Can a Two-Week insulin vacation help young diabetics?
NCT ID NCT00445627
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how type 2 diabetes affects young people aged 12 to 25. Researchers want to see if giving the pancreas a 2-week rest with insulin shots can improve its ability to make insulin. Participants take metformin, follow a diet, and some also get insulin. The study also compares them to healthy teens to understand differences in body fat, heart health, and emotional well-being.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Metformin, Insulin, Nutrition counseling, Exercise counseling
What this could lead to
If successful, this study could reveal whether giving beta cells a short rest with insulin improves their function in young people with type 2 diabetes, pointing toward better early treatments.
What could go wrong
This is an early, small observational and interventional study with only 82 participants, so results may not apply broadly. The 2-week insulin rest may not lead to lasting benefits.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States