New diabetes pill takes on popular drug in Head-to-Head trial

NCT ID NCT06415773

Completed Disease control Sponsor: Shenzhen HighTide Biopharmaceutical Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 2 times

Summary

This study tested a new drug called HTD1801 (berberine ursodeoxycholate) against the standard diabetes drug dapagliflozin in 367 adults with type 2 diabetes whose blood sugar was not well controlled by metformin alone. The main goal was to see how well HTD1801 lowers blood sugar levels over 24 weeks. The trial is complete, but results have not yet been shared.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: berberine ursodeoxycholate (HTD1801)
What this could lead to: If successful, HTD1801 could offer a new oral option for managing blood sugar in people with type 2 diabetes.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. It compares against an existing drug, so it may not prove superior or may have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

T2DM (TYPE 2 DIABETES MELLITUS)

Contacts and locations

Locations

Affiliated Hospital of Jiangsu University

Zhenjiang, China
Affiliated Hospital of Nantong University

Nantong, China
Beijing Pinggu Hospital

Beijing, China
Binzhou Medical University Hospital

Binzhou, China
Bishan Hospital of Chongqing

Chongqing, China
Handan First Hospital

Handan, China
Hebei Petro China Central Hospital

Langfang, China
Huadong Hospital Affiliated to Fudan University

Shanghai, China
Huanggang Central Hospital

Huanggang, China
Huangshi Central Hospital

Huangshi, China
Huizhou Municipal Central Hospital

Huizhou, China
Jilin Province FAW General Hospital

Changchun, China
Jincheng General Hospital

Jincheng, China
Liaocheng People's Hospital

Liaocheng, China
Luoyang Third People's Hospital

Luoyang, China
Nanjing Drum Tower Hospital - The Affiliated Hospital of Nanjing University Medical School

Nanjing, China
Panjin Liaohe Oilfield GEM Flower Hospital

Panjin, China
Peking University People's Hospital

Beijing, China
People's Hospital of Deyang City

Deyang, China
Pingxiang People's Hospital

Pingxiang, China
Sanmenxia Central Hospital

Sanmenxia, China
Shandong Guoxinyiyang Group Zaozhuang Central Hospital

Zaozhuang, China
Shanghai Sixth People's Hospital

Shanghai, China
Shengjing Hospital of China Medical University

Shenyang, China
The Central Hospital of Xiangtan

Xiangtan, China
The First Affiliated Hospital of Henan University of Science & Technology (Jinghua)

Luoyang, China
The First Affiliated Hospital of Henan University of Science & Technology (Kaiyuan)

Luoyang, China
The First Affiliated Hospital of Nanchang University

Nanchang, China
The First Affiliated Hospital of Nanyang Medical College

Nanyang, China
The First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, China
The First Hospital of Changsha City

Changsha, China
The First Hospital of Qiqihar

Qiqihar, China
The First People's Hospital of Changde City

Changde, China
The First People's Hospital of Xiangtan City

Xiangtan, China
The Fourth Hospital of Changsha

Changsha, China
The Fourth Hospital of Harbin Medical University

Harbin, China
The People's Hospital of Liaoning Province

Shenyang, China
The Second Affiliated Hospital of Nanchang University

Nanchang, China
The Second Affiliated Hospital of Nanjing Medical University

Nanjing, China
The Second Affiliated Hospital of Xi'an Jiaotong University

Xi'an, China
The Second Affiliated Hospital of Zhengzhou University

Zhengzhou, China
The Second Hospital of Jilin University

Changchun, China
The Second People's Hospital of Huai'an

Huai'an, China
The Second People's Hospital of Lianyungang

Lianyungang, China
The Second People's Hospital of Yibin

Yibin, China
The Second Xiangya Hospital of Central South University

Changsha, China
The Third Xiangya Hospital of Central South University

Changsha, China
Wuhan Third Hospital

Wuhan, China
Xianyang Hospital of Yan'an University

Xianyang, China
Xuzhou Cancer Hospital

Xuzhou, China
Yiyang Central Hospital

Yiyang, China
Yueyang People's Hospital

Yueyang, China
Zhumadian Central Hospital

Zhumadian, China

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