Could a probiotic boost weight loss after surgery?

NCT ID NCT05170867

Completed Disease control Sponsor: Universidade Nova de Lisboa Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking a probiotic called Hafnia alvei HA4597 can help people lose more weight and control blood sugar better after gastric bypass surgery. 49 adults with obesity and type 2 diabetes took either the probiotic or a placebo twice a day for 90 days, starting one month after surgery. Researchers tracked weight loss and blood sugar levels over a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hafnia alvei HA4597 probiotic supplement
What this could lead to: If it works, this could point toward a simple probiotic to help people lose more weight and control blood sugar after weight-loss surgery.
What could go wrong: This is a small, early-stage trial with only 49 participants. The results may not apply to everyone, and the supplement may not provide any extra benefit beyond standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY TYPE 2 DIABETES

Contacts and locations

Locations

NOVA Medical School|Faculdade de Ciências Médicas, Universidade NOVA de Lisboa

Lisbon, 1169-056, Portugal

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