Low-carb diet may help type 1 diabetes patients keep making some insulin
NCT ID NCT05536232
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study tests whether a low-carbohydrate diet (under 75 grams per day) can help adults with type 1 diabetes preserve their remaining insulin production. The idea is that the diet might calm the immune attack on insulin-making cells. Participants will follow the diet for a period while researchers measure insulin levels, blood sugar control, and immune markers.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- low carbohydrate diet (under 75 g per day)
- What this could lead to
- If it works, this could point toward a way to preserve some natural insulin production in type 1 diabetes, potentially reducing the amount of insulin needed.
- What could go wrong
- This is a small, early study with only 30 participants. The diet carries a risk of ketoacidosis, and it is not yet known whether any immune benefits will be seen.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Started
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Oct 2022
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18 years old or older * type 1 diabetes for less than 20 years * willing to start a low carbohydrate diet of less than 75 g per day * under continuous glucose monitoring * having been informed about the study and having given their written and informed consent Exclusion Criteria: * already on a low carbohydrate diet of less than 100 g per day * history of ketoacidosis within the last 5 years, except during diabetes diagnosis * autoimmune disease, except thyroiditis * immunosuppressive treatment * hepatitis B virus, hepatitis C virus or human immunodeficiency virus infection * ongoing cancer or history of cancer within the past 5 years, except in situ cervical cancer or basal cell cancer with early treatment * participation to another interventional study within the past 3 months * pregnancy or breast feeding * no affiliation to a social security scheme * patients subject to legal protection measures * unability to give consent for the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AP-HP - Pitié-Salpêtrière Hospital
Paris, 75013, France
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