Diabetes drug cocktail tested in healthy volunteers

NCT ID NCT06495931

Completed Knowledge-focused Sponsor: Shandong Suncadia Medicine Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 1 trial tested how four diabetes medications (HRS-1780, henagliflozin, metformin, and HRS-7535) affect each other's levels in the body. Twenty-four healthy men took the drugs in a fixed order, and researchers measured drug concentrations and side effects. The goal was to gather safety and interaction data, not to treat diabetes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HRS-1780, henagliflozin, metformin, and HRS-7535 tablets
What this could lead to: If successful, this study could help doctors understand how these drugs work together, potentially leading to safer combination treatments for type 2 diabetes.
What could go wrong: This is a very early, small study in healthy people, not patients. It only looks at drug levels in the body, not whether the drugs actually improve diabetes. Results may not apply to real-world patients.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 2 DIABETES MELLITUS

Contacts and locations

Locations

Xuanwu Hospital ,Capital Medical University

Beijing, Beijing Municipality, 100032, China

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