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Gum disease may alter key hormone and oxidative markers in diabetes patients

NCT ID NCT07691060

Knowledge-focused Sponsor: Saglik Bilimleri Universitesi Source: ClinicalTrials.gov ↗

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Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This observational study investigates how different levels of gum health influence asprosin (a hormone) and total oxidant/antioxidant levels in people with type 2 diabetes. Researchers will collect fluid from around the gums and blood samples from 67 participants to compare these markers between those with healthy gums, gingivitis, and periodontitis. The goal is to better understand the connection between oral health and systemic diabetes-related changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal how gum disease influences diabetes-related hormones and oxidative stress, pointing toward better monitoring or treatment strategies.
What could go wrong
This is an observational study, not a treatment trial. It measures associations, not cause and effect, and results may not apply to all people with diabetes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

67 people

The number who actually took part.

Started

Jul 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consisted of adults aged 18-65 years. The gingivitis and periodontitis groups included patients diagnosed with type 2 diabetes mellitus (T2DM), whereas the healthy control group consisted of systemically healthy individuals. Participants were required to be non-smokers, have more than 20 natural teeth, and have no systemic conditions or medication use that could affect the immune response of the periodontal tissues.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with type 2 diabetes mellitus (T2DM) in the gingivitis and periodontitis groups * Systemically healthy individuals without any systemic disease in the healthy control group * Age between 18 and 65 years * Non-smokers * Individuals with no diseases or medication use that could alter the immune response of the periodontal tissues * Participants with more than 20 natural teeth Exclusion Criteria: * Age younger than 18 years or older than 65 years * Smokers * Individuals with any disease or medication use that could alter the immune response of the periodontal tissues * Pregnant women * Individuals who had received periodontal treatment within the previous 6 months * Patients with type 1 diabetes mellitus (T1DM) * Individuals who had used antibacterial medications within the previous 6 months

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Conditions

The condition(s) this trial relates to.

Arachnodactyly gingival disorder gingivitis periodontal disorder periodontitis type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival diseases Periodontal diseases Type 2 diabetes

Contacts and locations

Locations

  • University of Health Sciences Türkiye, Gülhane Faculty of Dentistry

    Ankara, Ankara, 06100, Turkey (Türkiye)

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