TYPE 1 DIABETES MELLITUS

This study tests a new drug called Tegoprubart in people with type 1 diabetes who have dangerous low blood sugar and are getting islet cell transplants. The drug aims to prevent the immune system from attacking the new cells without using standard anti-rejection medicines that ca…

This study compares a new online survey (Spotlight AQ) to standard check-in forms for teens and young adults aged 16-25 with type 1 diabetes. Researchers want to see if using the survey before clinic visits leads to better blood sugar levels (A1c) and if patients and doctors find…

This study checks if a new insulin pump (NMX8) and a continuous glucose monitor are safe for people with type 1 or type 2 diabetes. About 400 participants aged 7 to 85 will use the system for up to 90 days while tracking meals and exercise. The goal is to see how well the system …

This study tests a 14-day IV treatment called teplizumab in 10 Japanese people aged 8 to 34 who have Stage 2 type 1 diabetes. The goal is to see if it can safely delay the disease from getting worse. Teplizumab is already approved in the US for this purpose, and this trial focuse…

This study tests an inhaled insulin called Afrezza, taken with a long-acting insulin shot, in 100 teens aged 10 to 18 who were just diagnosed with type 1 diabetes. The goal is to see if this combination helps keep blood sugar in a healthy range and makes treatment easier for teen…

This study looks at whether a 15-minute brisk walk can help people with type 1 diabetes manage high blood sugar when they forget to take their insulin before a meal. Researchers will ask 30 adults aged 18-24 to take their insulin after eating and then walk. The goal is to see if …

This study tests whether taking a specific probiotic (Desulfovibrio piger) for 4 weeks can lower inflammation and help preserve the body's ability to make insulin in adults who have had type 1 diabetes for more than 5 years. Twenty participants will be randomly assigned to receiv…

This study tests a drug called MTX228 to see if it can help regrow insulin-producing beta cells in adults with type 1 diabetes. About 24 participants will receive different doses to find the best one. The goal is to reduce the amount of insulin they need to inject and improve blo…

This study tests an experimental drug called rezpegaldesleukin in people diagnosed with type 1 diabetes within the past 100 days. The goal is to see if the drug can help the body keep making its own insulin, reducing the need for injected insulin. About 66 participants will recei…

This study compares a continuous glucose monitor (CGM) to standard finger-prick testing in 270 adults with type 1 or type 2 diabetes who use insulin injections. The goal is to see if the CGM helps people spend more time with blood sugar in the target range of 70-180 mg/dL. Partic…

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells enclosed in a protective capsule, for people with unstable type 1 diabetes who still experience dangerous low blood sugar episodes despite using an automated insulin pump and continuous glucos…

This study watches how the Twiist insulin pump works in everyday life for people with type 1 diabetes. It includes about 1,875 adults and children aged 6 and older who already use the pump. Researchers will track serious low blood sugar events, diabetic ketoacidosis, and any hosp…

This study tests a drug called frexalimab in 192 adults and teens recently diagnosed with type 1 diabetes who are already using insulin. The goal is to see if frexalimab can help preserve the body's ability to produce some insulin, reducing the amount of insulin needed long-term.…

This early-stage study tests a new cell therapy called GNTI-122 in 16 adults recently diagnosed with type 1 diabetes. The therapy is made from the participant's own blood cells and aims to help the body better manage blood sugar by preserving insulin-making cells. The main goal i…

This study follows about 30 people with type 1 diabetes who previously received islet cell transplants in earlier trials. The goal is to see how long the transplanted cells continue to work and to monitor safety. Participants will need to stay on lifelong immunosuppressive medica…

This study tests whether fluoxetine (Prozac) and/or DHEA (a natural hormone) can improve the body's ability to defend against low blood sugar in people with type 1 diabetes. About 60 adults aged 18-50 will receive either one or both treatments or a placebo. The goal is to see if …

This study tests whether dimethyl fumarate, a drug used for multiple sclerosis, can help preserve the body's ability to produce insulin in adults with type 1 diabetes. About 96 adults aged 18-65 with recent-onset type 1 diabetes will take the drug or receive standard insulin ther…

This study tests a new medicine called CNP-103 in people aged 12 to 35 who were diagnosed with type 1 diabetes within the last 6 months. The goal is to see if the drug is safe and can help preserve the body's ability to produce some insulin, reducing the need for lifelong insulin…

This early-phase study is testing a new medicine called LY3938577 in healthy volunteers and people with type 1 diabetes. The main goals are to see how the drug moves through the body, how safe it is, and whether it can lower blood sugar. The study has four parts and compares the …

This study tests a drug called teplizumab in people aged 1 to 25 who were recently diagnosed with type 1 diabetes. The goal is to see if it helps control blood sugar and reduces the need for insulin at mealtimes. Participants receive either teplizumab or a placebo by IV, and rese…

This study looks at whether the drug Myfortic can prevent the body from developing antibodies that would make future transplants harder. It involves 18 adults with type 1 diabetes whose islet transplants have stopped working. Participants take Myfortic for two years to see if it …

This study checks how accurate a new glucose sensor called LabPatch is for people with type 1 or type 2 diabetes who use insulin. About 60 adults will wear the sensor for 6 hours while their blood sugar is measured and compared to standard lab tests and two commercial meters. The…

This study is testing how well a new continuous glucose monitor, the CareSens Air 3, measures blood sugar levels in adults with type 1 diabetes. About 32 adults aged 18-65 who use insulin therapy will wear the device to check its accuracy and precision. The goal is to see if this…

This study tests a smartphone app called PACTAID in 20 adults with type 1 diabetes who use automated insulin delivery systems. The app helps manage blood sugar during and after exercise. The goal is to improve glucose control and reduce cardiovascular risks.

This study tests whether a 4-week online self-compassion training program is feasible and helpful for adults with type 1 or type 2 diabetes who feel distressed about their condition. About 50 participants will be randomly assigned to the program or a control group. The goal is to…

This study tests whether teaching children with type 1 diabetes through games (gamification) can improve their health knowledge and quality of life. About 52 children aged 8-12 will be split into two groups: one gets standard education, the other gets game-based lessons too. Rese…

This study is testing whether a structured education course can help adults with type 1 diabetes improve their self-management skills and blood sugar levels. Researchers will enroll 150 participants who will attend classes covering diet, exercise, insulin use, and more, followed …

This study looks at why insulin pumps and continuous glucose monitors can cause skin irritation, eczema, or fatty lumps in children with type 1 diabetes. Researchers will use safe, non-invasive tools to measure skin health and blood flow. The goal is to find better ways to preven…

This study follows 60 people with type 1 diabetes who have had an islet transplant that no longer works. Researchers want to learn how the body's immune system changes after the transplant fails. Participants will be monitored over time to track these changes.

This study is creating a system to identify people at high risk for type 1 diabetes (T1D) before symptoms appear. Researchers will follow 340 participants—including T1D patients, their close relatives, and healthy volunteers—for up to 4 years. They will collect blood, urine, and …

This early-phase study looks at whether reducing high insulin levels with an SGLT2 inhibitor can improve heart and blood sugar health in people with type 1 diabetes. Researchers will compare results with people who have a mild genetic form of diabetes (GCK-MODY) and healthy volun…

This observational study looks at whether a combination of treatments can lower the oxygen demand of the heart and kidneys in people with type 1 diabetes. Researchers will compare those receiving intensive care to those on standard treatment. Forty adults with long-standing type …

This study looks at oxidative stress—a kind of cellular wear and tear—in people with type 1 diabetes or LADA (a slow-progressing form of autoimmune diabetes). Researchers will collect blood samples from 150 adults to measure stress markers and see how they relate to blood sugar c…

This study looks at why some teens with type 1 diabetes are more active than others. Researchers will ask 55 teens aged 9-18 to wear an activity tracker for a week and fill out surveys about their habits, feelings, and support. The goal is to find out what helps or hinders physic…

This study looks at whether diabetic ketoacidosis (DKA) causes early injury to the kidneys and heart in children newly diagnosed with type 1 diabetes. Researchers will measure specific markers in the blood and urine of 45 children with and without DKA, plus healthy controls. The …

This study aims to find different subgroups among people with type 1 diabetes using artificial intelligence. Researchers will analyze health and glucose data from 800 adults who already use continuous glucose monitors. Participants do not need extra tests or visits—just permissio…

This study looks at how caring for a child with type 1 diabetes affects parents' work, daily life, and well-being. Researchers will survey 100 Canadian caregivers to measure lost productivity, healthcare use, and quality of life. The goal is to better understand the real-world bu…

This study looks at whether entering 'fake carbs' into an insulin pump improves blood sugar control in children and teens with type 1 diabetes. About 40 kids aged 7-18 who use the MiniMed 780G system will be observed over two weeks. The goal is to see if this common practice actu…

This study tests two experimental insulin formulas to see if they work faster than a standard insulin in adults with type 1 diabetes. Twenty participants will receive each insulin during three separate visits, and blood samples will track how quickly the insulin enters the bloods…

This study is observing people who previously participated in type 1 diabetes treatment trials. Researchers will follow them for up to five years to see how long their bodies continue to produce insulin naturally and how their immune systems change over time. The goal is to gathe…