University Of Minnesota

This study tests whether a combination of two medications, phentermine and topiramate, can help teenagers with severe obesity avoid regaining weight after losing it. About 100 teens aged 12 to 18 will first follow a meal replacement plan to lose weight, then take either the medic…

This study follows 433 people with long-term pancreatitis who have surgery to remove the pancreas and then receive their own insulin-making cells back. The goal is to see if the surgery reduces pain, improves quality of life, and helps control blood sugar. Participants are observ…

This study follows 201 people who had surgery to fix a dislocating kneecap. Researchers want to see if the shape of the knee bones affects how well the surgery works. Participants will be tracked for at least two years to check if the kneecap stays in place and how well the knee …

This study tests whether empagliflozin, a diabetes medication, is safe and tolerable for overweight adults with cystic fibrosis-related diabetes (CFRD). Eight participants will receive either the drug or a placebo, then switch after a washout period. The goal is to gather early d…

This study tests a device that uses sound and mild stimulation to help people with tinnitus (ringing in the ears). The sound is customized to avoid the exact pitch of each person's tinnitus, which may make it more comfortable to use. Twenty adults with moderate to severe tinnitus…

This study tests whether a 12-week mobile intervention can improve cognitive function and motivation in people with early psychosis. Researchers will follow 400 participants already receiving coordinated specialty care for 18 months, comparing those who use the mobile program to …

This study tests whether giving doctors real-time feedback during colonoscopy helps them find more polyps, which could improve colorectal cancer detection. Over 4,000 procedures will be analyzed. The study is currently suspended.

This study looks at whether a special training program for senior companions helps people with memory loss or dementia feel less lonely and have a better quality of life. About 342 volunteers and clients in Minnesota are taking part. The training is being added to the usual onboa…

This study aims to develop better ways to take and analyze MRI pictures of the body. It will involve 500 healthy adults aged 18 and older. The goal is to improve how MRI works, not to treat any disease.

This study was designed to see if giving new anesthesia residents access to a library of real intubation videos helps them learn to intubate more quickly and with less stress. It planned to compare the number of attempts, time, difficulty, and stress levels between residents who …

This study looks at how different types of exercise affect the way your body processes fat and sugar, which is linked to insulin resistance and type 2 diabetes. Researchers will study healthy lean people and overweight or obese individuals before and after 16 weeks of supervised …

This study looks at whether special exercises for the throat muscles can improve obstructive sleep apnea. Thirty adults with sleep apnea will use myofunctional therapy devices for 3 months. Researchers will measure muscle pressure in the throat before and after the exercises to u…

This study follows 60 people with Parkinson's disease who are scheduled for deep brain stimulation (DBS) surgery. Researchers will track their brain activity, movement, and thinking skills before, during, and after the procedure. The goal is to learn more about how DBS works and …

This study looks at whether the Club 25 program, where students pledge to donate blood 25 times in their life, can increase blood donations in Malawian secondary schools. About 35,000 students from 30 schools will take part, with half the schools using Club 25 and the other half …

This study compares two teaching methods to help children aged 5 to 9 with developmental language disorder learn grammar. One method uses direct instruction (explicit), while the other relies on natural learning (implicit). About 111 children will participate, and researchers wil…