Weekly combo shot shows promise for better blood sugar control

NCT ID NCT05259033

First seen Jun 18, 2026 · Last updated Jun 18, 2026

Summary

This study tested a new once-a-week injection called IcoSema, which combines insulin and semaglutide, against semaglutide alone in 683 adults with type 2 diabetes. The goal was to see if IcoSema improves blood sugar levels more effectively. Participants received weekly shots for about a year, with regular check-ups and blood tests.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for DIABETES MELLITUS TYPE 2 are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • "Ippokrateio" G.H. of Thessaloniki

    Thessaloniki, 54642, Greece

  • "Thermi" Private Hosital

    Thessaloniki, 57001, Greece

  • "University Clinic" of Dnipro State Medical University - Endocrinology department

    Dnipro, 49038, Ukraine

  • 'G. Gennimatas' General Hospital of Athens

    Athens, 115 27, Greece

  • AM Diabetes And Endocrinology Center

    Bartlett, Tennessee, 38133, United States

  • Accellacare

    Wilmington, North Carolina, 28401, United States

  • ActivMed Practice & Research LLC

    Methuen, Massachusetts, 01844, United States

  • Adult Medicine of Lake County, Inc.

    Mt. Dora, Florida, 32757, United States

  • Albuquerque Clin Trials, Inc.

    Albuquerque, New Mexico, 87102, United States

  • Amarillo Med Spec LLP

    Amarillo, Texas, 79106, United States

  • Anhui Provincial Hospital-Endocrinology

    Hefei, Anhui, 230001, China

  • Aphp-Hopital Lariboisiere

    Paris, 75010, France

  • BC Diabetes Canada

    Vancouver, British Columbia, V5Y 3W2, Canada

  • BHI of Omsk Region "City Hospital № 3"

    Omsk, 644029, Russia

  • BR Trials - Ensaios Clínicos e Consultoria Ltda.

    São Paulo, São Paulo, 01236-030, Brazil

  • Bluewater Clin Res Group,Inc

    Sarnia, Ontario, N7T 4X3, Canada

  • Békés Megyei Központi Kórház - dr. Réthy Pál Tagkórház

    Békéscsaba, 5600, Hungary

  • Cedar Research

    Dallas, Texas, 75038, United States

  • Cedar-Crosse Research Center

    Chicago, Illinois, 60607, United States

  • Central Illinois Diabetes and Clinical Research

    Springfield, Illinois, 62711, United States

  • Centre Hospitalier Universitaire de Besancon-Hopital Jean Minjoz

    Besançon, 25030, France

  • Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec

    Saint-Herblain, 44800, France

  • Centre Hospitalier Universitaire de Rouen - Hopital de Bois Guillaume

    Bois-Guillaume, 76230, France

  • Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-2

    Toulouse, 31054, France

  • Centre Medical Acadie

    Montreal, Quebec, H4N 2W2, Canada

  • Centre Medico Chirurgical Ambroise Pare Hartmann

    Neuilly-sur-Seine, 92200, France

  • Centre de Recherche Clinique Portes Du Sud

    Vénissieux, 69200, France

  • Centre of Innovative Medical Technologies of NASU - Therapeutic and Endocrinology Department

    Kyiv, 04053, Ukraine

  • Centro de Diabetes Curitiba

    Curitiba, Paraná, 80810-040, Brazil

  • Centro de Diabetes Metabolismo e Endocrinologia

    Fortaleza, Ceará, 60150-162, Brazil

  • Centro de Estudos Em Diabetes E Hipertensão

    Fortaleza, Ceará, 60115-282, Brazil

  • Centrum for Diabetes, Academical Specialist Centrum

    Stockholm, 113 65, Sweden

  • Chang Gung Medical Foundation - Linkou Branch

    Taoyuan, 333, Taiwan

  • Changzhou No.2 People's Hospital, Yanghu Branch

    Changzhou, Jiangsu, 213003, China

  • Chattanooga Medical Research, LLC

    Chattanooga, Tennessee, 37404, United States

  • Chi Mei Medical Center

    Tainan, 710, Taiwan

  • Chongqing University Three Gorges Hospital

    Chongqing, Chongqing Municipality, 404000, China

  • Chrysalis Clinical Research

    St. George, Utah, 84790, United States

  • Chung Shan Medical University Hospital

    Taichung, 402, Taiwan

  • Clalit sick fund Herzeliya

    Herzeliya, Israel, 4630945, Israel

  • Clinical Neuroscience Solution

    Orlando, Florida, 32801, United States

  • Clinical Research Institute of Arizona

    Sun City West, Arizona, 85375, United States

  • Clinical Trials Research_Sacramento

    Lincoln, California, 95821, United States

  • Commonwealth Medical Clinic

    Mount Pearl, Newfoundland and Labrador, A1N 1W7, Canada

  • Cotton-O'Neil Diab & Endo Ctr

    Topeka, Kansas, 66606, United States

  • Ctr Méd. et pro d l'Ost d port

    Saint-Marc-des-Carrieres, Quebec, G0A 4B0, Canada

  • DCOL Ctr for Clin Res

    Longview, Texas, 75605, United States

  • DIA - KONTROL s.r.o.

    Levice, 93401, Slovakia

  • DIABETOL, s.r.o.

    Prešov, 080 01, Slovakia

  • DIADAN, s.r.o. Kosice

    Košice, 04011, Slovakia

  • DIOLI s.r.o.

    Košice, 040 01, Slovakia

  • Dawson Clinical Research

    Cambridge, Ontario, N1H 1B1, Canada

  • Debreceni Egyetem Belgyógyászati Klinika

    Debrecen, Hajdú-Bihar, 4032, Hungary

  • Debreceni Egyetem Klinikai Központ Belgyógyászati Klinika D épület

    Debrecen, Hajdú-Bihar, H-4043, Hungary

  • Diab & Endo Assoc of Stark Co

    Canton, Ohio, 44718, United States

  • Diabetes Adipositas Zentrum Zürich

    Zollikerberg, 8125, Switzerland

  • Diabetes Clinic Meir MC

    Kfar Saba, 44281, Israel

  • Diabetes and Thyroid Ctr of FW

    Fort Worth, Texas, 76132, United States

  • Diabetologicka ambulancia SchronerMED, s.r.o.

    Moldava nad Bodvou, 045 01, Slovakia

  • Diex Recherche Quebec

    Québec, G1V 4T3, Canada

  • Downtown LA Res Ctr. Inc.

    Los Angeles, California, 90017, United States

  • East West Med Res Inst

    Honolulu, Hawaii, 96814, United States

  • Encore Medical Research LLC

    Hollywood, Florida, 33024, United States

  • Endeavor Health

    Skokie, Illinois, 60077, United States

  • Endo Res Solutions Inc

    Roswell, Georgia, 30076, United States

  • Endocrine Associates of Long Island, PC

    Smithtown, New York, 11787, United States

  • Enheten för Kliniska Studier (EKS), Örebro

    Örebro, 701 85, Sweden

  • Enheten för Kliniska Studier (EKS), Örebro

    Örebro, 703 62, Sweden

  • Est Cst Inst for Rsrch,Jksnvil

    Jacksonville, Florida, 32216, United States

  • Evangelismos Hospital

    Athens, 10676, Greece

  • FNsP L. Pasteura

    Košice, 04190, Slovakia

  • FSBI 'I.I. Dedov National Medical Research Center of Endocrinology' of the MH of Russia

    Moscow, 117292, Russia

  • Florida Institute For Clinical Research

    Orlando, Florida, 32825, United States

  • Four Rivers Clinical Research Inc

    Paducah, Kentucky, 42001, United States

  • Futata Tetsuhiro Clinic Meinohama

    Fukuoka-shi, Fukuoka, 819-0006, Japan

  • Futata Tetsuhiro Clinic Meinohama_Internal medicine

    Fukuoka-shi, Fukuoka, 819-0006, Japan

  • G.A. Research Associates Ltd.

    Moncton, New Brunswick, E1G 1A7, Canada

  • General Hospital Of Athens Korgialenio Benakio H.R.C. - Department of Endocrinology

    Athens, GR-11526, Greece

  • General Hospital of Thessaloniki "G.Papanikolaou"

    Thessaloniki, 57010, Greece

  • General Hospital of Thessaloniki 'G. Gennimatas

    Thessaloniki, 54635, Greece

  • Gifu University Hospital_The Third Dept. of Internal Medicine

    Gifu, 501-1194, Japan

  • Groupe Sos Sante-Hopital Le Creusot-Hotel Dieu

    Le Creusot, 71200, France

  • HUMAN-CARE, s.r.o.

    Košice, 040 01, Slovakia

  • Hadassah Ein Karam MC - Diabetes Unit

    Jerusalem, 91120, Israel

  • Heiwadai Hospital_Internal Medicine

    Miyazaki, Miyazaki, 880-0034, Japan

  • Hillcrest Clinical Research

    Simpsonville, South Carolina, 29681-1538, United States

  • Hillcrest Family Health Center

    Waco, Texas, 76710, United States

  • Hospices Civils de Lyon-Hopital Lyon Sud-2

    Pierre-Bénite, 69495, France

  • Huashan Hospital Fudan University-Endocrinology

    Shanghai, Shanghai Municipality, 200040, China

  • Huizhou Central People's Hospital-Endocrinology

    Huizhou, Guangdong, 516001, China

  • Iatriko Psychicou Private Clinic

    Athens, 115 25, Greece

  • Ileana J Tandron APMC

    Slidell, Louisiana, 70461-4231, United States

  • Instituto São José dos Campos em Pesquisas Médicas

    São José dos Campos, São Paulo, 12243-280, Brazil

  • Instituto de Ciências Farmacêuticas de Estudos e Pesquisas

    Aparecida de Goiânia, Goiás, 74935-530, Brazil

  • Iowa Diab & Endo Res Center

    West Des Moines, Iowa, 50266, United States

  • Irkutsk State Medical Academy of Postgraduate Education

    Irkutsk, 664049, Russia

  • Javara Inc. / Privia Medical Group LLC_Forest

    Forest, Virginia, 24551, United States

  • Javara Inc/Privia Md GpLLC Fst

    Forest, Virginia, 24551, United States

  • Javara/Privia Med Grp GA,LLC

    Albany, Georgia, 31707, United States

  • Jinan Central Hospital

    Jinan, Shandong, 250013, China

  • John J Shelmet, MD

    Lawrenceville, New Jersey, 08648, United States

  • John Muir Physicians Network

    Concord, California, 94520, United States

  • Kantonsspital Olten

    Olten, 4600, Switzerland

  • Kantonsspital St. Gallen

    Sankt Gallen, 9007, Switzerland

  • Kinderspital Endokrinologie, Zürich

    Zurich, Switzerland

  • Komisarenko Institute of Endocrinology and Metabolism of NAMSU - Department of paediatric endocrine pathology

    Kyiv, 04114, Ukraine

  • L-MARC Research Center

    Louisville, Kentucky, 40213, United States

  • LMC Clin Rsrch Inc. (Montreal)

    Montreal, Quebec, H4T 1Z9, Canada

  • LMC Clin Rsrch Inc. (Montreal)

    Saint-Laurent, Quebec, H4T 1Z9, Canada

  • LMC Clinical Res Thornhill

    Concord, Ontario, L4K 4M2, Canada

  • LMC Endo Centres Ltd.(Bayview)

    Toronto, Ontario, M4G 3E8, Canada

  • Les Hopitaux de Chartres-Hopital Louis Pasteur

    Le Coudray, 28630, France

  • Limited Law Company "Healthy Family" Medicine Center"

    Novosibirsk, 630099, Russia

  • Linn clinic - Diabetes Unit

    Haifa, 35152, Israel

  • Luzerner Kantonsspital

    Lucerne, 6004, Switzerland

  • MED-TIMA Kft.

    Budapest, 1132, Hungary

  • MUDr. Alena Lomencikova, s.r.o

    Turčianske Teplice, 039 01, Slovakia

  • Macoupin Research Group

    Gillespie, Illinois, 62033, United States

  • MedStar Hlth Res Institute

    Hyattsville, Maryland, 20782, United States

  • Medical Trust Clinics, Inc.

    Courtice, Ontario, L1E2J5, Canada

  • Metabolic Research Institute Inc

    West Palm Beach, Florida, 33401, United States

  • NE Clin Res of San Antonio

    San Antonio, Texas, 78233, United States

  • Naka Kinen Clinic_Internal medicine

    Ibaraki, 311-0113, Japan

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • New Venture Medical Research

    Wadsworth, Ohio, 44281, United States

  • North Texas Endocrine Center

    Dallas, Texas, 75231, United States

  • Northeast Res Inst. Inc.

    Jacksonville, Florida, 32204, United States

  • Northeast Research Institute

    Fleming Island, Florida, 32003, United States

  • Northern Pines Hlth Ctr, PC

    Buckley, Michigan, 49620, United States

  • Osvaldo A. Brusco MD

    Corpus Christi, Texas, 78414, United States

  • Oviedo Medical Research, LLC

    Oviedo, Florida, 32765, United States

  • PTE-AOK II. Belgyogyaszati Klinika es Nephrologiai Centrum

    Pécs, Baranya Vármegye, 7623, Hungary

  • Palm Research Center Inc-Vegas

    Las Vegas, Nevada, 89148, United States

  • Palmetto Clinical Research

    Summerville, South Carolina, 29485, United States

  • Peking University People's Hospital-Endocrinology

    Beijing, Beijing Municipality, 100044, China

  • Penza Regional Clinical Hospital named after N.N. Burdenko

    Penza, 440052, Russia

  • PharmQuest Life Sciences LLC

    Greensboro, North Carolina, 27408, United States

  • Phoenician Centers for Research & Innovation PCRI

    Phoenix, Arizona, 85021, United States

  • Polyclinic #2 in Yoshkar-Ola

    Yoshkar-Ola, 424004, Russia

  • Premier Clinical Trial Research Network (PCTRN)

    Hamilton, Ontario, L8M 1K7, Canada

  • Premier Medical Center, Inc.

    Toluca Lake, California, 91602, United States

  • Pri Med Grp dba/Gil Ctr Fam

    Gilbert, Arizona, 85296, United States

  • Primary Care Trial Center, PTC ,Gothia Forum

    Gothenburg, 413 46, Sweden

  • PrimeCare Medical Group

    Houston, Texas, 77024, United States

  • Quanta Diagnóstico Nuclear / Medicina Nuclear Alto da XV

    Curitiba, Paraná, 80045-110, Brazil

  • Recherche Clinique Sigma inc

    Québec, G1G 5X1, Canada

  • Recherche GCP Research

    Montreal, Quebec, H1M 1B1, Canada

  • Recherche GCP Research

    Montreal, Quebec, H1Y 3H5, Canada

  • Recherche GCP Research_Montreal

    Montreal, Quebec, H2R 1V6, Canada

  • Rivergrove Medical Clinic

    Winnipeg, Manitoba, R2V 4W3, Canada

  • Rostov State Medical University_Rostov-on-Don

    Rostov-on-Don, 344022, Russia

  • Saltzer Medical Group Research

    Nampa, Idaho, 83686-6011, United States

  • San Diego Family Care_San Diego

    San Diego, California, 92111, United States

  • Scripps Whittier Diabetes Inst

    La Jolla, California, 92037, United States

  • Shanghai Fifth People's Hospital-Endocrinology

    Shanghai, Shanghai Municipality, 200240, China

  • Shanghai Huashan Hospital, Affiliated to Fudan University

    Shanghai, Shanghai Municipality, 200040, China

  • Sheba MC - Endocrinology Clinic

    Tel Litwinsky, 52621, Israel

  • Shimizu Clinic Fusa

    Saitama, 336-0967, Japan

  • Shinden Higashi Clinic_Internal medicine

    Sendai-shi, Miyagi, 983-0039, Japan

  • Soka Sugiura Internal Medicine Clinic_Internal Medicine

    Saitama, 340-0015, Japan

  • South Broward Research LLC

    Miramar, Florida, 33027, United States

  • Southern New Hampshire Diabete

    Nashua, New Hampshire, 03060, United States

  • Southgate Medical Group, LLP

    West Seneca, New York, 14224, United States

  • St Pauls Hospital

    Vancouver, Canada

  • Sugar Lakes Family Practice PA

    Sugar Land, Texas, 77479, United States

  • TPMG Clinical Research

    Newport News, Virginia, 23606, United States

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

  • Takatsuki Red Cross Hospital_Diabetes and Endocrine Div.

    Osaka, 569-1045, Japan

  • Texas Diab & Endo, P.A.

    Austin, Texas, 78731, United States

  • Texas Diabetes & Endocrinology

    Austin, Texas, 78749, United States

  • Texas Diabetes & Endocrinology_Round Rock

    Round Rock, Texas, 78681, United States

  • The Institute of Medical Science, Asahi Life Foundation_Internal Medicine

    Chuo-ku, Tokyo, 103-0002, Japan

  • The Second Affiliated Hospital of Nanjing Medical University-Endocrinology

    Nanjing, Jiangsu, 210011, China

  • Thomas Jefferson Univ Di Rsrch Ctr

    Philadelphia, Pennsylvania, 19107, United States

  • Tianjin Medical University Chu Hsien-I Memorial Hospital-Endocrinology

    Tianjin, Tianjin Municipality, 300070, China

  • Tianjin Medical University General Hospital-Endocrinology

    Tianjin, Tianjin Municipality, 300052, China

  • UT Southwestern Med Cntr

    Dallas, Texas, 75390-9302, United States

  • Univ Gen Hospital Larisa

    Larissa, 41110, Greece

  • Univ of AL at Birmingham_BRM

    Birmingham, Alabama, 35294, United States

  • Univ of Nebraska Medical CTR

    Omaha, Nebraska, 68198-3020, United States

  • University Of Miami

    Miami, Florida, 33136, United States

  • Valley Clinical Trials, Inc.

    Northridge, California, 91325, United States

  • Velocity Clin Res Los Angeles

    Los Angeles, California, 90017, United States

  • Velocity Clin Res Wstlke

    Los Angeles, California, 90057, United States

  • Velocity Clin. Res Valparaiso

    Valparaiso, Indiana, 46383, United States

  • ViaCar Recherche Clinique Inc

    Brossard, Quebec, J4Z 2K9, Canada

  • Vinnytsia Regional Clinical Endocrinological Centre - Therapeutic department #2

    Vinnytsia, 21010, Ukraine

  • Wade Family Medicine

    Bountiful, Utah, 84010, United States

  • Western Univ. Cnt for Studies in Fam Med

    London, Ontario, N6G 2M1, Canada

  • Wharton Medical Clinic Clinical Trials (Hamilton)

    Hamilton, Ontario, L8L 5G8, Canada

  • Winnipeg Clinic

    Winnipeg, Manitoba, R3C 0N2, Canada

  • Wolfson MC - Diabetes Clinic

    Holon, 58100, Israel

  • Yuri Ono Clinic

    Sapporo-shi, Hokkaido, 060-0001, Japan

Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.