Engineered immune cells take on Hard-to-Treat cancers in early trial
NCT ID NCT05539430
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial is testing a new treatment called LB1908, which uses a patient's own immune cells (T-cells) that have been modified in the lab to recognize and attack cancer cells that have a protein called claudin 18.2 on their surface. The study includes up to 56 adults with advanced stomach, gastroesophageal junction, esophageal, or pancreatic cancer that cannot be removed by surgery or has spread. The main goals are to check the safety of the treatment and find the best dose to use in future studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LB1908 (a type of CAR T-cell therapy that targets claudin 18.2 on cancer cells)
What this could lead to
If successful, this could lead to a new treatment option for people with advanced stomach, esophageal, or pancreatic cancers that have not responded to standard therapies.
What could go wrong
This is an early Phase 1 trial with only 56 participants, so it is primarily testing safety and dosing. The treatment may not shrink tumors or improve survival, and there are risks of serious side effects like cytokine release syndrome.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Duke University
Durham, North Carolina, 27705, United States
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Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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John Theurer Cancer Center at HackensackUMC
Hackensack, New Jersey, 07601, United States
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Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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OHSU Knight Cancer Institute
Portland, Oregon, 97239, United States
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Roswell Park Comprehensive Cancer Center
Buffalo, New York, 14263, United States
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Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232, United States