Could a diabetes prevention strategy also fight heart disease and cancer?
NCT ID NCT00038727
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and cancer. Researchers are tracking participants for years to understand the lasting effects of these interventions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- metformin (Glucophage) and lifestyle intervention
- What this could lead to
- If successful, this could show that metformin or lifestyle changes not only prevent diabetes but also reduce the risk of heart disease and cancer in high-risk individuals.
- What could go wrong
- This is a long-term follow-up study, and results may take years to emerge. The benefits seen in the original trial may not persist, and metformin can cause gastrointestinal side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
George Washington University
Rockville, Maryland, 20852, United States
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