Scientists hunt for hidden fat molecules that sabotage insulin

NCT ID NCT03077360

Completed Knowledge-focused Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study investigates how specific fat molecules called diacylglycerols and sphingolipids inside muscle cells influence insulin resistance. Researchers will measure these lipids in different parts of muscle cells before and after weight loss or exercise in people with obesity, prediabetes, or type 2 diabetes. The goal is to pinpoint which fat types and locations drive insulin resistance, potentially guiding future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lifestyle changes including diet-induced weight loss or exercise training
What this could lead to: If successful, this research could identify specific fat molecules to target for new type 2 diabetes treatments.
What could go wrong: This is an observational and exploratory study, not a treatment trial. The findings may not lead directly to new therapies.

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Conditions

The condition(s) this trial relates to.

glucose intolerance Obesity obesity disorder prediabetes syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 2 OBESITY PRE-DIABETES

Contacts and locations

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Locations

University of Colorado

Aurora, Colorado, 80045, United States

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