TYPE 2 DIABETES MELLITUS (T2DM)

This trial tests whether a pulse electric field ablation system can help adults with type 2 diabetes whose blood sugar is not well controlled by oral medications. The study enrolls 20 people aged 18 to 70 with a specific range of blood sugar levels. Researchers will measure chang…

This study compares continuous glucose monitoring (CGM) to standard fingerstick testing for pregnant women with type 2 diabetes. Researchers want to see if CGM leads to better blood sugar control and fewer complications for both mother and baby. Participants wear a CGM device or …

This phase 3 trial is testing a once-weekly injection called enicepatide in 300 Chinese adults who are obese or overweight, with or without type 2 diabetes. The drug works by mimicking two gut hormones to reduce appetite and improve blood sugar control. Participants will receive …

This study tests whether meals designed for South Asian and Filipino cultures, following diabetes guidelines, can improve blood sugar control in people with type 2 diabetes. Thirty participants will wear a continuous glucose monitor for a month while eating their usual diet and t…

This study compares two ways of tracking blood sugar in people with type 2 diabetes who use insulin after leaving the hospital. One group uses a continuous glucose monitor (CGM) that shows real-time levels and trends, while the other group uses traditional fingerstick tests. The …

This study is testing an education program for people with type 2 diabetes who also have chronic kidney disease. The program provides patients with information about their kidney health and suggests medications that could slow kidney damage. Researchers will see if this approach …

This study tests a single dose of a new drug, ALN-4324, to see if it improves how the body uses insulin in people with type 2 diabetes. About 40 adults who are on a stable dose of metformin will take part. The main goal is to measure changes in insulin sensitivity using a glucose…

This early-stage study tests an experimental drug called ALN-4324 in two groups: healthy overweight volunteers and overweight patients with type 2 diabetes. The goal is to check the drug's safety and how well it controls blood sugar. Participants receive either the drug or a plac…

This study tests whether regularly screening for diabetes-related emotional distress and offering support can improve blood sugar control in adults with type 2 diabetes. About 1,250 participants with high blood sugar (A1C over 8%) will take part. The goal is to see if addressing …

This study tests whether dapagliflozin, a diabetes medication, can slow or reverse plaque buildup in the heart arteries of people with type 2 diabetes. About 144 adults with stable heart disease will take either the drug plus standard care or standard care alone for 18 months. Re…

This study is testing whether giving people with type 2 diabetes a Fitbit and sending them personalized text messages from an AI chatbot can help them become more active and improve their health. Thirty-six sedentary adults will wear the Fitbit daily for 12 weeks and receive week…

This study tests whether personalized marketing messages and discounts can encourage people with prediabetes or type 2 diabetes to switch from refined grains to whole grains when shopping for groceries online. About 216 adults aged 45-70 from the Philadelphia area who already sho…

This study tests a program called 'Disfrutando' designed to help people with type 2 diabetes, especially those in high-burden communities, better manage their condition. The program focuses on practical self-management skills and addressing social factors that make diabetes harde…

This study tests a new surgical device (a metal clip) to create a second food pathway in the stomach for people with type 2 diabetes who are overweight or mildly obese (BMI 25-35). The goal is to improve blood sugar control without causing too much weight loss or needing lifelong…

This study tests whether breathing a special mix of low and high oxygen air (called intermittent hypoxic-hyperoxic training) can help lower blood sugar in people with type 2 diabetes. About 250 adults aged 50-74 will be split into groups receiving either a 3-day or 10-day course …

This study tests whether starting two diabetes drugs early—metformin plus either oral semaglutide or empagliflozin—controls blood sugar better than metformin alone in adults recently diagnosed with type 2 diabetes. About 90 participants will take the combination or just metformin…

This study compares weekly semaglutide injections to a calorie-restricted diet in 100 adults with type 2 diabetes and fatty liver disease. Over 12 weeks, researchers will measure changes in blood sugar, weight, inflammation, and liver fat. The goal is to see which approach works …

This study looks at whether providing healthy food and lifestyle coaching can help adults with high blood pressure and type 2 diabetes who live in areas with limited access to fresh groceries. About 80 participants from Baltimore will be randomly assigned to receive either standa…

This study tests four different drug combinations in 178 adults with type 2 diabetes whose blood sugar is not well controlled on metformin and an SGLT-2 inhibitor. Over 12 weeks, researchers will measure how much and how often blood sugar swings. The goal is to find which combo o…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce food insecurity and improve insulin resistance. About 200 adults with HIV from a clinic…

This study tests whether a special toothpaste and mouthwash containing natural 'para-probiotics' can improve gum health and help control blood sugar in people with type 2 diabetes. Forty adults with gum disease and diabetes will use either the para-probiotic products or a standar…

This study tests whether giving people with type 2 diabetes a continuous glucose monitor and a smart insulin pen cap (Insulclock) at hospital discharge helps them stick to their insulin schedule and control blood sugar better than standard finger-prick checks. About 80 adults age…

This study tests whether eating quinoa-based foods instead of regular starches can improve blood sugar and fat levels in people with early-stage type 2 diabetes. Sixty adults with diabetes for less than 5 years will eat quinoa noodles, powder, or cookies for 14 weeks. Researchers…

This study tests whether a continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes track their blood sugar better than traditional finger-stick testing. Seventy participants will be randomly assigned to use either a CGM or a glucometer from enrollment until del…

This study is testing whether wearing a smartwatch and getting personalized health coaching through a mobile app can help people with high blood pressure, diabetes, obesity, or related conditions improve their lifestyle. About 1,700 adults aged 21-75 will wear a smartwatch for at…

This study compares two dental procedures—complete pulpotomy and root canal treatment—in 106 adults with type 2 diabetes who have a painful tooth condition called irreversible pulpitis. The goal is to see which treatment is more successful at relieving pain, healing the tooth, an…

This study is testing a new, non-invasive liver scan called iLivTouch to see if it can accurately detect a serious liver condition called MASH in people who have both type 2 diabetes and fatty liver disease. The scan measures liver inflammation, fat, and stiffness without any nee…

This study will enroll nearly 3,000 people with type 2 diabetes to improve how diabetic retinopathy (an eye disease) is diagnosed and managed. Researchers will use eye exams, blood tests, and continuous glucose monitors to build better models for predicting and treating the condi…

This study is translating and testing a questionnaire called PainPREDICT for Thai-speaking people with diabetes. The goal is to create a mobile app that can screen for painful diabetic neuropathy, a common complication that causes nerve pain. Researchers will check if the Thai ve…

This study tests whether a diet tailored to a person's unique metabolism (called a 'metabotype') can prevent type 2 diabetes better than standard healthy eating advice. Overweight or obese adults at risk for diabetes will follow either a personalized or standard diet for 12 month…

This pilot study is testing whether a virtual reality (VR) cognitive training program can help protect memory and thinking skills in adults aged 45-80 with type 2 diabetes and mild cognitive impairment. Forty participants will be randomly assigned to either 16 weeks of VR-based t…

This study will give a steroid and numbing injection to 60 people with carpal tunnel syndrome, half of whom also have type 2 diabetes. Researchers will track pain, nerve function, and hand strength for 12 weeks to see if the diabetes group recovers as well as those without diabet…

This study tests whether a 12-week multimodal exercise program—combining supervised training, home exercises, and digital support—can improve muscle function, physical performance, and blood sugar control in adults aged 45 to 85 with both type 2 diabetes and sarcopenia (age-relat…

This study tests whether a four-week online self-compassion course can reduce diabetes-related distress, self-criticism, and shame in adults with type 1 or type 2 diabetes. Researchers will enroll 50 participants to see if the program is feasible and acceptable. The course includ…

This study looks at whether using a continuous glucose monitor (CGM) after hospital discharge helps people with diabetes feel more in control and satisfied with their care. About 60 adults with type 1 or type 2 diabetes who need insulin will use a CGM at home and answer questionn…

This study is testing whether mixed reality (using a Meta Quest 3 headset) can reliably measure walking ability, balance, and leg strength in people with type 2 diabetes. Researchers will compare the digital versions of three common physical tests (6-minute walk, timed up and go,…

This study looks at whether sending home test kits or ordering standard lab tests can help more people with type 2 diabetes get screened for chronic kidney disease (CKD). About 750 adults who are missing key kidney function tests will be enrolled. The goal is to see if these appr…

This study follows 296 Vietnamese adults with type 2 diabetes for one year to compare how insulin-producing beta cells change in people diagnosed before age 40 versus those diagnosed at 40 or older. Researchers will measure blood markers like C-peptide and HbA1C at 3, 6, 9, and 1…

This observational study will examine how the pancreas works in 310 adults with type 2 diabetes. Researchers will use blood tests, stool samples, and ultrasound to measure both hormone and digestive functions. The goal is to identify a different form of diabetes called pancreatog…

This study looks at how people with type 2 diabetes break down polyphenols—natural compounds found in plants—compared to healthy individuals of the same age. Researchers will measure polyphenol levels in urine after participants take a special pill. The goal is to understand how …

This study looks at how people with type 2 diabetes imagine movements, sense their own bodies, and perform thinking tasks. Researchers will test 100 adults aged 18–65 who have had diabetes for at least 5 years. No treatments or drugs are given—only questionnaires and simple tasks…

This study is observing 500 adults with type 2 diabetes to understand how their mental well-being, depression, and quality of life are connected. Participants will fill out questionnaires about their feelings and daily life. The goal is to find patterns that can help doctors offe…

This observational study follows 334 adults with type 2 diabetes or drug-induced diabetes who are malnourished or at risk. Researchers will track their nutritional treatment patterns after being prescribed a special high-calorie, high-protein supplement with fiber. Participants f…

This study gives continuous glucose monitors (CGMs) to 40 Hispanic/Latinx young adults aged 18-45 with type 2 diabetes for 30 days. Researchers want to learn what helps or hinders CGM use, how users become more aware of their glucose patterns, and what kind of support they'd like…

This study looks at how common memory problems are in older adults (65+) with type 2 diabetes. It then tests a program that combines several lifestyle changes to see if it can prevent or slow down memory loss. About 420 people will take part, and their thinking skills will be com…

This study tests an experimental drug called MKP10241 in healthy people, people with obesity, and those with obesity plus type 2 diabetes. Researchers want to see if taking the drug with food changes how it works, and whether different doses are safe. About 68 participants will t…

This study looks at how body weight influences physical activity, balance, and quality of life in 50 adults with type 2 diabetes. Researchers will measure body composition, muscle strength, walking ability, and balance using simple tests and questionnaires. The goal is to better …