Double immune attack: can two drugs save Insulin-Making cells in new diabetes?

NCT ID NCT03929601

Ongoing Disease control Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving two immune-calming drugs (rituximab followed by abatacept) can better preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes, compared to rituximab alone. About 74 participants aged 8 to 45 will receive the drug combo or a placebo over 24 months. The goal is to see if the combination helps maintain natural insulin production longer, potentially easing diabetes management.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 1 DIABETES MELLITUS

Contacts and locations

Locations

Barbara Davis Center for Childhood Diabetes

Aurora, Colorado, 80045, United States
Benaroya Research Institute

Seattle, Washington, 98101, United States
Childrens Hospital of Orange County

Orange, California, 92868, United States
Columbia University

New York, New York, 10032, United States
Indiana University - Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Joslin Diabetes Center

Boston, Massachusetts, 02215, United States
Queensland Children's Hospital

South Brisbane, Queensland, 4101, Australia
Sanford Children's Specialty Clinic

Sioux Falls, South Dakota, 57105, United States
Stanford University

Palo Alto, California, 94304, United States
The Children's Mercy Hospital

Kansas City, Kansas, 64114, United States
University of California San Francisco

San Francisco, California, 94158, United States
University of Florida

Gainesville, Florida, 32610, United States
University of Miami

Maimi, Florida, 33136, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Pittsburg

Pittsburgh, Pennsylvania, 15224, United States
University of Texas Southwestern

Dallas, Texas, 75390, United States
Vanderbilt Eskind Diabetes Center

Nashville, Tennessee, 37232, United States
Walter and Eliza Hall Institute of Medical Research

Melbourne, Victoria, 3050, Australia
Yale University

New Haven, Connecticut, 06520, United States

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