Heart drug entresto may double as diabetes treatment, small study hints

NCT ID NCT03508739

Terminated Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a heart failure medication called Entresto (sacubitril/valsartan) can boost a natural hormone that helps control blood sugar after meals. Researchers will give the drug or a comparison drug (valsartan) to 25 adults with type 2 diabetes or prediabetes and high blood pressure. They will measure levels of GLP-1, insulin, and glucose after a meal to see if Entresto improves sugar metabolism.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sacubitril/Valsartan (Entresto) and Valsartan (Diovan)
What this could lead to: If successful, this could point toward a new way to treat type 2 diabetes by using an existing heart failure medication to improve blood sugar control.
What could go wrong: This is a small, early-phase study that is currently suspended, so results are uncertain. It only tests short-term effects on hormone levels, not long-term diabetes outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glucose intolerance hypertensive disorder prediabetes syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 2 ELEVATED BLOOD PRESSURE HYPERTENSION PRE DIABETIC

Contacts and locations

Locations

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

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