CF breakthrough: kids may ditch daily enzyme pills after modulator treatment
NCT ID NCT07632768
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study looked at whether children with cystic fibrosis (CF) who are taking CFTR modulator drugs and have regained normal pancreatic function can safely stop taking pancreatic enzyme replacement therapy (PERT). Seventeen children were followed for six months after stopping enzymes. Researchers monitored their growth, nutrition, and digestive symptoms to see if stopping enzymes caused any problems.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CFTR modulator therapy (ivacaftor, elexacaftor/tezacaftor/ivacaftor, or vanzacaftor/tezacaftor/deutivacaftor)
- What this could lead to
- If successful, this could show that some children with CF can safely stop taking daily pancreatic enzyme pills, simplifying their treatment and improving quality of life.
- What could go wrong
- This is a small, completed study with only 17 participants, so results may not apply to everyone. Stopping enzymes could cause nutritional problems or worsen symptoms in some children.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
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