Tight glucose control may preserve insulin-making cells in type 2 diabetes
NCT ID NCT05040087
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This trial tests whether adjusting diabetes medications to keep blood sugar levels in the normal range can preserve the body's insulin-producing beta-cells and slow the natural worsening of type 2 diabetes. Adults aged 40 to 75 with type 2 diabetes will be assigned to either usual care guided by HbA1c or intensive care guided by self-monitored blood glucose. Researchers will compare changes in beta-cell function, blood sugar control, and diabetes-related eye and kidney complications between the two groups.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- intensification of diabetes medication based on self-monitored blood glucose levels
- What this could lead to
- If successful, this approach could help preserve the body's own insulin production and slow the worsening of type 2 diabetes, potentially reducing complications and healthcare costs.
- What could go wrong
- This is a relatively small study, and the intensive glucose monitoring required may be burdensome. It is not yet known whether this strategy will meaningfully preserve beta-cell function or prevent complications over the long term.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Atlanta VA Medical Center
Decatur, Georgia, 30033, United States
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