New cocktail of four chemo drugs shows promise for tough pancreatic cancer
NCT ID NCT06225999
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tested a combination of four chemotherapy drugs—irinotecan liposome, oxaliplatin, 5-fluorouracil, and levoleucovorin—in 41 Japanese adults with metastatic pancreatic cancer who had not received prior treatment. The goal was to see how well the drugs shrank tumors and to check safety. Participants received the drugs by IV on days 1 and 15 of each 28-day cycle until the disease worsened or side effects became too severe. The study is complete, and results may help guide future treatment options for this aggressive cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- irinotecan liposome, oxaliplatin, 5-fluorouracil, and levoleucovorin
- What this could lead to
- If this drug combination works well, it could offer a new first-line treatment option for people with metastatic pancreatic cancer, potentially improving tumor shrinkage and survival.
- What could go wrong
- This is a small, early-phase study with only 41 participants, so results may not apply to everyone. The drugs can cause serious side effects, and the combination may not prove better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aichi Cancer Center (007)
Nagoya, 464-8681, Japan
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Chiba Cancer Center (011)
Chiba, 260-8717, Japan
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Chiba University Hospital (015)
Chiba, 260-8677, Japan
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Hokkaido University Hospital (004)
Sapporo, 060-8648, Japan
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Kanagawa Cancer Center (002)
Kanagawa, 241-8515, Japan
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Kanazawa University Hospital (008)
Ishikawa, 920-8641, Japan
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National Cancer Center Hospital (001)
Tokyo, 104-0045, Japan
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National Cancer Center Hospital East (003)
Kashiwa, Chiba, 277-8577, Japan
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National Hospital Organization Kyushu Cancer Center (005)
Fukuoka, 811-1395, Japan
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National Hospital Organization Shikoku Cancer Center (013)
Ehime, 791-0280, Japan
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Osaka International Cancer Institute (009)
Osaka, 541-8567, Japan
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Saitama Cancer Center (012)
Saitama, 362-0806, Japan
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The Cancer Institute Hospital of JFCR (006)
Tokyo, 135-8550, Japan
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Yamaguchi University Hospital (010)
Yamaguchi, 755-8505, Japan
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