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New mRNA vaccine shows promise in fighting solid tumors

NCT ID NCT03313778

Ongoing Disease control Sponsor: ModernaTX, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests an experimental mRNA-based cancer vaccine (mRNA-4157) in 161 people with solid tumors. The vaccine is designed to train the immune system to attack cancer cells. Some participants receive the vaccine alone, while others get it with the immunotherapy drug pembrolizumab. The main goal is to check safety and immune response, not to cure the disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cutaneous melanoma gastric adenocarcinoma gastroesophageal junction adenocarcinoma neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMORS

Contacts and locations

Locations

  • Angeles Clinic and Research Institute

    Los Angeles, California, 90025, United States

  • Florida Cancer Specialists

    Sarasota, Florida, 34232, United States

  • H Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, 33612-9416, United States

  • Imperial College Healthcare NHS Trust Hammersmith Hospital

    London, W12 0HS, United Kingdom

  • Kindai University Hospital

    Osakasayama-Shi, Ôsaka, 589-0014, Japan

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • NYU Langone Medical Center

    New York, New York, 10016, United States

  • National Cancer Center East

    Kashiwa-Shi, Chiba, 277-8577, Japan

  • National Cancer Center Hospital

    Chuo-Ku, Tokyo, 104-0045, Japan

  • Ninewells Hospital - PPDS

    Dundee, Scotland, DD1 9SY, United Kingdom

  • One Clinical Research Perth

    Nedlands, Western Australia, 6009, Australia

  • Orlando Health Cancer Institute

    Orlando, Florida, 32806, United States

  • Royal Mardsen Sutton

    Sutton, Surrey, SM2 5PT, United Kingdom

  • St Vincents Hospital Sydney

    Darlinghurst, New South Wales, Australia

  • The Cancer Institute Hospital of Japanese Foundation For Cancer Research

    Tokyo, 135-8550, Japan

  • The Cleveland Clinic Foundation

    Cleveland, Ohio, 44195-0001, United States

  • The George Washington Cancer Center

    Washington D.C., District of Columbia, 20037, United States

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15219, United States

  • UT Southwest Medical Center

    Dallas, Texas, 75390, United States

  • Westmead Hospital-Cnr Hawkesbury and Darcy Road

    Westmead, New South Wales, 2145, Australia

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