Can a new injection tackle obesity, diabetes, and liver disease?
NCT ID NCT07801313
First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time
Summary
This early-stage trial tests an investigational drug called MWN105, given as an injection under the skin, in healthy Chinese volunteers aged 18 to 45. The study aims to check the drug's safety, how the body processes it, and whether it triggers an immune response. Researchers will give single or multiple rising doses to different groups, with some participants receiving a placebo. The results will help decide whether MWN105 can move forward as a potential treatment for conditions like obesity, type 2 diabetes, and a liver disease called MASH.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- MWN105 injection, an investigational drug given under the skin
- What this could lead to
- If MWN105 proves safe and tolerable, it could advance toward treatments for obesity, type 2 diabetes, and a liver condition called MASH.
- What could go wrong
- This is an early, small phase 1 study focused on safety in healthy people, not on effectiveness. The drug may cause side effects or fail in later trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
-
55 people
The number who actually took part.
- Started
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Dec 2024
- Finished
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Jul 2025
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 45 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. The selected subjects should be healthy male or female individuals aged 18 to 45 years (inclusive). 2. Female subjects should have a body weight of at least 50.0 kg, and male subjects should have a body weight of at least 55.0 kg. Their body mass index (BMI) should be within the range of 19.0-28.0 kg/m² (inclusive). 3. Physical examination, vital signs, 12-lead electrocardiogram (ECG), abdominal ultrasound, and clinical laboratory test results (including serum calcitonin, coagulation function, and thyroid function) should show no clinically significant abnormalities. 4. Subjects are required to abstain from sexual activity or use two effective contraceptive methods simultaneously starting from 1 month before screening through 6 months after the last administration, and must have no plans for sperm or egg donation. Exclusion Criteria: 1. Any history of clinical severe diseases or current presence of any clinically significant diseases. 2. Those with a known history or family history of medullary thyroid carcinoma, type 2 multiple endocrine neoplasia syndrome (MEN2), or those with a history of hypothyroidism or abnormal thyroid hormone levels. 3. Subjects with a history of acute or chronic pancreatitis, symptomatic gallbladder disease, history of pancreatic injury, or other high-risk factors that may cause pancreatitis, or those with an amylase level \> 1.5 times the upper limit of the normal range (ULN) during screening. 4. Those with clinically significant gastric emptying abnormalities (such as gastric outlet obstruction), severe chronic gastrointestinal diseases (such as having had active ulcers within 6 months), long-term use of drugs that directly affect gastrointestinal motility (including but not limited to mosapride, cispamide), or those who have undergone gastrointestinal surgery within 12 weeks before screening and are assessed by the investigator as not suitable to participate in this clinical study. 5. Used any prescription drugs, herbal medicines, over-the-counter drugs, or dietary supplements within 2 weeks before administration. 6. Had an infectious disease within 4 weeks before screening, severe trauma, or a history of major surgery. 7. Received vaccines or planned to receive vaccines during the trial screening. 8. Donated blood, experienced significant blood loss (\> 450 mL), or received a blood transfusion within 12 weeks before screening.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hangzhou First People's Hospital
Hangzhou, Zhejiang, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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