Radioactive microparticles aim to boost chemo against tough pancreatic cancer

NCT ID NCT05466799

Ongoing Disease control Sponsor: OncoSil Medical Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether adding tiny radioactive beads (OncoSil™) directly into the tumor can improve outcomes for people with locally advanced pancreatic cancer that cannot be removed by surgery. About 88 participants will receive either standard FOLFIRINOX chemotherapy alone or chemotherapy plus the implanted radiation. The study tracks safety and how well the tumor is controlled at 16 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: OncoSil™ (phosphorus-32 microparticles) plus FOLFIRINOX chemotherapy
What this could lead to: If successful, this could offer a new treatment option that improves local tumor control and survival for people with inoperable pancreatic cancer.
What could go wrong: This is a phase 2 trial with only 88 participants, so results are preliminary. Adding a device to chemotherapy may increase side effects, and the treatment may not improve outcomes enough to reach standard practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED PANCREATIC CANCER

Contacts and locations

Locations

AZ Maria Middelares

Ghent, Belgium
Azienda Ospedaliera Universitaria Integrata Verona

Verona, Italy
Clínica Universidad de Navarra

Pamplona, 31008, Spain
Freeman Hospital

Newcastle upon Tyne, United Kingdom
Guy's Hospital

London, United Kingdom
Hospital General Universitario Gregorio Marañón

Madrid, Spain
Hospital Universitari Vall d'Hebron

Barcelona, Spain
Hospital Universitario 12 de Octobre

Madrid, Spain
Hospital Universitario Ramón y Cajal

Madrid, Spain
Hospital Universitario de Fuenlabrada

Madrid, Spain
Royal Adelaide Hospital

Adelaide, South Australia, Australia
San Camillo Forlanini

Rome, Italy
The Christie Hospital/Manchester Royal Infirmary

Manchester, United Kingdom
University Hospital Southampton

Southampton, United Kingdom

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