New diabetes drug shows promise in early trial

NCT ID NCT06542874

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This study tested a new medicine called NNC0487-0111 in 448 adults with type 2 diabetes. Participants received either a once-weekly injection, a daily pill, or a placebo for about 43 weeks. The goal was to see how well different doses lower blood sugar and body weight.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NNC0487-0111 (a new medicine given as a tablet or injection)
What this could lead to: If successful, this could offer a new option for managing blood sugar and weight in type 2 diabetes.
What could go wrong: This is an early dose-finding study, so results may not lead to a treatment. The medicine may not work better than existing options or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 2 DIABETES (T2D)

Contacts and locations

Locations

"Laiko" General Hospital of Athens

Goudi/Athens, 11527, Greece
"Thermi" Private Hosital

Thessaloniki, 57001, Greece
"Thermi" Private Hosital

Thessaloniki, GR-57001, Greece
424 Military General Training Hospital

Thessaloniki, 564 29, Greece
424 Military General Training Hospital - 2nd Department of Internal Medicine

Thessaloniki, 564 29, Greece
AIPSMC Dr. Artin Magardichyan EOOD

Varna, 9020, Bulgaria
AMC Community Endocrinology

Albany, New York, 12203, United States
ActivMed Practice & Research LLC

Methuen, Massachusetts, 01844, United States
Advanced Internal Medicine, PLLC

Paducah, Kentucky, 42001, United States
Akaicho Clinic

Chiba-shi, Chiba, 260-0804, Japan
Alliance for Multispec Res

Norman, Oklahoma, 73069, United States
Arcturus HC PLC Troy Med Res

Troy, Michigan, 48098, United States
Arcturus Healthcare, PLC

Troy, Michigan, 48098, United States
Bajcsy-Zsilinszky Kórház

Budapest, 1106, Hungary
Beata Miklaszewicz & Dariusz Dabrowski "CARDIAMED" s.j.

Legnica, Lower Silesian Voivodeship, 59-220, Poland
Beata Mikłaszewicz & Dariusz Dąbrowski "CARDIAMED" s.j.

Legnica, Lower Silesian Voivodeship, 59-220, Poland
Brigham & Women's Hospital

Boston, Massachusetts, 02115, United States
Békés Megyei Központi Kórház

Gyula, 5700, Hungary
Cabinet Medical Dr Geru SRL

Timișoara, 300288, Romania
Cedar-Crosse Research Center

Chicago, Illinois, 60607, United States
Centricity Rsrch MHCity Multi

Morehead City, North Carolina, 28557, United States
Chase Medical Research LLC

Waterbury, Connecticut, 06708, United States
Clinical Hospital Centre Rijeka_Endocrinology

Rijeka, Primorje-Gorski Kotar County, 51 000, Croatia
Clinical Research Associates

Nashville, Tennessee, 37203, United States
Clinical Research Professionals

Chesterfield, Missouri, 63005, United States
Clínica Nuevas Tecnologías en Diabetes y Endocrinología

Seville, 41003, Spain
Complejo Hospitalario Universitario A Coruña

A Coruña, 15006, Spain
Complejo Hospitalario de Pontevedra - Hospital de Montecelo

Pontevedra, Spain
Cotton O'Neil Clinical Research Center

Topeka, Kansas, 66606, United States
DCC Sveti Georgi EOOD

Plovdiv, 4002, Bulgaria
DENTAVIA s.r.o.

Poprad, 05801, Slovakia
DIABETOL, s.r.o.

Prešov, 080 01, Slovakia
Debreceni Egyetem

Debrecen, Hajdú-Bihar, 4032, Hungary
Debreceni Egyetem

Debrecen, 4031, Hungary
Debreceni Egyetem

Debrecen, H-4031, Hungary
Debreceni Egyetem

Debrecen, H-4032, Hungary
Diagnostic-Consultative Centre "Sveti Georgi" Eood

Plovdiv, 4002, Bulgaria
EKAMED sp. z o.o.

Lublin, Lublin Voivodeship, 20-718, Poland
EKAMED sp. z o.o.

Lublin, 20-718, Poland
ETG Siedlce

Siedlce, Masovian Voivodeship, 08-110, Poland
EUROMEDICA Gen Clinic The/ki, Endocrin,Metabolism,Diabetes

Thessaloniki, 54645, Greece
EUROMEDICA Gen Clinic The/ki, Endocrin,Metabolism,Diabetes

Thessaloniki, GR-54643, Greece
Encore Medical Research LLC

Hollywood, Florida, 33024, United States
Fleming Island Ctr for Clin Res

Fleming Island, Florida, 32003, United States
Florida Inst For Clin Res

Orlando, Florida, 32825, United States
Florida Institute for Clinical research

Orlando, Florida, 32825, United States
Formed 2 Sp. z o.o.

Oświęcim, Lesser Poland Voivodeship, 32-600, Poland
Fukuwa Clinic

Tokyo, 104-0031, Japan
Fukuwa Clinic_Internal Medicine

Tokyo, 104-0031, Japan
Grandmed SRL

Oradea, Bihor County, 410159, Romania
H. Infanta Luisa_Endocrino y Obesidad

Seville, 41010, Spain
Health Concepts

Rapid City, South Dakota, 57702, United States
Heiwadai Hospital

Miyazaki, Miyazaki, 880-0034, Japan
Heiwadai Hospital_Internal Medicine

Miyazaki, Miyazaki, 880-0034, Japan
Hillcrest Family Health Center

Waco, Texas, 76708, United States
Holston Medical Group

Kingsport, Tennessee, 37660, United States
Hospital Clinic i Provincial

Barcelona, 08036, Spain
Hospital Gregorio Marañón

Madrid, 28007, Spain
Hospital Infanta Luisa

Seville, 41010, Spain
Hospital Nisa Sevilla Aljarafe

Seville, 41950, Spain
Hospital Universitario Marqués de Valdecilla

Santander, 39008, Spain
Hospital Vithas Sevilla

Castilleja de la Cuesta, 41950, Spain
IPSOMC Dr. Miglena Rizova Ltd.

Kyustendil, 2500, Bulgaria
Iatriko Psychicou Private Clinic

Athens, 115 25, Greece
Individual Practice For Specialized Outpatient Medical Care Doctor Miglena Rizova Ltd.

Kyustendil, 2500, Bulgaria
InnoDiab Forschung GmbH

Essen, 45136, Germany
Institut für Diabetesforschung GmbH Münster - Dr. med. Rose

Münster, 48145, Germany
Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila

Bucharest, Bucharest, 020475, Romania
Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila

Bucharest, Bucurestii, 020475, Romania
Jefferson Endocrinology Assocs

Philadelphia, Pennsylvania, 19107-6810, United States
KBC Rijeka, Endokrinologija

Rijeka, Primorje-Gorski Kotar County, 51 000, Croatia
Klinicki bolnicki centar Osijek

Osijek, 31 000, Croatia
Klinicki bolnicki centar Osijek_Endocrinology

Osijek, 31 000, Croatia
Lillestol Research LLC

Fargo, North Dakota, 58104, United States
MD Medical Research

Oxon Hill, Maryland, 20745, United States
MEDIVASA, s.r.o., Diabetologicka ambulancia

Žilina, 010 01, Slovakia
MH Egészségügyi Központ

Budapest, 1134, Hungary
Mariodiab Clinic SRL

Brasov, 500101, Romania
Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET

Krakow, Lesser Poland Voivodeship, 31-261, Poland
Medical centre Regina Life Clinic EOOD

Sofia, 1000, Bulgaria
Medstar Research Institute_Hyattsville

Hyattsville, Maryland, 20782, United States
MidState Endocrine Associates

Nashville, Tennessee, 37203, United States
NZOZ Vita-Diabetica Malgorzata Buraczyk

Bialystok, Podlaskie Voivodeship, 15-879, Poland
Naka Kinen Clinic

Ibaraki, 311-0113, Japan
Naka Kinen Clinic_Internal medicine

Ibaraki, 311-0113, Japan
Niepubliczny Zaklad Opieki Zdrowotnej Przychodnia Specjalistyczna A Wittek H Rudzki Sp. j.

Ruda Śląska, Gornoslaskie, 41-709, Poland
Niepubliczny Zaklad Opieki Zdrowotnej Przychodnia Specjalistyczna A Wittek H Rudzki Sp. j.

Ruda Śląska, 41-709, Poland
Novus Medical Clinica SRL

Ploieşti, Prahova, 100018, Romania
OLIVER - MED s.r.o.

Rimavská Sobota, 979 01, Slovakia
Opca bolnica Karlovac

Karlovac, 47000, Croatia
Opca bolnica Varazdin

Varaždin, 42 000, Croatia
Opca bolnica Varazdin_Endocrinology

Varaždin, 42 000, Croatia
PANSTWOWY INSTYTUT MEDYCZNY MSWiA

Warsaw, 02-507, Poland
Peter Farkas MD, s.r.o.

Šahy, Slovak Republic, 93601, Slovakia
Piedmont Healthcare/Research

Statesville, North Carolina, 28625, United States
Plains Clinical Research Center, LLC_Fargo

Fargo, North Dakota, 58104, United States
PlanIt Research, PLLC

Houston, Texas, 77079, United States
Poliklinika Solmed

Zagreb, City of Zagreb, 10000, Croatia
Preferred Primary Care Physicians_Pittsburgh

Pittsburgh, Pennsylvania, 15236, United States
RED-Institut für medizinische Forschung und Fortbildung GmbH

Oldenburg in Holstein, 23758, Germany
Radiance Clinical Research

Lampasas, Texas, 76550, United States
SC Grand Med SRL

Oradea, Bihor County, 410025, Romania
Santa Sp. z o.o, Santa Familia Centrum Badan, Profilaktyki i Leczenia

Lodz, Łódź Voivodeship, 90-302, Poland
Sc Mediab Srl

Târgu Mureş, Mureș County, 540142, Romania
Somogy Vármegyei Kaposi Mór Oktató Kórház

Kaposvár, 7400, Hungary
Somogy Vármegyei Kaposi Mór Oktató Kórház

Kaposvár, H-7400, Hungary
South Broward Research LLC

Miramar, Florida, 33027, United States
Southern Cal Clinical Research

Santa Ana, California, 92701, United States
Specderm Poznanska Sp. j.

Bialystok, Podlaskie Voivodeship, 15-375, Poland
Specderm Poznańska Spółka Jawna

Bialystok, 15-375, Poland
Specijalna Bolnica za medicinsku rehabilitaciju Krapinske Toplice_Endocrinology

Krapinske Toplice, 49217, Croatia
Specijalna bolnica Krapinske Toplice - Endokrinologija

Krapinske Toplice, 49217, Croatia
Spitalul Clinic Judetean De Urgenta Pius Brinzeu Timisoara

Timișoara, 300723, Romania
Spitalul Clinic Judetean Urgenta Cluj-Napoca

Cluj-Napoca, Cluj, 400006, Romania
StudyMetrix Research LLC

City of Saint Peters, Missouri, 63303, United States
Synergy Groups Medical

Houston, Texas, 77061, United States
TOSAKI Clinic for Diabetes and Endocrinology_Diabetes and Endocrinology

Aichi, 468-0009, Japan
Tekton Research

McKinney, Texas, 75069, United States
Tokuyama clinic

Chiba, 261-0004, Japan
Tokuyama clinic_Diabetic internal medicine

Chiba, 261-0004, Japan
Tokyo-Eki Center-building Clinic

Tokyo, 103-0027, Japan
Tokyo-Eki Center-building Clinic_Internal Medicine

Tokyo, 103-0027, Japan
U.G.H of Athens "Attikon"

Athens, 12462, Greece
UMHAT "Aleksandrovska"

Sofia, 1431, Bulgaria
UMHAT "Kaspela", Depart. Endocrinology and Metab. Diseases

Plovdiv, 4001, Bulgaria
UMHAT Aleksandrovska EAD, Densitometry and Bone Metabolic Diseases

Sofia, 1431, Bulgaria
UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic

Plovdiv, 4001, Bulgaria
USHATE "Akad. Ivan Penchev" Second Clinic of Endocrinology

Sofia, 1431, Bulgaria
USHATE Akad. Ivan Penchev EAD, Second Clinic of Endocrinology

Sofia, 1431, Bulgaria
Uni of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
Velocity Clin Research LA

Los Angeles, California, 90057, United States
Velocity Clinical Res-Dallas

Dallas, Texas, 75230, United States
Victorium Clinical Research

Houston, Texas, 77024, United States
Wendisch - Dahl Hamburg - DZHW

Hamburg, 22607, Germany
Wendisch/Dahl Hamburg

Hamburg, 22607, Germany
Zentrum fuer klinische Studien Suedbrandenburg GmbH

Elsterwerda, 04910, Germany
Zentrum für klinische Studien Südbrandenburg GmbH

Elsterwerda, 04910, Germany

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