks at how people with type 2 diabetes imagine movements, sense their bodies, and think. Researchers will test 100 adults aged 18-65 who have had diabetes for at least 5 years. No treatment is given; the goal is to understand relationships between these abilities.

This study tests an experimental drug called MKP10241 in healthy adults and people with obesity, with or without type 2 diabetes. The main goals are to see if food changes how the drug works, how safe it is, and how the body processes it. About 68 participants will take either th…

This study is observing 500 adults with type 2 diabetes to understand how their mental well-being, depression, and quality of life are related. Participants will fill out questionnaires about their feelings and daily life. The goal is to find patterns that can help doctors offer …

This study looks at whether giving people with type 2 diabetes a Fitbit and sending them personalized text messages can help them become more active and improve their health. About 36 adults who are not very active will wear a Fitbit and answer texts for 12 weeks. The goal is to …