University Of Minnesota

This study tests whether a daily breathing exercise called Inspiratory Muscle Strength Training (IMST) can lower blood pressure in adults with high systolic blood pressure (120 mmHg or higher). Over 6 weeks, 144 participants will perform one of three different breathing intensiti…

This study tests whether adding brain stimulation (TMS) to a standard behavioral therapy (CBIT) can help teens and young adults with chronic tics or Tourette syndrome better control their tics. About 60 participants aged 12-21 will receive both treatments to see if the combinatio…

This study tests if weighing yourself every day can help teens ages 12 to 18 with obesity manage their weight. About 99 teens will be split into three groups: usual care, usual care plus a simple scale, or usual care plus a smart scale that sends weights to their doctor. Research…

This study tests several new antifungal drug combinations for cryptococcal meningitis, a brain infection that is fatal without treatment and still kills many people with HIV. Researchers will enroll 2,000 adults with HIV and this infection to see which combination works best and …

This study tests whether empagliflozin, a drug originally for diabetes, can improve heart function in 80 adults over 60 with high blood pressure and obesity who are at risk for heart failure. Participants take either the drug or a placebo daily for 9 months, and heart function is…

This study tests whether taking capsules containing donor gut bacteria can help people with Crohn's disease. The main goal is to see if the donor bacteria can settle in the intestine. Researchers will also look at changes in symptoms and gut health over two months. The study invo…

This study tests whether giving probiotics to pregnant women with diabetes can improve their babies' brain development. Researchers will measure how babies' brains respond to sounds and images at 1 and 6 months old. The study involves 60 mothers and their infants. It aims to find…

This study tests whether a single infusion of concentrated antibodies against COVID-19 can help adults with early, mild COVID-19 recover faster and avoid serious illness. About 820 participants at higher risk (age 55+ or with weakened immune systems) will receive either the antib…

This study aims to find the ideal length of time for remote blood pressure monitoring after childbirth for women who had high blood pressure during pregnancy. Researchers will compare different monitoring durations (from 2 to 6 weeks) to see which leads to the best health outcome…

This study aims to help African American adults who don't get enough sleep and have overweight or obesity. Researchers will first talk with community members to understand their sleep habits and then test a program designed to help them sleep longer and be more active. The goal i…

This early study tests whether taking a capsule of healthy gut bacteria (microbiota transplant) can improve hidradenitis suppurativa, a chronic skin condition causing painful boils. The study will enroll 16 adults with the disease to see if the transplant changes gut and skin bac…

This study tests a new way to train youth mentors and their supervisors to deliver a proven depression prevention program to teens in rural areas. About 96 teens aged 12-17 and their parents, along with mentors, will take part. The goal is to see if this just-in-time training app…

This study tests whether an antibody drug called CMVIG can prevent CMV infection in kidney transplant patients who are switching to a new anti-rejection medicine (belatacept). About 30 adults who are at high risk for CMV will receive CMVIG infusions, and researchers will measure …

This study tests three school-based programs to help high school students who are at risk for conduct problems like defiance or rule-breaking. About 120 students will be randomly assigned to a mindfulness program, a mindfulness program with a mobile app, or a life skills program.…

This study tests whether telehealth coaching for parents can improve communication and behavior in children with autism while reducing parental stress. Researchers will train community providers to deliver the coaching to 90 families, including those in remote areas or military f…

This study tests whether a safe, non-invasive brain stimulation technique called TACS can improve cognitive flexibility and decision-making in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will enroll 30 adults (including healthy volunteers) to …

This study tests whether a community-based exercise program can help people with peripheral artery disease (PAD) walk longer and improve heart health after a procedure to open blocked leg arteries. About 30 adults who recently had such a procedure will take part. The program invo…

This study tests if freezing the nerves between the ribs (cryoablation) provides better pain control than a standard nerve block (ESP catheter) for people with broken ribs. About 48 adults with multiple rib fractures will be randomly assigned to one of the two treatments. The mai…

This study tests whether different levels of vibration applied to neck muscles can improve head posture in people with cervical dystonia, a condition causing abnormal head positioning. Fifty adults with the condition will make one 3-hour lab visit to receive various vibration int…

This pilot study tests whether blocking certain blood vessels around the knee (geniculate artery embolization) can safely reduce pain and improve function in people with mild-to-moderate knee osteoarthritis. Twenty participants will be randomly assigned to receive the procedure p…

This study looks at how different parts of the brain work together in people with Parkinson's disease who are getting deep brain stimulation (DBS). The goal is to understand brain activity related to movement and thinking, which could help make DBS therapy more effective in the f…

This study tests whether computer models can help doctors find the best settings for deep brain stimulation (DBS) in people with essential tremor. Researchers will create personalized brain models to predict which stimulation settings work best, aiming to make the programming pro…

This study is testing whether measuring nerve signals during a procedure called rhizotomy can help doctors better target the treatment for trigeminal neuralgia, a condition that causes severe facial pain. Researchers will record these signals from the face and brain in about 30 a…

This study tests whether a special ultrasound machine can take pictures of brain tumors during surgery. Researchers will compare these images to standard MRI scans to see if ultrasound is a good alternative. The goal is to find a cheaper, faster way to see brain tumors. About 15 …

This study looks at whether walking in nature or in built-up city areas is better for reducing stress and anxiety in adults with prediabetes. About 216 people will walk 150 minutes each week for six weeks in both types of environments. Researchers will measure mood, stress, and h…

This study aims to help prevent behavior problems in children by improving how doctors refer families to parenting programs and by testing an online parenting intervention called eGen. About 600 parents and doctors will take part. The goal is to see if these approaches make paren…

This study uses a special brain scan (MRS) to measure chemicals that show how healthy nerve cells are in adults with Type 3 Gaucher disease. Researchers want to find markers that could help track the disease and response to treatment in the future. About 5 adults with this condit…

This study looks at tiny particles released by cells, called extracellular vesicles, in people with Gaucher disease, carriers, and healthy volunteers. Researchers want to see if these particles are different in size, number, and content, and if they can help explain brain inflamm…

This study follows 40 people with DNA repair disorders such as Cockayne syndrome, xeroderma pigmentosum, and trichothiodystrophy. Researchers will measure changes in movement, balance, and brain function over time. No treatments are given—the goal is to better understand how thes…

This study looks at brain activity in 100 adults with Parkinson's disease who already have a deep brain stimulation (DBS) device. Researchers will use brain scans and tests of movement and thinking to understand how different brain circuits work. The goal is to gather knowledge t…

This study looks at how ongoing jaw pain (TMD) influences the way people drink alcohol. Researchers will compare heavy drinkers with and without TMD pain, both in a lab setting and in daily life. The goal is to understand if pain makes people drink more or differently, which coul…

This study looks at how deep brain stimulation (DBS) affects walking and movement in people with Parkinson's disease who already have a Medtronic Percept DBS device. Researchers will measure brain signals and walking patterns in the lab and at home over several weeks. The goal is…

This study tests a video camera that records the eye to estimate pressure inside the skull, without needles, anesthesia, or touching the eye. About 90 people with and without existing brain pressure monitors will participate. If successful, this could lead to a safer, easier way …

This study tests whether low-intensity focused ultrasound (LIFU) can safely improve thinking and memory in healthy adults. Researchers will use MRI to see if the ultrasound reaches deep brain targets and measure changes in cognitive performance. The goal is to understand how LIFU…

This study looks at what happens in the body during a long fast (up to 3 days) and whether blood changes during fasting can make cancer cells more sensitive to chemotherapy. 15 healthy adults aged 18-65 will complete a supervised fast and provide blood samples. The goal is to und…

This study looks at why people with Parkinson's disease have trouble activating their leg muscles. Researchers will test if stimulating a nerve in the neck (vagus nerve) can improve muscle activation, walking, and balance. The study involves 75 participants and aims to better und…

This study looks at whether adding radiation therapy after surgery for Dupuytren's disease (a hand condition that causes fingers to curl) actually helps patients. About 50 adults who already plan to have surgery will receive radiation afterward. Researchers will track hand functi…

This study is creating a large database of information from 10,000 people who have received or donated an organ at the University of Minnesota. The goal is to collect and store data for future research to improve transplant care. No new treatments or procedures are being tested.

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Researchers will monitor brain activity and sleep quality in 64 adults who already have or will get DBS implants. The goal is to understand which brain circuits are involved in …

This study tests whether giving transmasculine patients a simple educational handout before their surgical consultation helps them feel more confident about deciding to keep or remove their ovaries during a gender-affirming hysterectomy. About 250 transgender and non-binary adult…

This study tests if synchronizing magnetic brain stimulation with specific brain wave patterns can improve treatment for stimulant use disorder. Researchers will enroll 50 adults currently in treatment and abstinent for at least two weeks, plus up to 10 healthy controls. Particip…

This study looks at why young women with post-traumatic stress disorder (PTSD) have a higher risk of heart disease later in life. Researchers will test if drinking beetroot juice, which is rich in nitric oxide, can improve blood vessel function. The study involves 30 premenopausa…

This study looks at how the brain's reward system might keep bulimia nervosa going. Researchers will use brain scans and daily surveys to compare 100 people with bulimia and healthy controls. The goal is to understand what drives binge-purge behavior, not to test a treatment.