Could a gut procedure help control diabetes?

NCT ID NCT04419779

First seen Nov 16, 2025 · Last updated May 16, 2026 · Updated 24 times

Summary

This study tests a procedure called duodenal mucosal resurfacing (DMR) to see if it can improve blood sugar control in people with type 2 diabetes. About 320 adults whose diabetes is not well managed with current medications will either receive the DMR procedure or a sham (fake) procedure. The main goal is to measure changes in blood sugar levels over 24 weeks.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AHN - Avon

    Avon, Indiana, 46123, United States

  • AHN - Greenfield

    Greenfield, Indiana, 46140, United States

  • AHN - Muncie

    Muncie, Indiana, 47304, United States

  • AHN- Franklin

    Franklin, Indiana, 46131, United States

  • AcellaCare Piedmont

    Statesville, North Carolina, 28625, United States

  • AcellaCare Salisbury

    Salisbury, North Carolina, 28144, United States

  • AcellaCare Wilmington

    Wilmington, North Carolina, 28401, United States

  • Advent Health Orlando

    Orlando, Florida, 32804, United States

  • Alcanza Clinical Research, LLC

    Methuen, Massachusetts, 01844, United States

  • Angel City Research , Inc.

    Los Angeles, California, 90010, United States

  • Baylor St. Luke's Medical Center

    Houston, Texas, 77030, United States

  • Biopharma Informatic, Llc

    Houston, Texas, 77089, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Care Access Santa Clarita

    Newhall, California, 91321, United States

  • Care Access Warwick

    Warwick, Rhode Island, 02886-4463, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Cleveland Clinic London

    London, England, SW1X &AW, United Kingdom

  • Cliniques Universitaires de Bruxelles Hopital Erasme

    Brussels, Belgium

  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire, 03756, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Endocrine Associates of West Village

    Long Island City, New York, 77089, United States

  • Helios CR, Inc

    Phoenix, Arizona, 85028, United States

  • Hoag Hospital

    Newport Beach, California, 92663, United States

  • HonorHealth Research Institute

    Scottsdale, Arizona, 85258, United States

  • IMA Clinical Research St. Louis

    St Louis, Missouri, 63117, United States

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Indiana University School of Medicine

    Indianapolis, Indiana, 46202, United States

  • Investigators Research Group

    Brownsburg, Indiana, 46112, United States

  • Italy Gemelli

    Roma, Italy

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216, United States

  • Jefferson City Medical Group

    Jefferson City, Missouri, 65109, United States

  • King's College Hospital

    London, United Kingdom

  • M3 Wake Research

    Raleigh, North Carolina, 27612, United States

  • Mayo Clinic Arizona

    Scottsdale, Arizona, 85259, United States

  • Mills Peninsula Health Center

    San Mateo, California, 94401, United States

  • NYU Langone Gastroenterology Associates

    New York, New York, 10016, United States

  • Northeast Research Institute, Llc

    Fleming Island, Florida, 32003, United States

  • Northwestern Unviersity

    Evanston, Illinois, 60611, United States

  • Preferred PCP - Pittsburgh

    Pittsburgh, Pennsylvania, 15201, United States

  • Preferred Primary Care Physicians

    Pittsburgh, Pennsylvania, 15236, United States

  • Seattle Cancer Care Alliance

    Seattle, Washington, 98104, United States

  • Simcare Medical Research, Llc.

    Sugar Land, Texas, 77478, United States

  • Stanford University Medical Center

    Redwood City, California, 94063, United States

  • Synexus Clinical Research, New York

    New York, New York, 10017, United States

  • Synexus Research

    Orlando, Florida, 32806, United States

  • Tulane University

    New Orleans, Louisiana, 70112, United States

  • UCLA Health

    Los Angeles, California, 90095, United States

  • Universiteit Van Amsterdam Academisch Medisch Centrum

    Amsterdam, Netherlands

  • University College Dublin

    Dublin, Ireland

  • University Hospital Zurich

    Zurich, CH-8091, Switzerland

  • University of Louisville

    Louisville, Kentucky, 40202, United States

  • University of Miami

    Miami, Florida, 33136, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Weill Cornell Medicine

    New York, New York, 10065, United States

  • West Orange Endocrinology

    Ocoee, Florida, 34761, United States

  • West Virginia University

    Morgantown, West Virginia, 26506, United States

Conditions

Explore the condition pages connected to this study.