Could a gut zapping procedure free diabetics from insulin?
NCT ID NCT06655740
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tests a device that uses radiofrequency vapor to ablate (remove) a thin layer of the duodenum (the first part of the small intestine) in 16 adults with type 2 diabetes who need insulin. The goal is to see if this procedure, with or without the drug semaglutide, is safe and can help patients stop insulin therapy while keeping blood sugar under control. Participants will be followed for about 6 months to check safety and whether they remain insulin-free with an HbA1c of 7.5% or lower.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
RF vapor ablation device and semaglutide
What this could lead to
If successful, this could offer a non-drug procedure to help some type 2 diabetes patients stop insulin injections, possibly combined with semaglutide.
What could go wrong
This is a very small early pilot study (16 people) with no control group. The procedure involves ablating part of the gut, which carries risks like bleeding or infection. Results may not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Clinica Colonial
Santiago, Chile