New hope for pancreatic cancer: experimental drug quemliclustat in Late-Stage trial

NCT ID NCT06608927

Ongoing Disease control Sponsor: Arcus Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial is testing whether adding an experimental drug called quemliclustat to standard chemotherapy (nab-paclitaxel and gemcitabine) helps people with metastatic pancreatic cancer live longer. About 610 participants who have not yet received treatment for their advanced cancer will be randomly assigned to receive either the experimental drug or a placebo, alongside chemotherapy. The main goal is to compare overall survival between the two groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

quemliclustat (an experimental drug) combined with chemotherapy (nab-paclitaxel and gemcitabine)

What this could lead to

If it works, this could provide a new treatment option that extends survival for people with metastatic pancreatic cancer.

What could go wrong

This is an early-stage Phase 3 trial, so results are not yet known. The experimental drug may not improve survival and could cause additional side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

pancreatic ductal adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC PANCREATIC DUCTAL ADENOCARCINOMA

Contacts and locations

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Locations

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Phoenix, Arizona, 85054, United States
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Tucson, Arizona, 85724, United States
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La Jolla, California, 92093, United States
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Los Alamitos, California, 90720, United States
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Los Angeles, California, 90033-5315, United States
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Roseville, California, 95661, United States
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San Francisco, California, 94158, United States
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Santa Monica, California, 90404, United States
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Denver, Colorado, 80218, United States
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New Haven, Connecticut, 06520, United States
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Jacksonville, Florida, 32224-1865, United States
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Miami, Florida, 33176, United States
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Atlanta, Georgia, 30318, United States
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Atlanta, Georgia, 30322, United States
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Arlington Heights, Illinois, 60005, United States
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Chicago, Illinois, 60611, United States
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Indianapolis, Indiana, 46202, United States
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Wichita, Kansas, 67208, United States
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Baton Rouge, Louisiana, 70809, United States
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Ann Arbor, Michigan, 48109, United States
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Grand Rapids, Michigan, 49503, United States
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Minneapolis, Minnesota, 55404, United States
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Rochester, Minnesota, 55905, United States
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Hattiesburg, Mississippi, 39401, United States
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Kansas City, Missouri, 64111, United States
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Omaha, Nebraska, 68105, United States
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New Brunswick, New Jersey, 08903-2681, United States
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Buffalo, New York, 14263, United States
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New York, New York, 10016, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
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New York, New York, 10128, United States
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Rochester, New York, 14642, United States
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Cleveland, Ohio, 44106, United States
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Oklahoma City, Oklahoma, 73104, United States
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Philadelphia, Pennsylvania, 19111-2497, United States
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Pittsburgh, Pennsylvania, 15232, United States
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Nashville, Tennessee, 37232, United States
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Austin, Texas, 78705, United States
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Dallas, Texas, 75246, United States
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Dallas, Texas, 75390, United States
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Houston, Texas, 77030, United States
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San Antonio, Texas, 78240, United States
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Webster, Texas, 77598, United States
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Fairfax, Virginia, 22031, United States
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Seattle, Washington, 98101, United States
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Spokane, Washington, 99208, United States
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Vancouver, Washington, 98684, United States
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Madison, Wisconsin, 53792, United States
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Camperdown, Australia
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Clayton, Australia
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Murdoch, Australia
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Wollongong, Australia
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Salzburg, Austria
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Sankt Pölten, Austria
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Vienna, Austria
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Anderlecht, Belgium
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Bonheiden, Belgium
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Kortrijk, Belgium
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Ottawa, Canada
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Sherbrooke, Canada
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Toronto, Canada
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Brno, Czechia
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Nový Jičín, Czechia
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Prague, Czechia
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Dijon, France
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Lille, France
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Lyon, France
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Poitiers, France
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Villejuif, France
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Bochum, Germany
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Frankfurt am Main, Germany
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Hamburg, Germany
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Hanover, Germany
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Heilbronn, Germany
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Magdeburg, Germany
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Riesa, Germany
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Ulm, Germany
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Würzburg, Germany
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Bologna, Italy
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Cremona, Italy
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Florence, Italy
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Milan, Italy
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Modena, Italy
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Padova, Italy
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Piacenza, Italy
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Roma, Italy
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Rozzano, Italy
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Torrette, Italy
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Verona, Italy
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Kashiwa-shi, Japan
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Kōtō City, Japan
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Osaka, Japan
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Tokyo, Japan
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Toyama, Japan
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Ube, Japan
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Yokohama, Japan
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Hwasun, South Korea
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Seongnam, South Korea
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Seoul, South Korea
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Barcelona, Spain
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Elche, Spain
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Girona, Spain
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Madrid, Spain
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Pamplona, Spain
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Vigo, Spain
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Zaragoza, Spain
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Birmingham, United Kingdom
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Cottingham, United Kingdom
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London, United Kingdom
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Manchester, United Kingdom