Weekly insulin shot could replace daily pokes for diabetes

NCT ID NCT06340854

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 12, 2026 · Updated 4 times

Summary

This study tested a new insulin called icodec that is injected just once a week, compared to the standard daily insulin glargine, in 429 adults with type 2 diabetes. Participants received either the weekly or daily insulin for 6 months. The goal was to see if the weekly shot controls blood sugar as well as the daily one, and to check for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: insulin icodec (once-weekly injection)
What this could lead to: If it works, this could offer people with type 2 diabetes a simpler option with just one insulin shot per week instead of daily injections.
What could go wrong: This is a completed phase 3 trial, but results are not yet published. Weekly insulin may not control blood sugar as well as daily insulin for some people, and there is always a risk of low blood sugar or other side effects.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES TYPE 2

Contacts and locations

Locations

ABS La Roca CAP Vicenç_Endocrino

La Roca Del Vallés, 08430, Spain
Accellacare Wilmington

Wilmington, North Carolina, 28401, United States
Advanced Clinical Research LLC

Bayamón, 00959, Puerto Rico
Advanced Investigative Medicine, Inc.

Hawthorne, California, 90250, United States
Amarillo Medical Specialists

Amarillo, Texas, 79124, United States
Amrita Institute Of Medical Sciences & Research Centre

Kochi, Kerala, 682041, India
Belgaum Diabetes Centre

Belagavi, Karnataka, 590001, India
Botho ke Bontle Health Services

Pretoria, Gauteng, 0184, South Africa
Capital Clin Res Ctr,LLC

Olympia, Washington, 98502, United States
Centre for Diabetes

Johannesburg, Gauteng, 2198, South Africa
Centrum Medyczne Pratia Gdynia

Gdynia, Pomeranian Voivodeship, 81-338, Poland
Centrum Medyczne Pratia Katowice

Katowice, 40-081, Poland
Chellaram Diabetes Institute

Pune, Maharashtra, 411021, India
Christian Medical College and Hospital

Ludhiana, 141008, India
Chrysalis Clinical Research

St. George, Utah, 84790, United States
Cotton-Oneill Diabetes and End

Topeka, Kansas, 66606-2806, United States
Diabetes and Thyroid Ctr of FW

Fort Worth, Texas, 76132, United States
Dr A Amod

Durban, KwaZulu-Natal, 4092, South Africa
Dr MB Moosa's Practice

Durban, KwaZulu-Natal, 4092, South Africa
Dr Mahesh Duki Research And Trial Site

Durban, KwaZulu-Natal, 4339, South Africa
Dr Moosa's Rooms

Lenasia, Gauteng, 1827, South Africa
Endo Res Solutions Inc

Roswell, Georgia, 30076, United States
FS Endocrine and diabetes Center

Saidābād, Telangana, 500059, India
Futata Tetsuhiro Clinic Meinohama_Internal medicine

Fukuoka-shi, Fukuoka, 819-0006, Japan
Gandhi Hospital & Medical college

Hyderabad, Telangana, 500003, India
Government Institute of Medical Sciences

Noida, Uttar Pradesh, 201310, India
Grant Medical Foundation Ruby Hall Clinic

Pune, Maharashtra, 411001, India
H. Clinico Univ. Virgen de la Victoria

Málaga, 29010, Spain
H.U. Quirónsalud Madrid

Pozuelo de Alarcón, 28223, Spain
Headlands Research CTR Lincoln

Lincoln, California, 95648, United States
Heiwadai Hospital_Internal Medicine

Miyazaki, Miyazaki, 880-0034, Japan
Hemant Makan

Johannesburg, Gauteng, 1827, South Africa
Hospital Clinic i Provincial

Barcelona, 08036, Spain
Hospital de Basurto

Bilbao, Vizcaya, 48013, Spain
InnoDiab Forschung GmbH

Essen, 45136, Germany
Institut für Diabetesforschung GmbH Münster - Dr. med. Rose

Münster, 48145, Germany
Institut für Diabetesforschung Osnabrück

Osnabrück, 49080, Germany
International Diabetes Center

Minneapolis, Minnesota, 55416, United States
Iowa Diab & Endo Res Center

West Des Moines, Iowa, 50266, United States
Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)

Puducherry, Tamil Nadu, 605006, India
Jefferson City Medical Group, PC

Jefferson City, Missouri, 65109, United States
Lifecare Hospital and Research Centre

Bangalore, Karnataka, 560092, India
MC Berbatov EOOD, Beli Drin

Yambol, 8600, Bulgaria
MHAT Knyaginya Klementina - Sofia EAD

Sofia, 1233, Bulgaria
Malla Reddy Narayana Multispeciality Hospital

Hyderabad, Telangana, 500055, India
Manati Ctr For Clin Research

Manati, 00674, Puerto Rico
Manipal Hospital, Old Airport Road, Bengaluru

Bengaluru, Karnataka, 560017, India
Medi-Clinic Bloemfontein

Bloemfontein, Free State, 9301, South Africa
Medical Center Viva Feniks OOD

Dobrich, 9300, Bulgaria
Medical Centre - Clinic Nova EOOD

Varna, 9000, Bulgaria
Medical Institute of Ministry of interior

Sofia, 1606, Bulgaria
MedicalCenter am Clemenshospital - Schwerpunktpraxis für Diabetologie und Ernährungsmedizin

Münster, 48153, Germany
NZOZ Euromedica Sp. z o.o.

Grudziądz, 86-300, Poland
NZOZ Specjalistyczny Osrodek Internistyczno-Diabetologiczny Małgorzata Arciszewska

Bialystok, Podlaskie Voivodeship, 15-435, Poland
NZOZ Vita-Diabetica Malgorzata Buraczyk

Bialystok, Podlaskie Voivodeship, 15-879, Poland
Noritake Clinic

Ushiku-shi, Ibaraki, 300-1207, Japan
Northeast Research Institute of Florida

Fleming Island, Florida, 32003, United States
Oyama East Clinic_Internal Medicine

Tochigi, 323-0022, Japan
Palm Research Center Inc-Vegas

Las Vegas, Nevada, 89148, United States
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych I Administracji

Warsaw, 02-507, Poland
PharmQuest Life Sciences LLC

Greensboro, North Carolina, 27408, United States
PlanIt Research, PLLC

Houston, Texas, 77079, United States
Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh

Chandigarh, 160012, India
RED-Institut für medizinische Forschung und Fortbildung GmbH

Oldenburg in Holstein, 23758, Germany
Rainier Clin Res Ctr Inc

Renton, Washington, 98057, United States
Rocky Mountain Diab&Osteo Ctr

Idaho Falls, Idaho, 83404-7596, United States
Scripps Whittier Diabetes Inst

La Jolla, California, 92037, United States
Seth GS Medical College & KEM Hospital

Mumbai, Maharashtra, 400012, India
South Broward Research LLC

Miramar, Florida, 33027, United States
Southern NH Diabetes and Endo_Nashua

Nashua, New Hampshire, 03060, United States
Swasthya Diabetes Care

Ahmedabad, Gujarat, 390013, India
TOTALL Diabetes Hormone Institute

Indore, Madhya Pradesh, 452010, India
Tokyo Medical Univ. Hospital_Diabetes, Metabolism and Endocrinology

Shinjuku-ku, Tokyo, Tokyo, 160-0023, Japan
Trial Management Associates

Myrtle Beach, South Carolina, 29572, United States
Trialmed CRS

Piotrkow Trybunalski, Łódź Voivodeship, 97-300, Poland
UMHAT Aleksandrovska EAD, Clinic of Endocrinology and Metabolic Diseases

Sofia, 1431, Bulgaria
Univ of Nebraska Medical CTR

Omaha, Nebraska, 68198-3020, United States
Uniwersytecki Szpital Kliniczny w Opolu

Opole, Opole Voivodeship, 45-401, Poland
Valley Research

Fresno, California, 93720, United States
Velocity Clinical Res-Dallas

Dallas, Texas, 75230, United States
Velocity Clinical_Valparaiso

Valparaiso, Indiana, 46383, United States
Victorium Clinical Research

Houston, Texas, 77024, United States
Zentrum für klinische Studien Allgäu Oberschwaben

Wangen, 88239, Germany

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