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Kidney clues may predict eye swelling after cataract surgery in diabetes patients

NCT ID NCT07723846

Knowledge-focused Sponsor: Thammasat University Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (paused)
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Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jul 23, 2026 · Last updated Sep 01, 2026 · Updated 3 times

Summary

This study looks at whether diabetic kidney disease and blood-sugar control before surgery can help predict a common complication called pseudophakic macular edema (PME) — swelling of the central retina — after cataract surgery in people with type 2 diabetes. Researchers will review medical records of about 428 patients who had uncomplicated cataract surgery, comparing those with and without kidney damage. The goal is to see if kidney function tests add useful information beyond standard blood-sugar levels for identifying who is at higher risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If kidney markers prove useful, doctors could better identify which diabetes patients need closer monitoring after cataract surgery.
What could go wrong
This is a retrospective study using existing records, so it can show links but not prove cause and effect. Results may not apply to all diabetes patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 428 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults with type 2 diabetes mellitus who underwent uncomplicated phacoemulsification with posterior-chamber intraocular lens implantation in the in-patient and out-patient services of the Department of Ophthalmology, Thammasat University Hospital, during the study window, and who have a preoperative HbA1c, a preoperative renal function assessment (eGFR and/or UACR), and baseline and postoperative macular OCT documented in the electronic medical record.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of type 2 diabetes mellitus at the time of surgery * Aged ≥18 years * Underwent uncomplicated phacoemulsification with posterior-chamber IOL implantation at TUH during the study period * Preoperative HbA1c documented within 3 months before surgery * Preoperative renal function within 6 months before surgery: serum creatinine (for CKD-EPI 2021 eGFR) and/or spot urine albumin-creatinine ratio (UACR) * Baseline spectral-domain macular OCT within 1 month before surgery * Postoperative OCT available at both 1 month and 3 months after surgery * Minimum 3 months of postoperative follow-up documented Exclusion Criteria: * Pre-existing macular disease (age-related macular degeneration, epiretinal membrane, macular hole, central serous chorioretinopathy, or clinically significant diabetic macular edema at the time of surgery) * Intraoperative complication (posterior-capsule rupture, vitreous loss, zonulolysis, or dropped nucleus) * Prior intraocular surgery in the study eye (vitrectomy, glaucoma surgery, or previous cataract surgery) * Prior intravitreal injection before cataract surgery * Prior posterior-segment or macular laser photocoagulation within 6 months before surgery * Uveitis, retinal vein occlusion, retinal detachment, or any non-diabetic retinal pathology * Prostaglandin-analogue use at the time of surgery * Type 1 diabetes mellitus (may be examined in a sensitivity analysis) * Insufficient data (missing HbA1c, renal function, or postoperative OCT) * Bilateral simultaneous surgery (only the first operated eye is included if surgery is sequential)

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Conditions

The condition(s) this trial relates to.

cataract diabetic kidney disease macular retinal edema type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cataract (post-operative cataract surgery follow-up) Cataract and iol surgery Diabetes mellitus, type 2 Diabetic nephropathies Pseudophakic macular edema

Contacts and locations

Locations

  • Thammasat University Hospital, Department of Ophthalmology

    Pathum Thani, Khlong Luang, 12120, Thailand

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