New heat treatment may cut cancer pain without extra drugs

NCT ID NCT05535894

Completed Symptom relief Sponsor: West Virginia University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) to treat pain in 19 people with advanced pancreatic cancer that could not be removed by surgery. The goal was to see if zapping the celiac ganglion—a bundle of nerves—could reduce pain and improve quality of life. Researchers measured pain levels, medication use, and well-being before and after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiofrequency ablation of the celiac ganglion
What this could lead to: If it works, this could offer a new way to manage severe pain and reduce the need for strong painkillers in people with advanced pancreatic cancer.
What could go wrong: This was a small, early study with only 19 participants, so results may not apply to everyone. The procedure carries risks like bleeding or infection, and pain relief may not last long.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for PANCREATIC CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC CANCER

Contacts and locations

Locations

Shailendra Singh

Morgantown, West Virginia, 26508, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.