Pancreas disorder

Researchers are testing whether home-delivered medically tailored meals help older adults with type 2 diabetes improve their blood sugar, diet, and mental health. The trial compares three approaches: meals dropped off without interaction, meals delivered in person with human cont…

Researchers in Kenya are studying whether continuous glucose monitors help people with type 1 diabetes control their blood sugar better than standard finger-prick testing. The trial enrolls about 246 people with type 1 diabetes, including children and adolescents, at three clinic…

This study looks at whether extra help from a pharmacist can improve blood sugar control in adults with uncontrolled type 2 diabetes. About 60 participants will receive pharmacist-led education and follow-up over 10 months. The goal is to lower HbA1C levels and help people feel m…

This study tests a web-based tool called the BMI-CDS (Weight Loss Wizard) in 40 primary care clinics. The tool gives doctors and patients with type 2 diabetes and obesity personalized estimates of the benefits and risks of treatments like weight-loss surgery or medication. Over 1…

Researchers are testing whether adding two drugs to standard chemotherapy can shrink tumors and extend life in people with metastatic pancreatic cancer. Participants receive gemcitabine and nab-paclitaxel (standard chemo), plus cemiplimab (an immunotherapy approved for skin cance…

This phase 2 trial tests whether adding pembrolizumab (an immunotherapy) to olaparib (a targeted therapy) works better than olaparib alone for controlling metastatic pancreatic cancer in people with inherited BRCA1 or BRCA2 mutations. About 88 participants will receive either the…

This phase 2 trial is testing whether oral semaglutide (Rybelsus), a drug already used for type 2 diabetes, can improve bone health in people aged 50-85 with diabetes and weak bones (osteopenia). Over 52 weeks, 64 participants will receive either the drug or a placebo. Researcher…

This study tests an experimental drug called AZD5305, a PARP inhibitor, either alone or combined with other cancer drugs in people with advanced solid tumors (like ovarian, breast, pancreatic, and lung cancers). The goal is to see if the treatment is safe and can shrink tumors. A…

This early study looks at whether taking tirzepatide (Mounjaro) after sleeve gastrectomy surgery helps people lose more weight and improve conditions like diabetes and high blood pressure. About 42 adults with obesity will be split into two groups: one gets surgery alone, the oth…

This pilot study tests the safety and feasibility of empagliflozin (Jardiance) in 8 overweight or obese adults with cystic fibrosis-related diabetes (CFRD) who are already on insulin. Participants will receive either the drug or a placebo in a crossover design. The goal is to gat…

This trial is testing whether giving a single dose of radiation directly to the tumor area during surgery is safe for people with localized pancreatic cancer. Participants first receive standard chemotherapy and stereotactic body radiation therapy (SBRT), then at the time of surg…

This study tests a device called the iLet Bionic Pancreas, which automatically adjusts insulin delivery based on continuous glucose monitor readings, in people with cystic fibrosis-related diabetes. About 150 participants aged 14 and older will either use the bionic pancreas or t…

This study looks at how well a new insulin called icodec controls blood sugar in adults with type 2 diabetes who are switching from their current daily insulin. About 214 participants in Italy will use icodec as prescribed by their doctor for 22 to 30 weeks. Researchers will meas…

This study tests whether the Ask Me 3® educational program, which encourages patients to ask three key questions during doctor visits, can improve blood sugar control in adults with type 2 diabetes. Participants are randomly assigned to receive the program plus standard care or s…

This study tests a new drug called ARV-806 in adults with advanced solid tumors that have a specific KRAS G12D mutation. The drug aims to break down the mutated protein that helps tumors grow. The trial has two parts: first, finding a safe dose in small groups, then testing that …

This study tests AIDANET, an automated insulin delivery algorithm, in 40 adults with type 1 diabetes. Participants will use the system in three modes: fully automatic (no meal announcements), hybrid (with meal announcements), or a mix. The goal is to see which mode keeps blood su…

This study gives the drug metreleptin to 29 people with partial lipodystrophy, a rare condition that causes high blood fats and diabetes. Participants have already shown improvement from the drug in earlier studies. The goal is to keep providing the treatment and check its long-t…

This study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes severe fat loss and leads to high blood fats and diabetes. Participants, aged 6 months and older, have already received metreleptin in past NIH studies but cannot get it i…

This early-stage study tests an experimental drug called ALN-4324 in two groups: healthy overweight volunteers and overweight patients with type 2 diabetes. The goal is to check the drug's safety and how well it controls blood sugar. Participants receive either the drug or a plac…

This study looks at how well a new once-weekly insulin, called insulin icodec, works for people with type 2 diabetes who are switching from a daily insulin. Researchers will track blood sugar control, treatment satisfaction, and how well patients stick to the new regimen over abo…

Steroid injections for knee arthritis can temporarily raise blood sugar in people with type 2 diabetes. This trial tests whether giving a short course of NPH insulin right after the injection can prevent those high blood sugar episodes. Adults with type 2 diabetes and knee osteoa…

This trial tests whether a multilingual interactive voice response (IVR) system can help adults with type 2 diabetes and low health literacy adjust their insulin doses. Participants use a feature phone to report blood sugar levels and receive algorithm-guided dose recommendations…

Researchers are testing an experimental antibody called ONC-392 in people with advanced solid tumors, including non-small cell lung cancer and melanoma. The trial gives ONC-392 alone or with pembrolizumab, an approved immunotherapy, to see what doses are safe and how the body pro…

This study tests a program called 'Type 1 Doing Well' for youth aged 10–13 with type 1 diabetes and their parents. The program uses a smartphone app, goal-setting, and family meetings to build on the teen's diabetes strengths. Researchers want to see if it improves blood sugar co…

This study tests a combination of two drugs, BXCL701 and pembrolizumab, in 22 people with advanced pancreatic cancer that has spread. The goal is to see if this treatment can stop the cancer from growing for at least 18 weeks. Participants must have already tried one prior treatm…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

Researchers at Stanford University are testing whether a program that combines weekly healthy food deliveries with group lifestyle coaching helps Latino patients with type 2 diabetes. The study enrolls adults who receive care at partner clinics, have type 2 diabetes, and report f…

This phase II trial tests whether combining two drugs, atezolizumab and bevacizumab, can shrink rare solid tumors like appendix cancer, anal cancer, and mesothelioma. About 133 participants with various rare cancers will receive the drugs intravenously. The goal is to see if the …

This early-phase study tests a two-part approach for people with advanced pancreatic cancer. First, a special scan identifies cancer cells. Then, a targeted radioactive treatment is given to destroy those cells. The goal is to check safety and find the right dose in 30 participan…

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can help lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will receive either CBT-I or a patient education program. The main goal is to see if improv…

Researchers are testing whether a structured primary care program can help adults aged 40 to 90 with higher heart or diabetes risk reach recommended prevention targets. The program trains doctors and nurses, uses routine data to flag at-risk patients before visits, and provides d…

This study tests whether adding two experimental drugs (elraglusib and losartan) to standard chemotherapy (FOLFIRINOX) can prevent metastatic pancreatic cancer from becoming resistant to treatment. About 70 adults with untreated, advanced pancreatic cancer will receive the combin…

This phase II trial is testing whether adding the drug veliparib to standard chemotherapy (gemcitabine and cisplatin) can shrink tumors or slow cancer growth in people with advanced pancreatic cancer who have BRCA1, BRCA2, or PALB2 gene mutations. The study has two parts: one com…

This Phase 2 study tests a new injectable drug called maridebart cafraglutide in 409 adults with type 2 diabetes. The main goal is to see if it improves blood sugar control compared to a placebo. Researchers will also check if it helps with weight loss. The trial is active but no…

This phase 2 trial tests a combination of two drugs, atezolizumab and cabozantinib, in 30 people with metastatic pancreatic cancer that has not responded to standard treatments. The goal is to see if the combination can shrink tumors or stop them from growing. Researchers will al…

This study is testing two simple tools to help women with type 2 diabetes better manage their condition and understand reproductive health risks. The tools include a personalized medication list for patients and an alert for doctors during checkups. Researchers will track blood s…

This trial tests whether trained village health workers, using a smartphone app, can provide effective type 2 diabetes care in rural Lesotho. 252 adults with diabetes will either receive community-based care (lifestyle advice, metformin, statins) or be referred to a clinic. The g…

This study tests two methods for adjusting basal insulin in people with type 2 diabetes who fast during Ramadan. One method follows standard guidelines, while the other uses a personalized carbohydrate fasting test. The goal is to see which approach better controls blood sugar an…

This early-phase trial tests a new drug called BAY 1895344 combined with standard chemotherapy (irinotecan or topotecan) in people with advanced solid tumors, especially small cell lung cancer, poorly differentiated neuroendocrine cancer, and pancreatic cancer. The goal is to fin…

This trial tests a procedure called High-Intensity Focused Ultrasound (HIFU) for people with pancreatic cancer that cannot be removed by surgery. The study has two parts: first, checking how safe the procedure is, and second, seeing if it helps patients live longer. About 26 part…

Researchers compare a very low calorie ketogenic diet with a Mediterranean-style low-calorie diet in 40 adults who have type 2 diabetes, obesity, and non-alcoholic fatty liver disease. Participants follow one of the two diets for several weeks. The study measures changes in weigh…

This early-phase trial tests VX-264, a therapy made from stem cells that produce insulin, in 7 people with long-standing type 1 diabetes. The goal is to see if it is safe and can help control blood sugar. If successful, it may reduce or replace the need for insulin injections.

This study tests whether delivering healthy food boxes, remote health monitoring, and one-on-one coaching can help low-income Black adults with type 2 diabetes better control their blood sugar. The trial enrolls 304 participants in the Deep South and tracks changes in HbA1c level…

This study looks at whether semaglutide, a medicine for type 2 diabetes, can slow or prevent diabetic eye disease over 5 years. About 1500 adults with type 2 diabetes will receive either semaglutide or a placebo injection once a week, in addition to their usual diabetes medicatio…

This early-phase study tested a combination of three drugs (gemcitabine, dasatinib, and erlotinib) in 19 people with advanced pancreatic cancer that had spread or could not be removed by surgery. The main goal was to find the safest dose and look at side effects. Researchers also…

People with MEN1 syndrome inherit a high risk of developing multiple pancreatic neuroendocrine tumors. Surgery is the only curative option but causes major complications. Researchers are testing high-dose, high-precision MR-guided radiotherapy to see if it can shrink these tumors…

This early-stage trial tests a new drug called CA-4948 combined with standard chemotherapy (gemcitabine and nab-paclitaxel) in people with pancreatic cancer that has spread or cannot be removed by surgery. The goal is to find the safest dose and see if the combination can shrink …

This Phase 2 trial tests whether adding a personalized cancer vaccine (autogene cevumeran) and an immunotherapy drug (atezolizumab) to standard chemotherapy (mFOLFIRINOX) can keep pancreatic cancer from coming back after surgery. About 260 people whose tumors were completely remo…

This Phase 3 study tests whether a daily pill combining obicetrapib and ezetimibe, or obicetrapib alone, can lower LDL (bad) cholesterol more than placebo in 300 people with type 2 diabetes or metabolic syndrome. Participants continue their standard cholesterol medications. The m…

This study tests an experimental oral medication, KAI-7535, taken once daily to help people with obesity or overweight lose weight. About 320 adults with at least one weight-related condition (like high blood pressure or sleep apnea) will receive either the drug or a placebo for …

This study observes how well insulin icodec controls blood sugar in 245 people with type 1 diabetes who have never used it before. Participants take the insulin as prescribed by their doctor, and researchers track changes in HbA1c and treatment satisfaction over about 22 to 30 we…

This study tests whether adding a person's own bone marrow stem cells to their islet transplant can help the islets survive longer and work better. It includes 42 adults with chronic pancreatitis who are already scheduled for pancreas removal and islet auto-transplant. Participan…

This Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts a…

This Phase 2 trial tests two experimental injections, HRS-7249 and SHR-1918, in 108 adults with severely high triglycerides who are at high risk of acute pancreatitis. The study aims to see if these drugs can safely lower fat levels in the blood and reduce the chance of a pancrea…

This early-phase study tests a combination of two targeted drugs (vismodegib and erlotinib) with or without a standard chemotherapy drug (gemcitabine) in people with advanced pancreatic cancer or other solid tumors that cannot be removed by surgery. The main goal is to find the s…

This phase II trial tests whether adding an experimental drug called SHR-1701 to a standard chemotherapy regimen can improve outcomes for people with pancreatic cancer that is resectable or borderline resectable. Participants receive the combination before surgery, with the goal …

Researchers are testing a digital program called Centering Appetite in African American adults with type 2 diabetes and binge eating. The program includes web-based lessons to help people relearn their body's hunger and fullness signals, along with diabetes education and a Fitbit…

This study tests a new medicine called cagrilintide to help people who are overweight or have obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to see how much weight they lose and how …

This phase III trial tests whether giving chemotherapy before and after surgery (perioperative) works better than giving it only after surgery (adjuvant) for people with pancreatic cancer that can be removed. The study involves 358 participants and uses a combination of four chem…

This study looks at whether a team of clinical pharmacists and community health workers can help people with type 2 diabetes improve their blood sugar levels using continuous glucose monitors (CGMs). About 318 adults aged 25-75 with high blood sugar will be enrolled. The goal is …

This study will test whether an artificial intelligence (AI) system can help community doctors better manage patients who have high blood pressure along with diabetes or high cholesterol. About 6,800 adults will be split into two groups: one where doctors use the AI tool to guide…

This trial tests whether an AI system that flags at-risk Medicare Advantage members and suggests care actions, reviewed by a nurse, can reduce overall healthcare spending over a year. About 9,900 participants in Utah are assigned to either this AI-supported navigation or usual ca…

This study tests a new medicine, EYP-1901, given as an eye injection to people with diabetic macular edema (DME), a condition that causes blurry vision in people with diabetes. The goal is to see if EYP-1901 works as well as the standard treatment (aflibercept) but with fewer inj…

This early trial tests a radioactive drug called MNPR-101-PCTA-177Lu in adults with advanced solid tumors, including bladder, breast, lung, and pancreatic cancers. Participants receive three equal doses by IV over two 12-week cycles. The main goal is to find a safe dose and under…

This phase 3 trial tests EYP-1901, a new eye injection, against the standard treatment aflibercept for diabetic macular edema (DME), a condition that causes vision loss in people with diabetes. The study will enroll 240 participants and compare how well each drug improves vision …

This study tests whether simple text messages and online activities can encourage people with Type 2 Diabetes to get more preventive dental care, like cleanings, instead of waiting for expensive treatments. Researchers will track dental insurance claims from 10,000 adults over 18…

This early-stage trial tests an experimental mRNA-based cancer vaccine (mRNA-4157) in 161 people with solid tumors. The vaccine is designed to train the immune system to attack cancer cells. Some participants receive the vaccine alone, while others get it with the immunotherapy d…

This phase 2 trial tests two oral drugs, abrocitinib and ritlecitinib, in 78 people aged 12-35 who were diagnosed with type 1 diabetes within the last 100 days. The goal is to see if these JAK inhibitors can help preserve the body's ability to produce insulin, measured by a stimu…

This study is checking if a new insulin pump (NMX8) and continuous glucose monitor (DS5/Simplera Sync) are safe for people with type 1 or type 2 diabetes. About 400 participants, ages 7 to 85, will first wear the sensor for up to 40 days, then use the pump for about 90 days while…

This early-phase trial is testing a new treatment called LB1908, which uses a patient's own immune cells (T-cells) that have been modified in the lab to recognize and attack cancer cells that have a protein called claudin 18.2 on their surface. The study includes up to 56 adults …

This Phase 3 trial is testing whether adding an experimental drug called quemliclustat to standard chemotherapy (nab-paclitaxel and gemcitabine) helps people with metastatic pancreatic cancer live longer. About 610 participants who have not yet received treatment for their advanc…

This trial compares two treatment approaches for pancreatic neuroendocrine tumors that have spread or cannot be removed surgically. One group receives lutetium Lu 177 dotatate, a radioactive drug that targets tumor cells, while the other receives a combination of chemotherapy dru…

This phase 1 trial tests an experimental cell therapy called IX001 TCR-T in adults with advanced pancreatic or colorectal cancer that has not responded to at least two standard treatments. The therapy uses a patient's own immune cells, engineered to recognize cancer cells with KR…

This study tests a new drug called futibatinib combined with standard immunotherapy and chemotherapy in people with advanced esophageal or pancreatic cancer. The goal is to see if the combination can shrink tumors and control the disease. About 53 adults who have not had prior tr…

This study tests a new oral drug called IPN01194 in 36 adults with advanced solid tumours (melanoma, colorectal, pancreatic, or head and neck cancer) that have not responded to standard treatments. The goal is to find the right dose and check if it is safe, while also looking for…

This study investigates whether omega-3 fatty acids, natural fats found in fish and flaxseed, can help manage blood sugar and reduce inflammation in people with type 2 diabetes and heart disease. Participants take omega-3 supplements or a placebo for 28 days, and researchers meas…

This study compares a new insulin that is injected once a week (insulin icodec) to a standard daily insulin (insulin glargine) in about 877 adults with type 1 diabetes. The goal is to see if the weekly insulin controls blood sugar just as well as the daily one. Participants will …

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes better manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals…

This program offers daraxonrasib to adults with metastatic pancreatic cancer that has worsened after prior treatment and who have no other good options. It is for patients who cannot join ongoing clinical trials. The goal is to provide access to this experimental drug when no sta…

This study tests whether giving two immune-calming drugs (rituximab followed by abatacept) can better preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes, compared to rituximab alone. About 74 participants aged 8 to 45 will receive the drug …

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, type 2 diabetes, or high blood pressure. Participants use a tablet, scale, and activity tracker at home, and some get extra support from a co…

This study is testing a combination of two chemotherapy drugs (gemcitabine and nab-paclitaxel) with a precise type of radiation called proton therapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to find the highest safe dose of…

This study tests whether early, personalized nutritional support and a simple home exercise program can prevent weight loss and improve quality of life in 200 adults with lung, colorectal, ovarian, or pancreatic cancer starting palliative chemotherapy. Participants receive guidan…

This trial tests whether community pharmacies can run a produce prescription program for adults with type 2 diabetes or hypertension. Participants receive a monthly card loaded with funds to buy healthy foods like fruits, vegetables, beans, nuts, and seafood at their usual grocer…

This early-stage trial tests whether adding three new drugs (nogapendekin alfa inbakicept, sotevtamab, and zabadinostat) to standard chemotherapy can safely shrink pancreatic tumors that are hard to remove. About 30 adults with borderline resectable or locally advanced pancreatic…

This trial tests whether a combination of dapagliflozin, saxagliptin, and metformin can help control blood sugar in 600 adults with type 2 diabetes who have controlled cancers. Participants take the drugs by mouth for at least 90 days. Researchers measure blood sugar and insulin …

This early-stage trial is testing whether a rosemary extract supplement can improve markers of oxidative stress and inflammation in people with type 2 diabetes. Forty adults with stable diabetes will take either the extract or a placebo for 12 weeks. The study focuses on blood bi…

This study looks at whether providing medically tailored groceries can help people with type 2 diabetes and high blood pressure keep up healthy eating habits and control their blood sugar and blood pressure. About 80 adults who already took part in a meal delivery study will rece…

This study tests a new tool called the Snouda Metabolic Score (SMS) that helps doctors identify the specific metabolic problems driving Type 2 Diabetes in each patient. 150 adults will follow a personalized 24-week lifestyle and nutrition plan based on their SMS results. The goal…

This study tests whether a diabetes care program using continuous glucose monitors (CGM) and remote patient monitoring can help adults with uncontrolled type 2 diabetes improve their blood sugar levels and reduce diabetes-related distress. Participants will wear a CGM that shows …

This study tests whether giving people with type 2 diabetes and food insecurity monthly vouchers for fruits and vegetables can improve blood sugar control. Participants receive $100 per month in produce-only gift cards along with dietary education for five months, then switch to …

This trial tests whether adjusting diabetes medications to keep blood sugar levels in the normal range can preserve the body's insulin-producing beta-cells and slow the natural worsening of type 2 diabetes. Adults aged 40 to 75 with type 2 diabetes will be assigned to either usua…

This pilot trial tests whether the timing of carbohydrates and protein across meals can improve glucose metabolism in people with prediabetes or type 2 diabetes who are overweight or obese. Participants follow two different isocaloric diets—one with a high-protein breakfast and h…

This study tests whether a lab-made antibody called Tegoprubart can safely prevent the immune system from attacking transplanted islet cells in people with type 1 diabetes who have dangerous low blood sugar. The goal is to help patients stop needing insulin without using standard…

This study tests three different non-drug approaches to help older adults in nursing homes manage their type 2 diabetes. One group uses a device that sends mild electrical pulses to the leg muscles, another does supervised exercise, and the third receives health education. The ma…

This study tests whether drinking 15 ml of apple cider vinegar twice a day for two weeks can improve blood sugar stability and cholesterol in adults with type 2 diabetes. Thirty-eight participants will compare the vinegar to plain water using a continuous glucose monitor. It's a …

This study is testing a procedure called duodenal mucosal resurfacing (DMR) to see if it can safely improve blood sugar control in people with type 2 diabetes who are not on insulin. About 18 adults will be randomly assigned to receive DMR or a sham (fake) procedure. The study wi…

This trial asks whether real-time continuous glucose monitoring (CGM) can improve blood sugar control in adults with type 2 diabetes who do not use insulin. Participants will either use a CGM device or stick to standard self-monitoring with a blood glucose meter. The study tracks…

This trial tests whether providing monthly food vouchers for farmers markets and mailed food stock boxes, alongside diabetes education, can help African American adults with type 2 diabetes and food insecurity achieve better blood sugar control. Participants are randomly assigned…

This trial tests whether proglumide, an older drug that blocks a specific receptor, can safely reduce pain and slow or reverse the scarring seen in chronic pancreatitis. The study includes adults with confirmed chronic pancreatitis and compares proglumide against a placebo over 1…

This study looks at whether adding menopausal hormone therapy to a GLP-1 drug (semaglutide) improves blood sugar control in early postmenopausal women who have or are at risk for type 2 diabetes. About 96 women with menopausal symptoms and a BMI of 27 or higher will be enrolled. …

This study is testing the Omnipod 5, a tubeless insulin pump that automatically adjusts insulin delivery, in real-world settings for people with type 1 diabetes. About 304 participants aged 2 and older will use the system for the first time. Researchers will track blood sugar con…

This study tests an experimental pill called cadisegliatin taken alongside insulin in adults with type 1 diabetes. The goal is to see if it can lower the number of dangerously low blood sugar events (hypoglycemia) without worsening overall blood sugar control. About 150 participa…

This trial tests whether a low-calorie or low-carbohydrate diet can help people with type 2 diabetes achieve remission—meaning blood sugar returns to normal without medication. One hundred adults aged 20–80 with type 2 diabetes and a BMI of 27 or higher will follow a structured d…

This study tests whether student pharmacists can help older Asian adults (age 50+) with uncontrolled type 2 diabetes improve their blood sugar through lifestyle coaching, education, and adherence support. Participants will receive non-pharmacological guidance from student pharmac…

This study tests whether a digital platform called Haibu Diabetes helps children with type 1 diabetes manage their condition better. The platform collects health data from devices and shares it with patients, caregivers, and doctors through a single dashboard. Researchers will co…

This study looks at the best time to start medication for gestational diabetes during pregnancy. About 416 pregnant women with the condition are randomly assigned to start medicine when 20% or 40% of their blood sugar readings are too high. The goal is to see which approach leads…

This study tests whether semaglutide, a drug already used for obesity and type 2 diabetes, can reduce liver scarring in people with non-alcoholic fatty liver disease (NAFLD). Participants are adults aged 40 to 80 who are overweight or have type 2 diabetes. The trial will also val…

This study investigates whether adding two common drugs—valsartan (for high blood pressure) and celecoxib (for arthritis pain)—to standard metformin therapy can improve blood sugar control in people with type 2 diabetes. The trial enrolls adults with obesity, high blood pressure,…

This study tests whether transferring gut bacteria from a healthy donor (fecal transplant) can improve blood sugar control in 16 adults with type 2 diabetes. Participants receive either the transplant or a placebo, and researchers measure insulin sensitivity and blood sugar level…

This study tests whether giving a precise dose of radiation directly to the tumor during surgery (intraoperative radiation therapy, or IORT) can help people with pancreatic cancer that has grown into nearby blood vessels. Participants first receive standard chemotherapy and radia…

This trial tests a culturally adapted program called Health Without Barriers/Salud Sin Barreras for teens aged 11–19 and their families in Northern Colorado. The program combines mindfulness, nutrition education, physical activity, and parenting support over several sessions. Res…

This trial compares changing the dressing on a PICC line (a type of central catheter) every week versus every two weeks in people with colon or pancreas cancer receiving chemotherapy. The goal is to see if less frequent changes are just as safe, with no increase in skin injuries,…

This phase 2 trial tests whether a daily low dose of colchicine, an anti-inflammatory drug used for gout, can reduce inflammation and heart disease risk in adults with type 1 diabetes. 102 participants aged 35–80 will take either colchicine or a placebo for 26 weeks, with an opti…

This phase 1 trial tests a new method of delivering chemotherapy for people with cancers that have spread to the lining of the abdomen (peritoneal carcinomatosis) from gastrointestinal cancers like colorectal, stomach, or pancreatic cancer. The drug, nanoliposomal irinotecan (Oni…

This study investigates whether SGLT2 inhibitors, a class of diabetes medications, can slow cognitive decline in people aged 50 and older with type 2 diabetes. Participants are randomly assigned to receive either standard diabetes care plus an SGLT2 inhibitor (empagliflozin or da…

This study tests whether taking agave inulin, a natural fiber, for eight weeks can improve blood sugar control and increase healthy gut bacteria in adults with type 2 diabetes. Participants receive either 10 grams of agave inulin or a placebo daily. Researchers measure changes in…

This study tests whether people with type 2 diabetes who take their usual metformin on the morning of surgery have better blood sugar control and fewer problems like infections. Participants are randomly assigned to receive either metformin or a placebo before their operation. Th…

This study tests whether a smart order set in electronic health records can help primary care doctors better manage blood sugar in people with type 2 diabetes who use insulin. About 150 participants will use continuous glucose monitors, and doctors will get decision support from …

This study looks at whether a special program called Primary Care Connect (PC2) helps cancer survivors who also have conditions like high blood pressure, diabetes, or high cholesterol keep their heart risks under control during cancer treatment. About 266 adults with early-stage …

This early-phase trial tests an experimental immunotherapy called ELI-002 7P in people with pancreatic or other solid tumors that have specific KRAS or NRAS gene mutations. The treatment aims to train the immune system to attack cancer cells. About 158 participants will receive t…

This expanded access program offers ELI-002 7P, an immunotherapy, to pancreatic cancer patients with specific KRAS or NRAS gene mutations who have had their tumor removed but are at high risk of the cancer coming back. The treatment aims to stimulate the immune system to target a…

This study is testing different combinations of diet and exercise to find the best weight loss plan for people with prediabetes who also have physical or mobility disabilities. Thirty participants will start with either a high or reduced carbohydrate diet. After four weeks, those…

This trial tests whether taking hydrocortisone once a day (as a dual-release pill) leads to more stable blood sugar levels compared to the standard three-times-a-day regimen in adults who have both insulin-treated diabetes and Addison's disease. Participants will try both schedul…

This study will test whether sending reminders by text, email, or secure patient portal messages helps people with heart disease or diabetes refill their statin prescriptions. About 22,000 adults who have not refilled their statin in the last 3 months will receive one of these me…

This trial tests whether a chelation therapy infusion—a cocktail that removes toxic metals from the blood—can reduce the risk of heart attacks, strokes, and leg amputations in people with diabetes and critical limb ischemia (severe blockage in leg arteries). Half of the 50 partic…

This study tests whether giving financial incentives — including monthly cash, rewards for buying healthy food, and bonuses for lowering blood sugar — can improve diabetes control in adults who also struggle with food insecurity. Participants receive diabetes education and are ra…

This phase 2 trial tests a combination of three drugs—daratumumab, a KRAS vaccine, and nivolumab—in people with advanced pancreatic cancer or non-small cell lung cancer that has not responded to prior treatment. The goal is to see if the combination can shrink tumors or slow canc…

This study tests a program called Share plus for adults aged 60+ with type 1 diabetes and their care partners. The program helps them better use continuous glucose monitor data together. Researchers want to see if it improves blood sugar control and reduces diabetes-related stres…

This study tests a culturally tailored education program for African Americans with type 2 diabetes. The program teaches resilience and self-management skills through group sessions led by nurses, plus support groups and booster sessions. Researchers are tracking blood sugar leve…

This study compares a new three-drug combination (NABPLAGEM) against a standard two-drug chemo regimen for people with advanced pancreatic cancer that has spread and carries a BRCA or PALB2 gene mutation. The trial enrolls 10 participants whose cancer worsened after initial treat…

This study is testing whether a daily semaglutide tablet can safely reduce the risk of heart attacks, strokes, and related deaths in over 21,000 adults with type 2 diabetes who have never had a heart attack or stroke. Participants take either semaglutide or a placebo pill for sev…

This study tests whether a short-term program combining health coaching and medication can help people with type 2 diabetes achieve remission without surgery. It involves 118 adults diagnosed within the last 5 years, recruited from a primary care clinic in Hamilton, Ontario. The …

This early-phase trial tests an experimental drug called IPH5301, which targets a protein called CD73 on cancer cells. The study involves 27 people with advanced solid tumors, including breast, lung, and pancreatic cancers. In the first part, IPH5301 is given alone to find a safe…

This study tests a team-based approach to help African American and Latinx adults with uncontrolled type 2 diabetes lower their blood sugar levels. Participants will receive extra support from a multidisciplinary team, while a comparison group gets usual care plus educational mat…

This study tests whether home visits by female community health volunteers plus regular SMS messages can help adults in Pokhara, Nepal, better control high blood pressure, type 2 diabetes, and smoking. About 2100 participants are split into two groups: one gets the home visits an…

This study is testing whether a combination of two drugs, sotagliflozin and volagidemab, can improve blood sugar control in adults with type 1 diabetes. The 24 participants will receive both drugs or a placebo in a crossover design. The goal is to see if this approach can help ma…

This trial investigates whether adding proglumide, a drug that blocks cholecystokinin receptors, to standard chemotherapy can improve treatment for metastatic pancreatic cancer. About 30 adults with advanced pancreatic cancer will receive either proglumide or a placebo alongside …

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study was designed to see if taking metformin or salsalate on the morning of surgery could help control blood sugar and reduce complications in people with type 2 diabetes. It planned to enroll patients having elective surgery who regularly take metformin. However, the trial…

This study looks at whether using a continuous glucose monitor (CGM) along with a mobile app can help people with type 2 diabetes control their blood sugar better than standard care. Sixty adults will be randomly assigned to either the digital tool group or usual care, and their …

This study tests whether time-restricted eating (eating all meals within an 8-10 hour window each day) can help people with type 2 diabetes better control their blood sugar and improve heart health. About 60 adults with type 2 diabetes will either follow their usual care or add t…

This study tests whether an AI-based counseling program on a smartphone can help women with gestational diabetes manage their condition. 80 pregnant women will either get standard nutrition advice or AI-powered guidance. The goal is to see if the AI approach leads to healthier bi…

This study tests a new program where schools, families, and doctors work together to help children manage type 1 diabetes. About 30 kids will take part to see if the program is practical and well-liked. The goal is to improve daily diabetes care at school.

This study tests whether monthly home visits from trained health agents can help people in poor, high-altitude communities in Peru better control their high blood pressure and diabetes. Over 1,000 participants will either receive these visits for a year or get usual care. The goa…

This study compares two methods of tracking blood sugar in people with type 2 diabetes: traditional fingerstick testing and continuous glucose monitors (CGMs). About 360 adults aged 18 to 75 who use insulin will be followed for 12 months to see which method better lowers A1C leve…

This study tests whether using a continuous glucose monitor (CGM) along with remote dietitian support helps people with type 2 diabetes better control their blood sugar. About 160 adults across Australia will use a CGM and receive online dietary advice for several months. The goa…

This study follows 1,600 people with type 1 diabetes, including young children aged 2-6, who use hybrid closed-loop insulin pumps (Medtronic, Tandem, or Omnipod). These devices automatically adjust insulin based on blood sugar readings but still require users to enter meal inform…

This study tests a health support program for 600 people with disabilities who also have chronic conditions like diabetes or obesity. The program includes weekly nutrition classes, three exercise sessions per week, and help managing chronic conditions. Researchers want to see if …

This study is testing whether a real-time continuous glucose monitor (CGM) can help 200 adults with type 2 diabetes who use insulin in Saudi Arabia. Participants wear a CGM device that tracks blood sugar levels continuously. The main goal is to see if it improves HbA1c, a measure…

This early-stage trial is testing a combination of pelareorep (a reovirus) and atezolizumab (an immunotherapy) along with standard chemotherapies in people with advanced anal or pancreatic cancers. The study aims to find safe doses, look for biomarkers that predict response, and …

This study tests whether giving chemotherapy both before and after surgery helps people with pancreatic cancer live longer compared to chemotherapy only after surgery. About 378 patients with resectable pancreatic cancer will be randomly assigned to one of two treatment schedules…

This study tests a culturally tailored medical nutrition therapy for African patients with type 2 diabetes. The program includes personalized meal plans, nutrition counseling, and group education. Researchers will measure blood sugar levels and diet adherence after 6 months, and …

This study looks at whether supervised exercise classes or doing physical activity on your own works better for controlling blood sugar in adults with type 2 diabetes. About 120 people whose diabetes is not well controlled with diet or non-insulin medications will take part. Part…

This study tests a community-based program to help Black and Latino adults with diabetes, prediabetes, high blood pressure, or obesity. Participants receive lifestyle coaching, help connecting to health and social services, and digital skills training. The goal is to see if this …

This study tests whether an AI tool that shows patients how their blood sugar control compares to others, combined with home monitoring, can improve risk perception and blood sugar levels in adults with poorly controlled type 2 diabetes. About 360 participants aged 36–65 will be …

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy (mFOLFIRINOX) before surgery is safe and tolerable for people with pancreatic cancer that can be removed. About 20 adults with resectable or borderline resectable pancreatic cancer will rec…

This phase 2 trial tests whether giving a higher-than-standard dose of radiation, along with chemotherapy, can shrink pancreatic tumors enough to make them removable by surgery. The study includes 47 people with locally advanced pancreatic cancer that currently cannot be surgical…

This study tests whether a mobile app that trains girls to manage food cravings can help them eat more fruits and vegetables. About 150 girls aged 14-18 will use the app twice a week for a year. Researchers will track diet quality, weight, and blood sugar to see if the app leads …

This phase 2 trial tests whether a precise, high-dose radiation technique called SBRT can lower the chance of cancer coming back in the pancreas area after surgery. The study involves 50 adults with pancreatic cancer who had surgery and are at high risk of recurrence. They will r…

This phase 2 trial tests whether ixekizumab (Taltz), a drug already approved for psoriasis, can help people newly diagnosed with type 1 diabetes keep making their own insulin. The study involves 127 adults aged 18-45 who were diagnosed within the last 100 days. Participants recei…

This study tests a new daily pill, aleniglipron, in 58 adults with type 2 diabetes who are overweight or obese. The main goal is to check if the drug is safe and tolerable at different doses. Researchers will also measure weight loss and blood sugar changes. The study is not yet …

This study tests whether a diet with more protein (25% of daily calories) helps children aged 7-14 with overweight or obesity lose weight and reduce diabetes risk. Over 10 weeks at a lifestyle camp, one group eats a higher-protein diet while another eats a lower-protein diet, bot…

This study planned to test whether a virtual weight control program (WW, formerly Weight Watchers) could help adults with type 2 diabetes and obesity lower their blood sugar levels. Participants would have used the WW SmartPoints system and attended weekly online workshops. Howev…

This study looks at whether using an over-the-counter continuous glucose monitor (CGM) every 30 or 90 days can help people with type 2 diabetes who do not use insulin better manage their blood sugar. About 188 participants will wear the Dexcom Stelo device periodically over six m…

This study was designed to compare two ways to treat walled-off necrosis (a pocket of dead tissue) caused by severe pancreatitis. One method uses a scope through the mouth to clean out the pocket, the other uses surgery through the stomach. The goal was to see which approach work…

This study tests whether a special heat probe, inserted through an endoscope, can help people with inoperable pancreatic cancer live longer. About 108 participants will either receive the heat treatment plus standard care, or standard care alone. The trial is currently on hold, s…

This study tests whether a Mediterranean diet combined with intermittent fasting can reduce liver scarring (fibrosis) better than the weight-loss medication naltrexone/bupropion. About 70 adults with overweight or obesity and heart or metabolic risks (like type 2 diabetes or high…

This study tests whether transplanting insulin-producing cells into the arm muscle can prevent diabetes after partial or full pancreas removal. Researchers aim to see if the arm is a better spot than the liver for these cells to survive and work. About 35 adults with non-cancerou…

This early-stage trial is studying whether an experimental drug called AZD6793 changes how the common diabetes medicine metformin works in people with type 2 diabetes. About 28 participants will take both AZD6793 and a placebo alongside their usual metformin to compare effects on…

This study looks at whether doing light aerobic exercise five days a week can improve heart rate variability—a sign of heart health—in adults with type 1 diabetes. Over one year, 35 participants were split into two groups: one exercised regularly, the other less often. Researcher…

This study follows 433 people with chronic pancreatitis who undergo a surgery called TPIAT, where the entire pancreas is removed to stop pain and the patient's own insulin-producing islet cells are infused back to lower diabetes risk. Researchers track pain relief, quality of lif…

This study tests whether a smartphone app called Hedia Diabetes Assistant can help adults with type 1 diabetes keep their blood sugar in a healthy range more often. About 154 people with poorly controlled diabetes will either use the app plus their usual care or just usual care f…

This early-phase study tests whether insulin-making cells grown from a patient's own pancreatic tissue can be safely transplanted under the belly skin to reduce or replace insulin shots. Twenty-four adults with insulin-dependent type 2 diabetes will take part. The main goal is sa…

This study tests whether levodopa, a drug used for Parkinson's, can slow blood vessel changes in the eyes of people with diabetes. Researchers will give the drug or a placebo to 244 patients with early diabetic retinopathy and measure retinal electrical activity and imaging over …

This study tests whether a hybrid closed-loop insulin pump system (mylife CamAPS FX) can improve blood sugar control and quality of life in 30 adults with type 1 diabetes who have chronically high blood sugar and psychological challenges. Participants either start the pump immedi…

This early-stage trial tests whether applying electrochemotherapy (electric pulses plus the drug bleomycin) to the area where a pancreatic tumor was removed can lower the chance of cancer coming back. Ten patients with resectable pancreatic cancer will receive the treatment durin…

This study is testing whether daily shakes made from bilberries and oats can lower LDL cholesterol and improve exercise capacity in people who have had a heart attack or have type 2 diabetes. 900 participants will drink either a bilberry shake, an oat shake, a combination shake, …

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study was designed to test whether a program called Lifestyle MIND can help people with serious mental illness (like schizophrenia or bipolar disorder) prevent or manage type 2 diabetes. The program includes group exercise and health classes twice a week for 10 weeks. Howeve…

This Phase I trial tests a combination of two oral drugs, defactinib and VS-6766, in people with advanced solid tumors such as non-small cell lung cancer, low-grade serous ovarian cancer, and pancreatic cancer. The study aims to find the safest dose and evaluate how well the drug…

This study tests a mobile phone program (MOSAIC) that changes over time to fit each person's needs, helping adults manage type 2 diabetes. About 547 participants will be assigned to either the phone program or printed materials for 16 months. Researchers will check blood sugar le…

This early-stage trial is testing whether a combination of two drugs, naporafenib and trametinib, can shrink or control advanced solid tumors that have a specific genetic change called RAS Q61X. About 86 people whose cancer has not responded to standard treatments will receive th…

This study tests whether a hybrid closed-loop system (CamAPS FX) can improve blood sugar control in people aged 16 and older with cystic fibrosis-related diabetes. The system combines an insulin pump, continuous glucose monitor, and smartphone app to automatically adjust insulin.…

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This study tests a digital tool called DIPAR that sends reminders to adults with type 2 diabetes to get important lab tests, like kidney function and blood sugar checks. About 200 participants use the tool through a patient portal to see if it helps them stay on track with their …

This study tests whether a specially designed app can help women who had high blood pressure or diabetes during pregnancy get the recommended heart check-ups after giving birth. About 400 women from Oslo University Hospital will either use the app or receive standard care. The go…

This phase 2 trial tests whether adding tiny radioactive beads (OncoSil™) directly into the tumor can improve outcomes for people with locally advanced pancreatic cancer that cannot be removed by surgery. About 88 participants will receive either standard FOLFIRINOX chemotherapy …

This study tests a drug called Aramchol for people with nonalcoholic steatohepatitis (NASH), a serious fatty liver disease that can lead to scarring. About 150 adults with NASH and liver scarring (stages 1-3) will take Aramchol or a placebo for up to 72 weeks. The goal is to see …

This study tests whether a 12-week program of very-low-calorie diet or high-intensity exercise can improve blood sugar control in adults aged 40-70 who are newly diagnosed with type 2 diabetes and overweight. Participants are randomly assigned to diet, exercise, or standard educa…

This study compares two weight loss surgeries for people with severe obesity: sleeve gastrectomy with transit bipartition (SG+TB) and Roux-en-Y gastric bypass (RYGB). About 320 participants will be followed for two years to see which surgery leads to greater weight loss and fewer…

This study tests a drug called teplizumab in 20 children under 8 who have early signs of type 1 diabetes (Stage 2). The goal is to check if the drug is safe and how the body handles it. Teplizumab works by calming the immune system to protect insulin-making cells. If successful, …

This study tests stereotactic body radiotherapy (SBRT), a precise, high-dose radiation given over 2 weeks, for people with high-risk localized pancreatic cancer. The goal is to see if it can stop the tumor from growing locally for at least 12 months. The trial includes 30 partici…

This study tests a dual GIP/GLP-1 drug (a type of diabetes medication) in 120 adults in Kazakhstan who have both chronic heart failure and type 2 diabetes. Participants take the drug for 40 weeks and have regular heart tests, blood work, and genetic checks. The goal is to see if …

This study tests if weight-loss surgery (sleeve gastrectomy) can help people with newly diagnosed type 2 diabetes and a BMI of 30-42 achieve diabetes remission without medication. About 30 adults will be randomly assigned to either surgery or standard medical care and followed fo…

This study looks at whether adding the drug insulin detemir to a low-calorie diet helps obese adults with type 2 diabetes lose more weight and improve brain function related to food reward. About 240 people will be split into two groups: one on diet only, the other on diet plus d…

This study tests whether adding a high-dose pancreatic enzyme replacement (Pancreaze) to standard care can help patients with advanced pancreatic cancer who have weight loss and trouble digesting food. About 36 adults will take the enzymes with meals and snacks for 8 weeks. The g…

This study tests whether regular exercise and cognitive training, alone or together, can improve physical and mental function in adults aged 60+ who have had a stroke and also have high blood pressure or diabetes. Over 400 participants from five Chinese cities will take part in 1…

This study tests whether fenofibrate, a drug typically used to lower blood fats, can slow the worsening of diabetic retinopathy (eye damage) in adults with type 1 diabetes. Over 400 participants take either fenofibrate or a placebo daily for three years. The goal is to see if the…

This study tests a new drug called DZ-002 in adults with metastatic pancreatic cancer that has been stabilized with initial chemotherapy. The goal is to find the best dose and see if it is safe and can help keep the cancer from growing. Participants receive weekly IV infusions of…

This study aimed to see if a 3-week course of antibiotics works as well as a 6-week course for treating bone infections in the feet of people with diabetes. The trial planned to include adults with diabetes and a forefoot bone infection treated without surgery. However, the study…

This study tests whether three culturally tailored diet patterns (U.S.-style, Mediterranean, and vegetarian) can improve eating habits and reduce type 2 diabetes risk in 198 African American adults. Participants attend weekly classes for 6 months, then bi-weekly for another 6 mon…

This early-phase study tests a new drug called OMO-103, which blocks a cancer-driving protein called MYC, combined with standard chemotherapy in 26 people with metastatic pancreatic cancer who have not had prior treatment for advanced disease. The main goals are to check safety a…

This study is testing a new continuous glucose monitor (CGM) called the iCan o3 in 70 adults with type 1 or type 2 diabetes. Participants will wear the device for 60 days to see if it improves their blood sugar control, especially the time spent in a healthy range. The goal is to…

This pilot study aimed to test whether a combination of four drugs—ATG, low-dose IL-2, adalimumab, and exenatide—could help people newly diagnosed with type 1 diabetes keep producing their own insulin. The trial planned to enroll adults aged 18-35 diagnosed within the last 120 da…

This study compares a less invasive procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) with standard surgery for treating pancreatic insulinoma, a rare tumor that causes low blood sugar. About 60 adults with small tumors (≤2 cm) will be randomly assig…

This study tests whether a device that gently stimulates the vagus nerve through the ear can improve how the body handles sugar and affect mood in people with obesity and prediabetes. Seventy participants will use the device for 45 minutes, three times a week for three months. Th…

This study tests an investigational drug called RZ358 for people with congenital hyperinsulinism, a rare condition causing dangerously low blood sugar. The trial involves 56 participants aged 3 months to 45 years who still have low blood sugar despite standard treatments. Over 24…

This study tests whether giving people with type 2 diabetes money to buy healthy foods online, plus free delivery, helps lower their blood sugar levels. About 1,000 adults with poorly controlled diabetes will either get money for healthy food plus free delivery, or just free deli…

This program gives adults with locally advanced pancreatic cancer access to a device that delivers gentle electric fields to the abdomen, combined with standard chemotherapy. The goal is to see if this approach is safe and feasible while the device awaits FDA approval. Participan…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This phase IIb trial tests whether adding ATRA (a vitamin A derivative) to standard chemotherapy (gemcitabine and nab-paclitaxel) can help people with locally advanced pancreatic cancer live longer without their cancer growing. About 170 participants will receive either the combo…

This study tests whether myo-inositol, an oral dietary supplement, can help pregnant women with gestational diabetes control their blood sugar without needing insulin shots. About 1,080 women with newly diagnosed gestational diabetes will receive either myo-inositol or a placebo …

This early-phase study tests a treatment called extracorporeal photopheresis (ECP) for people with type 1 diabetes. ECP filters and treats a patient's blood with light and a drug, then returns it to the body. The goal is to see if this approach can reduce the need for insulin inj…

This study tests a 10-lesson family cooking and diabetes education program called DICE for 32 youth aged 8-14 with type 1 diabetes who struggle with blood sugar control. The program aims to improve blood sugar management and reduce health disparities by teaching families practica…

This study aimed to see if a single pill combining two diabetes medications works better than taking them separately for people with type 2 diabetes already on metformin. The goal was to improve blood sugar control and reduce side effects like weight gain and swelling. However, t…

This study planned to test whether adding two newer diabetes drugs (Forxiga and Januvia) to standard metformin treatment could better control blood sugar in people with type 2 diabetes. It aimed to enroll adults aged 18–80 whose diabetes was not well controlled on metformin alone…

This study compares the long-term effects of tirzepatide, a newer diabetes medication, with standard treatments in 780 adults who were diagnosed with type 2 diabetes within the last 4 years. Participants must be on metformin alone and have moderately high blood sugar levels. The …

This phase 3 study tests a new injectable drug called GZR18 in about 1,100 Chinese adults with type 2 diabetes whose blood sugar is not well controlled by metformin or other oral medications. Participants receive either GZR18 or the approved drug semaglutide to compare how well e…

This study tests whether metformin, a drug used for type 2 diabetes, can slow the buildup of calcium in leg arteries of people with type 1 diabetes. 230 adults will take either metformin or a placebo for two years. The goal is to see if metformin reduces artery hardening, which c…

This Phase 3 study tests an injectable drug called GZR18 in 274 Chinese adults with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. Participants receive either GZR18 or a placebo to see if the drug improves blood sugar levels, weight, and wais…

This study looks at whether combining diabetes nutrition classes with vouchers for fruits and vegetables helps American Indian and Alaska Native adults better manage their type 2 diabetes. About 67 participants will be split into three groups: some get both classes and vouchers, …

This study tests a procedure called duodenal mucosal resurfacing (DMR) using the Revita system in people with type 2 diabetes whose blood sugar is not well controlled with medication. About 320 adults will be randomly assigned to receive either the real procedure or a sham (fake)…

This study tests a program called FAMS-T1D that helps young adults (ages 18-24) with type 1 diabetes set goals and get support from a friend or family member. The goal is to see if this approach improves blood sugar control, reduces diabetes distress, and helps the support person…

This study tests whether transplanting insulin-producing islet cells from donors into the liver can help people with type 1 diabetes control blood sugar without insulin shots. Ten participants receive strong anti-rejection drugs to protect the new cells. Researchers will track bl…

This pilot study tests a device that uses radiofrequency vapor to ablate (remove) a thin layer of the duodenum (the first part of the small intestine) in 16 adults with type 2 diabetes who need insulin. The goal is to see if this procedure, with or without the drug semaglutide, i…

Researchers are testing whether a device called ANSiScope Plus can identify autonomic dysfunction by measuring heart rate variability. Participants include healthy adults and people with prediabetes or type 2 diabetes, some with complications like nerve, kidney, or eye damage. Ea…

Researchers are testing whether a brain imaging measurement can predict how strongly the body reacts to low blood sugar. The study enrolls healthy adults aged 18 to 40 with a body mass index between 20 and 30. Participants undergo two procedures: a brain scan to measure glial ace…

Researchers test whether flushing the biopsy needle with heparin, a blood thinner, helps collect more and better tissue from solid abdominal tumors during endoscopic ultrasound-guided fine needle biopsy. They also test whether using a microsieve to prepare the tissue improves the…

Pancreatic neuroendocrine tumors behave unpredictably: some stay slow for years while others spread quickly, and doctors lack reliable tests to tell them apart before surgery. This study examines cell-free DNA, tiny genetic fragments shed by tumors into the bloodstream, from abou…

This study tests a new way to screen for type 2 diabetes by measuring sugar levels in fingernails. Researchers will compare results from 100 adults (half with known diabetes, half without) to standard blood tests. The goal is to see if this simple, non-invasive method can accurat…

This early-stage trial tests a radioactive imaging agent called RAD301 in 9 people: healthy volunteers and patients with pancreatic, lung, esophageal, cervical, endometrial, or ovarian cancer. The goal is to see how safe it is and how it travels through the body. If it works, it …

Researchers are testing an experimental imaging agent called MNPR-101-DFO*-89Zr in people with several types of solid tumors, including bladder, breast, lung, and pancreatic cancers. The agent combines an antibody with a radioactive label, which may help PET scans reveal where tu…

This early-phase trial at Memorial Sloan Kettering is testing whether a special PET scan using an experimental tracer called 18F-FAC can show how much of the standard chemotherapy drug gemcitabine is taken up by pancreatic tumors. About 30 people with pancreatic ductal adenocarci…

This study is testing a mixed meal test to better diagnose a specific type of diabetes (type 3c) that occurs in people with pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 84 who have new-onset diabetes and one of these pancreatic conditio…

This study tests whether two imaging tools—laser speckle contrast imaging (LSCI) and digital thermography—can objectively grade mesenteric traction syndrome (MTS), a frequent complication during abdominal surgery that causes low blood pressure, rapid heart rate, and facial flushi…

This study is working on a new way to detect pancreatic cancer early using a simple urine and blood test. Researchers are collecting samples from 3500 people, both with and without pancreatic disease, to see if a panel of biomarkers can accurately identify cancer. The goal is to …

This study looks for tiny particles in the blood, called exosomes, that might signal the start of type 1 diabetes. Researchers will compare children recently diagnosed with type 1 diabetes to healthy children, all aged 12 to 18. The goal is to find a better way to catch the disea…

This study looks at whether two blood markers, PLIN2 and RAB14, can accurately diagnose NASH (a serious liver disease) and advanced scarring, without needing a liver biopsy. Researchers will test these markers in 828 adults with NASH, type 2 diabetes, or obesity. If successful, t…

This study is testing whether an artificial intelligence (AI) program can spot early signs of diabetic retinopathy—a condition that can lead to blindness—in people with prediabetes and diabetes. Researchers will take pictures of the retina and use the AI to analyze them. The goal…

This study tests whether a blood test for NT-proBNP can spot undiagnosed heart failure in 706 people with diabetes who are at high risk. Those with elevated levels get a heart ultrasound and exam. The goal is to see if this screening strategy leads to more early diagnoses and pro…

This study explores whether a community-based cooking program can help African-American adults at risk for heart disease cook and eat healthier. About 43 participants from Washington, D.C. will take surveys, attend cooking classes led by a chef, and track their eating habits. The…

Women who develop gestational diabetes are far more likely than other women to develop type 2 diabetes within a few years after giving birth. This trial tests whether a smartphone app that delivers personalized coaching on diet, exercise, sleep, and mental well-being can help pre…

Researchers are testing an experimental vaccine called Ad5.F35-hGCC-PADRE in adults who have had surgery and standard treatment for gastrointestinal cancers, including pancreatic, colorectal, esophageal, gastric, and small bowel adenocarcinomas. The trial aims to find a safe dose…

Researchers at Cornell University are testing whether a produce prescription program helps adults who have diet-related conditions and trouble affording food. Participants receive weekly boxes of fresh local produce for 8 to 24 weeks and attend eight nutrition education classes. …

This study tests whether the anti-inflammatory drug sulindac can prevent high-risk pancreatic cysts (IPMNs) from progressing to pancreatic cancer. About 100 adults with these cysts will receive either sulindac or a placebo for up to 3 years, alongside standard monitoring. The goa…

This study tests whether screening children with a high genetic risk for type 1 diabetes, along with regular follow-up and family education, leads to an earlier diagnosis of the disease. Researchers will track 600 children to see if this approach prevents severe symptoms and diab…

This study tests whether sending personalized screening invitations based on a person's race, ethnicity, and diabetes risk, plus offering phone navigation for those who don't respond, leads to more people getting tested for diabetes compared to generic invitations or usual care. …

This trial tests whether adding a real-time continuous glucose monitor (CGM) to a YMCA healthy lifestyle program helps adults with prediabetes improve their glucose levels, diet, and physical activity. Participants attend health coaching sessions and YMCA classes, with some weari…

This trial tests an online program to help women who had gestational diabetes get the recommended diabetes screening and lifestyle programs after giving birth. The program includes standard health information plus optional interactive components like values reflection and persona…

This pilot study will test whether providing Mediterranean diet groceries plus virtual nutrition classes helps overweight adults at risk for type 2 diabetes improve their diet and lose weight. Forty participants in the US South will be randomly assigned to receive either weekly g…

This trial tests whether giving women who had gestational diabetes a continuous glucose monitor and a FitBit can help them adopt healthier habits and prevent type 2 diabetes. Participants will wear the sensor for up to 14 days and use the tracker to monitor their activity. The st…

This trial tests whether adding recreational basketball to the standard National Diabetes Prevention Program (NDPP) helps adults aged 18-44 with prediabetes lose more weight, lower blood sugar, and become more active. Participants are randomly assigned to either the standard prog…

This study tests whether providing fresh meals, health coaching, and education to high-risk pregnant women can reduce the chance of developing gestational diabetes, high blood pressure, or preeclampsia. 69 women in Milwaukee are randomly assigned to either receive the program or …

This trial tests a wearable insole system that monitors foot pressure, temperature, and movement, giving real-time alerts to help users shift weight and avoid injury. The study includes people with type 1 or 2 diabetes who have nerve damage and a recent history of healed foot ulc…

This study looks at whether giving children with a genetic risk for celiac disease a low-gluten diet (less than 3 grams per day) during their first three years of life can lower their chance of developing the disease by age 7. About 1,100 children from Sweden are taking part. The…

This study looks at whether alerting clinical pharmacists about diabetes risk can help prevent type 2 diabetes in younger adults with serious mental illness. People with conditions like schizophrenia or bipolar disorder are at higher risk for diabetes, partly due to medication si…

This study tests whether the BCG vaccine, normally used for tuberculosis, can prevent type 2 diabetes in people with pre-diabetes. Researchers in Guinea-Bissau will give two doses of BCG or a placebo to 200 adults and track their blood sugar levels. The goal is to see if the vacc…

This study looks at whether a community-based program focused on healthy eating and exercise during and after pregnancy can lower the chances of obesity and type 2 diabetes in mothers and their children. About 1,000 pregnant women in urban areas will take part. The goal is to see…

This large, phase 4 trial is testing whether berberine, a natural compound, can prevent heart disease and diabetes in over 2,000 high-risk adults in China. Participants take berberine or a placebo twice daily, plus receive lifestyle advice. The study tracks blood sugar and heart …

This study tests whether cookies made from golden rice and red betel leaf can help prevent diabetic neuropathy, a common nerve damage complication of diabetes. 102 adults with diabetes will eat one cookie daily for 28 days. Researchers will measure changes in nerve symptoms and b…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This early-phase study tests an oral drug called ropidoxuridine (IPdR) in people with advanced gastrointestinal cancers that cannot be cured. The goal is to find the safest dose and see if it can make radiation therapy more effective at shrinking tumors. Nineteen participants wit…

This pilot study tests MPowerHub, a smartphone app that helps adults with type 2 diabetes make sense of data from continuous glucose monitors and activity trackers. The app shows combined trends and prompts daily questions about diet, sleep, stress, and medication. Researchers wa…

This study tests a program of exercise, protein drinks, and mind-body activities like yoga for people aged 65 and older with advanced ovarian or pancreatic cancer. The goal is to see if patients can stick with the program while on chemotherapy before surgery. The study is small, …

This study tests whether adding mental health care to standard diabetes treatment improves mood and blood sugar control in adults with type 1 diabetes. Eighty participants will be randomly assigned to usual care or a collaborative care model that includes a behavioral health cons…

This study compares high-effort versus low-effort resistance exercise sessions to see which better controls blood sugar in people with prediabetes or type 2 diabetes. Fifteen participants will complete both types of sessions plus a no-exercise control day, with blood sugar monito…

This pilot study tests a mobile phone program called STRIDE for adults with type 2 diabetes and a close friend or family member. The program includes monthly coaching calls and text message support to help with medication and goals. The study will enroll 180 people to see if the …

This pilot study tests a training program designed to improve eHealth literacy—the ability to find and use health information online—among Bangladeshi adults with type 2 diabetes in Ancona, Italy. The program, co-designed with patients and community members, includes four modules…

This trial tests whether tocilizumab, an anti-inflammatory drug used for arthritis, can reduce pain and improve quality of life in people with chronic pancreatitis. Participants receive either tocilizumab or a placebo every four weeks for 24 weeks. The study measures changes in p…

This study tests a remote education program called REST, designed to help adults aged 65 and older with insulin-treated diabetes start and keep using continuous glucose monitors (CGMs). The goal is to reduce dangerous low blood sugar episodes and improve overall glucose control. …

This trial tests whether giving older adults with diabetes and other chronic conditions audio recordings of their clinic visits helps them take a more active role in their own care. Participants either receive these recordings for a year or standard after-visit summaries. The stu…

This early-phase trial tests whether paricalcitol, a vitamin D analog, can improve quality of life in adults with chronic pancreatitis. Researchers will enroll 24 participants to take either the drug or a placebo for 12 months. The main goal is to see if the study is feasible and…

This study tests a non-invasive light therapy called photobiomodulation (low-level laser) for people with diabetic peripheral neuropathy—nerve damage causing pain, tingling, and numbness in the feet. 36 adults with type 2 diabetes and foot pain for at least 6 months will receive …

This study tests whether a prebiotic supplement called galacto-oligosaccharide (GOS) can lower blood sugar spikes after eating. Fifty healthy adults will drink either a GOS supplement or a glucose control beverage, and their blood sugar and insulin levels will be measured over se…

This study tests a self-guided digital program called covivio to help adults with type 2 diabetes manage emotional distress tied to their condition. About 250 participants will either use the app alongside their usual care or continue with usual care alone. The goal is to see if …

This early-phase trial tests whether adding lacosamide, a drug normally used for seizures, can safely help people with chronic pancreatitis who still have abdominal pain despite taking opioids. The study involves 21 adults who will take lacosamide for 7 days alongside their usual…

This study tests a smartphone app called PACTAID in 20 adults with type 1 diabetes. The app gives real-time advice during exercise to help keep blood sugar levels stable while using an automated insulin pump. Researchers will check if the app improves glucose control during and a…

This study compares two minimally invasive procedures to drain blocked bile ducts in patients with incurable cancer. One method drains the bile duct into the intestine, the other drains the gallbladder into the stomach. The goal is to see which approach causes fewer complications…

This study aimed to see if a food supplement called ARACOMPLEX® could help maintain quality of life in patients with advanced pancreatic cancer receiving chemotherapy. The supplement contains maca extract, vitamins, and minerals. However, the trial was withdrawn before enrolling …

This study looks at whether adding a palliative care team early, before surgery, helps cancer patients manage symptoms like pain, fatigue, and anxiety. About 236 adults having certain abdominal cancer surgeries will either get usual care or usual care plus palliative support. The…

This study tests a new way of caring for children under 10 with diabetes. The clinic uses play, nutrition advice, mental health support, and parent groups to help families feel calmer and more in control. About 100 children and their families will take part to see if this approac…

This study looks at whether ketorolac, a common anti-inflammatory drug, is safe and can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing cachexia (severe weight loss). About 28 participants will take the drug four times daily for fi…

This study aimed to see if making physical activity into a game could help older hospital patients move more. Participants would have received daily text messages, set step goals, earned points, and worn a Fitbit to track their steps. The study was withdrawn before any patients w…

This study was designed to test a new drug called N0750 against two standard pain medications (Cymbalta and Lyrica) for painful diabetic peripheral neuropathy. It planned to enroll adults with diabetes and nerve pain for at least 3 months. However, the trial was withdrawn before …

Researchers are sequencing the gut microbiomes of people with a wide range of conditions, from autism and Alzheimer's to Crohn's disease and multiple sclerosis, to see whether bacterial patterns differ by disease. The study also enrolls healthy participants for comparison. By mat…

Researchers at the University of Illinois at Chicago are studying how the bodies of adults with sickle cell disease handle glucose, cholesterol, and triglycerides, and why some of them develop diabetes. The study enrolls 75 adults over 35 with major sickle cell genotypes. Partici…

This study tests whether a heart failure medication called Entresto (sacubitril/valsartan) can boost a natural hormone that helps control blood sugar after meals. Researchers will give the drug or a comparison drug (valsartan) to 25 adults with type 2 diabetes or prediabetes and …

Researchers are building a large bank of blood and stool samples from people with advanced lung, breast, colorectal, and pancreatic cancers, plus healthy volunteers. The goal is to learn whether the mix of bacteria in a person's gut can predict how well cancer treatment works and…

This study checks if a Turkish version of a questionnaire about managing low blood sugar (hypoglycemia) is accurate and reliable. Researchers will ask 200 adults with type 2 diabetes who have had low blood sugar to fill out the questionnaire. The goal is to make sure the scale wo…

This early-stage study looks at how taking a new tablet called CX11 with or without food changes the amount of drug in the blood. It involves 32 healthy adults and does not aim to treat any disease. The results will help researchers decide how to give the drug in future studies f…

This pilot study is testing whether wearable activity trackers, like fitness watches, can help monitor fatigue in people with pancreatic or breast cancer who are undergoing treatment. Researchers want to see if patients will use the device daily and find it easy to use. The study…

This study is looking at how nerve pain (neuropathic pain) affects the ability to care for oneself and overall quality of life in people with type 2 diabetes. Researchers will measure pain levels and quality of life in 128 adults with type 2 diabetes. The goal is to better unders…

This study looks at the genetic and molecular factors behind type 2 diabetes, obesity, and related complications like kidney disease. Researchers will collect health information, blood and urine samples, and perform tests like eye exams and ultrasounds from over 2,300 adults, foc…

This study looks at whether a website and a genetic family navigator can help more relatives of people with hereditary cancer get genetic testing. About 205 participants will use the online hub and work with a navigator to learn about their cancer risk. The goal is to see if this…

This long-term study follows over 3,700 adults in Baltimore to understand why some people age healthier than others. Researchers are looking at how race, income, and neighborhood affect risks for diseases like diabetes, heart disease, and memory loss. Participants visit mobile he…

This pilot study is testing a device called LabClasp that measures blood sugar without needles. Researchers want to see if regular, non-invasive glucose checks can help predict gestational diabetes and preeclampsia in pregnant women. The study plans to enroll 100 women with at le…

This study collects health information and test results from 317 people at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. Researchers aim to build a database to find better ways to detect the disease early or prevent it. No …

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study investigates why brown fat, which burns calories to generate heat, stops working when it's warm. Researchers will use cold vests on 8 healthy and obese adults to see how genes and proteins change. The goal is to find new targets for treating obesity and related metabol…

This study tests a web-based education tool called HOPE-Genomics that teaches cancer patients about their genetic test results. About 465 adults with breast, colorectal, lung, ovarian, pancreatic, or prostate cancer are taking part. The goal is to see if the tool helps patients r…

Researchers are testing a transition program for 17-year-olds with type 1 diabetes, asthma, or obesity who are preparing to move from pediatric to adult healthcare. The program includes a consultation with the teen and family, a solo visit where the teen completes a readiness che…

This study aims to understand how genes affect obesity, diabetes, and heart disease in people of African ancestry. Researchers will collect blood samples and health information from 1,100 adults, including African Americans, Afro-Caribbeans, and migrants from sub-Saharan Africa. …

This large study is looking at the genes of over 9,000 people with diabetes and kidney disease, along with their family members. The goal is to find which genes make some people more likely to get diabetic kidney disease. By understanding the genetic roots, researchers hope to de…

This pilot study is testing whether it's possible to run a larger study that focuses on heart disease in women. Researchers will gather information from 176 women aged 25-55 in Ontario who have had certain female-specific health issues like pre-eclampsia, gestational diabetes, or…

Researchers are studying whether a mother's weight and blood sugar during pregnancy affect the makeup of her breast milk, and whether those differences influence how her baby grows. The study will follow pregnant women with a range of body sizes, including those with gestational …

This large study is testing whether a risk-scoring tool (called ENDPAC) can identify people with new-onset diabetes who are at higher risk for pancreatic cancer. About 8,800 participants aged 50-85 will have their medical records checked for age, weight changes, and blood sugar t…

This study follows 121 adults who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring or cancer. Participants are monitored for up to 10 years with regular tests, scans, and occasional liver biopsies. The goal is to learn …

This study monitors heart rate variability in 150 adults with type 2 diabetes who also have heart failure, chronic kidney disease, or both. Participants will wear a 24-hour heart monitor before and after starting a standard SGLT2 inhibitor medication. The goal is to understand ho…

This pilot study tests a digital tool that doctors use during visits to help patients with prediabetes become more active in managing their health. The tool asks patients a few questions and then gives the doctor tips on how to talk about lifestyle changes and resources like heal…

This study follows 5,000 people with diabetes who use a Dexcom continuous glucose monitoring (CGM) system in their daily routine. Researchers will track how the device performs when used as labeled and ask participants to complete questionnaires over four years. The goal is to un…

This study tests whether a clinical decision framework helps hospital doctors feel more confident when prescribing medications for older adults (65+) with chronic conditions like diabetes and high blood pressure. About 150 doctors will attend an educational session and complete s…

Researchers at Amsterdam UMC are studying tumor samples from 180 people with advanced melanoma or pancreatic cancer that has stopped responding to immunotherapy. Participants give one extra tumor biopsy and a blood sample. The team will analyze the tumor's full genetic code and t…

This study looks back at dental implant cases to see if bone-related conditions—like vitamin D deficiency, calcium problems, or kidney disease—make implant failure more likely. Researchers will compare 192 failed implants with successful ones from similar patients. The goal is to…

This study looks at whether diabetic kidney disease and blood-sugar control before surgery can help predict a common complication called pseudophakic macular edema (PME) — swelling of the central retina — after cataract surgery in people with type 2 diabetes. Researchers will rev…

This completed study observed 40 people with type 2 diabetes to find blood markers that could identify those at risk for a serious liver condition called NASH. Researchers measured liver stiffness and calculated scores like FIB-4 and ELF to see which patients might have liver sca…

This study looks at how not having reliable access to enough food might make it harder to lose weight. Researchers are giving 12 women who face food insecurity and have obesity and prediabetes a steady supply of healthy, low-calorie meals for a period. They will measure changes i…

This study gathers real-world information from pregnant women with type 1 diabetes in the United States to understand how they manage their condition. Participants share data from their continuous glucose monitors and insulin pumps, and complete online surveys. The goal is to lea…

This study tests a smartphone app designed to help adults taking GLP-1 medications for obesity or type 2 diabetes eat better. About 50 participants will use the app for 6 weeks to track their diet and learn about nutrition. The goal is to see if the app is helpful and easy to use…

This study investigates whether people with type 2 diabetes who have or are at risk for chronic kidney disease produce too much aldosterone, a hormone that regulates salt and blood pressure. Participants undergo several suppression tests—including oral sodium, saline infusion, an…

This study looks at health records from over 780,000 people with type 2 diabetes to compare four common second-line medications: SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas. The goal is to see which drug class is most effective at preventing hea…

This study is screening 115 underserved children and adults who are at risk for type 1 diabetes or celiac disease. Researchers will use blood tests to find early signs of these conditions, aiming to improve how we detect them. The goal is to catch these diseases sooner, especiall…

This study tests two different drug combinations in people with advanced colorectal, pancreatic, or leiomyosarcoma cancers that have not responded to standard treatments. Participants receive either olaparib plus durvalumab or cediranib plus durvalumab. The main goal is to unders…

This study tests a program called SHIFT2 that helps teens and young adults with type 1 diabetes prepare for the switch from pediatric to adult medical care. Participants work with a transition coach and receive messages to encourage self-management. The goal is to see if this sup…

This study looks at whether a telehealth program called ECHO can help healthcare teams in New Mexico better care for patients with diabetes and other chronic conditions. The program connects primary care providers with specialists through video sessions for training and case disc…

This study looks at whether two common diabetes drug combinations (SGLT2 inhibitors plus metformin vs. DPP-4 inhibitors plus metformin) affect memory and depression risk in older adults with type 2 diabetes. Researchers will track 300 participants over time using memory tests and…

This study follows 50 adults who are about to start GLP-1 therapy for obesity or type 2 diabetes. Researchers will track how their eating habits change over 12 weeks using diet quality scores and body weight. The goal is to understand what dietary support people need while on the…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study was designed to see how accurately patients report their own medication and healthcare use in diaries compared to official health insurance records. It planned to include people with diabetes, arthritis, kidney disease, or prostate cancer. However, the study was withdr…

This study is following 964 people with type 2 diabetes to see if three blood markers (hs-cTnI, NT-proBNP, and sST2) can predict who will die or have heart problems. Participants gave blood samples and are being tracked for years. No treatment is being tested—the goal is to learn…

This study looks at how frailty—a state of weakness and reduced physical function—affects the risk of severe side effects from chemotherapy in people aged 70 and older with cancer. Researchers will assess 160 patients using various tests for frailty, muscle loss, and overall heal…

This study is testing whether a special PET scan using a tracer called 68Ga-PSMA can identify patients with advanced upper digestive tract cancers (like stomach or esophageal cancer) who might be eligible for a type of targeted radiation therapy called endoradiotherapy. The resea…

This study looks at how a measure called the hemoglobin glycation index (HGI) changes over time in 750 adults with diabetes who use continuous glucose monitors. HGI compares lab-measured blood sugar levels with estimated levels from a glucose monitor. Researchers will collect dat…

This study was designed to see if giving a carbohydrate drink before bariatric surgery helps control blood sugar after the operation, compared to the standard fasting approach. It planned to enroll patients with high blood sugar who were scheduled for weight-loss surgery. However…

This study looks at whether diabetes or blood sugar problems can worsen thinking and memory issues in people with myotonic dystrophy type 1. Researchers will use MRI brain scans and thinking tests over 4 years to track changes. The goal is to understand why some patients have mor…

This study looks at why up to 40% of people with type 1 diabetes develop kidney disease, even with better blood sugar control. Researchers will use kidney biopsies and advanced imaging in 100 adults to find hidden risk factors like insulin resistance and inflammation. The goal is…

This study tests whether a remotely delivered resistance training program is practical and helpful for Black women aged 30-64 who are overweight, have prediabetes or diabetes, or have high blood pressure. About 37 women will participate from home using their own devices. The goal…

This study looks at how newer diabetes medications (SGLT2 inhibitors and GLP-1 receptor agonists) affect the eyes of people with type 2 diabetes. Researchers will monitor 40 adults who take metformin and are starting these newer drugs. The goal is to see if these drugs cause any …

This study is a long-term follow-up for 400 people who previously received A2 Bio gene therapy for various solid tumors, including colorectal, lung, pancreatic, and ovarian cancers. No new treatment is given; instead, researchers will track participants over time to check for del…

Over two million people in the UK have a chronic condition like diabetes or heart disease without knowing it. This study will use information from 4.5 million hospital patients to build a digital platform that spots those at risk. The goal is to help doctors diagnose these condit…

This study is testing whether wearable devices like continuous glucose monitors and the Oura Ring can help predict how well the pancreas is working in people with prediabetes or type 2 diabetes. The goal is to develop remote tools that allow personalized treatment to preserve ins…

This large study looks back at medical records of 100,000 Chinese patients with type 2 diabetes to compare heart and kidney outcomes between those taking Ozempic and those on other diabetes drugs. Researchers will track major heart problems, strokes, and kidney events. The goal i…

This study follows over 800 people who either have type 2 diabetes or have a strong family history of it. Researchers track who develops diabetes over time using blood tests and questionnaires. The goal is to improve a risk prediction model for type 2 diabetes. The study is curre…

This study tests whether a swallowable camera capsule, controlled by magnets from outside the body, can safely and effectively examine the stomach and esophagus in 30 people preparing for weight loss surgery. Participants swallow the capsule after fasting, and a surgeon guides it…

This study looks at whether giving extra support to community health centers helps them screen patients for non-medical needs like food or housing and refer them to community resources. Twenty health centers will be randomly assigned to get this support or not. The goal is to see…

This study looks at over 1,200 adults with type 2 diabetes and heart muscle problems to see if diabetic cardiomyopathy is a unique condition. Researchers will use detailed medical tests, imaging, and biological data to find patterns. The goal is to better understand and diagnose …

This study compares 20 women who had gestational diabetes with 20 who did not, all matched by age and weight. Researchers will measure body composition, insulin sensitivity, and other metabolic markers before and after 8 weeks of high-intensity interval training. The goal is to u…

This study uses a continuous glucose monitor (a small sensor) to track blood sugar levels in 40 adults with diabetes and end-stage kidney disease who are on dialysis. The goal is to see how glucose changes during and between dialysis sessions over two weeks, and whether those pat…

This study is collecting saliva, stool, blood, bile, and tumor samples from 200 people undergoing surgery for pancreatic or related cancers. Researchers want to see if the types of bacteria in these samples can help predict who will have complications after surgery and how the ca…

This study tests a new monitoring method for patients who have had pancreatic surgery. After surgery, a thin probe is placed near the surgical connection to measure chemicals that may signal a leak before symptoms appear. Half of the 201 participants will receive this monitoring …

This study compares two types of guide wires (short vs long) used during a procedure called ERCP, which helps doctors examine the bile and pancreatic ducts. The goal is to see which wire allows faster and safer cannulation (insertion of a tube) and whether either reduces the risk…

This study aims to create a questionnaire that measures how patients feel about their experience during endoscopic ultrasound, a procedure used to examine the pancreas and bile ducts. Researchers will ask 171 outpatients at a hospital in Italy to rate their experience, and compar…

This study tests whether using game-like rewards and personal coaching can encourage older adults to walk more after leaving the hospital. About 350 people aged 50 and older with conditions like high blood pressure or heart failure will wear a Fitbit to track their steps. The goa…

This study looks at whether fat in the liver, detected by ultrasound during pregnancy, can help predict blood sugar problems after delivery in women with gestational diabetes. Researchers will follow 189 women for 6-12 weeks after birth, measuring insulin resistance and other mar…

This study looks at why some people with type 2 diabetes do not get the usual health benefits from exercise. Researchers will measure how well cells produce energy before and after exercise. The goal is to find factors that make exercise less effective for certain individuals.

This study looks at how exercise training changes the way muscles and fat tissue handle insulin in people with type 2 diabetes. About 39 adults aged 30-65 who are sedentary and have type 2 diabetes will take part. Researchers will use PET scans and small tissue samples to measure…

This study looks at organ changes in people recovering from COVID-19, comparing those with and without type 2 diabetes. Researchers will use scans to measure organ size and volume. The goal is to learn more about how COVID-19 affects the body long-term in diabetic patients.

This study aims to find new biological markers (biomarkers) for Adult Onset Autoimmune Diabetes (AOnAD) by analyzing blood samples from 25 adults with type 1 diabetes. Researchers will measure changes in specific microRNAs from tiny particles in the blood. No treatment is given; …

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and simple blood and urine tests to find hidden signs of atherosclerosis, pre-diabetes, and kidney disease…

This study was designed to learn why some children with type 1 diabetes, especially those with public insurance, do not use helpful diabetes technology like continuous glucose monitors. Researchers planned to interview and survey healthcare providers to understand barriers and fi…

This study looks at whether a standard set of guidelines, called the Methodist Acute Pancreatitis Protocol (MAPP), improves care for people with acute pancreatitis. Researchers will compare outcomes like hospital stay length and discharge status before and after the protocol was …

This study looks at whether a biomarker called GATA6 can help predict how well patients with resectable pancreatic cancer respond to chemotherapy before and after surgery. About 84 participants will provide tumor samples to measure GATA6 levels, then receive a standard chemo regi…

This study is building a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genetic and other markers to find better ways to predict serious complications like kidney failure, heart disease, and stroke. Th…

This study follows 50 obese patients who are having weight-loss surgery (laparoscopic sleeve gastrectomy). Researchers use MRI scans and blood tests before surgery and at 1, 3, and 6 months after to measure changes in pancreatic fat and insulin function. The goal is to see if los…

This study observes heart function in 216 newborns born at 35 weeks or later. Researchers will use ultrasound to measure how the heart relaxes and fills with blood, creating normal reference values. They will also check if factors like mother's health or birth conditions affect h…

This registry collects information from 2000 people who have had pancreatic surgery for benign or malignant tumors. Researchers track complications and long-term results to understand what works best. The goal is to improve quality of care and support future research.

This study aims to understand how the body's response to insulin changes during pregnancy in people with type 1 diabetes. Researchers will analyze data from continuous glucose monitors and insulin pumps used by 100 participants from before pregnancy to six months after birth. The…

This study follows about 800 pregnant women in Somaliland to understand the physical, cultural, and social factors affecting their health during pregnancy, childbirth, and after birth. Researchers will also work with the community to create better contraceptive counseling materia…

This study looks at how the complement system, a part of the immune system, may contribute to kidney damage in people with diabetes. Researchers will measure complement proteins in blood and urine from 90 participants to see if they are linked to kidney disease severity and blood…

This study looks at differences in body composition, fitness, and temperature control during exercise between young soccer players with type 1 diabetes and healthy ones. Forty boys who have trained for at least 5 years will be monitored with thermal cameras and continuous glucose…

This study enrolls 200 people with pancreatic cancer across Ontario. Researchers collect tumor tissue, blood, and stool samples to perform genetic sequencing and grow mini-tumors in the lab. The goal is to see if this detailed analysis helps more patients receive a treatment matc…

This study creates a database to track how safe and effective a procedure called endoscopic ultrasound radiofrequency ablation (EUS RFA) is for treating tumors or swollen lymph nodes in the pancreas. About 100 people aged 14 and older who are already scheduled for this procedure …

This study aimed to learn more about using a CT scan to check for calcium buildup in the heart arteries of people with diabetes. The goal was to improve screening and treatment decisions. However, the study was withdrawn before enrolling any participants, so no new information wa…

This study looks at how different root canal cleaning methods—laser and ultrasound—affect the immune response in people with and without type 2 diabetes who have a tooth infection called apical periodontitis. Researchers will measure certain immune markers in fluid from around th…

This study follows over 5,000 Black and White men and women from age 18-30 for many years to see how their lifestyles and health habits affect their risk of heart disease later in life. Researchers measure things like blood pressure, weight, and cholesterol to understand why some…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related health problems. Researchers aimed to identify risks and understand what leads to disability or death after a heart event. The study did not test a new treat…

This study looks at whether certain genes influence how people respond to a meal and a single dose of metformin, a common diabetes medication. Over 1,000 adults without diabetes will take a special drink and then have their blood sugar and other markers measured. The goal is to u…

This study looks at whether routine screening for heart disease is a good use of healthcare money for people with type 2 diabetes who are at very high risk but have no known heart problems. Researchers will analyze data from 90,000 patients in French health databases to compare c…

This study looks at whether checking for two proteins, ATRX and DAXX, in biopsy samples can help predict how aggressive non-functional pancreatic neuroendocrine tumors (NF-pNETs) are. Researchers will compare biopsy results with surgical tissue from 100 adults to see if the test …

This study looks at how two types of diabetes medicines affect the pancreas in Black patients with type 2 diabetes. About 60 adults will take either a GLP-1 receptor agonist or an SGLT-2 inhibitor for 16 weeks. The goal is to see which drug better helps the pancreas make insulin,…

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This observational study looks at how well antibiotics given through a vein reach infected fluid collections in the pancreas of people with acute pancreatitis. About 40 adults who are already scheduled for drainage of these collections will provide a small fluid sample and a bloo…

This study follows 317 adults with type 2 diabetes who were first examined between 2019 and 2023. Researchers will repeat advanced liver scans, blood tests, and body composition measurements to see how liver fat and scarring change over time. The goal is to find out who is most a…

This study follows 400 adults aged 65 and older with type 1 diabetes to understand how they age compared to people without diabetes. Researchers will measure physical ability, thinking skills, and emotional well-being. The goal is to learn what helps some people age well despite …

This study aimed to see if exercising in the morning versus the evening changes how the body handles sugar in adults with prediabetes. Participants would have completed short bouts of morning exercise, evening exercise, and no exercise, with their blood sugar and insulin levels m…

This study looks at how vitamin D levels might influence high blood pressure in people with type 2 diabetes. Researchers will collect blood samples from 40 participants to study immune cells called monocytes and see if they trigger a hormone that raises blood pressure. The goal i…

This study looks at blood stem cells (called EPCs) in people with and without diabetes to see if they work differently. Researchers want to know if these cells can predict diabetic retinopathy, an eye disease that can cause vision loss. The study involves 78 adults, including 39 …

This study explores whether a simple urine protein test can help doctors decide which type 2 diabetes patients need extra medications to protect their heart and kidneys. Fifty adults with type 2 diabetes will receive semaglutide (Ozempic) and finerenone, and researchers will chec…

This study asks 29 adults with type 1 diabetes to complete a 75 km gravel bike ride while wearing a continuous glucose monitor and providing saliva and urine samples. Researchers want to collect detailed data to help build artificial intelligence models that can predict how exerc…

This study brings together cancer experts to agree on standard definitions for key measurements used in cancer clinical trials, such as how long patients live without their cancer getting worse. Currently, different trials define these measurements in different ways, making it ha…

This study looks at how well a daily 80 mg dose of enteric-coated aspirin works in 50 adults with type 2 diabetes who have not taken aspirin recently. Researchers measure blood platelet function before and after 7 days of treatment to see if the aspirin fully prevents clotting. T…

This study aimed to see if diabetic patients have slower stomach emptying than non-diabetic patients before scheduled surgery, using a simple ultrasound. It was designed to compare stomach contents after fasting in both groups. However, the study was withdrawn before enrolling an…

This study aims to find out how many people with type 2 diabetes also have non-alcoholic fatty liver disease (NAFLD). Researchers will use a special ultrasound scan (FibroScan) to check the liver health of 385 adults with type 2 diabetes. The study does not test any new treatment…

This study follows 135 adults with type 2 diabetes over several years, using special MRI scans to check their liver, kidneys, and heart. The goal is to find out which patients are more likely to develop serious complications. No new treatments are being tested—just a better way t…

This observational study is looking at 1,000 people with type 2 diabetes to understand why some develop serious complications like eye, kidney, or heart problems while others do not, even with similar blood sugar levels. Researchers will collect medical history and blood samples …

This study tests whether a Patient Navigator can help 150 people with type 1 diabetes use their continuous glucose monitors more effectively. The goal is to reduce health disparities and improve outcomes. Participants will receive extra support while using their standard CGM devi…

This study looks at whether a continuous glucose monitor (Dexcom G6) helps pilots with insulin-treated diabetes keep their blood sugar in a safe range during flights. Seventeen pilots wore the device for six months, comparing its readings with their usual finger-stick tests. The …

This study looks at whether analyzing CT scans with a computer technique called radiomics can predict which patients with advanced pancreatic cancer will not respond to chemotherapy. Researchers will study 400 patients and track survival over time. The goal is to find early signs…

This study follows 500 adults with pancreatic cancer who had surgery intended to remove all visible cancer. Researchers want to learn how often the cancer returns within the first year, where it shows up (like the liver or lungs), and how it is detected. Participants receive stan…

This study looks at a type of bacteria called Staphylococcus pettenkoferi, often found in diabetic foot ulcers. Researchers will analyze the DNA of 230 bacterial samples to see if certain strains are more harmful. The goal is to understand if this bacteria plays a role in making …