Cancer cocktail shows promise in early trial
NCT ID NCT05945823
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests a new drug called futibatinib combined with standard immunotherapy and chemotherapy in people with advanced esophageal or pancreatic cancer. The goal is to see if the combination can shrink tumors and control the disease. About 53 adults who have not had prior treatment will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Futibatinib (a targeted cancer drug) combined with pembrolizumab (an immunotherapy) and chemotherapy
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced esophageal or pancreatic cancer, potentially shrinking tumors and delaying disease progression.
- What could go wrong
- This is an early Phase 2 study with only 53 participants and no comparison group. The combination may cause significant side effects, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ESOPHAGEAL ADENOCARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Alliance Cancer Specialists
Horsham, Pennsylvania, 19044, United States
-
Blue Ridge Cancer Care
Roanoke, Virginia, 24014, United States
-
Centre Hospitalier Regional Universitaire Poitiers
Poitiers, 86000, France
-
Centre Hospitalier Regional Universitaire de Lille
Lille, 59037, France
-
Dallas VA Medical Center
Dallas, Texas, 75216, United States
-
Gabrail Cancer Center Research LLC
Canton, Ohio, 44718, United States
-
Gundersen Lutheran Health System
La Crosse, Wisconsin, 54601, United States
-
Henry Ford Health System
Detroit, Michigan, 48202, United States
-
Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
-
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
-
Inova Schar Cancer Institute
Fairfax, Virginia, 22031, United States
-
Krankenhaus Nordwest gGmbH
Frankfurt, 60488, Germany
-
Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612, United States
-
Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida, 33140, United States
-
NYU Langone
New York, New York, 10016, United States
-
Rocky Mountain Cancer Centers Midtown
Denver, Colorado, 80218, United States
-
Roswell Park Comprehensive Cancer Center (RPCCC) (Roswell Park Cancer Institute (RPCI))
Buffalo, New York, 14203, United States
-
The Minniti Center - Medical Oncology and Hematology
Mickleton, New Jersey, 08056, United States
-
Universitaetsmedizin Mainz
Mainz, 55131, Germany
-
University of California Los Angeles UCLA - Cancer Care - Santa Monica
Santa Monica, California, 90404, United States
-
Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
-
Virginia Mason Medical Center
Seattle, Washington, 98101, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can pancreatic Cancer's inflammatory footprint be stopped?
- Could a vaccine help fight Hard-to-Treat cancers?
- Blood and gut clues may flag pancreatic cancer risk early
- A high-tech camera may take the guesswork out of spotting a dangerous surgery complication
- MRI might reveal hidden pancreatic risks in obesity
- Can a new drug combo shrink Hard-to-Treat tumors?