Pancreas removal plus islet transplant: a new hope for chronic pancreatitis pain?
NCT ID NCT03260387
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study follows 433 people with chronic pancreatitis who undergo a surgery called TPIAT, where the entire pancreas is removed to stop pain and the patient's own insulin-producing islet cells are infused back to lower diabetes risk. Researchers track pain relief, quality of life, and whether patients stay off insulin. The goal is to see if this complex procedure offers lasting benefits.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Total pancreatectomy with islet autotransplantation (TPIAT)
What this could lead to
If successful, this could confirm TPIAT as a standard option to relieve severe pancreatitis pain while reducing long-term diabetes risk.
What could go wrong
This is an observational study, not a controlled trial, so results may not prove cause and effect. The surgery is major and carries risks, and many patients still need insulin afterward.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baylor University Medical Center
Dallas, Texas, 75246, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
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Johns Hopkins Hospital
Baltimore, Maryland, 21287, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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The Ohio State University Wexner Medical Center
Columbus, Ohio, 43210, United States
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The University of Chicago Medical Center
Chicago, Illinois, 60637, United States
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University of California, San Francisco
San Francisco, California, 94143, United States
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University of Louisville
Louisville, Kentucky, 40292, United States
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University of Minnesota
Minneapolis, Minnesota, 55455, United States
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University of Pittsburgh Medical Center, Thomas E. Starzl Transplantation Institute
Pittsburgh, Pennsylvania, 15213, United States