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New daily pill aims to tame type 2 diabetes safely over the long haul

NCT ID NCT06010004

Completed Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests the long-term safety of an experimental oral drug called orforglipron in adults with type 2 diabetes whose blood sugar is not well controlled by diet, exercise, or other diabetes pills. Participants take the drug once daily for about a year, and researchers monitor for side effects and changes in blood sugar levels. The goal is to see if orforglipron can be a safe, long-term treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

orforglipron (LY3502970)

What this could lead to

If successful, this could provide a new, convenient once-daily oral option for managing type 2 diabetes long-term.

What could go wrong

This is a safety-focused study, so effectiveness is not the primary goal. Side effects may emerge, and results may not apply to all diabetes patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 2 DIABETES

Contacts and locations

Locations

  • Abe Clinic

    Ōita, 870-0039, Japan

  • Fujii Clinic

    Ube, Yamaguchi, 755-0049, Japan

  • Fukuwa Clinic

    Chuo-ku, Tokyo, 104-0031, Japan

  • Gibo Hepatology Clinic

    Matsumoto, Nagano, 399-0036, Japan

  • Hachioji Diabetes Clinic

    Hachioji-shi, Tokyo, 192-0083, Japan

  • Hasegawa Medical Clinic

    Chitose, Hokkaido, 066-0032, Japan

  • Heishinkai Medical Group ToCROM Clinic

    Shinjuku-ku, Tokyo, 160-0008, Japan

  • Heiwadai Hospital

    Miyazaki, 880-0034, Japan

  • Jinnouchi Hospital

    Kumamoto, 862-0976, Japan

  • Kanno Naika

    Mitaka, Tokyo, 181-0013, Japan

  • Kansai Electric Power Hospital

    Osaka, 553-0003, Japan

  • Kashiwa City Hospital

    Kashiwa, Chiba, 277-0825, Japan

  • Kitada Clinic

    Osaka, Osaka, 538-0044, Japan

  • Matsuda Clinic

    Kobe, Hyōgo, 651-2135, Japan

  • Medical Corporation Heishinkai OCROM Clinic

    Suita-shi, Osaka, 565-0853, Japan

  • Medical Corporation Tao Internal Medicine Clinic

    Ube, Yamaguchi, 755-0047, Japan

  • Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic

    Yamato-shi, Kanagawa, 242-0004, Japan

  • Mikannohana Clinic, Diabetes, Endocrinology and Metabolism

    Matsuyama, Ehime, 790-0034, Japan

  • MinamiAkatsukaClinic

    Mito, Ibaraki, 311-4153, Japan

  • Morinaga Ueno Clinic

    Kumamoto, 860-0863, Japan

  • Nakakinen clinic

    Naka, Ibaraki, 311-0113, Japan

  • Nakamoto Internal Medicine Clinic

    Mito, Ibaraki, 310-0826, Japan

  • Nakayama Clinic

    Nagoya, Aichi-ken, 456-0058, Japan

  • Nishiyamadou Keiwa Hospital

    Naka, Ibaraki, 311-0133, Japan

  • OHAMA Diabetes Clinic

    Kawaguchi, Saitama, 332-0015, Japan

  • Odori Diabetes

    Sapporo, Hokkaido, 060-0001, Japan

  • Seiwa Clinic

    Adachi-ku, Tokyo, 120-0011, Japan

  • Shinkashiwa Clinic

    Kashiwa, Chiba, 277-0084, Japan

  • Shiraiwa Medical Clinic

    Kashihara, Osaka, 582-0005, Japan

  • Shonan Takai Clinic

    Kamakura, Kanagawa, 247-0055, Japan

  • Steel Memorial Yawata Hospital

    Kitakyushu, Fukuoka, 805-8508, Japan

  • Sugiura Internal Medicine Clinic

    Sōka, Saitama, 340-0015, Japan

  • Takai Internal Medicine Clinic

    Kamakura-shi, Kanagawa, 247-0056, Japan

  • Tashiro Endocrinology Clinic

    Fukuoka, 814-0153, Japan

  • Taya Clinic Koueikai Medical Corporation

    Tsuchiura, Ibaraki, 300-0047, Japan

  • The Institute for Adult Disease, Asahi Life Foundation

    Chuo-ku, Tokyo, 103-0002, Japan

  • Tokuyama Clinic

    Mihama-ku,Chiba City, Chiba, 261-0004, Japan

  • Tokyo-Eki Center-building Clinic

    Chuo-ku, Tokyo, 103-0027, Japan

  • Yokkaichi Diabetes Clinic

    Yokkaichi, Mie-ken, 510-0829, Japan

  • Yokohama Minoru Clinic

    Yokohama, Kanagawa, 232-0064, Japan