TYPE 1 DIABETES MELLITUS

This study tests whether teplizumab, a drug already approved in the US, can safely delay the start of full-blown type 1 diabetes in Japanese people aged 8 to 34 who are at high risk (Stage 2). Participants will receive a 14-day IV treatment and be monitored for side effects and h…

This study tests a new drug, CNP-103, in people aged 12 to 35 who were diagnosed with stage 3 type 1 diabetes within the last 6 months. The goal is to see if the drug is safe and can help control the disease. Participants will receive either the drug or a placebo, and researchers…

This Phase 2 trial tests a drug called rezpegaldesleukin in people recently diagnosed with type 1 diabetes (within 100 days). The goal is to see if it can help the body keep producing some insulin, reducing the need for injected insulin. 66 participants will receive either the dr…

This study tests a new approach for teens (ages 10-17) recently diagnosed with type 1 diabetes. They will use an inhaled insulin called Afrezza along with a long-acting injected insulin. The goal is to see if this combination helps keep blood sugar in a healthy range and is safe …

This study compares a continuous glucose monitor (CGM) to standard fingerstick testing in 270 adults with type 1 or type 2 diabetes who use insulin injections. Participants wear the Accu-Chek SmartGuide sensor to track blood sugar levels continuously. The goal is to see if the CG…

This study tests a drug called teplizumab in people aged 1 to 25 who were recently diagnosed with type 1 diabetes. The goal is to see if teplizumab can help control blood sugar and reduce the need for insulin at mealtimes. Participants will receive either teplizumab or a placebo …

This study tests a digital tool that helps children under 12 with type 1 diabetes calculate their insulin doses. The tool considers factors like carbs, blood sugar levels, and trends. Researchers will compare blood sugar control (HbA1c) over 6 months between kids using the tool p…

This study is checking if a new insulin pump (NMX8) and continuous glucose monitor (DS5/Simplera Sync) are safe for people with type 1 or type 2 diabetes. About 400 participants, ages 7 to 85, will first wear the sensor for up to 40 days, then use the pump for about 90 days while…

This study compares a new insulin pump system, Omnipod 6, to the current Omnipod 5 in 200 people with type 1 or type 2 diabetes who have poor blood sugar control. Participants will use both pumps for a set time to see which one helps keep blood sugar in a healthy range more effec…

This study tests whether tirzepatide, a weekly injection already used for type 2 diabetes, can help adults with type 1 diabetes use an automated insulin pump without needing to count carbohydrates at meals. About 105 participants will be randomly assigned to receive tirzepatide o…

This study tests whether taking a probiotic called Desulfovibrio piger for 4 weeks can lower inflammation and help preserve the body's own insulin production in people who have had type 1 diabetes for more than 5 years. Twenty adults with remaining beta cell function will receive…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This early-stage study is testing a new treatment called GNTI-122 for adults who were recently diagnosed with type 1 diabetes. The therapy is made from a person's own blood cells and is designed to help rebalance the immune system. Sixteen participants will receive either a low o…

This study tests whether dimethyl fumarate, a drug already used for multiple sclerosis, can help preserve the body's ability to make insulin in adults with type 1 diabetes. About 96 people will either receive the drug plus standard insulin therapy or insulin alone for 24 weeks, t…

This phase 2 trial is testing a drug called MTX228 (Tolimidone) in 24 adults with type 1 diabetes who still produce some insulin. The goal is to see if the drug can help regrow the beta cells that make insulin, which could lower the amount of insulin they need to inject and impro…

This study follows up to 30 people with type 1 diabetes who previously received islet cell transplants. Researchers want to see how long the transplanted cells keep working to control blood sugar. Participants must continue taking immunosuppressive drugs to prevent rejection.

This study tests whether the drug Myfortic can prevent the immune system from becoming sensitized after a failed islet transplant in people with type 1 diabetes. Participants have already lost their graft and will take Myfortic alone for two years. The goal is to see if this redu…

This study tests whether a 15-minute brisk walk, taken right after a missed insulin dose, can prevent high blood sugar in people with type 1 diabetes. Researchers will compare blood sugar levels in 30 adults aged 18-24 who either take insulin before a meal, after a meal, or after…

This study tests whether a lab-made antibody called Tegoprubart can safely prevent the immune system from attacking transplanted islet cells in people with type 1 diabetes who have dangerous low blood sugar. The goal is to help patients stop needing insulin without using standard…

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells enclosed in a protective capsule, for people with unstable type 1 diabetes who still experience severe low blood sugar episodes despite using an automated insulin pump and continuous glucose m…

This Phase 3 trial is testing a drug called Neovasculgen, given as injections into the leg muscles, to see if it can help heal foot ulcers in people with diabetes. The study will include 144 adults with type 1 or type 2 diabetes who have a non-healing foot ulcer. Participants wil…

This early-stage study tests an experimental drug called LY3938577 in healthy volunteers and people with type 1 diabetes. The main goals are to see how the body processes the drug and whether it can safely lower blood sugar. The study has four parts, comparing the drug to insulin…

This study is tracking 1,875 people with type 1 diabetes (ages 6 and up) who are already using the Twiist automated insulin delivery system. Researchers are monitoring for severe low blood sugar events, diabetic ketoacidosis, and hospitalizations related to the device. The goal i…

This study is testing a mobile app called glUCModel that uses artificial intelligence to predict glucose levels and help people with type 1 diabetes decide how much insulin to take. About 34 adults aged 18 to 65 will use the app for several weeks while wearing a continuous glucos…

This study is testing how well a new continuous glucose monitor, called CareSens Air 3, measures blood sugar levels in adults with type 1 diabetes. Researchers will compare the monitor's readings to standard lab measurements. The goal is to see if the device is accurate and preci…

This study tests a group-based program called Supporting Teen Problem Solving (STePS) designed to reduce diabetes-specific emotional distress in teenagers with type 1 diabetes. The program is based on cognitive-behavioral and problem-solving approaches. Researchers will enroll 36…

This study tests whether a four-week online self-compassion course can reduce diabetes-related distress, self-criticism, and shame in adults with type 1 or type 2 diabetes. Researchers will enroll 50 participants to see if the program is feasible and acceptable. The course includ…

This study tests whether a gamified education program can improve health literacy and quality of life in children aged 8-12 with type 1 diabetes. Half of the 52 participants will receive the gamified program plus standard education, while the other half gets standard education al…

This study tests a survey called Spotlight AQ that teens and young adults with type 1 diabetes fill out before their clinic visit. The survey asks about their therapy, feelings, social life, and diabetes knowledge. Doctors then use the results to guide the visit. The goal is to s…

This study tests whether a structured education program, combined with regular follow-up visits, can help adults with type 1 diabetes better control their blood sugar. Researchers at Peking University First Hospital will enroll 150 participants and provide courses on diet, exerci…

This study looks at basic blood and clotting measures in children with type 1 diabetes compared to healthy children. Researchers want to see if diabetes causes changes in red blood cells or clotting that could lead to complications. The study involves children aged 1 month to 18 …

This study follows people who previously took part in type 1 diabetes trials to see how long their bodies continue to produce insulin. Researchers will also look at how immune system changes relate to insulin production. The goal is to gather information that could lead to better…

This study is testing a new device that combines an insulin pump with a continuous glucose monitor in one unit for adults with type 1 diabetes. The goal is to see how insulin delivery near the sensor affects glucose readings and to gather data to improve the design. About 40 part…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study looks at how social factors and health literacy affect the ability of people with diabetes to manage their own care. Researchers will survey 400 adults with type 1 or type 2 diabetes to understand these connections. The goal is to design better support programs that he…

This study is observing 55 adolescents with type 1 diabetes to understand the many factors that influence their physical activity, from personal motivation to school and community support. Participants will wear an activity tracker for a week and complete questionnaires about the…

This study tests whether a machine learning program can detect lipohypertrophy—hidden lumps under the skin caused by insulin injections—using portable ultrasound. About 100 people with diabetes will first have their injection sites scanned. In a second phase, 40 people found to h…

This observational study will measure oxidative stress and antioxidant levels in 75 people with type 1 diabetes and 75 with LADA (a slow-progressing form of autoimmune diabetes). Researchers will collect blood samples and compare markers like d-ROMs, BAP, and HbA1c to see if oxid…

This study follows people with type 1 diabetes who have had an islet transplant that later stopped working. Researchers want to learn how the body's immune system changes after the graft is lost. The goal is to gather information, not to test a new treatment.

This study looks at children aged 2-16 who are newly diagnosed with type 1 diabetes. It checks if those who also have diabetic ketoacidosis (a serious complication) show early signs of kidney or heart injury using special blood and urine tests. The goal is to better understand wh…

This study is working to create a system that can identify people at high risk for type 1 diabetes. Researchers will follow 340 people, including patients with type 1 diabetes and their close relatives, for four years. They will collect blood, urine, and stool samples each year t…

This study aims to identify different subgroups among people with type 1 diabetes by analyzing their health data using artificial intelligence. Researchers will look at clinical records and glucose monitoring information from 800 adults. Participants do not need to do anything ex…

This observational study will use special PET scans to measure how much oxygen the heart and kidneys use in people with type 1 diabetes. Researchers want to see if a more intensive treatment plan (multifactorial intervention) lowers oxygen demand compared to standard care. Forty …

This early-phase study looks at whether reducing high insulin levels (common in type 1 diabetes) with an SGLT2 inhibitor can improve heart and blood sugar health. Researchers will compare people with type 1 diabetes, those with a mild genetic diabetes (GCK-MODY), and healthy volu…

This study looks at how caring for a child recently diagnosed with type 1 diabetes affects caregivers' work, daily life, and well-being. About 100 Canadian caregivers will fill out online questionnaires about their productivity, healthcare use, and quality of life. No treatment i…

This early study tests whether two modified insulins (diluted U-200 Humalog and diluted U-500 Humulin) work faster than a current rapid insulin (Lyumjev) in 20 adults with type 1 diabetes who use insulin pumps. Participants receive each insulin after a meal, and researchers measu…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This early-phase study is testing whether the antidepressant fluoxetine (Prozac) and/or the hormone DHEA can improve the body's ability to defend against low blood sugar in people with type 1 diabetes. About 60 adults will take the drugs or a placebo for 8 weeks, then undergo two…

This study looks at whether entering fake carbohydrates into the MiniMed 780G insulin pump improves blood sugar control in children and teens with type 1 diabetes. Forty participants aged 7-18 will try two weeks with fake carbs and two weeks without, and their glucose levels will…

This study looks at why diabetes devices like insulin pumps and continuous glucose monitors can cause skin irritation, eczema, or fatty lumps. Researchers will use non-invasive tools to measure skin health in 150 people with type 1 diabetes. The goal is to find ways to prevent th…