Pancreas removal plus islet transplant: a new hope for chronic pancreatitis pain?

NCT ID NCT03260387

Ongoing Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 433 people with chronic pancreatitis who undergo a surgery called TPIAT, where the entire pancreas is removed to stop pain and the patient's own insulin-producing islet cells are infused back to lower diabetes risk. Researchers track pain relief, quality of life, and whether patients stay off insulin. The goal is to see if this complex procedure offers lasting benefits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Total pancreatectomy with islet autotransplantation (TPIAT)
What this could lead to: If successful, this could confirm TPIAT as a standard option to relieve severe pancreatitis pain while reducing long-term diabetes risk.
What could go wrong: This is an observational study, not a controlled trial, so results may not prove cause and effect. The surgery is major and carries risks, and many patients still need insulin afterward.

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Conditions

The condition(s) this trial relates to.

chronic pancreatitis hyperglycemia pancreatitis recurrent acute pancreatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATECTOMY; HYPERGLYCEMIA PANCREATITIS PANCREATITIS, CHRONIC

Contacts and locations

Locations

Baylor University Medical Center

Dallas, Texas, 75246, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
The University of Chicago Medical Center

Chicago, Illinois, 60637, United States
University of California, San Francisco

San Francisco, California, 94143, United States
University of Louisville

Louisville, Kentucky, 40292, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Pittsburgh Medical Center, Thomas E. Starzl Transplantation Institute

Pittsburgh, Pennsylvania, 15213, United States

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