Double immune attack: can two drugs save Insulin-Making cells in new diabetes?
NCT ID NCT03929601
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving two immune-calming drugs (rituximab followed by abatacept) can better preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes, compared to rituximab alone. About 74 participants aged 8 to 45 will receive the drug combo or a placebo over 24 months. The goal is to see if the combination helps maintain natural insulin production longer, potentially easing diabetes management.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Barbara Davis Center for Childhood Diabetes
Aurora, Colorado, 80045, United States
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Benaroya Research Institute
Seattle, Washington, 98101, United States
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Childrens Hospital of Orange County
Orange, California, 92868, United States
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Columbia University
New York, New York, 10032, United States
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Indiana University - Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
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Joslin Diabetes Center
Boston, Massachusetts, 02215, United States
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Queensland Children's Hospital
South Brisbane, Queensland, 4101, Australia
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Sanford Children's Specialty Clinic
Sioux Falls, South Dakota, 57105, United States
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Stanford University
Palo Alto, California, 94304, United States
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The Children's Mercy Hospital
Kansas City, Kansas, 64114, United States
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University of California San Francisco
San Francisco, California, 94158, United States
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University of Florida
Gainesville, Florida, 32610, United States
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University of Miami
Maimi, Florida, 33136, United States
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University of Minnesota
Minneapolis, Minnesota, 55455, United States
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University of Pittsburg
Pittsburgh, Pennsylvania, 15224, United States
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University of Texas Southwestern
Dallas, Texas, 75390, United States
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Vanderbilt Eskind Diabetes Center
Nashville, Tennessee, 37232, United States
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Walter and Eliza Hall Institute of Medical Research
Melbourne, Victoria, 3050, Australia
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Yale University
New Haven, Connecticut, 06520, United States