Can a Two-Week insulin vacation help young diabetics?
NCT ID NCT00445627
First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 4 times
Summary
This study looks at how type 2 diabetes affects young people aged 12 to 25. Researchers want to see if giving the pancreas a 2-week rest with insulin shots can improve its ability to make insulin. Participants take metformin, follow a diet, and some also get insulin. The study also compares them to healthy teens to understand differences in body fat, heart health, and emotional well-being.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Metformin, Insulin, Nutrition counseling, Exercise counseling
- What this could lead to
- If successful, this study could reveal whether giving beta cells a short rest with insulin improves their function in young people with type 2 diabetes, pointing toward better early treatments.
- What could go wrong
- This is an early, small observational and interventional study with only 82 participants, so results may not apply broadly. The 2-week insulin rest may not lead to lasting benefits.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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