Pancreas disorder

This phase 2 trial tests whether adding pembrolizumab (an immunotherapy) to olaparib (a targeted therapy) works better than olaparib alone for controlling metastatic pancreatic cancer in people with inherited BRCA1 or BRCA2 mutations. About 88 participants will receive either the…

This phase II trial is testing two different drug combinations for people with metastatic pancreatic cancer that has spread. One group gets a standard chemo plus S-1 and leucovorin; the other gets standard chemo plus oxaliplatin. The goal is to see which combo works better at shr…

This early-phase study tests a new drug called AB680, combined with immunotherapy (zimberelimab) and two chemotherapy drugs (nab-paclitaxel and gemcitabine), in people with advanced pancreatic cancer that has spread. The main goals are to check safety and find the right dose. Abo…

This early-phase trial is testing whether combining the targeted drug olaparib, the immunotherapy durvalumab, and radiation therapy is safe for people with locally advanced pancreatic cancer that cannot be surgically removed. The study enrolls 18 participants who have already rec…

This study is testing the Omnipod 5, a tubeless insulin pump that automatically adjusts insulin delivery, in real-world settings for people with type 1 diabetes. About 304 participants aged 2 and older will use the system for the first time. Researchers will track blood sugar con…

This study tests a system that combines a continuous glucose monitor (CGM) with daily insulin dose recommendations for people with type 2 diabetes who are starting basal insulin. Participants wear a Dexcom CGM sensor and receive suggested insulin doses through the DexBasal system…

This study tests a new drug called ARV-806 in adults with advanced solid tumors that have a specific KRAS G12D mutation. The drug aims to break down the mutated protein that helps tumors grow. The trial has two parts: first, finding a safe dose in small groups, then testing that …

This study tests whether the drug cabozantinib can slow the growth of advanced neuroendocrine tumors (including carcinoid tumors) compared to a placebo. About 298 adults whose cancer worsened after prior treatment will receive either cabozantinib or a placebo pill. The main goal …

This Phase 3 trial is testing whether adding an experimental drug called quemliclustat to standard chemotherapy (nab-paclitaxel and gemcitabine) helps people with metastatic pancreatic cancer live longer. About 610 participants who have not yet received treatment for their advanc…

This trial tests whether a chelation therapy infusion—a cocktail that removes toxic metals from the blood—can reduce the risk of heart attacks, strokes, and leg amputations in people with diabetes and critical limb ischemia (severe blockage in leg arteries). Half of the 50 partic…

This large study compares two diabetes drugs—oral semaglutide and sitagliptin—in over 25,000 people with type 2 diabetes and heart failure. Researchers want to see which drug better prevents heart failure worsening or death. The study uses existing medical records to mimic a clin…

This phase 2 trial tests whether adding galeterone to standard chemotherapy (gemcitabine) can shrink tumors or slow disease in people with advanced pancreatic cancer that has not responded to prior treatments. The study enrolls about 15 adults with metastatic disease who have alr…

This study tests a new treatment using specially engineered immune cells (TROP2 CAR-NK) delivered directly into the abdomen. It is for people with ovarian cancer that no longer responds to platinum chemotherapy, as well as certain rare ovarian and pancreatic cancers. The goal is …

This pilot study tests whether giving people with type 2 diabetes personalized diet advice based on their continuous glucose monitor (CGM) readings can help them better control their blood sugar. Twenty adults with type 2 diabetes will receive either standard dietary care or a ta…

This study tests whether the Ask Me 3® educational program, which encourages patients to ask three key questions during doctor visits, can improve blood sugar control in adults with type 2 diabetes. Participants are randomly assigned to receive the program plus standard care or s…

This study investigates whether omega-3 fatty acids, natural fats found in fish and flaxseed, can help manage blood sugar and reduce inflammation in people with type 2 diabetes and heart disease. Participants take omega-3 supplements or a placebo for 28 days, and researchers meas…

This study tests whether giving financial incentives — including monthly cash, rewards for buying healthy food, and bonuses for lowering blood sugar — can improve diabetes control in adults who also struggle with food insecurity. Participants receive diabetes education and are ra…

This study looks at the safety and performance of the Endogenex System in 50 adults with type 2 diabetes. Participants previously received a sham (fake) procedure in an earlier study. The main goal is to track any serious side effects related to the device or procedure.

This phase 2 trial tests a combination of three drugs—daratumumab, a KRAS vaccine, and nivolumab—in people with advanced pancreatic cancer or non-small cell lung cancer that has not responded to prior treatment. The goal is to see if the combination can shrink tumors or slow canc…

This study tests whether using a continuous glucose monitor (CGM) helps adults with type 2 diabetes who do not take insulin improve their blood sugar control. Participants are randomly assigned to either use a real-time CGM or receive routine care with occasional blinded CGM wear…

This study tests a new oral drug called IPN01194 in 36 adults with advanced solid tumours (melanoma, colorectal, pancreatic, or head and neck cancer) that have not responded to standard treatments. The goal is to find the right dose and check if it is safe, while also looking for…

This phase 2b trial tests frexalimab, an antibody that calms the immune system, in 192 adults and teens newly diagnosed with type 1 diabetes. The goal is to see if it can preserve the body's ability to produce insulin, reducing reliance on injections. Participants receive frexali…

This study explores how different amounts of carbohydrates and a fiber supplement called inulin-FOS affect blood sugar control in adults with type 1 diabetes. Participants will try three two-week diets: one with 30% carbs, one with 50-55% carbs, and one with 50-55% carbs plus inu…

This study tests a program called Share plus for adults aged 60+ with type 1 diabetes and their care partners. The program helps them better use continuous glucose monitor data together. Researchers want to see if it improves blood sugar control and reduces diabetes-related stres…

This study tests a combination of two drugs, neratinib and valproate, in people with advanced solid tumors that have not responded to standard treatments. The first part finds the safest dose, and the second part focuses on cancers with a RAS mutation, like certain colon and panc…

This study observes how well insulin icodec controls blood sugar in 245 people with type 1 diabetes who have never used it before. Participants take the insulin as prescribed by their doctor, and researchers track changes in HbA1c and treatment satisfaction over about 22 to 30 we…

This study tests whether delivering healthy food boxes, remote health monitoring, and one-on-one coaching can help low-income Black adults with type 2 diabetes better control their blood sugar. The trial enrolls 304 participants in the Deep South and tracks changes in HbA1c level…

This study is testing whether giving the BCG vaccine (normally used for tuberculosis) twice, four weeks apart, can improve blood sugar control and reduce insulin needs in children aged 8 to 17 who were recently diagnosed with type 1 diabetes. The trial involves 100 participants a…

This study tests whether giving the BCG vaccine (traditionally used for tuberculosis) twice, four weeks apart, can help children aged 8 to 18 with type 1 diabetes. The goal is to see if it improves blood sugar control, reduces insulin use, and lowers the risk of dangerously low b…

This phase II trial compares two chemotherapy regimens in 176 older patients with metastatic pancreatic cancer. One group receives gemcitabine plus nab-paclitaxel, the other receives fluorouracil, leucovorin, and liposomal irinotecan. The goal is to see which combination helps pa…

This study tests a culturally tailored education program for African Americans with type 2 diabetes. The program teaches resilience and self-management skills through group sessions led by nurses, plus support groups and booster sessions. Researchers are tracking blood sugar leve…

This study tests a new drug combination (AZD9550 and AZD6234) for weight loss in 166 adults who are overweight or obese, with or without type 2 diabetes. The main goals are to check safety, tolerability, and how the drug moves through the body. It is an early-stage trial, so it f…

This study tests a new immunotherapy for adults with advanced pancreatic cancer. The treatment uses a special protein and virus to help the immune system kill cancer cells, combined with an antibody called ezabenlimab. The goal is to find a safe dose and see if the combination ca…

This study tests a new weekly injection called enicepatide (CT-388) in 447 overweight or obese adults with type 2 diabetes. Participants receive either the drug or a placebo for 48 weeks. The goal is to see if the drug helps with weight loss and improves blood sugar levels.

This study compares a new three-drug combination (NABPLAGEM) against a standard two-drug chemo regimen for people with advanced pancreatic cancer that has spread and carries a BRCA or PALB2 gene mutation. The trial enrolls 10 participants whose cancer worsened after initial treat…

This study is testing whether a daily semaglutide tablet can safely reduce the risk of heart attacks, strokes, and related deaths in over 21,000 adults with type 2 diabetes who have never had a heart attack or stroke. Participants take either semaglutide or a placebo pill for sev…

This early-phase trial is testing whether adding an experimental drug called IM156 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe and tolerable for people with advanced pancreatic cancer. The study involves 19 participants and is being run by M.D. Anderson Canc…

This study tests whether a short-term program combining health coaching and medication can help people with type 2 diabetes achieve remission without surgery. It involves 118 adults diagnosed within the last 5 years, recruited from a primary care clinic in Hamilton, Ontario. The …

This large study looks at real-world data from 60,000 people with type 2 diabetes and obesity to compare four diabetes drugs—dulaglutide, semaglutide, tirzepatide, and sitagliptin—in preventing heart attacks, strokes, and death. Researchers are analyzing insurance claims to see w…

This early-phase trial tests an experimental drug called IPH5301, which targets a protein called CD73 on cancer cells. The study involves 27 people with advanced solid tumors, including breast, lung, and pancreatic cancers. In the first part, IPH5301 is given alone to find a safe…

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This phase 2 trial tests whether the drug DFMO can protect the body's remaining insulin-producing cells in people recently diagnosed with type 1 diabetes. About 81 participants will take either DFMO or a placebo twice daily for six months. Researchers will measure insulin product…

This study compares a combination diabetes drug (iGlarLixi) against insulin alone to see which better reduces liver fat in people with type 2 diabetes and a common fatty liver condition called MASLD. About 36 participants will take one of the two treatments for 12 weeks, and doct…

This study aimed to see if using an exercise phone app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose monitor and, if in the intervention group, used …

This study gives the drug metreleptin to 29 people with partial lipodystrophy, a rare condition that causes high blood fats and diabetes. Participants have already shown improvement from the drug in earlier studies. The goal is to keep providing the treatment and check its long-t…

This study tests a new combination for people with pancreatic cancer that cannot be surgically removed or has spread. It uses a light-activated drug (verteporfin) to make tumors more sensitive to immunotherapy (pembrolizumab), alongside standard chemotherapy. The goal is to see i…

This study tests a team-based approach to help African American and Latinx adults with uncontrolled type 2 diabetes lower their blood sugar levels. Participants will receive extra support from a multidisciplinary team, while a comparison group gets usual care plus educational mat…

This study tests a combination of two drugs, cediranib and olaparib, in people with advanced solid tumors that have spread or cannot be removed by surgery. The cancers include certain types of breast, lung, and pancreatic cancer. The goal is to see if the combination can shrink t…

This early-stage trial is testing a personalized peptide vaccine for people with advanced pancreatic or colorectal cancer that has spread. The vaccine is made from each patient's own tumor cells and blood, aiming to train the immune system to attack the cancer. The study will che…

This phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…

This study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes severe fat loss and leads to high blood fats and diabetes. Participants, aged 6 months and older, have already received metreleptin in past NIH studies but cannot get it i…

This phase II trial is testing whether combining two targeted drugs, palbociclib and binimetinib, can help people with cancers that have RAS mutations. The study includes patients with pancreatic cancer, ovarian cancer, and other solid tumors. Researchers want to see if the drug …

This early-phase study tests a new drug combination for people with advanced pancreatic cancer that has a specific marker (mesothelin). The treatment pairs a targeted chemotherapy with immunotherapy drugs and standard chemo to see if it's safe and what dose works best. About 74 a…

This phase 3 trial is testing whether the drug retatrutide can lower the chance of serious heart problems (like heart attacks and strokes) and slow kidney disease in 10,000 overweight adults who already have heart or kidney disease. Participants receive either retatrutide or a pl…

This study tests whether home visits by female community health volunteers plus regular SMS messages can help adults in Pokhara, Nepal, better control high blood pressure, type 2 diabetes, and smoking. About 2100 participants are split into two groups: one gets the home visits an…

This study is testing whether a combination of two drugs, sotagliflozin and volagidemab, can improve blood sugar control in adults with type 1 diabetes. The 24 participants will receive both drugs or a placebo in a crossover design. The goal is to see if this approach can help ma…

This early-stage trial tests whether adding the drug bosentan to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe and tolerable for people with pancreatic cancer that cannot be removed by surgery. The study involves 21 adults and aims to find the best dose of bosent…

This early-stage study tests an investigational drug called LY4086940 in healthy people and those with overweight, obesity, or type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will receive single or multiple doses …

This study looks at how well the diabetes drug empagliflozin (Jardiance) works in everyday medical practice, outside of a controlled research setting. Researchers are comparing it to other diabetes medicines in over 230,000 adults with type 2 diabetes. The goal is to see if the h…

This phase II trial is testing a combination of two experimental drugs (AZD0171 and durvalumab) plus standard chemotherapy in 126 people with advanced pancreatic cancer. The goal is to see if the combo is safe and helps patients live longer. Participants must have metastatic dise…

This early-stage study tests a new drug called PATAS in healthy volunteers to see if it is safe and how the body processes it. The study involves 56 people aged 18 to 55 who are in good health. The goal is to find the right dose and check for side effects before testing in people…

This trial investigates whether adding proglumide, a drug that blocks cholecystokinin receptors, to standard chemotherapy can improve treatment for metastatic pancreatic cancer. About 30 adults with advanced pancreatic cancer will receive either proglumide or a placebo alongside …

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study tests whether combining two immunotherapy drugs (nivolumab and ipilimumab) with radiation therapy can control or shrink tumors in people with colorectal or pancreatic cancer that has specific genetic features (MSS or MSI-high). About 84 adults with advanced disease are…

This study tests a treatment plan for people with advanced pancreatic cancer that has spread to a major artery. Participants receive chemotherapy and radiation before surgery, then more chemo after. The goal is to see if this approach is safe and helps patients live longer. The t…

This study looks at whether eating proteins and vegetables before carbohydrates (meal sequencing) can improve blood sugar control in 70 adults with diabetes or prediabetes who also experience food insecurity. Participants will receive free produce boxes and either standard nutrit…

This study tests whether a 12-week multimodal exercise program can improve physical performance and muscle function in adults aged 45-64 with type 2 diabetes. Participants are randomly assigned to either the exercise program or standard care. The goal is to find a practical way t…

This study was designed to see if taking metformin or salsalate on the morning of surgery could help control blood sugar and reduce complications in people with type 2 diabetes. It planned to enroll patients having elective surgery who regularly take metformin. However, the trial…

This study tests whether adding the drug surufatinib to standard chemotherapy can help shrink pancreatic tumors enough to allow successful surgery. It involves 29 adults with locally advanced or borderline resectable pancreatic cancer. The main goal is to see how many tumors can …

This study looks at whether using a continuous glucose monitor (CGM) along with a mobile app can help people with type 2 diabetes control their blood sugar better than standard care. Sixty adults will be randomly assigned to either the digital tool group or usual care, and their …

This study looks at whether the amount of effort you put into strength training can improve blood sugar control and mental health in people with type 2 diabetes. About 48 adults with type 2 diabetes will do resistance exercises at different effort levels. Researchers will track b…

This study tests whether time-restricted eating (eating all meals within an 8-10 hour window each day) can help people with type 2 diabetes better control their blood sugar and improve heart health. About 60 adults with type 2 diabetes will either follow their usual care or add t…

This early-stage study tests a new drug, maridebart cafraglutide, to see if it helps people with type 2 diabetes use insulin better. About 56 adults on metformin will receive either the drug or a placebo. The main goal is to measure changes in insulin sensitivity after 25 weeks.

This study tests whether an AI-based counseling program on a smartphone can help women with gestational diabetes manage their condition. 80 pregnant women will either get standard nutrition advice or AI-powered guidance. The goal is to see if the AI approach leads to healthier bi…

This study looks at health records of 120,000 people with type 2 diabetes and overweight to compare two injectable drugs: semaglutide and dulaglutide. Researchers want to see which one better reduces the risk of death, heart attack, or stroke. The goal is to understand how these …

This study tests a new investigational medicine called CagriSema against an approved drug, tirzepatide, in people with type 2 diabetes whose blood sugar is not well controlled by current pills. About 1,023 adults will receive either CagriSema or tirzepatide once a week for up to …

This study tests a new program where schools, families, and doctors work together to help children manage type 1 diabetes. About 30 kids will take part to see if the program is practical and well-liked. The goal is to improve daily diabetes care at school.

This study looks at whether allowing a slightly higher blood sugar range (70-110 mg/dL) during labor in mothers with diabetes can reduce the number of newborns with low blood sugar. Researchers will compare this approach to standard care in 169 pregnant women planning a vaginal d…

This early-phase trial tests whether adding immune cells—either the patient's own regulatory T cells or donor bone marrow cells—to a standard islet transplant can improve blood sugar control in people with brittle type 1 diabetes. About 24 adults aged 18 to 70 will receive one of…

This study looks at whether the diabetes drug metformin, combined with a low-calorie diet, helps overweight or obese adults with a large waistline lose weight. About 150 participants will take either metformin or a placebo for 24 weeks. The main goal is to see if at least 5% of b…

This early-phase study tests a new oral drug called E7386 in about 60 adults with advanced solid tumors (like desmoid tumors) that have not responded to other treatments. The main goals are to find the safest dose and check for side effects. Researchers will also watch for any tu…

This study tests a 3-month lifestyle program called the PILI Pasifika Program for Native Hawaiian and Pacific Islander adults who are overweight or have conditions like high blood pressure or diabetes. The program includes group lessons on healthy eating and physical activity, pl…

This study tests whether combining three immunotherapy drugs (domvanalimab, zimberelimab, and APX005M) can safely control metastatic pancreatic cancer. The trial enrolls 46 people whose cancer has spread and standard treatments have stopped working. Researchers will monitor side …

This study tests a new medicine called SHR-3167 in adults with type 2 diabetes whose blood sugar is not well controlled by pills. About 100 participants will receive different dosing plans to see which works best at lowering blood sugar while avoiding dangerously low sugar levels…

This study looks at whether dulaglutide, a drug used for type 2 diabetes, can help regulate menstrual cycles in adolescent girls with type 1 diabetes who have poor blood sugar control. Researchers will give some participants dulaglutide plus insulin, while others get only insulin…

This study tests whether adding zolbetuximab to standard chemotherapy helps people with metastatic pancreatic cancer live longer. Zolbetuximab targets a protein (CLDN18.2) found in most pancreatic tumors, helping the immune system attack the cancer. About 393 adults whose cancer …

This early-phase trial tests VX-264, a therapy made from stem cells that produce insulin, in 7 people with long-standing type 1 diabetes. The goal is to see if it is safe and can help control blood sugar. If successful, it may reduce or replace the need for insulin injections.

This study looks at whether giving low-income people with diabetes or hypertension a monthly grocery card ($80 or $120) helps them control their disease and feel less stressed about food. About 4,450 adults in California are taking part. Researchers will check changes in blood su…

This study tests different combinations of immunotherapy drugs given before and after surgery for people with pancreatic cancer that can be removed. The goal is to see if these treatments can help the immune system fight the cancer better and improve outcomes. About 76 participan…

This early-phase trial tests an experimental antibody called GEN1042, given alone or with the cancer drug pembrolizumab (and sometimes chemotherapy), in people with advanced solid tumors like lung, colon, melanoma, head and neck, or pancreatic cancer. The main goals are to check …

This study looks at whether providing medically tailored groceries can help people with type 2 diabetes and high blood pressure keep up healthy eating habits and control their blood sugar and blood pressure. About 80 adults who already took part in a meal delivery study will rece…

This phase 3 trial tests a new drug called daraxonrasib (RMC-6236) against standard treatments for people with metastatic pancreatic cancer that has already been treated. About 500 adults with a specific RAS gene mutation will be randomly assigned to receive either the new drug o…

This early-phase trial is testing a combination of two drugs—guadecitabine and durvalumab—in 55 people with advanced liver, pancreatic, bile duct, or gallbladder cancers that have spread. Guadecitabine aims to stop cancer cell growth, while durvalumab helps the immune system atta…

This phase 2 study tests a personalized immune cell therapy called tumor-infiltrating lymphocytes (TIL) in 20 people with advanced solid cancers (like stomach, colon, or pancreatic cancer) that have not responded to standard treatments. Patients first receive chemotherapy to prep…

This study tests a smartphone-based system called AIDANET that works with an insulin pump and continuous glucose monitor to automatically adjust insulin for children aged 6-13 with type 1 diabetes. The goal is to see if the system is safe and works as well as usual care in keepin…

This study tests a new insulin infusion set designed to last up to 7 days for people with type 1 diabetes. Twenty adults currently using a Tandem insulin pump and Dexcom CGM will try the SteadiSet at home. The goal is to see if the set can survive a full week without causing high…

This study tests whether adding the experimental drug navlimetostat to standard chemotherapy can help people with a specific type of advanced pancreatic cancer (one with an MTAP gene deletion) live longer or slow tumor growth. About 470 adults who have not had prior treatment for…

This phase 2 trial tests a low-dose combination of five chemotherapy drugs (gemcitabine, nab-paclitaxel, capecitabine, cisplatin, irinotecan) followed by two maintenance drugs (olaparib and pembrolizumab) in 38 people with untreated metastatic pancreatic cancer. The goal is to se…

This early-phase study tests a new drug called JANX008 in about 130 adults with advanced solid tumors, including lung, kidney, head and neck, colorectal, pancreatic, and breast cancers. The main goal is to check safety and find the right dose. Participants must have tried all sta…

This early-stage trial is testing a new drug called anvumetostat, given together with other standard chemotherapy drugs, for people with advanced cancers of the digestive system (stomach, bile ducts, or pancreas) that have a specific genetic change called MTAP deletion. The main …

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study tests whether a church-based program led by community health workers can help Black adults in Louisiana lower their risk of heart disease, high blood pressure, diabetes, and high cholesterol. About 812 participants from local churches will receive either a health worke…

This study tests whether simple text messages and online activities can encourage people with Type 2 Diabetes to get more preventive dental care, like cleanings, instead of waiting for expensive treatments. Researchers will track dental insurance claims from 10,000 adults over 18…

This phase II trial is testing whether adding the drug veliparib to standard chemotherapy (gemcitabine and cisplatin) can shrink tumors or slow cancer growth in people with advanced pancreatic cancer who have BRCA1, BRCA2, or PALB2 gene mutations. The study has two parts: one com…

This study looks at whether offering financial rewards, along with nurse coaching and home monitoring, helps adults with type 2 diabetes improve their blood sugar control. About 450 participants will be randomly assigned to receive either nurse coaching and home monitoring alone,…

This early-phase trial tests a new drug called BAY 1895344 combined with standard chemotherapy (irinotecan or topotecan) in people with advanced solid tumors, especially small cell lung cancer, poorly differentiated neuroendocrine cancer, and pancreatic cancer. The goal is to fin…

This phase II trial tests an adaptive chemotherapy approach for people with pancreatic cancer that can be removed by surgery. The goal is to see if adjusting the chemo regimen based on early response can increase the number of patients who become eligible for surgery. About 32 pa…

This study tests whether monthly home visits from trained health agents can help people in poor, high-altitude communities in Peru better control their high blood pressure and diabetes. Over 1,000 participants will either receive these visits for a year or get usual care. The goa…

This study compares two methods of tracking blood sugar in people with type 2 diabetes: traditional fingerstick testing and continuous glucose monitors (CGMs). About 360 adults aged 18 to 75 who use insulin will be followed for 12 months to see which method better lowers A1C leve…

This study looks at how well the Joslin Why WAIT? program helps people with type 2 diabetes and obesity lose weight and improve their health. About 110 participants who have a BMI over 35 are included. The main goal is to see if they can lose at least 7% of their body weight and …

This study tests an experimental drug called LY3537982 in people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if the drug is safe and shrinks tumors. About 540 participants with lung, colorectal, endometrial, ovarian, pancreatic, or bile …

This treatment program tests a personalized cell therapy for people with advanced pancreatic or colorectal cancers that have a specific genetic mutation (KRAS G12D). Patients' own immune cells are collected, genetically engineered to recognize and attack the cancer, and then infu…

This study tests if washing the abdomen with distilled water or saline right after removing a pancreatic tumor can help patients live longer. About 845 adults having surgery for pancreatic or related cancers are randomly assigned to one of three groups: washing with saltwater, wa…

This study tests whether adding two extra medications (semaglutide and dapagliflozin) to insulin helps adults with type 1 diabetes control their blood sugar better than insulin alone or with just one extra drug. The 78 participants, aged 18-70 with a BMI of 25 or higher, will be …

This phase 2 trial tests two oral drugs, abrocitinib and ritlecitinib, in 78 people aged 12-35 who were diagnosed with type 1 diabetes within the last 100 days. The goal is to see if these JAK inhibitors can help preserve the body's ability to produce insulin, measured by a stimu…

This study looks at whether taking a yerba mate extract can help improve health markers in overweight adults. Eighty people aged 40-65 will take either the extract or a placebo for 90 days. Researchers will measure changes in weight, blood sugar, cholesterol, and inflammation to …

This early-phase trial is testing whether two drugs, HRS-4642 and nimotuzumab, can safely shrink tumors in people with recurrent or metastatic pancreatic ductal adenocarcinoma. About 20 patients will receive the combination to find the best dose and see how well it works. The goa…

This study tests an experimental drug called M9140 in people with advanced solid tumors (gastric, lung, or pancreatic cancer) that have a specific protein (CEACAM5). The drug is designed to deliver a toxin directly to cancer cells. About 250 adults will receive the drug alone or …

This study tests whether using a continuous glucose monitor (CGM) along with remote dietitian support helps people with type 2 diabetes better control their blood sugar. About 160 adults across Australia will use a CGM and receive online dietary advice for several months. The goa…

This study tests a health support program for 600 people with disabilities who also have chronic conditions like diabetes or obesity. The program includes weekly nutrition classes, three exercise sessions per week, and help managing chronic conditions. Researchers want to see if …

This study follows 1,600 people with type 1 diabetes, including young children aged 2-6, who use hybrid closed-loop insulin pumps (Medtronic, Tandem, or Omnipod). These devices automatically adjust insulin based on blood sugar readings but still require users to enter meal inform…

This phase 2 study tests the drug entrectinib in over 500 people with advanced solid tumors that have specific gene changes (NTRK, ROS1, or ALK fusions). The goal is to see if the drug can shrink tumors and control the disease. Participants have various cancer types, including lu…

This early-stage trial is testing a new oral drug called LY4066434, which blocks several types of KRAS proteins that drive cancer growth. The study includes up to 750 people with advanced pancreatic, lung, colorectal, or other solid tumors that have specific KRAS mutations. The d…

This early-stage trial is testing a new oral drug called S095035, alone or combined with another drug (TNG462), in 60 adults with advanced solid tumors that have a specific genetic deletion (MTAP). These cancers have not responded to at least one prior treatment. The study aims t…

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This study is testing whether a real-time continuous glucose monitor (CGM) can help 200 adults with type 2 diabetes who use insulin in Saudi Arabia. Participants wear a CGM device that tracks blood sugar levels continuously. The main goal is to see if it improves HbA1c, a measure…

This early-phase trial tests a new approach for people with pancreatic cancer that cannot be removed right away. Tiny nanoparticles called NBTXR3 are injected directly into the tumor and then activated by radiation therapy. The goal is to find a safe dose and see if this combinat…

This study tests whether a daily injection of liraglutide (3.0 mg) can help children aged 6 to 12 with obesity lose weight. Over 56 weeks, 78 children will receive either liraglutide or a placebo, along with counseling on diet and exercise. The main goal is to see how much their …

This early-phase trial tests a new type of radiation called pulsed low-dose-rate (PLDR) for people with pancreatic cancer that cannot be removed right away. The radiation is given in small, spaced-out bursts along with the chemotherapy drug gemcitabine. The goal is to see if this…

This early-phase trial tests whether transferring healthy gut bacteria from donor stool can help control pancreatic cancer. Ten patients scheduled for tumor-removal surgery will receive the transplant to see if it is safe and affects the disease. The study is currently suspended.

This early-phase trial tests the drug phentermine/topiramate (Qsymia) in 13 adolescents aged 12-20 who have both obesity and type 2 diabetes. The drug is already approved for weight loss in adults. The study aims to see if it can safely lower body mass index (BMI) and improve blo…

This study tests whether a combination of three drugs (paricalcitol, hydroxychloroquine, and losartan) can safely modify the supportive tissue around pancreatic tumors before surgery. About 20 adults with resectable pancreatic cancer will take these drugs for at least 4 weeks bet…

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This early-stage trial tests a new drug called LY4101174 in people with advanced solid tumors, including bladder, breast, and lung cancers. The drug is an antibody-drug conjugate designed to target and kill cancer cells. The study will check if the drug is safe, tolerable, and ef…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. Twenty-five participants who are at least three months post-transplant will follow a plant-based diet for 16 weeks after a two-…

This study compares continuous glucose monitoring using the FreeStyle Libre 3 sensor to standard finger-stick testing in 470 adults with type 2 diabetes whose blood sugar is not well controlled. Participants continue their usual medications (basal insulin plus SGLT2 inhibitor and…

This Phase 2 trial tests a chemotherapy regimen called NALIRIFOX combined with precise radiation (SBRT) in 42 people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this approach can delay cancer growth and improve survival. Partic…

This early-stage trial is testing a combination of pelareorep (a reovirus) and atezolizumab (an immunotherapy) along with standard chemotherapies in people with advanced anal or pancreatic cancers. The study aims to find safe doses, look for biomarkers that predict response, and …

This study tests a special magnet system that creates a new connection between the stomach and intestine without traditional surgery. It is designed for adults with obesity (BMI 30-50) who also have type 2 diabetes or have regained weight after a previous sleeve gastrectomy. The …

This study tests whether a short course of two drugs, dasatinib and quercetin, can clear senescent (aging) cells in people with chronic kidney disease. The goal is to see if this reduces frailty and improves stem cell function. Thirty participants aged 40-80 with moderate-to-seve…

This study tests a new magnetic device (MagDI System) that creates a connection between the duodenum and ileum, bypassing part of the small intestine. The goal is to help with weight loss and blood sugar control in 60 adults with obesity and type 2 diabetes. Researchers are check…

This study tests a new magnetic system (MagDI) that creates a connection between two parts of the small intestine to help with weight loss and blood sugar control. It involves 25 adults with obesity and type 2 diabetes. The goal is to see if the device is safe, works as intended,…

This early-phase trial tests an experimental immunotherapy called ELI-002 7P in people with pancreatic or other solid tumors that have specific KRAS or NRAS gene mutations. The treatment aims to train the immune system to attack cancer cells. About 158 participants will receive t…

This study looks at different methods to help patients with high cholesterol and heart disease get the right medicines to lower their cholesterol. About 300 adults at high risk will take part. The goal is to see which approach helps more people reach their target LDL cholesterol …

This early-stage trial tests a new drug called CA-4948 combined with standard chemotherapy (gemcitabine and nab-paclitaxel) in people with pancreatic cancer that has spread or cannot be removed by surgery. The goal is to find the safest dose and see if the combination can shrink …

This early-phase trial tests a new drug called M6620 (berzosertib) combined with the chemotherapy irinotecan in people with advanced solid tumors that have spread or can't be removed. The goal is to find the safest dose and see if the combination can slow tumor growth. About 66 p…

This study tests whether eating dried Saskatoon berries daily for 10 weeks can improve blood sugar and cholesterol levels in people with untreated prediabetes or new type 2 diabetes. Researchers will compare the effects of Saskatoon berries to a control dried fruit in 92 adults a…

This large study compares two popular diabetes drugs, tirzepatide and semaglutide, in 26,000 people who have both type 2 diabetes and a type of heart failure. Researchers will track who ends up in the hospital for heart failure or dies, to see if one drug works better. The goal i…

This early-phase study tests a new treatment called EGFR-BATs for people with advanced pancreatic cancer that has not responded to standard chemotherapy. The treatment uses the patient's own immune cells, which are trained in a lab to better attack cancer cells. The main goal is …

This study tests whether giving chemotherapy both before and after surgery helps people with pancreatic cancer live longer compared to chemotherapy only after surgery. About 378 patients with resectable pancreatic cancer will be randomly assigned to one of two treatment schedules…

This study tests three different non-drug approaches to help older adults in nursing homes manage their type 2 diabetes. One group uses a device that sends mild electrical pulses to the leg muscles, another does supervised exercise, and the third receives health education. The ma…

This study tests a culturally tailored medical nutrition therapy for African patients with type 2 diabetes. The program includes personalized meal plans, nutrition counseling, and group education. Researchers will measure blood sugar levels and diet adherence after 6 months, and …

This study tests whether a probiotic called Limosilactobacillus fermentum CRL 1446 can improve health in 80 adults with heart disease risk factors like obesity, high blood pressure, and high cholesterol. Participants take either the probiotic or a placebo daily, and researchers m…

This early-phase study tests a new drug called RMC-6291 in adults with advanced cancers (lung, colon, pancreatic) that have a specific KRAS G12C mutation. The goal is to find the safest dose and see how well the drug works. About 222 participants will receive the drug by mouth, a…

This Phase 2 trial tests an oral drug called ESK981 in people with advanced pancreatic cancer, neuroendocrine tumors, or neuroendocrine prostate cancer. The goal is to see if the drug can keep the cancer from growing for at least 4 months. Participants take the drug for 5 days, t…

This study tests whether adding an SGLT2 inhibitor to standard ARB therapy better reduces protein in the urine (a sign of kidney damage) in diabetic patients without high blood pressure. Sixty adults aged 30-60 with diabetes and microalbuminuria will receive either ARBs alone or …

This study looks at whether supervised exercise classes or doing physical activity on your own works better for controlling blood sugar in adults with type 2 diabetes. About 120 people whose diabetes is not well controlled with diet or non-insulin medications will take part. Part…

This study tests whether adding culturally tailored heart-health education to medically tailored meal programs helps people with type 2 diabetes and high blood pressure eat better and improve their blood sugar and blood pressure. About 176 adults from low-income New York City nei…

This study tests a new treatment called Saltikva, a weakened Salmonella bacteria that carries a human immune-boosting gene (IL-2), in people with metastatic pancreatic cancer. Participants take Saltikva by mouth along with standard chemotherapy. The goal is to see if adding Salti…

This study looks at the best way to control blood sugar in pregnant women with diabetes who receive steroids to help their baby's lungs develop before a possible early birth. About 120 women will be randomly assigned to one of three insulin strategies. The goal is to find which a…

This study was designed to see if placing a stent in a blocked leg vein could help heal diabetic foot ulcers in people with diabetes and leg swelling. Patients would have received standard wound care plus either a stent or no stent. However, the trial was withdrawn before any par…

This early-stage trial is testing a new oral drug called ZE63-0302 in 60 adults with type 2 diabetes. The main goal is to check the drug's safety and how the body handles it, not yet whether it works. Participants will take either the drug or a placebo capsule twice a day for a s…

This phase 3 trial tests tirzepatide, a once-weekly injection, in 905 adults with type 1 diabetes who are also overweight or obese. Participants will receive either tirzepatide or a placebo for about 49 weeks. The study measures changes in blood sugar control (HbA1c) and body wei…

This study tests a community-based program to help Black and Latino adults with diabetes, prediabetes, high blood pressure, or obesity. Participants receive lifestyle coaching, help connecting to health and social services, and digital skills training. The goal is to see if this …

This study tests whether giving higher doses of radiation, guided by MRI, can help people with pancreatic cancer that cannot be removed by surgery. Participants must have already had several months of chemotherapy without the cancer spreading. The goal is to see if this approach …

This study tests whether an AI tool that shows patients how their blood sugar control compares to others, combined with home monitoring, can improve risk perception and blood sugar levels in adults with poorly controlled type 2 diabetes. About 360 participants aged 36–65 will be …

This study tracks 100 people with pancreatic cysts or tumors who receive a treatment called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA). A thin needle delivers heat directly to the lesion to destroy it. Researchers will monitor how well the procedure works and …

This study tests a new medicine called HM15136 for people aged 2 and older with congenital hyperinsulinism (CHI) who still have low blood sugar despite standard treatments. The medicine is given as a weekly shot for 8 weeks. The goal is to see if it is safe and helps control bloo…

This study is testing different combinations of diet and exercise to find the best weight loss plan for people with prediabetes who also have physical or mobility disabilities. Thirty participants will start with either a high or reduced carbohydrate diet. After four weeks, those…

This early study tests whether giving the drug Lutathera directly into the liver artery is safe and practical for people with neuroendocrine tumors that have spread mainly to the liver. Ten participants will receive two doses into the liver artery followed by two standard IV dose…

This early-phase trial tests a personalized vaccine made from a patient's own immune cells, combined with standard chemotherapy and an immunotherapy drug (nivolumab), for people whose pancreatic cancer was removed by surgery. The goal is to see if the vaccine can be made successf…

This study was designed to see if giving two chemotherapy drugs (gemcitabine and capecitabine) after surgery could help people with pancreatic cancer stay cancer-free longer. It was for patients who had already received chemotherapy before surgery. However, the trial was withdraw…

This study tests a 90-day fully virtual lifestyle program for adults aged 30-60 who are sedentary and at risk for heart disease. Participants exercise via Peloton, take daily supplements (Omega-3, Vitamin D3, Magnesium, fiber), and use wearable devices to track activity and sleep…

This study tests whether adding a drug called defactinib to targeted radiation therapy can help control advanced pancreatic cancer better than radiation alone. About 42 people with inoperable pancreatic cancer will take part. The goal is to see if the combination slows cancer gro…

This study looks at whether remotely monitoring continuous glucose monitor (CGM) data can improve diabetes management in children within the first year after diagnosis. About 100 kids and teens newly diagnosed with type 1 diabetes will have their CGM data shared with their care t…

This Phase 2 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve kidney health in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat and b…

This pilot study explores how a 6-month low-carbohydrate diet affects blood sugar control, body composition, and gut-brain interactions in 40 obese adults with or without glucose intolerance or diabetes. Participants follow a low-carb eating plan, and researchers measure changes …

This phase 2 trial tests a new drug called ZN-c3 combined with the chemotherapy gemcitabine in 12 people with advanced pancreatic cancer that has worsened after platinum-based treatment. The goal is to see if the combination is safe and can slow cancer growth. Participants take Z…

This study looks at how safe and effective Ozempic is for adults with type 2 diabetes when used in normal doctor visits. About 600 people in Korea will take Ozempic as their doctor prescribes, and the study lasts around 26 weeks. The main goal is to track any side effects and ser…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This study tests a new drug called narmafotinib, taken as a daily pill, together with a standard chemotherapy regimen (mFOLFIRINOX) in people whose pancreatic cancer has spread. The trial has two parts: first, finding a safe dose, then comparing two doses in 20 people each. The g…

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy (mFOLFIRINOX) before surgery is safe and tolerable for people with pancreatic cancer that can be removed. About 20 adults with resectable or borderline resectable pancreatic cancer will rec…

This phase 2 trial tests whether giving a higher-than-standard dose of radiation, along with chemotherapy, can shrink pancreatic tumors enough to make them removable by surgery. The study includes 47 people with locally advanced pancreatic cancer that currently cannot be surgical…

This study tests a new drug called LP-184 in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors or slow their growth. About 64 participants will receive the drug as an…

This study tests whether a text-message based mobile health program can help people with type 2 diabetes in Nepal better manage their condition. 154 adults with type 2 diabetes will be randomly assigned to receive either the text-message program plus standard care, or standard ca…

This study tests whether a mobile app that trains girls to manage food cravings can help them eat more fruits and vegetables. About 150 girls aged 14-18 will use the app twice a week for a year. Researchers will track diet quality, weight, and blood sugar to see if the app leads …

This early-phase study tests a new type of radiation therapy (SCART) for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to find the highest safe dose that can destroy the tumor while protecting nearby organs. About 24 participants wi…

This phase 2 trial tested whether a combination of temozolomide and capecitabine works better than the standard cisplatin and etoposide for people with advanced, hard-to-treat gastrointestinal neuroendocrine carcinomas. The study enrolled 67 participants whose cancer had spread o…

This study tests whether a transition coordinator can help 324 youth aged 17–18 with type 1 diabetes successfully move from pediatric to adult diabetes care. Participants get extra support before, during, and after the switch. Researchers will compare them to a group that didn't …

This early-stage study tests a new drug called AZD1705 in adults with high cholesterol (dyslipidemia). The main goal is to check if the drug is safe and how the body processes it. About 98 participants will receive either the drug or a placebo. This research helps determine if th…

This study looks at whether SGLT2 inhibitors, a type of diabetes medication, can help control ascites (fluid buildup in the belly) in people with liver cirrhosis and type 2 diabetes. Researchers will compare 40 patients who add the drug to their usual treatment against those who …

This study looks at whether semaglutide, a medicine for type 2 diabetes, can slow or prevent diabetic eye disease over 5 years. About 1500 adults with type 2 diabetes will receive either semaglutide or a placebo injection once a week, in addition to their usual diabetes medicatio…

This study tests an experimental tablet called ASC30 in 100 adults with type 2 diabetes. The goal is to see if it safely lowers blood sugar and helps with weight over 13 weeks compared to a placebo. Participants must have stable weight and a BMI of 23 or higher.

This phase 2 trial tests whether a precise, high-dose radiation technique called SBRT can lower the chance of cancer coming back in the pancreas area after surgery. The study involves 50 adults with pancreatic cancer who had surgery and are at high risk of recurrence. They will r…

This phase 2 trial tests whether ixekizumab (Taltz), a drug already approved for psoriasis, can help people newly diagnosed with type 1 diabetes keep making their own insulin. The study involves 127 adults aged 18-45 who were diagnosed within the last 100 days. Participants recei…

This study looks at whether wearing a continuous glucose monitor (CGM) after leaving the hospital helps people with type 2 diabetes control their blood sugar. About 108 adults who need insulin will wear a CGM for 12 weeks and answer surveys about their experience. The goal is to …

This phase II trial tests whether a combination of lenvatinib (a targeted drug) and pembrolizumab (an immunotherapy) can help keep advanced pancreatic cancer from progressing. The study includes 28 adults whose cancer has not spread further after initial treatment. Participants r…

This study tests a new daily pill, aleniglipron, in 58 adults with type 2 diabetes who are overweight or obese. The main goal is to check if the drug is safe and tolerable at different doses. Researchers will also measure weight loss and blood sugar changes. The study is not yet …

This study tests whether taking 4000 IU of vitamin D daily for six months can reduce inflammation in Mexican adults with type 2 diabetes. Researchers will measure blood markers like glucose, insulin, and C-reactive protein in 40 participants. The goal is to see if vitamin D can h…

This early-stage study tested a device called Beta-Air, which contains insulin-producing cells, in 4 adults with long-standing type 1 diabetes. The main goal was to see if the implant is safe. Researchers also checked if it could help control blood sugar and reduce dangerous low …

This study tests whether a diet with more protein (25% of daily calories) helps children aged 7-14 with overweight or obesity lose weight and reduce diabetes risk. Over 10 weeks at a lifestyle camp, one group eats a higher-protein diet while another eats a lower-protein diet, bot…

This study tests whether mentoring local clinic teams via telehealth can help them start a comprehensive diabetes program for low-income Latino(a)s with type 2 diabetes. The program includes community health workers, help getting medication, and diabetes education. Researchers wi…

This study planned to test whether a virtual weight control program (WW, formerly Weight Watchers) could help adults with type 2 diabetes and obesity lower their blood sugar levels. Participants would have used the WW SmartPoints system and attended weekly online workshops. Howev…

This study looks at whether using an over-the-counter continuous glucose monitor (CGM) every 30 or 90 days can help people with type 2 diabetes who do not use insulin better manage their blood sugar. About 188 participants will wear the Dexcom Stelo device periodically over six m…

This study tests whether giving people with obesity and diabetes a monthly $160 subsidy to buy fruits and vegetables online helps them eat healthier. 214 participants will be split into groups, some getting the subsidy and some not, to see if it increases their produce purchases …

This study tests whether transferring gut bacteria from a healthy donor (fecal transplant) can improve blood sugar control in 16 adults with type 2 diabetes. Participants receive either the transplant or a placebo, and researchers measure insulin sensitivity and blood sugar level…

This study tests a single infusion of stem cells from donated umbilical cord tissue (Wharton's jelly) in 66 children and teens aged 7–21 who were diagnosed with type 1 diabetes within the last 6 months. The goal is to see if the treatment is safe and can help the body produce mor…

This early-phase trial tests a new drug called sEphB4-HSA combined with standard chemotherapy in people with advanced or metastatic solid tumors, including head and neck, pancreatic, lung, and gallbladder cancers. The goal is to find the best dose and see if the combination is sa…

This study was designed to compare two ways to treat walled-off necrosis (a pocket of dead tissue) caused by severe pancreatitis. One method uses a scope through the mouth to clean out the pocket, the other uses surgery through the stomach. The goal was to see which approach work…

This study looks at how the timing of meals and sleep patterns influence blood sugar, heart health, and weight loss in adults with type 2 diabetes, obesity, or high blood pressure. Researchers will provide nutritional guidance and track changes in weight, lab results, and body me…

This Phase 3 trial is testing a once-daily pill called orforglipron to see if it helps people with obesity or overweight lose weight, both in those with and without type 2 diabetes. About 1,200 participants will take either the drug or a placebo for a set period. The goal is to f…

This study looks at whether extra help from a pharmacist can improve blood sugar control in adults with uncontrolled type 2 diabetes. About 60 participants will receive pharmacist-led education and follow-up over 10 months. The goal is to lower HbA1C levels and help people feel m…

This study tests a new medicine called raludotatug deruxtecan in about 160 adults with advanced gastrointestinal cancers (pancreatic, bile duct, gallbladder, colorectal, stomach, or gastroesophageal junction). The drug is designed to attach to cancer cells and deliver a treatment…

This early-stage trial tests whether a single infusion of umbilical cord stem cells can safely preserve insulin production in adults newly diagnosed with type 1 diabetes. Sixty participants will receive either the stem cells or a placebo. The main goal is to see if the treatment …

This study tests whether a special heat probe, inserted through an endoscope, can help people with inoperable pancreatic cancer live longer. About 108 participants will either receive the heat treatment plus standard care, or standard care alone. The trial is currently on hold, s…

This early-phase trial tests a new type of immunotherapy for type 1 diabetes. The treatment uses a vaccine made from the patient's own immune cells and a piece of insulin-producing cell protein. The goal is to teach the immune system to stop attacking the pancreas, potentially pr…

This study tests a new medicine called cagrilintide to help people who are overweight or have obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to see how much weight they lose and how …

This early-phase study tested a vaccine therapy given directly into the tumor along with a growth factor to boost the immune system in 18 people with advanced pancreatic cancer that could not be removed by surgery. The main goal was to find the safest dose and check for side effe…

This study tests whether a Mediterranean diet combined with intermittent fasting can reduce liver scarring (fibrosis) better than the weight-loss medication naltrexone/bupropion. About 70 adults with overweight or obesity and heart or metabolic risks (like type 2 diabetes or high…

This study looks at the long-term safety of relacorilant, a drug for people with Cushing syndrome. It includes 125 adults who previously completed a relacorilant study and may benefit from continued treatment. Researchers will track side effects over time to see if the drug is sa…

This study tests whether transplanting insulin-producing cells into the arm muscle can prevent diabetes after partial or full pancreas removal. Researchers aim to see if the arm is a better spot than the liver for these cells to survive and work. About 35 adults with non-cancerou…

This study tests a drug called ceralasertib, alone or with olaparib or durvalumab, in people with advanced solid tumors like kidney, bladder, pancreatic, and endometrial cancers. The goal is to see if these combinations can shrink tumors by blocking enzymes that help cancer grow.…

This early-stage trial is testing whether a rosemary extract supplement can improve markers of oxidative stress and inflammation in people with type 2 diabetes. Forty adults with stable diabetes will take either the extract or a placebo for 12 weeks. The study focuses on blood bi…

This early-stage trial is studying whether an experimental drug called AZD6793 changes how the common diabetes medicine metformin works in people with type 2 diabetes. About 28 participants will take both AZD6793 and a placebo alongside their usual metformin to compare effects on…

This Phase 3 trial is testing a once-daily pill called orforglipron in 600 adults who are overweight or have obesity and also have type 2 diabetes. The study compares the drug to a placebo to see if it helps lower blood sugar and body weight over about 18 months. Participants mus…

This study tests a combination of two experimental drugs (AGEN1423 and botensilimab) with or without standard chemotherapy in people with advanced pancreatic cancer that has worsened after at least one prior treatment. The goal is to see if the combination can shrink tumors or sl…

This study tests a drug called tisotumab vedotin, alone or with other cancer medicines, in people with advanced colorectal, lung, pancreatic, or head and neck cancers that have stopped responding to standard treatments. About 350 participants receive different dosing schedules to…

This early-phase study tests a new oral drug called MOMA-313, alone or with another drug (olaparib), in people with advanced solid tumors that have certain DNA repair flaws. The main goals are to check safety and find the right dose. About 220 adults with cancers like prostate, p…

This early-stage trial tests a new drug called BMS-986484, alone or with another drug (nivolumab), in people with advanced solid tumors like lung, colon, pancreatic, stomach, and head/neck cancers. The main goal is to check safety and find the right dose. About 213 participants w…

This study tests a drug called Diamyd in people aged 12 to 29 who were recently diagnosed with type 1 diabetes and have a specific genetic type (HLA DR3-DQ2). The goal is to see if Diamyd can help the body keep making its own insulin, which could improve blood sugar control and r…

This study tests whether semaglutide (Wegovy), a once-weekly injection, can preserve the pancreas's ability to produce insulin and reduce liver fat in 60 obese youth with prediabetes or early type 2 diabetes and fatty liver disease. Participants receive either semaglutide or a pl…

This study tests whether giving people free boxes of fruits and vegetables along with nutrition education can improve health in three Mississippi counties with high rates of diabetes, obesity, and poverty. About 300 adults with high blood sugar or obesity will receive produce and…

This study looks at whether doing light aerobic exercise five days a week can improve heart rate variability—a sign of heart health—in adults with type 1 diabetes. Over one year, 35 participants were split into two groups: one exercised regularly, the other less often. Researcher…

This study tests whether a smart order set in electronic health records can help primary care doctors better manage blood sugar in people with type 2 diabetes who use insulin. About 150 participants will use continuous glucose monitors, and doctors will get decision support from …

This study tests a combination of two chemotherapy drugs and two immunotherapy drugs given before surgery to people with pancreatic cancer that can be removed. The goal is to shrink the tumor and help the immune system fight the cancer, potentially improving outcomes. The trial i…

This study tests whether repeated doses of the BCG vaccine (originally for tuberculosis) can help adults with long-standing type 1 diabetes lower their blood sugar levels. About 150 participants receive either BCG or a placebo over 5 years, with follow-up for 10 years. The goal i…

This study is testing whether a smartphone app called Glucosano, combined with help from a community health worker, can make it easier for Black children and young adults with type 1 diabetes to use advanced diabetes technologies like automated insulin delivery systems. The goal …

This study tests a new weekly medicine, retatrutide, against an existing one, semaglutide, in about 1250 adults with type 2 diabetes whose blood sugar is not well controlled by metformin. The goal is to see which works better at lowering blood sugar and weight over 26 months. Par…

This study tests whether adding two experimental drugs (elraglusib and losartan) to standard chemotherapy (FOLFIRINOX) can prevent metastatic pancreatic cancer from becoming resistant to treatment. About 70 adults with untreated, advanced pancreatic cancer will receive the combin…

This early-stage trial tests whether a drug called RO7204239 can improve how the body uses insulin and affects muscle composition in 30 adults with type 2 diabetes who are overweight or obese. Participants will receive either the drug or a placebo, and researchers will measure ch…

This early-phase study tested a combination of three drugs (gemcitabine, dasatinib, and erlotinib) in 19 people with advanced pancreatic cancer that had spread or could not be removed by surgery. The main goal was to find the safest dose and look at side effects. Researchers also…

This Phase 3 trial tests retatrutide, a once-weekly injection, in 1000 adults with type 2 diabetes who are overweight or obese. The study also looks at a subset of participants with obstructive sleep apnea. Over 89 weeks, researchers will measure weight loss, changes in sleep apn…

This early-phase study tests a combination of two targeted drugs (vismodegib and erlotinib) with or without a standard chemotherapy drug (gemcitabine) in people with advanced pancreatic cancer or other solid tumors that cannot be removed by surgery. The main goal is to find the s…

This study follows 433 people with chronic pancreatitis who undergo a surgery called TPIAT, where the entire pancreas is removed to stop pain and the patient's own insulin-producing islet cells are infused back to lower diabetes risk. Researchers track pain relief, quality of lif…

This study tests whether the diabetes pill imeglimin can control blood sugar longer than two other common drugs, metformin and vildagliptin. About 567 adults with type 2 diabetes will take one of these pills for up to 3 years. The goal is to see which drug keeps HbA1c (a measure …

This phase 1 trial is testing a new imaging tracer called 68Ga-FAPI-46 to see where it collects in normal and cancerous tissues. About 30 people with various solid tumors or blood cancers will receive the tracer and then undergo a PET/CT scan. The goal is to understand how the tr…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This early-phase trial tests a radioactive imaging agent called Technetium-99m HYNIC-FAPI in 15 people with metastatic lung, pancreas, breast, or colorectal cancer. The goal is to see how well it highlights tumors on SPECT/CT scans. Researchers will measure where the agent goes i…

This study tests an artificial intelligence model called PANDAPro that helps doctors spot pancreatic cancer on regular CT scans. Researchers will compare how well the AI finds cancers versus standard reading, and see if it catches tumors that were missed. The goal is to make scre…

This study is testing a new imaging agent called 18F-FSPG to see if it can better detect liver cancer (hepatocellular carcinoma) and other liver tumors compared to standard PET scans. About 110 adults with liver cancer or benign liver tumors will receive the tracer before their s…

This study tests a new device called LabPatch that measures blood sugar from fluid just under the skin. About 60 adults with type 1 or type 2 diabetes who use insulin will wear the patch for 6 hours. Researchers will compare its readings to standard lab tests and two commercial g…

This study is testing whether a continuous glucose monitor (CGM) worn on the arm for 14 days can replace the standard oral glucose tolerance test (OGTT) for women who had gestational diabetes. Many women find the OGTT burdensome and skip it, missing a chance to catch lingering bl…

This study tests whether a new type of PET/CT scan, using a radioactive tracer called 68Ga-DOTATOC, can find neuroendocrine tumors (NETs) and similar tumors more safely and accurately than current imaging methods. About 800 people with known or suspected NETs will receive the sca…

This study tests whether using artificial intelligence (AI) to screen for diabetic eye disease during regular primary care visits helps more people get timely eye exams and follow-up care. About 1,700 adults with diabetes who haven't had an eye exam in the past year will take par…

This study aims to develop a blood test that predicts how well a patient's advanced pancreatic cancer will respond to different chemotherapy regimens. Researchers will analyze circulating tumor cells (CTCs) from 74 participants to see if the test can identify the most effective t…

This study is testing a computer model called PRISM that uses electronic health records to predict who might develop pancreatic cancer. Researchers will analyze data from over 6 million people aged 40 and older across 44 US healthcare centers. The goal is to see if the model can …

This early-phase study tests how well a special PET-CT scan called FAZA can measure oxygen levels in solid tumors like breast, colorectal, and pancreatic cancers. About 25 participants will receive the FAZA tracer and undergo imaging to see if the results are consistent over time…

This study aimed to compare two different needles used to take tissue samples from solid masses in the pancreas and digestive tract. The goal was to see which needle provides a more accurate diagnosis. The study was planned for adults needing this procedure, but it was withdrawn …

This study explores whether a community-based cooking program can help African-American adults at risk for heart disease cook and eat healthier. About 43 participants from Washington, D.C. will take surveys, attend cooking classes led by a chef, and track their eating habits. The…

This trial tests a wearable insole system that monitors foot pressure, temperature, and movement, giving real-time alerts to help users shift weight and avoid injury. The study includes people with type 1 or 2 diabetes who have nerve damage and a recent history of healed foot ulc…

This study tests whether the anti-inflammatory drug sulindac can prevent high-risk pancreatic cysts (IPMNs) from progressing to pancreatic cancer. About 100 adults with these cysts will receive either sulindac or a placebo for up to 3 years, alongside standard monitoring. The goa…

This study tests whether providing fresh meals, health coaching, and education to high-risk pregnant women can reduce the chance of developing gestational diabetes, high blood pressure, or preeclampsia. 69 women in Milwaukee are randomly assigned to either receive the program or …

This trial tests an online program to help women who had gestational diabetes get the recommended diabetes screening and lifestyle programs after giving birth. The program includes standard health information plus optional interactive components like values reflection and persona…

This study tests whether sending personalized screening invitations based on a person's race, ethnicity, and diabetes risk, plus offering phone navigation for those who don't respond, leads to more people getting tested for diabetes compared to generic invitations or usual care. …

This study tests whether a 6-week cooking education program can help prevent type 2 diabetes in adults who are at risk or have prediabetes, especially in underrepresented minority communities. Participants take cooking classes and some wear a continuous glucose monitor. The goal …

This study tests whether a combination of the diabetes drug metformin and a digital lifestyle program can safely prevent diabetes in adult survivors of childhood cancer who have prediabetes. About 96 participants will first try lifestyle changes alone for 12 weeks, then add metfo…

This study tests whether a 16-week family-focused lifestyle program can reduce type 2 diabetes risk in Latino children aged 10-16 who have obesity. The program includes nutrition education, behavior change skills, and physical activity. Researchers will measure glucose tolerance …

This phase II trial tests a drug called Diamyd, given as injections into lymph nodes, to see if it is safe and can prevent type 1 diabetes in children aged 8 to 17 who are at high risk. Only 5 participants are enrolled, and the study focuses on safety and whether the drug can sto…

This study looks at whether giving children with a genetic risk for celiac disease a low-gluten diet (less than 3 grams per day) during their first three years of life can lower their chance of developing the disease by age 7. About 1,100 children from Sweden are taking part. The…

This study tests a 12-week program that combines a Fitbit activity tracker with personalized nutrition counseling from a dietitian for people recovering from pancreatic cancer surgery. Participants log their food intake and share data remotely, while completing surveys about thei…

This study tests whether a device called RELiZORB™ can help critically ill adults with multiple organ failure better tolerate tube feedings. The device breaks down fats in the feeding to make them easier to digest. Researchers will compare how well patients meet their nutrition g…

This study tests whether a self-affirmation writing exercise—where people write about their core values—before routine diabetes checkups can reduce feelings of stigma and improve diabetes management. About 150 adults with type 2 diabetes who already use continuous glucose monitor…

This study tests a mobile health program called R2D2 designed to reduce diabetes distress in children aged 8-12 with type 1 diabetes and their parents. The program uses cognitive behavioral therapy, mindfulness, and behavioral strategies to help families cope. Researchers will me…

This study tests a non-invasive light therapy called photobiomodulation (low-level laser) for people with diabetic peripheral neuropathy—nerve damage causing pain, tingling, and numbness in the feet. 36 adults with type 2 diabetes and foot pain for at least 6 months will receive …

This study tests whether a prebiotic supplement called galacto-oligosaccharide (GOS) can lower blood sugar spikes after eating. Fifty healthy adults will drink either a GOS supplement or a glucose control beverage, and their blood sugar and insulin levels will be measured over se…

This study tests whether using telemedicine and remote monitoring can help people with advanced digestive cancers manage chemotherapy side effects at home, reducing the need for emergency room visits and hospital stays. About 750 patients and their caregivers will receive enhance…

This study tests a self-guided digital program called covivio to help adults with type 2 diabetes manage emotional distress tied to their condition. About 250 participants will either use the app alongside their usual care or continue with usual care alone. The goal is to see if …

This study tests whether cognitive behavioral therapy (a type of talking therapy) delivered online, along with a continuous glucose monitor, can reduce diabetes-related distress in adults with type 1 diabetes. About 93 adults aged 18-64 will be randomly assigned to receive either…

This study compares high-effort versus low-effort resistance exercise sessions to see which better controls blood sugar in people with prediabetes or type 2 diabetes. Fifteen participants will complete both types of sessions plus a no-exercise control day, with blood sugar monito…

This study looks at whether acupuncture can help manage pain after open abdominal surgery for colorectal or pancreatic cancer. About 70 patients will either receive acupuncture or standard care. The goal is to see if acupuncture reduces pain and the need for opioid painkillers, h…

This study tests a culturally tailored counseling and support program for Chinese and Korean American caregivers of relatives with dementia. The program includes family counseling sessions and online peer support groups. Researchers will measure whether it reduces stress, depress…

This early-phase trial tests whether adding lacosamide, a drug normally used for seizures, can safely help people with chronic pancreatitis who still have abdominal pain despite taking opioids. The study involves 21 adults who will take lacosamide for 7 days alongside their usual…

This study looks at whether screening for malnutrition and providing weekly nutritional support can improve quality of life for people with pancreatic cancer that cannot be removed by surgery. About 100 adults with this type of cancer are taking part. The goal is to see if better…

This study looks at whether regular exercise and behavioral skills training can improve physical fitness and quality of life in people with pancreatic cancer who are getting chemotherapy or radiation before surgery. About 128 participants will take part at MD Anderson. The main g…

This study tests a smartphone app called PACTAID in 20 adults with type 1 diabetes. The app gives real-time advice during exercise to help keep blood sugar levels stable while using an automated insulin pump. Researchers will check if the app improves glucose control during and a…

This study tests whether RELiZORB, a cartridge containing fat-digesting enzymes, can help adults with moderate to severe acute pancreatitis tolerate tube feeding better. Fifteen participants in the ICU will receive the device and be monitored for how much nutrition they can take …

This phase 2 trial tests a special hand and foot mask designed to ease nerve pain caused by chemotherapy or diabetes. Sixty adults will apply the mask daily for 5 minutes over one week. Researchers will measure changes in symptoms and quality of life using questionnaires.

This study compares two minimally invasive procedures to drain blocked bile ducts in patients with incurable cancer. One method drains the bile duct into the intestine, the other drains the gallbladder into the stomach. The goal is to see which approach causes fewer complications…

This early-stage study tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can reduce depression and anxiety in people with advanced pancreatic, biliary, or other gastrointestinal cancers. The study enrolls 24 adults aged 19-85 with stage IV or in…

This pilot study tests MPowerHub, a smartphone app that helps adults with type 2 diabetes make sense of data from continuous glucose monitors and activity trackers. The app shows combined trends and prompts daily questions about diet, sleep, stress, and medication. Researchers wa…

This study compares two procedures to relieve bile duct blockage caused by cancer. About 120 patients with pancreatic or bile duct cancer will be randomly assigned to get either a newer ultrasound-guided drainage or the standard ERCP procedure. The goal is to see which method has…

This study tests a new type of prosthetic socket and liner designed to better distribute pressure on the remaining limb. Combined with an exercise program, the goal is to help people who lost a leg due to diabetes walk more and improve their health. About 38 participants who alre…

This study tests a program that lets cancer patients receive care at home while undergoing chemotherapy or radiation. It includes remote monitoring and home visits to reduce the need for hospital stays or emergency room visits. The goal is to see if this approach improves quality…

This study tests whether a program that combines a smartphone app with face-to-face therapy sessions can improve psychological well-being in children and adolescents with type 1 diabetes. The goal is to reduce diabetes-related distress and help young patients better manage their …

This study tests a remote education program called REST, designed to help adults aged 65 and older with insulin-treated diabetes start and keep using continuous glucose monitors (CGMs). The goal is to reduce dangerous low blood sugar episodes and improve overall glucose control. …

This study tests whether an 8-week nutrition education program focused on fiber-rich foods (like fruits, vegetables, and whole grains) is acceptable and helpful for people with diabetes, prediabetes, or obesity. Researchers will track participants' weight and dietary changes over…

This study tests whether a supervised, at-home resistance training program using a tablet is safe and helpful for people with advanced pancreatic cancer or those recovering from surgery. About 25 participants will do guided exercises during chemotherapy or after surgery. The goal…

This study tests a 6-week supervised exercise program for people with pancreatic cancer. Participants will do aerobic and resistance training three times a week, plus home exercise tracked by a FitBit. The goal is to see if the program is feasible and safe, not to cure the cancer…

This early-phase study tests an oral drug called ropidoxuridine (IPdR) in people with advanced gastrointestinal cancers that cannot be cured. The goal is to find the safest dose and see if it can make radiation therapy more effective at shrinking tumors. Nineteen participants wit…

This phase II trial, called MATCH, is testing whether treating cancer based on the genetic makeup of a patient's tumor works better than standard treatments. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to prior therapy are …

This study explores the personal and social changes people with pancreatic cancer face while undergoing chemotherapy. Researchers will survey 55 patients about physical, emotional, social, and spiritual shifts at the start of treatment and again 4-6 weeks later. The goal is to be…

This study collects blood samples from people with pancreatic diseases to look for markers that might signal pancreatic cancer. The goal is to see if a blood test could detect the cancer earlier than current methods or help track how the disease changes during treatment. Samples …

This observational study follows 150,000 people with chronic kidney disease and type 2 diabetes to see how finerenone (Kerendia) works in everyday medical care. Researchers will compare those taking finerenone to those not taking it, looking at rates of heart attacks and heart fa…

This registry will follow 500 people with type 2 diabetes who have already been treated with the Endogenex System. The goal is to collect long-term safety data and see how the device performs in everyday use. Participants must agree to share their medical records and attend follo…

This study follows over 4,000 women who were tracked during their first pregnancy to see how pregnancy complications like high blood pressure or diabetes relate to future heart disease. Researchers will check for conditions like high blood pressure, diabetes, and obesity over tim…

This pilot study is testing whether it's possible to run a larger study that focuses on heart disease in women. Researchers will gather information from 176 women aged 25-55 in Ontario who have had certain female-specific health issues like pre-eclampsia, gestational diabetes, or…

This long-term study follows over 3,700 adults in Baltimore to understand why some people age healthier than others. Researchers are looking at how race, income, and neighborhood affect risks for diseases like diabetes, heart disease, and memory loss. Participants visit mobile he…

This study follows 121 adults who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring or cancer. Participants are monitored for up to 10 years with regular tests, scans, and occasional liver biopsies. The goal is to learn …

This large study is looking at the genes of over 9,000 people with diabetes and kidney disease, along with their family members. The goal is to find which genes make some people more likely to get diabetic kidney disease. By understanding the genetic roots, researchers hope to de…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study compares two ways of delivering a health and wellness program to people with chronic conditions like diabetes and high blood pressure. One group gets a kit with a tablet and home monitors for blood pressure and blood sugar; the other gets standard phone calls. The goal…

This observational study follows over 4,600 adults with chronic kidney disease and type 2 diabetes who are starting finerenone, a drug that helps slow kidney damage. Researchers will collect data from routine doctor visits over 12 months to understand why doctors prescribe it, ho…

This study looks at whether a blood test that measures tumor DNA (ctDNA) can predict how well chemotherapy is working in people with advanced pancreatic cancer. Researchers will compare the blood test results with CT scans taken before and two months after starting treatment. The…

This study is creating a biobank—a collection of blood, tumor tissue, and health data—from 500 people with pancreatic cancer. Researchers want to learn why some groups are affected more than others and how cachexia (severe weight loss) develops. Participants donate samples and fi…

This early-stage trial in 48 healthy volunteers checks whether a new drug called elecoglipron changes how the body processes two common statins (atorvastatin and rosuvastatin). Participants take the statin alone and later with elecoglipron, and researchers measure drug levels in …

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study uses healthcare claims data from nearly 40,000 people to see if the results of a major clinical trial (EMPEROR-Preserved) can be reproduced in a real-world setting. Researchers are comparing two diabetes drugs, empagliflozin and sitagliptin, in patients with heart fail…

This study aimed to see if a personalized exercise app (Gingko Active) could improve physical function in adults aged 45 and older better than a standard exercise booklet. The trial was withdrawn before any participants enrolled, so no results are available. The app was designed …

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

This study was designed to see how accurately patients report their own medication and healthcare use in diaries compared to official health insurance records. It planned to include people with diabetes, arthritis, kidney disease, or prostate cancer. However, the study was withdr…

This study looks at whether taking short walks throughout the day is better for kids at risk for type 2 diabetes than one longer exercise session. Researchers will measure blood sugar, insulin, and thinking skills in 188 children aged 8-11 with overweight or obesity. The goal is …

This study reviews medical records of 1200 Indian adults with chronic kidney disease and type 2 diabetes who started finerenone between August 2022 and April 2024. Researchers will analyze how doctors prescribed the drug, dose changes, and lab results like kidney function and pot…

This study looks at health insurance claims from about 30,000 people with type 2 diabetes to see if real-world data can produce similar results to a large clinical trial called REWIND. The goal is to learn when and how to trust real-world data for answering medical questions. No …

This study looks at how gastric bypass surgery changes the way the small intestine processes sugar and other fuels, which may explain why the surgery improves obesity and type 2 diabetes. Researchers will collect intestinal tissue and blood samples from 32 people before and up to…

This study is following 964 people with type 2 diabetes to see if three blood markers (hs-cTnI, NT-proBNP, and sST2) can predict who will die or have heart problems. Participants gave blood samples and are being tracked for years. No treatment is being tested—the goal is to learn…

This study uses healthcare claims data from nearly 24,000 people to see if it can reproduce the results of the EMPEROR-Reduced trial, which tested the diabetes drug empagliflozin against sitagliptin in heart failure patients. The goal is not to test a new treatment, but to learn …

This pilot study looks at how environmental stress affects daily blood sugar changes in 30 Hispanic adults whose parent has type 2 diabetes. Researchers use continuous glucose monitors to track glucose and aim to design a future program to prevent diabetes. The study does not tes…

This study looks at whether the adrenaline (epinephrine) commonly added to local anesthesia for tooth extraction raises blood sugar levels. Researchers will measure blood glucose before, during, and after the procedure in 90 adults—half with type 2 diabetes and half without. The …

This study looks at how frailty—a state of weakness and reduced physical function—affects the risk of severe side effects from chemotherapy in people aged 70 and older with cancer. Researchers will assess 160 patients using various tests for frailty, muscle loss, and overall heal…

This pilot study tests a digital tool that doctors use during visits to help patients with prediabetes become more active in managing their health. The tool asks patients a few questions and then gives the doctor tips on how to talk about lifestyle changes and resources like heal…

This pilot study at Mayo Clinic tests whether personalized education and genetic counseling can increase genetic testing in people with a first-degree relative who had pancreatic cancer. About 50 participants will receive tailored information and counseling. The goal is to see if…

This study aims to understand how genes affect obesity, diabetes, and heart disease in people of African ancestry. Researchers will collect blood samples and health information from 1,100 adults, including African Americans, Afro-Caribbeans, and migrants from sub-Saharan Africa. …

This study tests different ways to invite adults with diabetes who struggle to take their medications as prescribed. Researchers will compare letters and phone call strategies to see which approach gets more people to schedule and attend a pharmacist appointment. The goal is to f…

This pilot study tests whether an enhanced telemedicine program is practical for adults with complex type 2 diabetes who use insulin and have other health conditions. Fifty participants will receive either standard telemedicine care or an enhanced version with extra pre-visit pre…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) who are planning to have weight-loss surgery. Researchers will use special scans to measure liver function before and after surgery in 30 adults. The goal i…

This study looks at how the menstrual cycle changes blood sugar and energy use in women with type 1 diabetes. About 40 women will use a closed-loop insulin pump and continuous glucose monitor to track these changes. The goal is to understand how hormone shifts affect insulin need…

This study looks at how canagliflozin (Invokana), a diabetes drug, protects the kidneys in people with type 2 diabetes. Researchers will use advanced imaging, kidney biopsies, and function tests to uncover the mechanisms. The trial involves 45 adults and aims to explain the drug'…

This study looks at ways to help more adults with type 2 diabetes get screened for colorectal cancer. Researchers are testing a program that works with patients, their care teams, and clinics to make screening easier. The goal is to see if this approach increases the number of pe…

This study collects tissue and blood samples from 1,200 adults with known or suspected cancer. The samples are taken during standard surgeries or biopsies, with no extra procedures. Researchers will compare cancerous and normal tissues to identify differences that could lead to n…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study examines how common cardiac autonomic neuropathy (nerve damage affecting the heart) is in children and teens with type 1 diabetes. Researchers will monitor 75 participants using heart tests and check if longer diabetes duration or poor blood sugar control raises the ri…

This study looks at how often people with type 1 diabetes have fatty liver disease and serious liver scarring. Researchers used a special ultrasound and blood tests to check 533 adults. The goal is to find high-risk patients who need a liver specialist.

This study is testing whether a special PET scan using a tracer called 68Ga-PSMA can identify patients with advanced upper digestive tract cancers (like stomach or esophageal cancer) who might be eligible for a type of targeted radiation therapy called endoradiotherapy. The resea…

This study looks at how a measure called the hemoglobin glycation index (HGI) changes over time in 750 adults with diabetes who use continuous glucose monitors. HGI compares lab-measured blood sugar levels with estimated levels from a glucose monitor. Researchers will collect dat…

This study looks at whether removing overactive parathyroid glands (parathyroidectomy) can improve blood sugar control in people who also have type 2 diabetes. Researchers will compare 80 patients who have surgery with those who do not, measuring changes in blood sugar and bone h…

This study was designed to see if giving a carbohydrate drink before bariatric surgery helps control blood sugar after the operation, compared to the standard fasting approach. It planned to enroll patients with high blood sugar who were scheduled for weight-loss surgery. However…

This study looks at whether diabetes or blood sugar problems can worsen thinking and memory issues in people with myotonic dystrophy type 1. Researchers will use MRI brain scans and thinking tests over 4 years to track changes. The goal is to understand why some patients have mor…

This study looks at whether drinking a beverage with artificial sweeteners (erythritol or xylitol) changes how blood platelets clump together, which could affect heart attack or stroke risk. Researchers will measure platelet activity and blood levels of these sweeteners in 50 hea…

This study looks at why up to 40% of people with type 1 diabetes develop kidney disease, even with better blood sugar control. Researchers will use kidney biopsies and advanced imaging in 100 adults to find hidden risk factors like insulin resistance and inflammation. The goal is…

This study tests whether a remotely delivered resistance training program is practical and helpful for Black women aged 30-64 who are overweight, have prediabetes or diabetes, or have high blood pressure. About 37 women will participate from home using their own devices. The goal…

This study looks at how newer diabetes medications (SGLT2 inhibitors and GLP-1 receptor agonists) affect the eyes of people with type 2 diabetes. Researchers will monitor 40 adults who take metformin and are starting these newer drugs. The goal is to see if these drugs cause any …

This study is a long-term follow-up for 400 people who previously received A2 Bio gene therapy for various solid tumors, including colorectal, lung, pancreatic, and ovarian cancers. No new treatment is given; instead, researchers will track participants over time to check for del…

This study looks at how long you need to fast and how stopping the diabetes/weight-loss drug tirzepatide changes the amount of food left in your stomach after a meal. Researchers will use ultrasound to check stomach contents in 40 people with type 2 diabetes or obesity. The goal …

Over two million people in the UK have a chronic condition like diabetes or heart disease without knowing it. This study will use information from 4.5 million hospital patients to build a digital platform that spots those at risk. The goal is to help doctors diagnose these condit…

This study is testing whether wearable devices like continuous glucose monitors and the Oura Ring can help predict how well the pancreas is working in people with prediabetes or type 2 diabetes. The goal is to develop remote tools that allow personalized treatment to preserve ins…

This study is testing whether people with cancer or diabetes can use a Fitbit and a continuous glucose monitor (CGM) to track their daily exercise and glucose levels. The goal is to see if it's practical and if people will stick with it. Thirty-five participants will wear both de…

This large study looks back at medical records of 100,000 Chinese patients with type 2 diabetes to compare heart and kidney outcomes between those taking Ozempic and those on other diabetes drugs. Researchers will track major heart problems, strokes, and kidney events. The goal i…

This study looks at health records from over 780,000 people with type 2 diabetes to compare four common second-line medications: SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas. The goal is to see which drug class is most effective at preventing hea…

This study follows over 800 people who either have type 2 diabetes or have a strong family history of it. Researchers track who develops diabetes over time using blood tests and questionnaires. The goal is to improve a risk prediction model for type 2 diabetes. The study is curre…

This Phase 1 trial tests two experimental drugs (L03RD1 and L03RD2) in 48 healthy adults to see how safe they are and how the body processes them. Participants take the drugs alone or together in a single dose. The study does not aim to treat diabetes, but to gather information f…

This study tests whether a swallowable camera capsule, controlled by magnets from outside the body, can safely and effectively examine the stomach and esophagus in 30 people preparing for weight loss surgery. Participants swallow the capsule after fasting, and a surgeon guides it…

This early-stage study in 32 healthy adults looks at how a new drug called AZD5004 changes the way the body processes two diabetes medications, mitiglinide and pioglitazone. The goal is to understand potential drug interactions, not to treat any disease. Participants take the dru…

This study looks at how skin temperature and blood flow change in people with a leg amputation, especially those with diabetes. Researchers will test two types of prosthetic legs—rigid and shock-absorbing—to see which one keeps the skin cooler and healthier. Sixty participants wi…

This study reviews medical records from 300 cancer patients to see if the makeup of a tumor's surroundings (the tumor microenvironment) is linked to how well antibody-based therapies work. Researchers will analyze tissue samples and blood markers from patients with seven types of…

This study tests whether a tablet-based decision support system helps frontline health workers in India and Nepal provide better antenatal care. About 1,320 pregnant women will take part. The tool guides workers to check blood pressure, blood sugar, urine protein, and hemoglobin,…

This study follows 225 pregnant women—some who had gastric bypass or sleeve gastrectomy, and some without surgery—to see how blood sugar changes affect fetal growth. Participants wear a continuous glucose monitor and activity tracker for 10 days each trimester. The goal is to lea…

This study checks if a Turkish version of a questionnaire about managing low blood sugar (hypoglycemia) is accurate and reliable. Researchers will ask 200 adults with type 2 diabetes who have had low blood sugar to fill out the questionnaire. The goal is to make sure the scale wo…

This study looks at whether routine blood sugar testing during dental checkups can help find hidden high blood sugar in people with advanced gum disease. About 300 adults with severe gum disease will get a simple finger-prick blood test during their dental visit. The goal is to s…

This study explores whether artificial intelligence can detect stress in people with type 1 diabetes by analyzing their voice recordings. Participants record their voice four times a day for a period. The goal is to develop a tool that helps patients and doctors better understand…

This study tests a 10-week educational program called HomeStyles-China, designed to help Chinese American adults improve their diet, increase physical activity, and reduce risk factors for heart disease and diabetes. Researchers will enroll 400 participants and measure changes in…

This study looks at how everyday stress impacts blood sugar levels in people with type 1 diabetes. Researchers will ask 125 participants to rate their stress four times a day using a smartphone app, while a continuous glucose monitor tracks their blood sugar. The goal is to see i…

This study looks back at medical records of over 46,000 diabetic patients who had surgery in Alberta, Canada. Researchers want to see how often patients had a recent HbA1C test (a measure of long-term blood sugar control) before their operation. They also want to find out if poor…

This study looks at whether giving extra support to community health centers helps them screen patients for non-medical needs like food or housing and refer them to community resources. Twenty health centers will be randomly assigned to get this support or not. The goal is to see…

This study was designed to test new drug combinations for people with pancreatic cancer that hasn't spread. It planned to compare new treatments against standard chemotherapy in three groups based on how far the cancer had grown. However, the study was withdrawn before enrolling …

This study is testing a new type of clinic that screens people with prediabetes and type 2 diabetes for several hidden health problems at the same time, including fatty liver disease, sleep apnea, and heart failure. The goal is to see how common these undiagnosed conditions are a…

This study looks at over 1,200 adults with type 2 diabetes and heart muscle problems to see if diabetic cardiomyopathy is a unique condition. Researchers will use detailed medical tests, imaging, and biological data to find patterns. The goal is to better understand and diagnose …

This study looks at over 10,000 adults in Ecuador to understand why some people with diabetes develop kidney disease. Researchers will collect health surveys, blood and urine samples, and kidney tissue to study social, environmental, and biological factors. The goal is to find ne…

This study compares 20 women who had gestational diabetes with 20 who did not, all matched by age and weight. Researchers will measure body composition, insulin sensitivity, and other metabolic markers before and after 8 weeks of high-intensity interval training. The goal is to u…

This study tests whether virtual peer groups can help Latinx teenagers with type 1 diabetes use insulin pumps and continuous glucose monitors more effectively. About 120 teens and their caregivers will join online sessions covering topics like family relationships, school, and wo…

This study uses a continuous glucose monitor (a small sensor) to track blood sugar levels in 40 adults with diabetes and end-stage kidney disease who are on dialysis. The goal is to see how glucose changes during and between dialysis sessions over two weeks, and whether those pat…

This study looks at the genetic and molecular factors behind type 2 diabetes, obesity, and related complications like kidney disease. Researchers will collect health information, blood and urine samples, and perform tests like eye exams and ultrasounds from over 2,300 adults, foc…

This study is collecting saliva, stool, blood, bile, and tumor samples from 200 people undergoing surgery for pancreatic or related cancers. Researchers want to see if the types of bacteria in these samples can help predict who will have complications after surgery and how the ca…

This study explores whether ultrasound images analyzed by a special computer program can accurately measure the size of liver tumors in people with pancreatic or gastrointestinal cancer that has spread to the liver. Participants will have both a routine contrast-enhanced CT scan …

This study tests a new monitoring method for patients who have had pancreatic surgery. After surgery, a thin probe is placed near the surgical connection to measure chemicals that may signal a leak before symptoms appear. Half of the 201 participants will receive this monitoring …

This study looks at whether giving the BCG vaccine as a mist breathed into the lungs works better than the usual injection under the skin. It includes 36 healthy adults who have already had BCG, some with type 2 diabetes and some without. Researchers will measure immune responses…

This study looks at how fructose in meals influences fat production and blood sugar levels in people with prediabetes or insulin resistance. Researchers will give participants special labeled fructose or pyruvate in liquid meals to track these processes. The goal is to better und…

This study will measure nerve signals in 50 adults aged 45 to 76 with diabetic peripheral neuropathy. Researchers will compare these signals with blood sugar levels, diabetes duration, and neuropathy symptom scores. The goal is to find better ways to detect nerve damage early.

This study looks at ways to help adults in rural Pennsylvania become more physically active. It includes 880 people who are overweight, have type 2 diabetes, or are not very active. Researchers will track activity levels using questionnaires and wearable devices to see what works…

This study is a registry that will review medical records of 1,000 patients treated for benign or malignant gastrointestinal diseases between 2005 and 2030. Researchers will look at survival, symptoms like heartburn and swallowing trouble, and quality of life. The goal is to lear…

This study tests a tiny camera called SpyGlass that doctors insert into the pancreatic duct during surgery for a condition called IPMN (a type of cyst that can turn into cancer). The goal is to see if the camera can find small, hidden tumors that standard scans miss. About 100 pa…

This study is screening 115 underserved children and adults who are at risk for type 1 diabetes or celiac disease. Researchers will use blood tests to find early signs of these conditions, aiming to improve how we detect them. The goal is to catch these diseases sooner, especiall…

This study looks at how well blood sugar is controlled and how diet relates to heart health in people with type 1 diabetes. Researchers will study 90 patients who use the MiniMed 780G insulin pump. They will measure blood sugar patterns, diet quality, and markers of heart and blo…

This study investigates why brown fat, which burns calories to generate heat, stops working when it's warm. Researchers will use cold vests on 8 healthy and obese adults to see how genes and proteins change. The goal is to find new targets for treating obesity and related metabol…

This study tests whether a Learning Health System (LHS) can improve care for people with high blood pressure, diabetes, and kidney disease in Thai primary care clinics. The LHS uses electronic health records to help healthcare teams identify patients who need more active manageme…

This study looks at how fasting and temporarily stopping the diabetes drug dulaglutide affect how much food and liquid stays in the stomach after a meal. About 20 people with type 2 diabetes will have their stomachs checked with ultrasound after eating. The goal is to understand …

This study tests a program called SHIFT2 that helps teens and young adults with type 1 diabetes prepare for the switch from pediatric to adult medical care. Participants work with a transition coach and receive messages to encourage self-management. The goal is to see if this sup…

This study compares two types of guide wires (short vs long) used during a procedure called ERCP, which helps doctors examine the bile and pancreatic ducts. The goal is to see which wire allows faster and safer cannulation (insertion of a tube) and whether either reduces the risk…

This study trains Latino church members to become community health workers who help others manage diabetes and reduce health barriers. About 400 Spanish-speaking adults at risk for or with type 2 diabetes are taking part. The program uses an online platform to track progress and …

This study aims to create a questionnaire that measures how patients feel about their experience during endoscopic ultrasound, a procedure used to examine the pancreas and bile ducts. Researchers will ask 171 outpatients at a hospital in Italy to rate their experience, and compar…

This study aims to find the genes and other factors that explain why some people with cystic fibrosis develop diabetes while others do not. Researchers will analyze DNA from 1,500 people with cystic fibrosis and their parents. The goal is to better understand the causes of cystic…