METASTATIC PANCREATIC CANCER

This study is testing whether adding a new drug called setidegrasib to standard chemotherapy helps people with advanced pancreatic cancer that has a specific genetic change (KRAS G12D mutation) live longer. About 614 adults whose cancer has spread and cannot be cured by surgery w…

This study is testing a new three-drug combination (GCN) together with a device that uses electric fields (TTF) to treat metastatic pancreatic cancer. The goal is to see if this combined approach is safe and can help control the cancer for longer. It will involve about 40 adults …

This study is testing if giving two powerful chemotherapy combinations one after the other works better than the current standard single combination for people with newly diagnosed metastatic pancreatic cancer. It will involve 162 patients to see if this sequential approach helps…

This is the first human study testing a new drug called IPH5301 for people with advanced cancers that have spread. The trial has two parts: first finding the safest dose of IPH5301 alone, then testing it combined with standard chemotherapy in breast cancer patients. It's for adul…

This early-stage trial is testing a new treatment for people with metastatic pancreatic or breast cancer. The goal is to see if a combination of high-dose chemotherapy drugs, vitamins, and the patient's own stem cells is safe and can overcome the cancer's resistance to treatment.…

This study is testing the safety of a new treatment for advanced pancreatic cancer. It combines tiny radioactive implants placed directly into the tumor with standard chemotherapy. The goal is to see if this approach can help control the cancer, reduce pain, and potentially make …

This is the first-ever study in people of an experimental drug called metarrestin. The main goals are to find a safe dose and see if it can shrink tumors. It is for adults and teenagers (12+) with advanced solid tumors that have spread and have not been cured by standard treatmen…

This study tests whether a patient's own immune cells, removed from their tumor and multiplied in a lab, can shrink tumors when given back alongside the drug pembrolizumab. It's for adults with advanced digestive tract, breast, ovarian, or other cancers that have spread and stopp…

This study is testing whether adding two newer drugs (surufatinib and camrelizumab) to standard chemotherapy works better for people with metastatic pancreatic cancer. It will compare the new four-drug combination against the current two-drug standard. The main goal is to see if …

This study is testing whether adding two new immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemotherapy works better for people with metastatic pancreatic cancer. The trial will enroll 33 patients who haven't had any prior cancer treatment to see if this combinat…

This study is testing a new way to treat advanced pancreatic cancer by placing tiny radioactive seeds directly into the tumor. The seeds release a short-range radiation designed to kill cancer cells while sparing nearby healthy tissue. The main goals are to see if doctors can saf…

This is the first human study of an experimental drug called ERX-315 for people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to find a safe dose and understand how the body processes the drug. Researchers will also look for earl…

This study is testing whether a combination of low-dose chemotherapy drugs followed by two maintenance medications can help control advanced pancreatic cancer that has spread. The trial is for adults with newly diagnosed metastatic pancreatic cancer who haven't received any prior…

This study is testing if a drug called Kinisoquin™ can prevent dangerous blood clots in people with advanced pancreatic cancer who are starting chemotherapy. About 480 patients will receive either the study drug or a placebo for 16 weeks to see which group has fewer clots. The go…