Cold spray may take the sting out of insulin shots — a trial puts it to the test

NCT ID NCT07728162

Completed Symptom relief Sponsor: Abant Izzet Baysal University Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial tests whether a quick cold spray on the skin before a subcutaneous insulin injection can reduce pain compared to a placebo spray. Adults in the emergency department who need at least two insulin injections receive both sprays in random order, rating their pain after each. The goal is to see if this simple, low-cost approach can make injections more comfortable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a vapocoolant (cold) spray applied to the skin before injection
What this could lead to: If it works, this could offer a simple, drug-free way to ease injection pain for people with diabetes in emergency settings.
What could go wrong: This is a small, early-stage trial in a specific setting (emergency department), so results may not apply to routine daily insulin use. The effect may be modest or no better than placebo.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus Emergencies Insulin Resistance Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS PAIN

Contacts and locations

Locations

Bolu Izzet Baysal Training and Research Hospital

Bolu, 14030, Turkey (Türkiye)

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