New drug combo targets Hard-to-Treat cancers in early trial
NCT ID NCT03875820
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase I trial tests a combination of two oral drugs, defactinib and VS-6766, in people with advanced solid tumors such as non-small cell lung cancer, low-grade serous ovarian cancer, and pancreatic cancer. The study aims to find the safest dose and evaluate how well the drugs work together. About 87 participants will be enrolled in two parts: dose escalation and dose expansion.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- defactinib and VS-6766 (two oral drugs that target cancer cell growth signals)
- What this could lead to
- If successful, this could lead to a new treatment option for people with advanced solid tumors that have not responded to standard therapies.
- What could go wrong
- This is an early Phase I trial with a small number of participants, so the combination may not prove effective or may cause significant side effects. Results may not apply to all cancer types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Christie NHS Foundation Trust
Manchester, Greater Manchester, M20 4BX, United Kingdom
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The Newcastle Upon Tyne Hospitals NHS Foundation Trust - Freeman Hospital
Newcastle, NE7 7DN, United Kingdom
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The Royal Marsden NHS Foundation Trust
Sutton, Surrey, SM2 5PT, United Kingdom
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The Royal Marsden NHS Foundation Trust - Gynecology Unit
London, SW3 6JJ, United Kingdom
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The Royal Marsden NHS Foundation Trust - Gynecology Unit
Sutton, SM2 5PT, United Kingdom
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