Withdrawn study planned to test diabetes drugs before surgery

NCT ID NCT03816488

Terminated Disease control Sponsor: McMaster University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study was designed to see if taking metformin or salsalate on the morning of surgery could help control blood sugar and reduce complications in people with type 2 diabetes. It planned to enroll patients having elective surgery who regularly take metformin. However, the trial was withdrawn before any participants were enrolled, so no data were collected.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metformin or salsalate
What this could lead to: If this approach were tested and worked, it could point toward a simple way to reduce high blood sugar and infections after surgery in people with type 2 diabetes.
What could go wrong: This trial was withdrawn before enrolling anyone, so no results exist. Even if run, it was a small early feasibility study, not designed to prove effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hyperglycemia Postoperative Complications type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 2 HYPERGLYCEMIA PERIOPERATIVE/POSTOPERATIVE COMPLICATIONS SALSALATE TO IMPROVE NON-CARDIAC SURGERY GLUCOSE CONTROL

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