Diet or drugs? new study tests if fasting beats pills for fatty liver disease

NCT ID NCT06845345

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether a Mediterranean diet combined with intermittent fasting can reduce liver scarring (fibrosis) better than the weight-loss medication naltrexone/bupropion. About 70 adults with overweight or obesity and heart or metabolic risks (like type 2 diabetes or high blood pressure) will be followed for six months. The goal is to see if the diet approach is a safer or more effective way to manage fatty liver disease and prevent long-term liver damage.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver diabetes mellitus Dyslipidemias fatty liver disease fibrotic liver disease hypertensive disorder inherited lipid metabolism disorder Intermittent Fasting liver disorder metabolic dysfunction-associated steatotic liver disease Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Franciscus

    Rotterdam, 3045 PM, Netherlands