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New 'Alpha Bullets' radiation device targets tough pancreatic tumors

NCT ID NCT06698458

Recruiting now Disease control Sponsor: Alpha Tau Medical LTD. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new device called DaRT that delivers a special type of radiation directly into pancreatic tumors. It is being combined with standard chemotherapy in 30 people with advanced or metastatic pancreatic cancer. The main goal is to see if the combination is safe, and also to check if it helps control pain and shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Diffusing Alpha Radiation Emitters Therapy (DaRT) device
What this could lead to
If it works, this could offer a new way to control pancreatic tumors and improve survival when used with standard chemotherapy.
What could go wrong
This is an early safety study with only 30 participants, so results may not apply to everyone. The procedure is invasive and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC PANCREATIC CANCER PANCREATIC ADENOCARCINOMA PANCREATIC CANCER

Contacts and locations

Locations

  • Advent Health Cancer Institute

    NOT_YET_RECRUITING

    Orlando, Florida, 32804, United States

  • Banner MD Anderson Cancer Center

    RECRUITING

    Gilbert, Arizona, 85234, United States

    Contact Email: •••••@•••••

  • Bassett Healthcare Network

    RECRUITING

    Cooperstown, New York, 13326, United States

  • Baylor College of Medicine

    RECRUITING

    Houston, Texas, 77054, United States

  • Cedars-Sinai

    NOT_YET_RECRUITING

    Los Angeles, California, 90048, United States

  • City of Hope

    NOT_YET_RECRUITING

    Goodyear, Arizona, 85338, United States

  • Emory University

    RECRUITING

    Atlanta, Georgia, 30308, United States

  • Hadassah Ein Kerem

    RECRUITING

    Jerusalem, Israel

  • Honor Health

    RECRUITING

    Scottsdale, Arizona, 85258, United States

  • Jewish General Hospital

    RECRUITING

    Montreal, Quebec, Canada

  • Lenox hill Hospital

    NOT_YET_RECRUITING

    New York, New York, 10075, United States

  • Montefiore Medical Center

    RECRUITING

    The Bronx, New York, 10467, United States

  • NYU Langone Health

    RECRUITING

    New York, New York, 10016, United States

  • Texas Oncology

    NOT_YET_RECRUITING

    Houston, Texas, 75251, United States

  • University Cancer and Diagnostic

    RECRUITING

    Houston, Texas, 77089, United States

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