Blasting pancreatic tumors with extra radiation may open door to surgery

NCT ID NCT03523312

Ongoing Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether giving a higher-than-standard dose of radiation, along with chemotherapy, can shrink pancreatic tumors enough to make them removable by surgery. The study includes 47 people with locally advanced pancreatic cancer that currently cannot be surgically removed. The goal is to see if this approach increases the number of patients who can undergo surgery and potentially live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (hypofractionated ablative IMRT) and chemotherapy (capecitabine or 5-fluorouracil)
What this could lead to: If it works, this could help more people with locally advanced pancreatic cancer become eligible for surgery, which may improve survival.
What could go wrong: This is a small, early-phase trial with only 47 participants, so results may not apply to everyone. Higher radiation doses also carry increased risks of side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC CANCER

Contacts and locations

Show contact details

Locations

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Rockville Centre

Rockville Centre, New York, 11570, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.