New drug cocktail shows promise against Hard-to-Treat cancers

NCT ID NCT03682289

Ongoing Disease control Sponsor: Rahul Aggarwal Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called ceralasertib, alone or with olaparib or durvalumab, in people with advanced solid tumors like kidney, bladder, pancreatic, and endometrial cancers. The goal is to see if these combinations can shrink tumors by blocking enzymes that help cancer grow. About 83 adults whose cancer has spread or not responded to prior treatment will take part.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METASTATIC UROTHELIAL CARCINOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cancer castration-resistant prostate carcinoma clear cell renal carcinoma endometrial cancer endometrium neoplasm exocrine pancreatic carcinoma malignant pancreatic neoplasm metastatic malignant neoplasm metastatic prostate carcinoma Neoplasm Metastasis nonpapillary renal cell carcinoma ovarian cancer pancreatic adenocarcinoma pancreatic neoplasm renal cell carcinoma transitional cell carcinoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLEAR CELL RENAL CELL CARCINOMA ENDOMETRIAL CANCER LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM LOCALLY ADVANCED PANCREATIC CANCER METASTATIC CASTRATION-RESISTANT PROSTATE CANCER METASTATIC MALIGNANT SOLID NEOPLASM METASTATIC PANCREATIC CANCER METASTATIC RENAL CELL CARCINOMA METASTATIC UROTHELIAL CARCINOMA STAGE III PANCREATIC CANCER STAGE III RENAL CELL CANCER STAGE IV PANCREATIC CANCER STAGE IV RENAL CELL CANCER

Contacts and locations

Show contact details

Locations

City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
University of California, San Francisco

San Francisco, California, 94143, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States