TYPE 1 DIABETES MELLITUS

This study is testing a smartphone app called PACTAID, designed to help adults with type 1 diabetes manage their blood sugar levels during and after exercise. Participants will use the app while on their automated insulin pump system for several weeks. The goal is to see if the a…

This study is testing whether a structured education program helps adults with type 1 diabetes manage their condition better. 150 participants will attend classes covering diet, exercise, insulin use, and complication prevention, followed by regular check-ups for one year. Resear…

This is a very early safety study testing a one-time, personalized cell therapy called GNTI-122 in adults recently diagnosed with type 1 diabetes. The therapy is made from a patient's own blood cells and aims to help the body better control blood sugar. Researchers will monitor 1…

This study is testing whether an inhaled insulin called Afrezza, used with a daily long-acting insulin shot, is safe and effective for controlling blood sugar in young people (ages 10-18) who were just diagnosed with type 1 diabetes. It will measure how well the treatment keeps b…

This study aims to collect real-world safety data on the Twiist automated insulin delivery system, which is designed to help manage type 1 diabetes. It will follow 1,875 adults and children in the U.S. who are already using the Twiist system for 12 months. The main goal is to tra…

This study is testing whether a new automated insulin pump system called MiniMed NMX8 is safe for people with diabetes. The trial will include 400 children and adults with type 1 or type 2 diabetes who will use the pump for 90 days while researchers monitor their blood sugar leve…

This large, late-stage study is testing whether an intravenous drug called teplizumab can help young people (ages 1-25) who were recently diagnosed with type 1 diabetes. The goal is to see if the drug can help the body preserve its own ability to make some insulin, potentially re…

This study follows people with Type 1 diabetes who previously received experimental islet cell transplants to see how well the treatment continues to work over time. Researchers will monitor about 30 participants who still have functioning transplanted cells and are taking immune…

This study is testing if a new continuous glucose monitoring (CGM) system helps adults with type 1 or insulin-dependent type 2 diabetes keep their blood sugar in a healthy range better than the standard finger-prick method. About 270 participants will be randomly assigned to use …

This study is testing if a short, brisk walk can help control blood sugar when someone with type 1 diabetes takes their mealtime insulin late. Researchers are enrolling 30 young adults to see if combining a 15-minute walk with a late insulin dose works better than the late dose a…

This study aims to understand why insulin pumps and glucose monitors often cause skin irritation, rashes, or lumps in people with type 1 diabetes. Researchers will use non-invasive scans to measure skin health and blood flow at device attachment sites in 150 participants. The goa…

This study is testing a new drug, Tegoprubart, combined with standard medications to see if it can safely help transplanted islet cells survive and produce insulin in people with severe type 1 diabetes. The goal is to reduce or eliminate the need for insulin injections and preven…

This is the first human study testing a new treatment called OPF-310, which involves transplanting specially encapsulated insulin-producing cells from pigs into people with unstable type 1 diabetes. The goal is to see if these transplanted cells can safely help control blood suga…

This early-stage study is testing if two modified insulin formulas work faster than a standard one. It involves 20 adults with type 1 diabetes who use insulin pumps. Researchers will give participants different insulin shots and take frequent blood samples to see which one starts…

This study is testing a new digital survey platform called Spotlight AQ to see if it helps teens and young adults with Type 1 Diabetes better manage their condition. Researchers will compare the survey tool to standard clinic visits to see if it improves blood sugar control and i…

This study is testing whether teaching children with type 1 diabetes through games and interactive methods helps them understand their condition better and improves their daily life. Researchers will work with 52 children aged 8-12, comparing those who receive standard education …

This study is testing if using an add-on pill to lower the amount of insulin needed can improve heart and blood vessel health in people with type 1 diabetes. Researchers will compare people with type 1 diabetes to people with a milder genetic form of diabetes and healthy voluntee…

This early-stage clinical trial is testing an investigational drug called CNP-103 in people aged 12-35 who were recently diagnosed with type 1 diabetes. The main goal is to see if the treatment is safe and if it can help protect the body's remaining insulin-producing cells. Resea…

This is an early-stage study to check the safety and basic effects of a new investigational drug, LY3938577, for Type 1 Diabetes. It will involve healthy volunteers and people with well-controlled Type 1 Diabetes. Researchers will measure how the drug moves through the body and c…

This study is testing whether an experimental drug called frexalimab can help preserve the body's remaining ability to produce insulin in people recently diagnosed with type 1 diabetes. The trial will involve 192 adults and adolescents who started insulin treatment within the las…

This study is testing if a 14-day intravenous treatment called teplizumab can safely delay the progression to full-blown type 1 diabetes in Japanese children and adults aged 8 to 34. Participants are in an early stage of the disease, where they have signs of it but no major sympt…

This study is testing how accurate a new, painless glucose sensor is. The device, called the LabPatch, is a small patch placed on a finger to measure blood sugar without drawing blood. Researchers will compare its readings to standard finger-prick meters and a lab analyzer in 60 …

This study is testing how well a new continuous glucose monitor (CGM) called CareSens Air 3 measures blood sugar levels in adults with type 1 diabetes. Participants will wear the new device and a comparison device for 16 days while checking their blood sugar with fingersticks. Th…

This study aims to understand the differences between Type 1 diabetes and a similar adult-onset form called LADA by measuring specific stress-related chemicals in the blood. Researchers will recruit 150 adult patients to provide blood samples during a single visit, with a follow-…

This study aims to understand if a combination of medications targeting blood pressure, cholesterol, and blood sugar can reduce the workload and oxygen needs of the heart and kidneys in people with type 1 diabetes. It will observe 40 adults who are already enrolled in a larger tr…

This study is observing people who were in previous type 1 diabetes treatment trials. Researchers will follow them for up to five years to see how long their bodies continue to make insulin and how their immune systems change. The goal is to gather information that could help des…

This study aims to measure the real-world impact on parents who care for a child with Type 1 diabetes. Researchers will survey 100 caregivers in Canada to understand how it affects their work, healthcare use, and overall quality of life. The goal is to gather information, not to …

This study aims to understand if a serious diabetes complication called diabetic ketoacidosis (DKA) causes early, hidden damage to children's hearts and kidneys. Researchers will measure specific blood markers and perform heart ultrasounds in 45 children: those newly diagnosed wi…

This study aims to create a system to identify people at high risk of developing type 1 diabetes. Researchers will follow 340 people—including diabetes patients, their close family members, and healthy adults—for four years. They will collect blood, urine, and stool samples to lo…

This study aims to find out if a common practice among people using automated insulin pumps—entering 'fake carbs' to get extra insulin—actually helps control blood sugar in children and teens with type 1 diabetes. It will observe 40 young people who already use this method, havin…

This study aims to use artificial intelligence (AI) to analyze existing health records and glucose data from 800 adults with type 1 diabetes. The goal is to discover if there are distinct subgroups of patients who experience the disease differently. Participants will not receive …

This study is a survey to understand the experiences and choices of adults with type 1 diabetes regarding automated insulin delivery systems, often called 'artificial pancreas' or hybrid closed-loop systems. Researchers want to learn what factors influence people's decisions when…

This early research study aims to understand if two substances—the antidepressant fluoxetine (Prozac) and/or a hormone called DHEA—can help the body better defend itself against dangerously low blood sugar (hypoglycemia) in people with Type 1 diabetes. Researchers will measure th…