Can High-Dose vitamin c boost Chemo's punch against pancreatic cancer?
NCT ID NCT03410030
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This trial is testing whether adding high-dose vitamin C (ascorbic acid) to a standard three-drug chemotherapy cocktail can safely and effectively control metastatic pancreatic cancer in people who have not yet received any treatment. The study enrolls adults with stage IV pancreatic cancer and aims to find the best dose of vitamin C that can be given alongside the chemo. Researchers are watching for tumor shrinkage and how long the disease stays stable.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- high-dose vitamin C (ascorbic acid) plus a combination of chemotherapy drugs: nab-paclitaxel, cisplatin, and gemcitabine
- What this could lead to
- If it works, this could point toward a more effective first-line treatment for metastatic pancreatic cancer, a disease with very few good options.
- What could go wrong
- This is an early-phase trial with only 17 participants, so results may not apply broadly. High-dose vitamin C can cause kidney stones and other side effects, and the chemo combination itself is intense.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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HonorHealth Research Institute
Scottsdale, Arizona, 85258, United States
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